{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:12:08Z","timestamp":1768561928909,"version":"3.49.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T00:00:00Z","timestamp":1492992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T00:00:00Z","timestamp":1492992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1038\/bmt.2017.43","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T14:23:26Z","timestamp":1493043806000},"page":"863-869","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Associations between levels of insulin-like growth factor 1 and sinusoidal obstruction syndrome after allogeneic haematopoietic stem cell transplantation"],"prefix":"10.1038","volume":"52","author":[{"given":"S","family":"Weischendorff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Sengel\u00f8v","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C H","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A E","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L P","family":"Ryder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Juul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K G","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,4,24]]},"reference":[{"key":"BFbmt201743_CR1","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1056\/NEJMra052638","volume":"354","author":"EA Copelan","year":"2006","unstructured":"Copelan EA . Hematopoietic stem-cell transplantation. N Engl J Med 2006; 354: 1813\u20131826.","journal-title":"N Engl J Med"},{"key":"BFbmt201743_CR2","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/S0140-6736(09)60237-3","volume":"373","author":"JLM Ferrara","year":"2009","unstructured":"Ferrara JLM, Levine JE, Reddy P, Holler E . Graft-versus-host disease. Lancet 2009; 373: 1550\u20131561.","journal-title":"Lancet"},{"key":"BFbmt201743_CR3","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1182\/blood.V95.9.2754.009k25_2754_2759","volume":"95","author":"GR Hill","year":"2000","unstructured":"Hill GR, Ferrara JL . The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. Blood 2000; 95: 2754\u20132759.","journal-title":"Blood"},{"key":"BFbmt201743_CR4","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1038\/bmt.2011.65","volume":"46","author":"E Carreras","year":"2011","unstructured":"Carreras E, Diaz-Ricart M . The role of the endothelium in the short-term complications of hematopoietic SCT. Bone Marrow Transplant 2011; 46: 1495\u20131502.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt201743_CR5","doi-asserted-by":"publisher","first-page":"R150","DOI":"10.1186\/cc9218","volume":"14","author":"NE Spruijt","year":"2010","unstructured":"Spruijt NE, Visser T, Leenen LP . A systematic review of randomized controlled trials exploring the effect of immunomodulative interventions on infection, organ failure, and mortality in trauma patients. Crit Care 2010; 14: R150.","journal-title":"Crit Care"},{"key":"BFbmt201743_CR6","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/bmt.2015.52","volume":"50","author":"M Mohty","year":"2015","unstructured":"Mohty M, Malard F, Abecassis M, Aerts E, Alaskar AS, Aljurf M et al. Sinusoidal obstruction syndrome\/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant 2015; 50: 781\u2013789.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt201743_CR7","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1055\/s-2002-23204","volume":"22","author":"LD DeLeve","year":"2002","unstructured":"DeLeve LD, Shulman HM, McDonald GB . Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease). Semin Liver Dis 2002; 22: 27\u201342.","journal-title":"Semin Liver Dis"},{"key":"BFbmt201743_CR8","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.bbmt.2009.08.024","volume":"16","author":"JA Coppell","year":"2010","unstructured":"Coppell JA, Richardson PG, Soiffer R, Martin PL, Kernan NA, Chen A et al. Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. Biol Blood Marrow Transplant 2010; 16: 157\u2013168.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt201743_CR9","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S1096-6374(03)00038-8","volume":"13","author":"A Juul","year":"2003","unstructured":"Juul A . Serum levels of insulin-like growth factor I and its binding proteins in health and disease. Growth Horm IGF Res 2003; 13: 113\u2013170.","journal-title":"Growth Horm IGF Res"},{"key":"BFbmt201743_CR10","doi-asserted-by":"publisher","first-page":"S43","DOI":"10.1507\/endocrj.43.Suppl_S43","volume":"43","author":"CA Conover","year":"1996","unstructured":"Conover CA . Regulation and physiological role of insulin-like growth factor binding proteins. Endocr J 1996; 43: S43\u2013S48.","journal-title":"Endocr J"},{"key":"BFbmt201743_CR11","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0079-6603(08)60894-6","volume":"60","author":"LS Phillips","year":"1998","unstructured":"Phillips LS, Pao CI, Villafuerte BC . Molecular regulation of insulin-like growth factor-I and its principal binding protein, IGFBP-3. Prog Nucleic Acid Res Mol Biol 1998; 60: 195\u2013265.","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"BFbmt201743_CR12","first-page":"801","volume":"18","author":"S Rajaram","year":"1997","unstructured":"Rajaram S, Baylink DJ, Mohan S . Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. Endocr Rev 1997; 18: 801\u2013831.","journal-title":"Endocr Rev"},{"key":"BFbmt201743_CR13","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3109\/02844319409071186","volume":"28","author":"HH Steenfos","year":"1994","unstructured":"Steenfos HH . Growth factors and wound healing. Scand J Plast Reconstr Surg Hand Surg 1994; 28: 95\u2013105.","journal-title":"Scand J Plast Reconstr Surg Hand Surg"},{"key":"BFbmt201743_CR14","doi-asserted-by":"publisher","first-page":"260","DOI":"10.2174\/1389201033489793","volume":"4","author":"CJ Xian","year":"2003","unstructured":"Xian CJ . Roles of growth factors in chemotherapy-induced intestinal mucosal damage repair. Curr Pharm Biotechnol 2003; 4: 260\u2013269.","journal-title":"Curr Pharm Biotechnol"},{"key":"BFbmt201743_CR15","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/S1471-4892(01)00098-4","volume":"1","author":"GS Howarth","year":"2001","unstructured":"Howarth GS, Shoubridge CA . Enhancement of intestinal growth and repair by growth factors. Curr Opin Pharmacol 2001; 1: 568\u2013574.","journal-title":"Curr Opin Pharmacol"},{"key":"BFbmt201743_CR16","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s11010-013-1828-y","volume":"385","author":"SJ Liu","year":"2014","unstructured":"Liu SJ, Zhong Y, You XY, Liu WH, Li AQ, Liu SM . Insulin-like growth factor 1 opposes the effects of C-reactive protein on endothelial cell activation. Mol Cell Biochem 2014; 385: 199\u2013205.","journal-title":"Mol Cell Biochem"},{"key":"BFbmt201743_CR17","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1161\/01.RES.0000257912.78915.af","volume":"100","author":"T Thum","year":"2007","unstructured":"Thum T, Hoeber S, Froese S, Klink I, Stichtenoth DO, Galuppo P et al. Age-dependent impairment of endothelial progenitor cells is corrected by growth hormone mediated increase of insulin-like growth factor-1. Circ Res 2007; 100: 434\u2013443.","journal-title":"Circ Res"},{"key":"BFbmt201743_CR18","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/sji.12244","volume":"81","author":"K Kielsen","year":"2015","unstructured":"Kielsen K, Jordan KK, Uhlving HH, Pontoppidan PL, Shamim Z, Ifversen M et al. T cell reconstitution in allogeneic haematopoietic stem cell transplantation: prognostic significance of plasma interleukin-7. Scand J Immunol 2015; 81: 72\u201380.","journal-title":"Scand J Immunol"},{"key":"BFbmt201743_CR19","unstructured":"Department of Growth and Reproduction, Rigshospitalet Metodeliste: Copenhagen, Denmark, 2013. Available at: http:\/\/www.hormlabvejl.regionh.dk\/Metodeliste.asp (accessed on 29 January 2017)."},{"key":"BFbmt201743_CR20","unstructured":"The Danish Accreditation Fund. Accreditation for Medical Examination. The Danish Accreditation Fund: Skovlunde, Denmark, 2013. Available at: http:\/\/published.danak.dk\/register.asp?sag=06-1013&nohead=y&lang=e (accessed on 29 January 2017)."},{"key":"BFbmt201743_CR21","first-page":"507","volume":"54","author":"RA Rigby","year":"2005","unstructured":"Rigby RA, Stasinopoulos DM . Generalized additive models for location, scale and shape. Appl Stat 2005; 54: 507\u2013554.","journal-title":"Appl Stat"},{"key":"BFbmt201743_CR22","doi-asserted-by":"publisher","first-page":"e932","DOI":"10.1542\/peds.2008-2491","volume":"123","author":"L Aksglaede","year":"2009","unstructured":"Aksglaede L, Sorensen K, Petersen JH, Skakkebaek NE, Juul A . Recent decline in age at breast development: the copenhagen puberty study. Pediatrics 2009; 123: e932\u2013e939.","journal-title":"Pediatrics"},{"key":"BFbmt201743_CR23","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1210\/jc.2009-1478","volume":"95","author":"K S\u00f8rensen","year":"2010","unstructured":"S\u00f8rensen K, Aksglaede L, Petersen JH, Juul A . Recent changes in pubertal timing in healthy Danish boys: associations with body mass index. J Clin Endocrinol Metab 2010; 95: 263\u2013270.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFbmt201743_CR24","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.cca.2015.12.042","volume":"454","author":"A Damgaard-Olesen","year":"2016","unstructured":"Damgaard-Olesen A, Johannsen TH, Holmboe SA, S\u00f8eborg T, Petersen JH, Andersson A et al. Reference ranges of 17-hydroxyprogesterone, DHEA, DHEAS, androstenedione, total and free testosterone determined by TurboFlow-LC-MS\/MS and associations to health markers in 304 men. Clin Chim Acta 2016; 454: 82\u201388.","journal-title":"Clin Chim Acta"},{"key":"BFbmt201743_CR25","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.intimp.2014.12.038","volume":"25","author":"PL Pontoppidan","year":"2015","unstructured":"Pontoppidan PL, Jordan K, Carlsen AL, Uhlving HH, Kielsen K, Christensen M et al. Associations between gastrointestinal toxicity, micro RNA and cytokine production in patients undergoing myeloablative allogeneic stem cell transplantation. Int Immunopharmacol 2015; 25: 180\u2013188.","journal-title":"Int Immunopharmacol"},{"key":"BFbmt201743_CR26","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1111\/bjh.12558","volume":"163","author":"FL Dignan","year":"2013","unstructured":"Dignan FL, Wynn RF, Hadzic N, Karani J, Quaglia A, Pagliuca A et al. BCSH\/BSBMT guideline: diagnosis and management of veno-occlusive disease (sinusoidal obstruction syndrome) following haematopoietic stem cell transplantation. Br J Haematol 2013; 163: 444\u2013457.","journal-title":"Br J Haematol"},{"key":"BFbmt201743_CR27","first-page":"197","volume":"10","author":"HM Shulman","year":"1992","unstructured":"Shulman HM, Hinterberger W . Hepatic veno-occlusive disease\u2014liver toxicity syndrome after bone marrow transplantation. Bone Marrow Transplant 1992; 10: 197\u2013214.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt201743_CR28","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.bbmt.2015.09.024","volume":"22","author":"J-H Dalle","year":"2015","unstructured":"Dalle J-H, Giralt SA . Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: risk factors and stratification, prophylaxis, and treatment. Biol Blood Marrow Transplant 2015; 22: 400\u2013409.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt201743_CR29","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1097\/00000658-200002000-00014","volume":"231","author":"MG Jeschke","year":"2000","unstructured":"Jeschke MG, Barrow RE, Herndon DN . Insulinlike growth factor I plus insulinlike growth factor binding protein 3 attenuates the proinflammatory acute phase response in severely burned children. Ann Surg 2000; 231: 246\u2013252.","journal-title":"Ann Surg"},{"key":"BFbmt201743_CR30","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1007\/BF03402149","volume":"8","author":"MG Jeschke","year":"2002","unstructured":"Jeschke MG, Barrow RE, Suzuki F, Rai J, Benjamin D, Herndon DN . IGF-I\/IGFBP-3 equilibrates ratios of pro- to anti-inflammatory cytokines, which are predictors for organ function in severely burned pediatric patients. Mol Med 2002; 8: 238\u2013246.","journal-title":"Mol Med"},{"key":"BFbmt201743_CR31","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.2337\/dc08-0553","volume":"31","author":"E Succurro","year":"2008","unstructured":"Succurro E, Andreozzi F, Sciacqua A, Sciaqua A, Hribal ML, Perticone F et al. Reciprocal association of plasma IGF-1 and interleukin-6 levels with cardiometabolic risk factors in nondiabetic subjects. Diabetes Care 2008; 31: 1886\u20131888.","journal-title":"Diabetes Care"},{"key":"BFbmt201743_CR32","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1097\/00003246-200201000-00013","volume":"30","author":"M Spies","year":"2002","unstructured":"Spies M, Wolf SE, Barrow RE, Jeschke MG, Hendon DN . Modulation of types I and II acute phase reactants with insulin-like growth factor-1\/binding protein-3 complex in severely burned children. Crit Care Med 2002; 30: 83\u201388.","journal-title":"Crit Care Med"},{"key":"BFbmt201743_CR33","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1007\/s00520-013-1900-x","volume":"21","author":"N Al-Dasooqi","year":"2013","unstructured":"Al-Dasooqi N, Sonis ST, Bowen JM, Bateman E, Blijlevens N, Gibson RJ et al. Emerging evidence on the pathobiology of mucositis. Support Care Cancer 2013; 21: 3233\u20133241.","journal-title":"Support Care Cancer"},{"key":"BFbmt201743_CR34","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1748-717X-5-22","volume":"5","author":"ZY Ong","year":"2010","unstructured":"Ong ZY, Gibson RJ, Bowen JM, Stringer AM, Darby JM, Logan RM et al. Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis. Radiat Oncol 2010; 5: 22.","journal-title":"Radiat Oncol"},{"key":"BFbmt201743_CR35","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.ctrv.2007.03.001","volume":"33","author":"RM Logan","year":"2007","unstructured":"Logan RM, Stringer AM, Bowen JM, Yeoh AS-J, Gibson RJ, Sonis ST et al. The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs. Cancer Treat Rev 2007; 33: 448\u2013460.","journal-title":"Cancer Treat Rev"},{"key":"BFbmt201743_CR36","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.4161\/cbt.7.7.6207","volume":"7","author":"RM Logan","year":"2008","unstructured":"Logan RM, Stringer AM, Bowen JM, Gibson RJ, Sonis ST, Keefe DMK . Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs. Cancer Biol Ther 2008; 7: 1139\u20131145.","journal-title":"Cancer Biol Ther"},{"key":"BFbmt201743_CR37","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/sj.bmt.1703672","volume":"30","author":"R Schots","year":"2002","unstructured":"Schots R, Van Riet I, Othman TB, Trullemans F, De Waele M, Van Camp B et al. An early increase in serum levels of C-reactive protein is an independent risk factor for the occurrence of major complications and 100-\u2009day transplant-related mortality after allogeneic bone marrow transplantation. Bone Marrow Transplant 2002; 30: 441\u2013446.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt201743_CR38","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.bbmt.2009.10.036","volume":"16","author":"JL McNeer","year":"2010","unstructured":"McNeer JL, Kletzel M, Rademaker A, Alford K, O\u2019Day K, Schaefer C et al. Early elevation of C-reactive protein correlates with severe infection and nonrelapse mortality in children undergoing allogeneic stem cell transplantation. Biol Blood Marrow Transplant 2010; 16: 350\u2013357.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt201743_CR39","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.0902-4441.2005.00568.x","volume":"76","author":"M Pihusch","year":"2006","unstructured":"Pihusch M, Pihusch R, Fraunberger P, Pihusch V, Andreesen R, Kolb H-J et al. Evaluation of C-reactive protein, interleukin-6, and procalcitonin levels in allogeneic hematopoietic stem cell recipients. Eur J Haematol 2006; 76: 93\u2013101.","journal-title":"Eur J Haematol"},{"key":"BFbmt201743_CR40","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1182\/blood-2015-03-636753","volume":"126","author":"GB McDonald","year":"2015","unstructured":"McDonald GB, Tabellini L, Storer BE, Lawler RL, Martin PJ, Hansen JA . Plasma biomarkers of acute GVHD and nonrelapse mortality: predictive value of measurements before GVHD onset and treatment. Blood 2015; 126: 113\u2013120.","journal-title":"Blood"},{"key":"BFbmt201743_CR41","doi-asserted-by":"publisher","first-page":"S83","DOI":"10.1177\/014860719902300521","volume":"23","author":"WM Wong","year":"1999","unstructured":"Wong WM, Wright NA . Epidermal growth factor, epidermal growth factor receptors, intestinal growth, and adaptation. JPEN J Parenter Enteral Nutr 1999; 23: S83\u2013S88.","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"BFbmt201743_CR42","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1097\/00042737-200107000-00002","volume":"13","author":"AU Dignass","year":"2001","unstructured":"Dignass AU, Sturm A . Peptide growth factors in the intestine. Eur J Gastroenterol Hepatol 2001; 13: 763\u2013770.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"BFbmt201743_CR43","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/S1471-4892(01)00098-4","volume":"1","author":"G Howarth","year":"2001","unstructured":"Howarth G . Enhancement of intestinal growth and repair by growth factors. Curr Opin Pharmacol 2001; 1: 568\u2013574.","journal-title":"Curr Opin Pharmacol"},{"key":"BFbmt201743_CR44","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/oxfordjournals.jncimonographs.a003433","volume":"29","author":"D Booth","year":"2001","unstructured":"Booth D, Potten CS . Protection against mucosal injury by growth factors and cytokines. J Natl Cancer Inst Monogr 2001; 29: 16\u201320.","journal-title":"J Natl Cancer Inst Monogr"},{"key":"BFbmt201743_CR45","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1001\/archsurg.1993.01420130051009","volume":"128","author":"KF Huang","year":"1993","unstructured":"Huang KF, Chung DH, Herndon DN . Insulinlike growth factor 1 (IGF-1) reduces gut atrophy and bacterial translocation after severe burn injury. Arch Surg 1993; 128: 47\u201353.","journal-title":"Arch Surg"},{"key":"BFbmt201743_CR46","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ghir.2004.12.002","volume":"15","author":"JC Cool","year":"2005","unstructured":"Cool JC, Dyer JL, Xian CJ, Butler RN, Geier MS, Howarth GS . Pre-treatment with insulin-like growth factor-I partially ameliorates 5-fluorouracil-induced intestinal mucositis in rats. Growth Horm IGF Res 2005; 15: 72\u201382.","journal-title":"Growth Horm IGF Res"},{"key":"BFbmt201743_CR47","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1038\/sj.bmt.1701264","volume":"21","author":"G Eissner","year":"1998","unstructured":"Eissner G, Multhoff G, Holler E . Influence of bacterial endotoxin on the allogenicity of human endothelial cells. Bone Marrow Transplant 1998; 21: 1286\u20131288.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt201743_CR48","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.beha.2008.02.002","volume":"21","author":"A Tichelli","year":"2008","unstructured":"Tichelli A, Gratwohl A . Vascular endothelium as \u2018novel\u2019 target of graft-versus-host disease. Best Pract Res Clin Haematol 2008; 21: 139\u2013148.","journal-title":"Best Pract Res Clin Haematol"},{"key":"BFbmt201743_CR49","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.bbmt.2010.02.008","volume":"16","author":"M Palomo","year":"2010","unstructured":"Palomo M, Diaz-Ricart M, Carbo C, Rovira M, Fernandez-Aviles F, Martine C et al. Endothelial dysfunction after hematopoietic stem cell transplantation: role of the conditioning regimen and the type of transplantation. Biol Blood Marrow Transplant 2010; 16: 985\u2013993.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt201743_CR50","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1182\/blood-2015-10-676114","volume":"127","author":"M Palomo","year":"2016","unstructured":"Palomo M, Mir E, Rovira M, Carreras E, Diaz-Ricart M . What is going on between defibrotide and endothelial cells? Snapshots reveal the hot spots of their romance. Blood 2016; 127: 1719\u20131727.","journal-title":"Blood"},{"key":"BFbmt201743_CR51","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s12265-016-9677-1","volume":"9","author":"B Tesfamariam","year":"2016","unstructured":"Tesfamariam B . Endothelial repair and regeneration following intimal injury. J Cardiovasc Transl Res 2016; 9: 91\u2013101.","journal-title":"J Cardiovasc Transl Res"},{"key":"BFbmt201743_CR52","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1161\/01.CIR.0000144309.87183.FB","volume":"110","author":"E Conti","year":"2004","unstructured":"Conti E, Carrozza C, Capoluongo E, Volpe M, Crea F, Zuppi C et al. Insulin-like growth factor-1 as a vascular protective factor. Circulation 2004; 110: 2260\u20132265.","journal-title":"Circulation"},{"key":"BFbmt201743_CR53","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000360571","volume":"43","author":"Y Higashi","year":"2014","unstructured":"Higashi Y, Quevedo HC, Tiwari S, Sukhanov S, Shai SY, Anwar A et al. Interaction between insulin-like growth factor-1 and atherosclerosis and vascular aging. Front Horm Res 2014; 43: 107\u2013124.","journal-title":"Front Horm Res"},{"key":"BFbmt201743_CR54","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1038\/bmt.2016.130","volume":"51","author":"M Mohty","year":"2016","unstructured":"Mohty M, Malard F, Abecassis M, Aerts E, Alaskar AS, Aljurf M et al. Revised diagnosis and severity criteria for sinusoidal obstruction syndrome\/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation. Bone Marrow Transplant 2016; 51: 906\u2013912.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt201743_CR55","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1093\/jn\/133.7.2109","volume":"133","author":"GS Howarth","year":"2003","unstructured":"Howarth GS . Insulin-like growth factor-I and the gastrointestinal system: therapeutic indications and safety implications. J Nutr 2003; 133: 2109\u20132112.","journal-title":"J Nutr"},{"key":"BFbmt201743_CR56","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/0145-2126(94)00133-U","volume":"19","author":"I Shimon","year":"1995","unstructured":"Shimon I, Shpilberg O . The insulin-like growth factor system in regulation of normal and malignant hematopoiesis. Leuk Res 1995; 19: 233\u2013240.","journal-title":"Leuk Res"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/bmt201743.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt201743","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/bmt.2017.43","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/bmt201743.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T20:58:15Z","timestamp":1658955495000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bmt201743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,24]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["BFbmt201743"],"URL":"https:\/\/doi.org\/10.1038\/bmt.2017.43","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,24]]},"assertion":[{"value":"26 October 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}