{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:54:15Z","timestamp":1793890455252,"version":"4.8.0"},"reference-count":263,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T00:00:00Z","timestamp":1398729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"},{"start":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T00:00:00Z","timestamp":1398729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Res"],"DOI":"10.1038\/boneres.2014.3","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T10:22:19Z","timestamp":1409826139000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":272,"title":["Role of FGF\/FGFR signaling in skeletal development and homeostasis: learning from mouse models"],"prefix":"10.1038","volume":"2","author":[{"given":"Nan","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,4,29]]},"reference":[{"key":"BFboneres20143_CR1","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/S1534-5807(02)00157-0","volume":"2","author":"G Karsenty","year":"2002","unstructured":"Karsenty G, Wagner EF . Reaching a genetic and molecular understanding of skeletal development. Dev Cell 2002; 2: 389\u2013406.","journal-title":"Dev Cell"},{"key":"BFboneres20143_CR2","doi-asserted-by":"publisher","first-page":"2842","DOI":"10.2741\/2890","volume":"13","author":"N Su","year":"2008","unstructured":"Su N, Du X, Chen L . FGF signaling: its role in bone development and human skeleton diseases. Front Biosci 2008; 13: 2842\u20132865.","journal-title":"Front Biosci"},{"key":"BFboneres20143_CR3","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.2741\/1671","volume":"10","author":"L Chen","year":"2005","unstructured":"Chen L, Deng CX . Roles of FGF signaling in skeletal development and human genetic diseases. Front Biosci 2005; 10: 1961\u20131976.","journal-title":"Front Biosci"},{"key":"BFboneres20143_CR4","first-page":"1","volume":"60","author":"DE Johnson","year":"1993","unstructured":"Johnson DE, Williams LT . Structural and functional diversity in the FGF receptor multigene family. Adv Cancer Res 1993; 60: 1\u201341.","journal-title":"Adv Cancer Res"},{"key":"BFboneres20143_CR5","doi-asserted-by":"publisher","first-page":"15292","DOI":"10.1074\/jbc.271.25.15292","volume":"271","author":"DM Ornitz","year":"1996","unstructured":"Ornitz DM, Xu J, Colvin JS et al. Receptor specificity of the fibroblast growth factor family. J Biol Chem 1996; 271: 15292\u201315297.","journal-title":"J Biol Chem"},{"key":"BFboneres20143_CR6","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1677\/erc.0.0070165","volume":"7","author":"CJ Powers","year":"2000","unstructured":"Powers CJ, McLeskey SW, Wellstein A . Fibroblast growth factors, their receptors and signaling. Endocrine Relat Cancer 2000; 7: 165\u2013197.","journal-title":"Endocrine Relat Cancer"},{"key":"BFboneres20143_CR7","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.cytogfr.2005.02.003","volume":"16","author":"DM Ornitz","year":"2005","unstructured":"Ornitz DM . FGF signaling in the developing endochondral skeleton. Cytokine Growth Factor Rev 2005; 16: 205\u2013213.","journal-title":"Cytokine Growth Factor Rev"},{"key":"BFboneres20143_CR8","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/0012-1606(92)90157-C","volume":"152","author":"TP Yamaguchi","year":"1992","unstructured":"Yamaguchi TP, Conlon RA, Rossant J . Expression of the fibroblast growth factor receptor FGFR-1\/flg during gastrulation and segmentation in the mouse embryo. Dev Biol 1992; 152: 75\u201388.","journal-title":"Dev Biol"},{"key":"BFboneres20143_CR9","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1242\/dev.114.1.233","volume":"114","author":"KG Peters","year":"1992","unstructured":"Peters KG, Werner S, Chen G, Williams LT . Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse. Development 1992; 114: 233\u2013243.","journal-title":"Development"},{"key":"BFboneres20143_CR10","doi-asserted-by":"publisher","first-page":"4235","DOI":"10.1242\/dev.02001","volume":"132","author":"JM Verheyden","year":"2005","unstructured":"Verheyden JM, Lewandoski M, Deng C, Harfe BD, Sun X . Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. Development 2005; 132: 4235\u20134245.","journal-title":"Development"},{"key":"BFboneres20143_CR11","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.bone.2006.10.013","volume":"40","author":"JE Lazarus","year":"2007","unstructured":"Lazarus JE, Hegde A, Andrade AC, Nilsson O, Baron J . Fibroblast growth factor expression in the postnatal growth plate. Bone 2007; 40: 577\u2013586.","journal-title":"Bone"},{"key":"BFboneres20143_CR12","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1002\/aja.1002040410","volume":"204","author":"G Szebenyi","year":"1995","unstructured":"Szebenyi G, Savage MP, Olwin BB, Fallon JF . Changes in the expression of fibroblast growth factor receptors mark distinct stages of chondrogenesis in vitro and during chick limb skeletal patterning. Dev Dyn 1995; 204: 446\u2013456.","journal-title":"Dev Dyn"},{"key":"BFboneres20143_CR13","doi-asserted-by":"publisher","first-page":"5611","DOI":"10.1242\/dev.126.24.5611","volume":"126","author":"S Iseki","year":"1999","unstructured":"Iseki S, Wilkie AO, Morriss-Kay GM . Fgfr1 and Fgfr2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault. Development 1999; 126: 5611\u20135620.","journal-title":"Development"},{"key":"BFboneres20143_CR14","doi-asserted-by":"publisher","first-page":"27743","DOI":"10.1074\/jbc.M314323200","volume":"279","author":"L Xiao","year":"2004","unstructured":"Xiao L, Naganawa T, Obugunde E et al. Stat1 controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts. J Biol Chem 2004; 279: 27743\u201327752.","journal-title":"J Biol Chem"},{"key":"BFboneres20143_CR15","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.ydbio.2006.05.031","volume":"296","author":"AL Jacob","year":"2006","unstructured":"Jacob AL, Smith C, Partanen J, Ornitz DM . Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation. Dev Biol 2006; 296: 315\u2013328","journal-title":"Dev Biol"},{"key":"BFboneres20143_CR16","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s00774-011-0288-2","volume":"30","author":"A Kyono","year":"2012","unstructured":"Kyono A, Avishai N, Ouyang Z, Landreth GE, Murakami S . FGF and ERK signaling coordinately regulate mineralization-related genes and play essential roles in osteocyte differentiation. J Bone Miner Metab 2012; 30: 19\u201330.","journal-title":"J Bone Miner Metab"},{"key":"BFboneres20143_CR17","doi-asserted-by":"publisher","first-page":"3045","DOI":"10.1101\/gad.8.24.3045","volume":"8","author":"CX Deng","year":"1994","unstructured":"Deng CX, Wynshaw-Boris A, Shen MM, Daugherty C, Ornitz DM, Leder P . Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev 1994; 8: 3045\u20133057.","journal-title":"Genes Dev"},{"key":"BFboneres20143_CR18","doi-asserted-by":"publisher","first-page":"3032","DOI":"10.1101\/gad.8.24.3032","volume":"8","author":"TP Yamaguchi","year":"1994","unstructured":"Yamaguchi TP, Harpal K, Henkemeyer M, Rossant J . fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev 1994; 8: 3032\u20133044.","journal-title":"Genes Dev"},{"key":"BFboneres20143_CR19","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1101\/gad.12.15.2332","volume":"12","author":"J Partanen","year":"1998","unstructured":"Partanen J, Schwartz L, Rossant J . Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev 1998; 12: 2332\u20132344.","journal-title":"Genes Dev"},{"key":"BFboneres20143_CR20","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1006\/dbio.1999.9227","volume":"208","author":"X Xu","year":"1999","unstructured":"Xu X, Li C, Takahashi K, Slavkin HC, Shum L, Deng CX . Murine fibroblast growth factor receptor 1alpha isoforms mediate node regression and are essential for posterior mesoderm development. Dev Biol 1999; 208: 293\u2013306.","journal-title":"Dev Biol"},{"key":"BFboneres20143_CR21","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1006\/dbio.1997.8553","volume":"185","author":"C Deng","year":"1997","unstructured":"Deng C, Bedford M, Li C et al. Fibroblast growth factor receptor-1 (FGFR-1) is essential for normal neural tube and limb development. Dev Biol 1997; 185: 42\u201354.","journal-title":"Dev Biol"},{"key":"BFboneres20143_CR22","doi-asserted-by":"publisher","first-page":"3859","DOI":"10.1242\/dev.01945","volume":"132","author":"AO Perantoni","year":"2005","unstructured":"Perantoni AO, Timofeeva O, Naillat F et al. Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development. Development 2005; 132: 3859\u20133871.","journal-title":"Development"},{"key":"BFboneres20143_CR23","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.cell.2004.07.024","volume":"118","author":"BD Harfe","year":"2004","unstructured":"Harfe BD, Scherz PJ, Nissim S, Tian H, McMahon AP, Tabin CJ . Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 2004; 118: 517\u2013528.","journal-title":"Cell"},{"key":"BFboneres20143_CR24","doi-asserted-by":"publisher","first-page":"4755","DOI":"10.1242\/dev.02065","volume":"132","author":"C Li","year":"2005","unstructured":"Li C, Xu X, Nelson DK, Williams T, Kuehn MR, Deng CX . FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis. Development 2005; 132: 4755\u20134764.","journal-title":"Development"},{"key":"BFboneres20143_CR25","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1242\/dev.02242","volume":"133","author":"RV Hoch","year":"2006","unstructured":"Hoch RV, Soriano P . Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development. Development 2006; 133: 663\u2013673.","journal-title":"Development"},{"key":"BFboneres20143_CR26","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1086\/427956","volume":"76","author":"KE White","year":"2005","unstructured":"White KE, Cabral JM, Davis SI et al. Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation. Am J Hum Genet 2005; 76: 361\u2013367.","journal-title":"Am J Hum Genet"},{"key":"BFboneres20143_CR27","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/1096-8628(20000703)93:1<22::AID-AJMG5>3.0.CO;2-U","volume":"93","author":"T Roscioli","year":"2000","unstructured":"Roscioli T, Flanagan S, Kumar P et al. Clinical findings in a patient with FGFR1 P252R mutation and comparison with the literature. Am J Med Genet 2000; 93: 22\u201328.","journal-title":"Am J Med Genet"},{"key":"BFboneres20143_CR28","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1093\/hmg\/9.13.2001","volume":"9","author":"YX Zhou","year":"2000","unstructured":"Zhou YX, Xu X, Chen L, Li C, Brodie SG, Deng CX . A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures. Hum Mol Genet 2000; 9: 2001\u20132008.","journal-title":"Hum Mol Genet"},{"key":"BFboneres20143_CR29","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.bbrc.2009.09.123","volume":"390","author":"X Lu","year":"2009","unstructured":"Lu X, Su N, Yang J et al. Fibroblast growth factor receptor 1 regulates the differentiation and activation of osteoclasts through Erk1\/2 pathway. Biochem Biophys Res Commun 2009; 390: 494\u2013499.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFboneres20143_CR30","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1111\/j.1744-9987.2005.00287.x","volume":"9","author":"X Yu","year":"2005","unstructured":"Yu X, White KE . Fibroblast growth factor 23 and its receptors. Ther Apher Dial 2005; 9: 308\u2013312.","journal-title":"Ther Apher Dial"},{"key":"BFboneres20143_CR31","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/nrendo.2011.218","volume":"8","author":"LD Quarles","year":"2012","unstructured":"Quarles LD . Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism. Nat Rev Endocrinol 2012; 8: 276\u2013286.","journal-title":"Nat Rev Endocrinol"},{"key":"BFboneres20143_CR32","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1002\/jbmr.478","volume":"26","author":"S Wohrle","year":"2011","unstructured":"Wohrle S, Bonny O, Beluch N et al. FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone. J Bone Miner Res 2011; 26: 2486\u20132497.","journal-title":"J Bone Miner Res"},{"key":"BFboneres20143_CR33","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1046\/j.1471-4159.2002.00833.x","volume":"81","author":"H Peng","year":"2002","unstructured":"Peng H, Myers J, Fang X et al. Integrative nuclear FGFR1 signaling (INFS) pathway mediates activation of the tyrosine hydroxylase gene by angiotensin II, depolarization and protein kinase C. J Neurochem 2002; 81: 506\u2013524.","journal-title":"J Neurochem"},{"key":"BFboneres20143_CR34","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S0925-4773(98)00133-6","volume":"77","author":"AL Delezoide","year":"1998","unstructured":"Delezoide AL, Benoist-Lasselin C, Legeai-Mallet L et al. Spatio-temporal expression of FGFR 1, 2 and 3 genes during human embryo-fetal ossification. Mech Dev 1998; 77: 19\u201330.","journal-title":"Mech Dev"},{"key":"BFboneres20143_CR35","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1006\/dbio.1993.1205","volume":"158","author":"A Orr-Urtreger","year":"1993","unstructured":"Orr-Urtreger A, Bedford MT, Burakova T et al. Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). Dev Biol 1993; 158: 475\u2013486.","journal-title":"Dev Biol"},{"key":"BFboneres20143_CR36","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1242\/dev.00491","volume":"130","author":"K Yu","year":"2003","unstructured":"Yu K, Xu J, Liu Z et al. Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development 2003; 130: 3063\u20133074.","journal-title":"Development"},{"key":"BFboneres20143_CR37","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/S8756-3282(03)00163-7","volume":"33","author":"DP Rice","year":"2003","unstructured":"Rice DP, Rice R, Thesleff I . Fgfr mRNA isoforms in craniofacial bone development. Bone 2003; 33: 14\u201327.","journal-title":"Bone"},{"key":"BFboneres20143_CR38","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1242\/dev.127.9.1845","volume":"127","author":"DP Rice","year":"2000","unstructured":"Rice DP, Aberg T, Chan Y et al. Integration of FGF and TWIST in calvarial bone and suture development. Development 2000; 127: 1845\u20131855.","journal-title":"Development"},{"key":"BFboneres20143_CR39","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.bone.2007.11.019","volume":"42","author":"L Yin","year":"2008","unstructured":"Yin L, Du X, Li C et al. A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis. Bone 2008; 42: 631\u2013643.","journal-title":"Bone"},{"key":"BFboneres20143_CR40","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.cytogfr.2005.03.001","volume":"16","author":"AO Wilkie","year":"2005","unstructured":"Wilkie AO . Bad bones, absent smell, selfish testes: the pleiotropic consequences of human FGF receptor mutations. Cytokine Growth Factor Rev 2005; 16: 187\u2013203.","journal-title":"Cytokine Growth Factor Rev"},{"key":"BFboneres20143_CR41","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1097\/00006534-199802000-00052","volume":"101","author":"JA Britto","year":"1998","unstructured":"Britto JA, Chan JC, Evans RD, Hayward RD, Thorogood P, Jones BM . Fibroblast growth factor receptors are expressed in craniosynostotic sutures. Plast Reconstr Surg 1998; 101: 540\u2013543.","journal-title":"Plast Reconstr Surg"},{"key":"BFboneres20143_CR42","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1097\/00006534-200112000-00030","volume":"108","author":"JA Britto","year":"2001","unstructured":"Britto JA, Evans RD, Hayward RD, Jones BM . From genotype to phenotype: the differential expression of FGF, FGFR, and TGFbeta genes characterizes human cranioskeletal development and reflects clinical presentation in FGFR syndromes. Plast Reconstr Surg 2001; 108: 2026\u20132039; discussion 2040\u20132026..","journal-title":"Plast Reconstr Surg"},{"key":"BFboneres20143_CR43","doi-asserted-by":"publisher","first-page":"5082","DOI":"10.1073\/pnas.95.9.5082","volume":"95","author":"E Arman","year":"1998","unstructured":"Arman E, Haffner-Krausz R, Chen Y, Heath JK, Lonai P . Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development. Proc Natl Acad Sci USA 1998; 95: 5082\u20135087.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFboneres20143_CR44","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1242\/dev.125.4.753","volume":"125","author":"X Xu","year":"1998","unstructured":"Xu X, Weinstein M, Li C et al. Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development 1998; 125: 753\u2013765.","journal-title":"Development"},{"key":"BFboneres20143_CR45","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1083\/jcb.153.4.811","volume":"153","author":"X Li","year":"2001","unstructured":"Li X, Chen Y, Scheele S et al. Fibroblast growth factor signaling and basement membrane assembly are connected during epithelial morphogenesis of the embryoid body. J Cell Biol 2001; 153: 811\u2013822.","journal-title":"J Cell Biol"},{"key":"BFboneres20143_CR46","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1002\/jcb.20582","volume":"96","author":"PJ Marie","year":"2005","unstructured":"Marie PJ, Coffin JD, Hurley MM . FGF and FGFR signaling in chondrodysplasias and craniosynostosis. J Cell Biochem 2005; 96: 888\u2013896.","journal-title":"J Cell Biochem"},{"key":"BFboneres20143_CR47","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1601-6343.2007.00389.x","volume":"10","author":"ML Cunningham","year":"2007","unstructured":"Cunningham ML, Seto ML, Ratisoontorn C, Heike CL, Hing AV . Syndromic craniosynostosis: from history to hydrogen bonds. Orthod Craniofac Res 2007; 10: 67\u201381.","journal-title":"Orthod Craniofac Res"},{"key":"BFboneres20143_CR48","doi-asserted-by":"publisher","first-page":"3537","DOI":"10.1242\/dev.01914","volume":"132","author":"Y Wang","year":"2005","unstructured":"Wang Y, Xiao R, Yang F et al. Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+\/S252W) mouse. Development 2005; 132: 3537\u20133548.","journal-title":"Development"},{"key":"BFboneres20143_CR49","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1471-213X-10-22","volume":"10","author":"Y Wang","year":"2010","unstructured":"Wang Y, Sun M, Uhlhorn VL et al. Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2(+P253R) mice. BMC Dev Biol 2010; 10: 22.","journal-title":"BMC Dev Biol"},{"key":"BFboneres20143_CR50","first-page":"1","volume":"19","author":"S Kreiborg","year":"1999","unstructured":"Kreiborg S, Aduss H, Cohen MM Jr Cephalometric study of the Apert syndrome in adolescence and adulthood. J Craniofac Genet Dev Biol 1999; 19: 1\u201311.","journal-title":"J Craniofac Genet Dev Biol"},{"key":"BFboneres20143_CR51","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S8756-3282(03)00222-9","volume":"33","author":"L Chen","year":"2003","unstructured":"Chen L, Li D, Li C, Engel A, Deng CX . A Ser252Trp [corrected] substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosis. Bone 2003; 33: 169\u2013178.","journal-title":"Bone"},{"key":"BFboneres20143_CR52","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1172\/JCI62644","volume":"122","author":"Y Wang","year":"2012","unstructured":"Wang Y, Zhou X, Oberoi K et al. p38 Inhibition ameliorates skin and skull abnormalities in Fgfr2 Beare\u2013Stevenson mice. J Clin Invest 2012; 122: 2153\u20132164.","journal-title":"J Clin Invest"},{"key":"BFboneres20143_CR53","doi-asserted-by":"publisher","first-page":"18603","DOI":"10.1073\/pnas.0609157103","volume":"103","author":"VP Eswarakumar","year":"2006","unstructured":"Eswarakumar VP, Ozcan F, Lew ED et al. Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis. Proc Natl Acad Sci USA 2006; 103: 18603\u201318608.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFboneres20143_CR54","doi-asserted-by":"publisher","first-page":"3783","DOI":"10.1242\/dev.129.16.3783","volume":"129","author":"VP Eswarakumar","year":"2002","unstructured":"Eswarakumar VP, Monsonego-Ornan E, Pines M, Antonopoulou I, Morriss-Kay GM, Lonai P . The IIIc alternative of Fgfr2 is a positive regulator of bone formation. Development 2002; 129: 3783\u20133793.","journal-title":"Development"},{"key":"BFboneres20143_CR55","doi-asserted-by":"publisher","first-page":"12555","DOI":"10.1073\/pnas.0405031101","volume":"101","author":"VP Eswarakumar","year":"2004","unstructured":"Eswarakumar VP, Horowitz MC, Locklin R, Morriss-Kay GM, Lonai P . A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis. Proc Natl Acad Sci USA 2004; 101: 12555\u201312560.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFboneres20143_CR56","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1038\/ng2096","volume":"39","author":"V Shukla","year":"2007","unstructured":"Shukla V, Coumoul X, Wang RH, Kim HS, Deng CX . RNA interference and inhibition of MEK\u2013ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis. Nat Genet 2007; 39: 1145\u20131150.","journal-title":"Nat Genet"},{"key":"BFboneres20143_CR57","doi-asserted-by":"publisher","first-page":"e102","DOI":"10.1093\/nar\/gni100","volume":"33","author":"X Coumoul","year":"2005","unstructured":"Coumoul X, Shukla V, Li C, Wang RH, Deng CX . Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference. Nucleic Acids Res 2005; 33: e102.","journal-title":"Nucleic Acids Res"},{"key":"BFboneres20143_CR58","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1006\/dbio.1993.1040","volume":"155","author":"K Peters","year":"1993","unstructured":"Peters K, Ornitz D, Werner S, Williams L . Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis. Dev Biol 1993; 155: 423\u2013430.","journal-title":"Dev Biol"},{"key":"BFboneres20143_CR59","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/ng0496-390","volume":"12","author":"JS Colvin","year":"1996","unstructured":"Colvin JS, Bohne BA, Harding GW, McEwen DG, Ornitz DM . Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat Genet 1996; 12: 390\u2013397.","journal-title":"Nat Genet"},{"key":"BFboneres20143_CR60","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1101\/gad.990702","volume":"16","author":"DM Ornitz","year":"2002","unstructured":"Ornitz DM, Marie PJ . FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes Dev 2002; 16: 1446\u20131465.","journal-title":"Genes Dev"},{"key":"BFboneres20143_CR61","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/371252a0","volume":"371","author":"F Rousseau","year":"1994","unstructured":"Rousseau F, Bonaventure J, Legeai-Mallet L et al. Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia. Nature 1994; 371: 252\u2013254.","journal-title":"Nature"},{"key":"BFboneres20143_CR62","first-page":"368","volume":"56","author":"GA Bellus","year":"1995","unstructured":"Bellus GA, Hefferon TW, Ortiz de Luna RI et al. Achondroplasia is defined by recurrent G380R mutations of FGFR3. Am J Hum Genet 1995; 56: 368\u2013373.","journal-title":"Am J Hum Genet"},{"key":"BFboneres20143_CR63","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/(SICI)1098-1004(1999)14:2<115::AID-HUMU3>3.0.CO;2-2","volume":"14","author":"MR Passos-Bueno","year":"1999","unstructured":"Passos-Bueno MR, Wilcox WR, Jabs EW, Sertie AL, Alonso LG, Kitoh H . Clinical spectrum of fibroblast growth factor receptor mutations. Hum Mutat 1999; 14: 115\u2013125.","journal-title":"Hum Mutat"},{"key":"BFboneres20143_CR64","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1093\/hmg\/5.4.509","volume":"5","author":"F Rousseau","year":"1996","unstructured":"Rousseau F, el Ghouzzi V, Delezoide AL, Legeai-Mallet L, Le Merrer M, Munnich A, Bonaventure J . Missense FGFR3 mutations create cysteine residues in thanatophoric dwarfism type I (TD1). Hum Mol Genet 1996; 5: 509\u2013512.","journal-title":"Hum Mol Genet"},{"key":"BFboneres20143_CR65","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/(SICI)1096-8628(19990702)85:1<53::AID-AJMG10>3.0.CO;2-F","volume":"85","author":"GA Bellus","year":"1999","unstructured":"Bellus GA, Bamshad MJ, Przylepa KA et al. Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN): phenotypic analysis of a new skeletal dysplasia caused by a Lys650Met mutation in fibroblast growth factor receptor 3. Am J Med Genet 1999; 85: 53\u201365.","journal-title":"Am J Med Genet"},{"key":"BFboneres20143_CR66","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1086\/302275","volume":"64","author":"PL Tavormina","year":"1999","unstructured":"Tavormina PL, Bellus GA, Webster MK et al. A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene. Am J Hum Genet 1999; 64: 722\u2013731.","journal-title":"Am J Hum Genet"},{"key":"BFboneres20143_CR67","first-page":"537","volume":"21","author":"JM Wang","year":"2004","unstructured":"Wang JM, Du XL, Li CL et al. Gly374Arg mutation in Fgfr3 causes achondroplasia in mice. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2004; 21: 537\u2013541. Chinese","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"key":"BFboneres20143_CR68","doi-asserted-by":"publisher","first-page":"4455","DOI":"10.1073\/pnas.96.8.4455","volume":"96","author":"Y Wang","year":"1999","unstructured":"Wang Y, Spatz MK, Kannan K et al. A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3. Proc Natl Acad Sci USA 1999; 96: 4455\u20134460.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFboneres20143_CR69","doi-asserted-by":"publisher","first-page":"4977","DOI":"10.1242\/dev.125.24.4977","volume":"125","author":"MC Naski","year":"1998","unstructured":"Naski MC, Colvin JS, Coffin JD, Ornitz DM . Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Development 1998; 125: 4977\u20134988.","journal-title":"Development"},{"key":"BFboneres20143_CR70","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1172\/JCI6690","volume":"104","author":"L Chen","year":"1999","unstructured":"Chen L, Adar R, Yang X et al. Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis. J Clin Invest 1999; 104: 1517\u20131525.","journal-title":"J Clin Invest"},{"key":"BFboneres20143_CR71","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1093\/hmg\/9.11.1603","volume":"9","author":"T Iwata","year":"2000","unstructured":"Iwata T, Chen L, Li C et al. A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos. Hum Mol Genet 2000; 9: 1603\u20131613.","journal-title":"Hum Mol Genet"},{"key":"BFboneres20143_CR72","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1093\/hmg\/10.5.457","volume":"10","author":"L Chen","year":"2001","unstructured":"Chen L, Li C, Qiao W, Xu X, Deng C . A Ser(365)--&gt;Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh\/PTHrP signals and causes severe achondroplasia. Hum Mol Genet 2001; 10: 457\u2013465.","journal-title":"Hum Mol Genet"},{"key":"BFboneres20143_CR73","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1093\/hmg\/8.1.35","volume":"8","author":"C Li","year":"1999","unstructured":"Li C, Chen L, Iwata T, Kitagawa M, Fu XY, Deng CX . A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors. Hum Mol Genet 1999; 8: 35\u201344.","journal-title":"Hum Mol Genet"},{"key":"BFboneres20143_CR74","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/386288a0","volume":"386","author":"WC Su","year":"1997","unstructured":"Su WC, Kitagawa M, Xue N et al. Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism. Nature 1997; 386: 288\u2013292.","journal-title":"Nature"},{"key":"BFboneres20143_CR75","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1101\/gad.13.11.1361","volume":"13","author":"M Sahni","year":"1999","unstructured":"Sahni M, Ambrosetti DC, Mansukhani A, Gertner R, Levy D, Basilico C . FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway. Genes Dev 1999; 13: 1361\u20131366.","journal-title":"Genes Dev"},{"key":"BFboneres20143_CR76","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1101\/gad.1179104","volume":"18","author":"S Murakami","year":"2004","unstructured":"Murakami S, Balmes G, McKinney S, Zhang Z, Givol D, de Crombrugghe B . Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. Genes Dev 2004; 18: 290\u2013305.","journal-title":"Genes Dev"},{"key":"BFboneres20143_CR77","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/S1534-5807(02)00261-7","volume":"3","author":"E Minina","year":"2002","unstructured":"Minina E, Kreschel C, Naski MC, Ornitz DM, Vortkamp A . Interaction of FGF, Ihh\/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation. Dev Cell 2002; 3: 439\u2013449.","journal-title":"Dev Cell"},{"key":"BFboneres20143_CR78","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1083\/jcb.200302075","volume":"161","author":"L Dailey","year":"2003","unstructured":"Dailey L, Laplantine E, Priore R, Basilico C . A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation. J Cell Biol 2003; 161: 1053\u20131066.","journal-title":"J Cell Biol"},{"key":"BFboneres20143_CR79","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/S0092-8674(00)81069-7","volume":"84","author":"C Deng","year":"1996","unstructured":"Deng C, Wynshaw-Boris A, Zhou F, Kuo A, Leder P . Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 1996; 84: 911\u2013921.","journal-title":"Cell"},{"key":"BFboneres20143_CR80","doi-asserted-by":"publisher","first-page":"781","DOI":"10.2741\/A321","volume":"3","author":"MC Naski","year":"1998","unstructured":"Naski MC, Ornitz DM . FGF signaling in skeletal development. Front Biosci 1998; 3: 781\u2013794.","journal-title":"Front Biosci"},{"key":"BFboneres20143_CR81","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1359\/jbmr.2003.18.11.2043","volume":"18","author":"M Koike","year":"2003","unstructured":"Koike M, Yamanaka Y, Inoue M, Tanaka H, Nishimura R, Seino Y . Insulin-like growth factor-1 rescues the mutated FGF receptor 3 (G380R) expressing ATDC5 cells from apoptosis through phosphatidylinositol 3-kinase and MAPK. J Bone Miner Res 2003; 18: 2043\u20132051.","journal-title":"J Bone Miner Res"},{"key":"BFboneres20143_CR82","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1093\/hmg\/ddn339","volume":"18","author":"T Matsushita","year":"2009","unstructured":"Matsushita T, Wilcox WR, Chan YY et al. FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. Hum Mol Genet 2009; 18: 227\u2013240.","journal-title":"Hum Mol Genet"},{"key":"BFboneres20143_CR83","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1093\/hmg\/ddp590","volume":"19","author":"N Su","year":"2010","unstructured":"Su N, Sun Q, Li C et al. Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis. Hum Mol Genet 2010; 19: 1199\u20131210.","journal-title":"Hum Mol Genet"},{"key":"BFboneres20143_CR84","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3109\/08977194.2012.656761","volume":"30","author":"PJ Marie","year":"2012","unstructured":"Marie PJ, Miraoui H, Severe N . FGF\/FGFR signaling in bone formation: progress and perspectives. Growth Factors 2012; 30: 117\u2013123.","journal-title":"Growth Factors"},{"key":"BFboneres20143_CR85","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1093\/hmg\/ddh034","volume":"13","author":"G Valverde-Franco","year":"2004","unstructured":"Valverde-Franco G, Liu H, Davidson D et al. Defective bone mineralization and osteopenia in young adult FGFR3\u2212\/\u2212 mice. Hum Mol Genet 2004; 13: 271\u2013284.","journal-title":"Hum Mol Genet"},{"key":"BFboneres20143_CR86","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/nm971","volume":"10","author":"A Yasoda","year":"2004","unstructured":"Yasoda A, Komatsu Y, Chusho H et al. Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway. Nat Med 2004; 10: 80\u201386.","journal-title":"Nat Med"},{"key":"BFboneres20143_CR87","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.bone.2005.03.006","volume":"36","author":"A Ozasa","year":"2005","unstructured":"Ozasa A, Komatsu Y, Yasoda A et al. Complementary antagonistic actions between C-type natriuretic peptide and the MAPK pathway through FGFR-3 in ATDC5 cells. Bone 2005; 36: 1056\u20131064.","journal-title":"Bone"},{"key":"BFboneres20143_CR88","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s007740200011","volume":"20","author":"T Ogawa","year":"2002","unstructured":"Ogawa T, Yamagiwa H, Hayami T et al. Human PTH (1\u201334) induces longitudinal bone growth in rats. J Bone Miner Metab 2002; 20: 83\u201390.","journal-title":"J Bone Miner Metab"},{"key":"BFboneres20143_CR89","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.bone.2007.02.028","volume":"41","author":"K Ueda","year":"2007","unstructured":"Ueda K, Yamanaka Y, Harada D, Yamagami E, Tanaka H, Seino Y . PTH has the potential to rescue disturbed bone growth in achondroplasia. Bone 2007; 41: 13\u201318.","journal-title":"Bone"},{"key":"BFboneres20143_CR90","doi-asserted-by":"publisher","first-page":"3941","DOI":"10.1093\/hmg\/dds181","volume":"21","author":"Y Xie","year":"2012","unstructured":"Xie Y, Su N, Jin M et al. Intermittent PTH (1\u201334) injection rescues the retarded skeletal development and postnatal lethality of mice mimicking human achondroplasia and thanatophoric dysplasia. Hum Mol Genet 2012; 21: 3941\u20133955.","journal-title":"Hum Mol Genet"},{"key":"BFboneres20143_CR91","doi-asserted-by":"publisher","first-page":"5443","DOI":"10.1093\/hmg\/dds390","volume":"21","author":"M Jin","year":"2012","unstructured":"Jin M, Yu Y, Qi H et al. A novel FGFR3-binding peptide inhibits FGFR3 signaling and reverses the lethal phenotype of mice mimicking human thanatophoric dysplasia. Hum Mol Genet 2012; 21: 5443\u20135455.","journal-title":"Hum Mol Genet"},{"key":"BFboneres20143_CR92","first-page":"519","volume":"46","author":"S Cool","year":"2002","unstructured":"Cool S, Jackson R, Pincus P, Dickinson I, Nurcombe V . Fibroblast growth factor receptor 4 (FGFR4) expression in newborn murine calvaria and primary osteoblast cultures. Int J Dev Biol 2002; 46: 519\u2013523.","journal-title":"Int J Dev Biol"},{"key":"BFboneres20143_CR93","doi-asserted-by":"publisher","first-page":"3615","DOI":"10.1242\/dev.125.18.3615","volume":"125","author":"M Weinstein","year":"1998","unstructured":"Weinstein M, Xu X, Ohyama K, Deng CX . FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development 1998; 125: 3615\u20133623.","journal-title":"Development"},{"key":"BFboneres20143_CR94","doi-asserted-by":"publisher","first-page":"3539","DOI":"10.1002\/jcp.24075","volume":"227","author":"Y Fei","year":"2012","unstructured":"Fei Y, Hurley MM . Role of fibroblast growth factor 2 and Wnt signaling in anabolic effects of parathyroid hormone on bone formation. J Cell Physiol 2012; 227: 3539\u20133545.","journal-title":"J Cell Physiol"},{"key":"BFboneres20143_CR95","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1172\/JCI8641","volume":"105","author":"A Montero","year":"2000","unstructured":"Montero A, Okada Y, Tomita M et al. Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation. J Clin Invest 2000; 105: 1085\u20131093.","journal-title":"J Clin Invest"},{"key":"BFboneres20143_CR96","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1126\/science.7908145","volume":"264","author":"JF Fallon","year":"1994","unstructured":"Fallon JF, Lopez A, Ros MA, Savage MP, Olwin BB, Simandl BK . FGF-2: apical ectodermal ridge growth signal for chick limb development. Science 1994; 264: 104\u2013107.","journal-title":"Science"},{"key":"BFboneres20143_CR97","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1091\/mbc.6.12.1861","volume":"6","author":"JD Coffin","year":"1995","unstructured":"Coffin JD, Florkiewicz RZ, Neumann J et al. Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice. Mol Biol Cell. 1995; 6: 1861\u20131873.","journal-title":"Mol Biol Cell"},{"key":"BFboneres20143_CR98","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1242\/dev.128.11.2119","volume":"128","author":"M Sahni","year":"2001","unstructured":"Sahni M, Raz R, Coffin JD, Levy D, Basilico C . STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2. Development 2001; 128: 2119\u20132129.","journal-title":"Development"},{"key":"BFboneres20143_CR99","doi-asserted-by":"publisher","first-page":"5672","DOI":"10.1073\/pnas.95.10.5672","volume":"95","author":"S Ortega","year":"1998","unstructured":"Ortega S, Ittmann M, Tsang SH, Ehrlich M, Basilico C . Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2. Proc Natl Acad Sci USA 1998; 95: 5672\u20135677.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFboneres20143_CR100","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nm0298-201","volume":"4","author":"M Zhou","year":"1998","unstructured":"Zhou M, Sutliff RL, Paul RJ et al. Fibroblast growth factor 2 control of vascular tone. Nat Med 1998; 4: 201\u2013207.","journal-title":"Nat Med"},{"key":"BFboneres20143_CR101","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.bone.2010.05.021","volume":"47","author":"L Xiao","year":"2010","unstructured":"Xiao L, Sobue T, Esliger A et al. Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells. Bone 2010; 47: 360\u2013370.","journal-title":"Bone"},{"key":"BFboneres20143_CR102","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/jcb.20389","volume":"95","author":"T Sobue","year":"2005","unstructured":"Sobue T, Naganawa T, Xiao L et al. Over-expression of fibroblast growth factor-2 causes defective bone mineralization and osteopenia in transgenic mice. J Cell Biochem 2005; 95: 83\u201394.","journal-title":"J Cell Biochem"},{"key":"BFboneres20143_CR103","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/jcp.21661","volume":"219","author":"MG Sabbieti","year":"2009","unstructured":"Sabbieti MG, Agas D, Xiao L et al. Endogenous FGF-2 is critically important in PTH anabolic effects on bone. J Cell Physiol 2009; 219: 143\u2013151.","journal-title":"J Cell Physiol"},{"key":"BFboneres20143_CR104","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.bbrc.2005.10.215","volume":"339","author":"T Naganawa","year":"2006","unstructured":"Naganawa T, Xiao L, Abogunde E et al. In vivo and in vitro comparison of the effects of FGF-2 null and haplo-insufficiency on bone formation in mice. Biochem Biophys Res Commun 2006; 339: 490\u2013498.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFboneres20143_CR105","doi-asserted-by":"publisher","first-page":"21258","DOI":"10.1074\/jbc.M302113200","volume":"278","author":"Y Okada","year":"2003","unstructured":"Okada Y, Montero A, Zhang X et al. Impaired osteoclast formation in bone marrow cultures of Fgf2 null mice in response to parathyroid hormone. J Biol Chem 2003; 278: 21258\u201321266.","journal-title":"J Biol Chem"},{"key":"BFboneres20143_CR106","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.bbrc.2011.07.066","volume":"412","author":"Y Fei","year":"2011","unstructured":"Fei Y, Xiao L, Hurley MM . The impaired bone anabolic effect of PTH in the absence of endogenous FGF2 is partially due to reduced ATF4 expression. Biochem Biophys Res Commun 2011; 412: 160\u2013164.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFboneres20143_CR107","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1002\/jcp.22143","volume":"224","author":"MG Sabbieti","year":"2010","unstructured":"Sabbieti MG, Agas D, Marchetti L et al. Signaling pathways implicated in PGF2alpha effects on Fgf2+\/+ and Fgf2\u2212\/\u2212 osteoblasts. J Cell Physiol 2010; 224: 465\u2013474.","journal-title":"J Cell Physiol"},{"key":"BFboneres20143_CR108","doi-asserted-by":"publisher","first-page":"3170","DOI":"10.1074\/jbc.M804900200","volume":"284","author":"L Xiao","year":"2009","unstructured":"Xiao L, Liu P, Li X et al. Exported 18-kDa isoform of fibroblast growth factor-2 is a critical determinant of bone mass in mice. J Biol Chem 2009; 284: 3170\u20133182.","journal-title":"J Biol Chem"},{"key":"BFboneres20143_CR109","doi-asserted-by":"publisher","first-page":"2834","DOI":"10.1074\/jbc.M109.030577","volume":"285","author":"L Xiao","year":"2010","unstructured":"Xiao L, Naganawa T, Lorenzo J, Carpenter TO, Coffin JD, Hurley MM . Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO. J Biol Chem 2010; 285: 2834\u20132846.","journal-title":"J Biol Chem"},{"key":"BFboneres20143_CR110","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/jbmr.1721","volume":"28","author":"L Xiao","year":"2013","unstructured":"Xiao L, Esliger A, Hurley MM . Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23\/FGFR\/MAPK in vitro. J Bone Miner Res 2013; 28: 35\u201345.","journal-title":"J Bone Miner Res"},{"key":"BFboneres20143_CR111","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1242\/dev.127.5.989","volume":"127","author":"AM Moon","year":"2000","unstructured":"Moon AM, Boulet AM, Capecchi MR . Normal limb development in conditional mutants of Fgf4. Development 2000; 127: 989\u2013996.","journal-title":"Development"},{"key":"BFboneres20143_CR112","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/82609","volume":"26","author":"M Lewandoski","year":"2000","unstructured":"Lewandoski M, Sun X, Martin GR . Fgf8 signalling from the AER is essential for normal limb development. Nat Genet 2000; 26: 460\u2013463.","journal-title":"Nat Genet"},{"key":"BFboneres20143_CR113","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1126\/science.7809630","volume":"267","author":"B Feldman","year":"1995","unstructured":"Feldman B, Poueymirou W, Papaioannou VE, DeChiara TM, Goldfarb M . Requirement of FGF-4 for postimplantation mouse development. Science 1995; 267: 246\u2013249.","journal-title":"Science"},{"key":"BFboneres20143_CR114","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1097\/00001665-200107000-00019","volume":"12","author":"IM Mathijssen","year":"2001","unstructured":"Mathijssen IM, van Leeuwen H, Vermeij-Keers C, Vaandrager JM . FGF-4 or FGF-2 administration induces apoptosis, collagen type I expression, and mineralization in the developing coronal suture. J Craniofac Surg 2001; 12: 399\u2013400.","journal-title":"J Craniofac Surg"},{"key":"BFboneres20143_CR115","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1242\/dev.125.7.1241","volume":"125","author":"HJ Kim","year":"1998","unstructured":"Kim HJ, Rice DP, Kettunen PJ, Thesleff I . FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development. Development 1998; 125: 1241\u20131251.","journal-title":"Development"},{"key":"BFboneres20143_CR116","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/S8756-3282(99)00193-3","volume":"25","author":"S Kuroda","year":"1999","unstructured":"Kuroda S, Kasugai S, Oida S, Iimura T, Ohya K, Ohyama T . Anabolic effect of aminoterminally truncated fibroblast growth factor 4 (FGF4) on bone. Bone 1999; 25: 431\u2013437.","journal-title":"Bone"},{"key":"BFboneres20143_CR117","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1089\/scd.2007.0230","volume":"17","author":"SC Choi","year":"2008","unstructured":"Choi SC, Kim SJ, Choi JH, Park CY, Shim WJ, Lim DS . Fibroblast growth factor-2 and -4 promote the proliferation of bone marrow mesenchymal stem cells by the activation of the PI3K\u2013Akt and ERK1\/2 signaling pathways. Stem Cells Dev 2008; 17: 725\u2013736.","journal-title":"Stem Cells Dev"},{"key":"BFboneres20143_CR118","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1080\/08977190701345200","volume":"25","author":"J Farre","year":"2007","unstructured":"Farre J, Roura S, Prat-Vidal C et al. FGF-4 increases in vitro expansion rate of human adult bone marrow-derived mesenchymal stem cells. Growth Factors 2007; 25: 71\u201376.","journal-title":"Growth Factors"},{"key":"BFboneres20143_CR119","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1074\/jbc.M203750200","volume":"278","author":"HJ Kim","year":"2003","unstructured":"Kim HJ, Kim JH, Bae SC, Choi JY, Ryoo HM . The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2. J Biol Chem 2003; 278: 319\u2013326.","journal-title":"J Biol Chem"},{"key":"BFboneres20143_CR120","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0925-4773(94)90022-1","volume":"48","author":"M Heikinheimo","year":"1994","unstructured":"Heikinheimo M, Lawshe A, Shackleford GM, Wilson DB, MacArthur CA . Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system. Mech Dev 1994; 48: 129\u2013138.","journal-title":"Mech Dev"},{"key":"BFboneres20143_CR121","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/S0960-9822(95)00157-6","volume":"5","author":"R Mahmood","year":"1995","unstructured":"Mahmood R, Bresnick J, Hornbruch A et al. A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth. Curr Biol 1995; 5: 797\u2013806.","journal-title":"Curr Biol"},{"key":"BFboneres20143_CR122","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0092-8674(00)80999-X","volume":"84","author":"PH Crossley","year":"1996","unstructured":"Crossley PH, Minowada G, MacArthur CA, Martin GR . Roles for FGF8 in the induction, initiation, and maintenance of chick limb development. Cell 1996; 84: 127\u2013136.","journal-title":"Cell"},{"key":"BFboneres20143_CR123","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1101\/gad.13.14.1834","volume":"13","author":"X Sun","year":"1999","unstructured":"Sun X, Meyers EN, Lewandoski M, Martin GR . Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev 1999; 13: 1834\u20131846.","journal-title":"Genes Dev"},{"key":"BFboneres20143_CR124","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/ng0298-136","volume":"18","author":"EN Meyers","year":"1998","unstructured":"Meyers EN, Lewandoski M, Martin GR . An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat Genet 1998; 18: 136\u2013141.","journal-title":"Nat Genet"},{"key":"BFboneres20143_CR125","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/82601","volume":"26","author":"AM Moon","year":"2000","unstructured":"Moon AM, Capecchi MR . Fgf8 is required for outgrowth and patterning of the limbs. Nat Genet 2000; 26: 455\u2013459.","journal-title":"Nat Genet"},{"key":"BFboneres20143_CR126","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.ydbio.2004.06.012","volume":"273","author":"AM Boulet","year":"2004","unstructured":"Boulet AM, Moon AM, Arenkiel BR, Capecchi MR . The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth. Dev Biol 2004; 273: 361\u2013372.","journal-title":"Dev Biol"},{"key":"BFboneres20143_CR127","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0925-4773(99)00034-9","volume":"83","author":"J Xu","year":"1999","unstructured":"Xu J, Lawshe A, MacArthur CA, Ornitz DM . Genomic structure, mapping, activity and expression of fibroblast growth factor 17. Mech Dev 1999; 83: 165\u2013178.","journal-title":"Mech Dev"},{"key":"BFboneres20143_CR128","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1210\/en.2005-1502","volume":"147","author":"MP Valta","year":"2006","unstructured":"Valta MP, Hentunen T, Qu Q et al. Regulation of osteoblast differentiation: a novel function for fibroblast growth factor 8. Endocrinology 2006; 147: 2171\u20132182.","journal-title":"Endocrinology"},{"key":"BFboneres20143_CR129","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1002\/jcb.22012","volume":"106","author":"K Omoteyama","year":"2009","unstructured":"Omoteyama K, Takagi M . FGF8 regulates myogenesis and induces Runx2 expression and osteoblast differentiation in cultured cells. J Cell Biochem 2009; 106: 546\u2013552.","journal-title":"J Cell Biochem"},{"key":"BFboneres20143_CR130","doi-asserted-by":"publisher","first-page":"E142","DOI":"10.1152\/ajpendo.90743.2008","volume":"297","author":"JM Lin","year":"2009","unstructured":"Lin JM, Callon KE, Lin JS et al. Actions of fibroblast growth factor-8 in bone cells in vitro. Am J Physiol Endocrinol Metab 2009; 297: E142\u2013E150.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFboneres20143_CR131","doi-asserted-by":"publisher","first-page":"R90","DOI":"10.1186\/ar2474","volume":"10","author":"M Uchii","year":"2008","unstructured":"Uchii M, Tamura T, Suda T, Kakuni M, Tanaka A, Miki I . Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis. Arthritis Res Ther 2008; 10: R90.","journal-title":"Arthritis Res Ther"},{"key":"BFboneres20143_CR132","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3109\/08977199509036882","volume":"12","author":"D Hecht","year":"1995","unstructured":"Hecht D, Zimmerman N, Bedford M, Avivi A, Yayon A . Identification of fibroblast growth factor 9 (FGF9) as a high affinity, heparin dependent ligand for FGF receptors 3 and 2 but not for FGF receptors 1 and 4. Growth Factors 1995; 12: 223\u2013233.","journal-title":"Growth Factors"},{"key":"BFboneres20143_CR133","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1359\/jbmr.1999.14.11.1909","volume":"14","author":"S Garofalo","year":"1999","unstructured":"Garofalo S, Kliger-Spatz M, Cooke JL et al. Skeletal dysplasia and defective chondrocyte differentiation by targeted overexpression of fibroblast growth factor 9 in transgenic mice. J Bone Miner Res 1999; 14: 1909\u20131915.","journal-title":"J Bone Miner Res"},{"key":"BFboneres20143_CR134","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1002\/(SICI)1097-0177(199909)216:1<72::AID-DVDY9>3.0.CO;2-9","volume":"216","author":"JS Colvin","year":"1999","unstructured":"Colvin JS, Feldman B, Nadeau JH, Goldfarb M, Ornitz DM . Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene. Dev Dyn 1999; 216: 72\u201388.","journal-title":"Dev Dyn"},{"key":"BFboneres20143_CR135","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.ydbio.2007.04.048","volume":"307","author":"IH Hung","year":"2007","unstructured":"Hung IH, Yu K, Lavine KJ, Ornitz DM . FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod. Dev Biol 2007; 307: 300\u2013313.","journal-title":"Dev Biol"},{"key":"BFboneres20143_CR136","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1242\/dev.128.11.2095","volume":"128","author":"JS Colvin","year":"2001","unstructured":"Colvin JS, White AC, Pratt SJ, Ornitz DM . Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme. Development 2001; 128: 2095\u20132106.","journal-title":"Development"},{"key":"BFboneres20143_CR137","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/S0092-8674(01)00284-7","volume":"104","author":"JS Colvin","year":"2001","unstructured":"Colvin JS, Green RP, Schmahl J, Capel B, Ornitz DM . Male-to-female sex reversal in mice lacking fibroblast growth factor 9. Cell 2001; 104: 875\u2013889.","journal-title":"Cell"},{"key":"BFboneres20143_CR138","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.bone.2004.10.003","volume":"36","author":"A Fakhry","year":"2005","unstructured":"Fakhry A, Ratisoontorn C, Vedhachalam C et al. Effects of FGF-2\/-9 in calvarial bone cell cultures: differentiation stage-dependent mitogenic effect, inverse regulation of BMP-2 and noggin, and enhancement of osteogenic potential. Bone 2005; 36: 254\u2013266.","journal-title":"Bone"},{"key":"BFboneres20143_CR139","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-213X-6-7","volume":"6","author":"V Govindarajan","year":"2006","unstructured":"Govindarajan V, Overbeek PA . FGF9 can induce endochondral ossification in cranial mesenchyme. BMC Dev Biol 2006; 6: 7.","journal-title":"BMC Dev Biol"},{"key":"BFboneres20143_CR140","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/ng.316","volume":"41","author":"M Harada","year":"2009","unstructured":"Harada M, Murakami H, Okawa A et al. FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion. Nat Genet 2009; 41: 289\u2013298.","journal-title":"Nat Genet"},{"key":"BFboneres20143_CR141","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.ajhg.2009.06.007","volume":"85","author":"XL Wu","year":"2009","unstructured":"Wu XL, Gu MM, Huang L et al. Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene. Am J Hum Genet 2009; 85: 53\u201363.","journal-title":"Am J Hum Genet"},{"key":"BFboneres20143_CR142","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1002\/gene.20194","volume":"44","author":"Y Lin","year":"2006","unstructured":"Lin Y, Liu G, Wang F . Generation of an Fgf9 conditional null allele. Genesis 2006; 44: 150\u2013154.","journal-title":"Genesis"},{"key":"BFboneres20143_CR143","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1101\/gad.12.11.1571","volume":"12","author":"GR Martin","year":"1998","unstructured":"Martin GR . The roles of FGFs in the early development of vertebrate limbs. Genes Dev 1998; 12: 1571\u20131586.","journal-title":"Genes Dev"},{"key":"BFboneres20143_CR144","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1242\/dev.124.11.2235","volume":"124","author":"H Ohuchi","year":"1997","unstructured":"Ohuchi H, Nakagawa T, Yamamoto A et al. The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor. Development 1997; 124: 2235\u20132244.","journal-title":"Development"},{"key":"BFboneres20143_CR145","doi-asserted-by":"publisher","first-page":"3156","DOI":"10.1101\/gad.12.20.3156","volume":"12","author":"H Min","year":"1998","unstructured":"Min H, Danilenko DM, Scully SA et al. Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev 1998; 12: 3156\u20133161.","journal-title":"Genes Dev"},{"key":"BFboneres20143_CR146","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/5096","volume":"21","author":"K Sekine","year":"1999","unstructured":"Sekine K, Ohuchi H, Fujiwara M et al. Fgf10 is essential for limb and lung formation. Nat Genet 1999; 21: 138\u2013141.","journal-title":"Nat Genet"},{"key":"BFboneres20143_CR147","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1101\/gad.965602","volume":"16","author":"Z Liu","year":"2002","unstructured":"Liu Z, Xu J, Colvin JS, Ornitz DM . Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. Genes Dev 2002; 16: 859\u2013869.","journal-title":"Genes Dev"},{"key":"BFboneres20143_CR148","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1101\/gad.965702","volume":"16","author":"N Ohbayashi","year":"2002","unstructured":"Ohbayashi N, Shibayama M, Kurotaki Y et al. FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev 2002; 16: 870\u2013879.","journal-title":"Genes Dev"},{"key":"BFboneres20143_CR149","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.mod.2004.11.006","volume":"122","author":"A Mukherjee","year":"2005","unstructured":"Mukherjee A, Dong SS, Clemens T, Alvarez J, Serra R . Co-ordination of TGF-beta and FGF signaling pathways in bone organ cultures. Mech Dev 2005; 122: 557\u2013571.","journal-title":"Mech Dev"},{"key":"BFboneres20143_CR150","doi-asserted-by":"publisher","first-page":"7493","DOI":"10.1074\/jbc.M108653200","volume":"277","author":"T Shimoaka","year":"2002","unstructured":"Shimoaka T, Ogasawara T, Yonamine A et al. Regulation of osteoblast, chondrocyte, and osteoclast functions by fibroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF-10. J Biol Chem 2002; 277: 7493\u20137500.","journal-title":"J Biol Chem"},{"key":"BFboneres20143_CR151","doi-asserted-by":"publisher","first-page":"38209","DOI":"10.1074\/jbc.M404855200","volume":"279","author":"MI Reinhold","year":"2004","unstructured":"Reinhold MI, Abe M, Kapadia RM, Liao Z, Naski MC . FGF18 represses noggin expression and is induced by calcineurin. J Biol Chem 2004; 279: 38209\u201338219.","journal-title":"J Biol Chem"},{"key":"BFboneres20143_CR152","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.ydbio.2006.08.071","volume":"302","author":"Z Liu","year":"2007","unstructured":"Liu Z, Lavine KJ, Hung IH, Ornitz DM . FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate. Dev Biol 2007; 302: 80\u201391.","journal-title":"Dev Biol"},{"key":"BFboneres20143_CR153","doi-asserted-by":"publisher","first-page":"3417","DOI":"10.1128\/MCB.02249-06","volume":"27","author":"R Goetz","year":"2007","unstructured":"Goetz R, Beenken A, Ibrahimi OA et al. Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol Cell Biol 2007; 27: 3417\u20133428.","journal-title":"Mol Cell Biol"},{"key":"BFboneres20143_CR154","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/dvdy.21388","volume":"237","author":"N Itoh","year":"2008","unstructured":"Itoh N, Ornitz DM . Functional evolutionary history of the mouse Fgf gene family. Dev Dyn 2008; 237: 18\u201327.","journal-title":"Dev Dyn"},{"key":"BFboneres20143_CR155","doi-asserted-by":"publisher","first-page":"10853","DOI":"10.1073\/pnas.0904187106","volume":"106","author":"MJ Potthoff","year":"2009","unstructured":"Potthoff MJ, Inagaki T, Satapati S et al. FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci USA 2009; 106: 10853\u201310858.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFboneres20143_CR156","doi-asserted-by":"publisher","first-page":"4625","DOI":"10.1210\/en.2009-0119","volume":"150","author":"Y Hotta","year":"2009","unstructured":"Hotta Y, Nakamura H, Konishi M et al. Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology 2009; 150: 4625\u20134633.","journal-title":"Endocrinology"},{"key":"BFboneres20143_CR157","doi-asserted-by":"publisher","first-page":"4931","DOI":"10.1210\/en.2009-0532","volume":"150","author":"MK Badman","year":"2009","unstructured":"Badman MK, Koester A, Flier JS, Kharitonenkov A, Maratos-Flier E . Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. Endocrinology 2009; 150: 4931\u20134940.","journal-title":"Endocrinology"},{"key":"BFboneres20143_CR158","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.cmet.2007.05.003","volume":"5","author":"T Inagaki","year":"2007","unstructured":"Inagaki T, Dutchak P, Zhao G et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab 2007; 5: 415\u2013425.","journal-title":"Cell Metab"},{"key":"BFboneres20143_CR159","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.1073\/pnas.1200797109","volume":"109","author":"W Wei","year":"2012","unstructured":"Wei W, Dutchak PA, Wang X et al. Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor gamma. Proc Natl Acad Sci USA 2012; 109: 3143\u20133148.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFboneres20143_CR160","doi-asserted-by":"publisher","first-page":"26060","DOI":"10.1074\/jbc.M112.343707","volume":"287","author":"S Wu","year":"2012","unstructured":"Wu S, Levenson A, Kharitonenkov A, de Luca F . Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate. J Biol Chem 2012; 287: 26060\u201326067.","journal-title":"J Biol Chem"},{"key":"BFboneres20143_CR161","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1210\/en.2011-1909","volume":"153","author":"RA Kubicky","year":"2012","unstructured":"Kubicky RA, Wu S, Kharitonenkov A, de Luca F . Role of fibroblast growth factor 21 (FGF21) in undernutrition-related attenuation of growth in mice. Endocrinology 2012; 153: 2287\u20132295.","journal-title":"Endocrinology"},{"key":"BFboneres20143_CR162","doi-asserted-by":"publisher","first-page":"254S","DOI":"10.3945\/ajcn.2009.28449B","volume":"91","author":"SA Kliewer","year":"2010","unstructured":"Kliewer SA, Mangelsdorf DJ . Fibroblast growth factor 21: from pharmacology to physiology. Am J Clin Nutr 2010; 91: 254S\u2013257S.","journal-title":"Am J Clin Nutr"},{"key":"BFboneres20143_CR163","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1038\/nm.3250","volume":"19","author":"BM Owen","year":"2013","unstructured":"Owen BM, Bookout AL, Ding X et al. FGF21 contributes to neuroendocrine control of female reproduction. Nat Med 2013; 19: 1153\u20131156.","journal-title":"Nat Med"},{"key":"BFboneres20143_CR164","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1006\/bbrc.2000.3696","volume":"277","author":"T Yamashita","year":"2000","unstructured":"Yamashita T, Yoshioka M, Itoh N . Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. Biochem Biophys Res Commun 2000; 277: 494\u2013498.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFboneres20143_CR165","doi-asserted-by":"publisher","first-page":"37419","DOI":"10.1074\/jbc.M304544200","volume":"278","author":"S Liu","year":"2003","unstructured":"Liu S, Guo R, Simpson LG, Xiao ZS, Burnham CE, Quarles LD . Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX. J Biol Chem 2003; 278: 37419\u201337426.","journal-title":"J Biol Chem"},{"key":"BFboneres20143_CR166","doi-asserted-by":"publisher","first-page":"E38","DOI":"10.1152\/ajpendo.00008.2006","volume":"291","author":"S Liu","year":"2006","unstructured":"Liu S, Zhou J, Tang W, Jiang X, Rowe DW, Quarles LD . Pathogenic role of Fgf23 in Hyp mice. Am J Physiol Endocrinol Metab 2006; 291: E38\u2013E49.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFboneres20143_CR167","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1016\/j.bone.2007.01.017","volume":"40","author":"Y Yoshiko","year":"2007","unstructured":"Yoshiko Y, Wang H, Minamizaki T et al. Mineralized tissue cells are a principal source of FGF23. Bone 2007; 40: 1565\u20131573.","journal-title":"Bone"},{"key":"BFboneres20143_CR168","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1210\/jcem.82.2.3765","volume":"82","author":"MJ Econs","year":"1997","unstructured":"Econs MJ, McEnery PT . Autosomal dominant hypophosphatemic rickets\/osteomalacia: clinical characterization of a novel renal phosphate-wasting disorder. J Clin Endocrinol Metab 1997; 82: 674\u2013681.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFboneres20143_CR169","first-page":"287","volume":"7","author":"JW Bianchine","year":"1971","unstructured":"Bianchine JW, Stambler AA, Harrison HE . Familial hypophosphatemic rickets showing autosomal dominant inheritance. Birth Defects Orig Artic Ser 1971; 7: 287\u2013295.","journal-title":"Birth Defects Orig Artic Ser"},{"key":"BFboneres20143_CR170","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/81664","volume":"26","author":"A Consortium","year":"2000","unstructured":"Consortium A . Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet 2000; 26: 345\u2013348.","journal-title":"Nat Genet"},{"key":"BFboneres20143_CR171","doi-asserted-by":"publisher","first-page":"3179","DOI":"10.1210\/endo.143.8.8795","volume":"143","author":"T Shimada","year":"2002","unstructured":"Shimada T, Muto T, Urakawa I et al. Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo. Endocrinology 2002; 143: 3179\u20133182.","journal-title":"Endocrinology"},{"key":"BFboneres20143_CR172","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1046\/j.1523-1755.2001.00064.x","volume":"60","author":"KE White","year":"2001","unstructured":"White KE, Carn G, Lorenz-Depiereux B, Benet-Pages A, Strom TM, Econs MJ . Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23. Kidney Int 2001; 60: 2079\u20132086.","journal-title":"Kidney Int"},{"key":"BFboneres20143_CR173","doi-asserted-by":"publisher","first-page":"6500","DOI":"10.1073\/pnas.101545198","volume":"98","author":"T Shimada","year":"2001","unstructured":"Shimada T, Mizutani S, Muto T et al. Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc Natl Acad Sci USA 2001; 98: 6500\u20136505.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFboneres20143_CR174","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1172\/JCI18399","volume":"112","author":"M Riminucci","year":"2003","unstructured":"Riminucci M, Collins MT, Fedarko NS et al. FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting. J Clin Invest 2003; 112: 683\u2013692.","journal-title":"J Clin Invest"},{"key":"BFboneres20143_CR175","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1210\/jcem-67-1-88","volume":"67","author":"KW Lyles","year":"1988","unstructured":"Lyles KW, Halsey DL, Friedman NE, Lobaugh B . Correlations of serum concentrations of 1,25-dihydroxyvitamin D, phosphorus, and parathyroid hormone in tumoral calcinosis. J Clin Endocrinol Metab 1988; 67: 88\u201392.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFboneres20143_CR176","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1093\/hmg\/ddi034","volume":"14","author":"A Benet-Pages","year":"2005","unstructured":"Benet-Pages A, Orlik P, Strom TM, Lorenz-Depiereux B . An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. Hum Mol Genet 2005; 14: 385\u2013390.","journal-title":"Hum Mol Genet"},{"key":"BFboneres20143_CR177","doi-asserted-by":"publisher","first-page":"5523","DOI":"10.1210\/jc.2005-0301","volume":"90","author":"K Araya","year":"2005","unstructured":"Araya K, Fukumoto S, Backenroth R et al. A novel mutation in fibroblast growth factor 23 gene as a cause of tumoral calcinosis. J Clin Endocrinol Metab 2005; 90: 5523\u20135527.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFboneres20143_CR178","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1210\/jc.2004-2238","volume":"90","author":"T Larsson","year":"2005","unstructured":"Larsson T, Yu X, Davis SI et al. A novel recessive mutation in fibroblast growth factor-23 causes familial tumoral calcinosis. J Clin Endocrinol Metab 2005; 90: 2424\u20132427.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFboneres20143_CR179","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.bbrc.2003.12.102","volume":"314","author":"T Shimada","year":"2004","unstructured":"Shimada T, Urakawa I, Yamazaki Y et al. FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa. Biochem Biophys Res Commun 2004; 314: 409\u2013414.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFboneres20143_CR180","doi-asserted-by":"publisher","first-page":"3087","DOI":"10.1210\/en.2003-1768","volume":"145","author":"T Larsson","year":"2004","unstructured":"Larsson T, Marsell R, Schipani E et al. Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. Endocrinology 2004; 145: 3087\u20133094.","journal-title":"Endocrinology"},{"key":"BFboneres20143_CR181","doi-asserted-by":"publisher","first-page":"5269","DOI":"10.1210\/en.2004-0233","volume":"145","author":"X Bai","year":"2004","unstructured":"Bai X, Miao D, Li J, Goltzman D, Karaplis AC . Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders. Endocrinology 2004; 145: 5269\u20135279.","journal-title":"Endocrinology"},{"key":"BFboneres20143_CR182","doi-asserted-by":"publisher","first-page":"5372","DOI":"10.1073\/pnas.95.9.5372","volume":"95","author":"L Beck","year":"1998","unstructured":"Beck L, Karaplis AC, Amizuka N, Hewson AS, Ozawa H, Tenenhouse HS . Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc Natl Acad Sci USA 1998; 95: 5372\u20135377.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFboneres20143_CR183","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1359\/JBMR.0301264","volume":"19","author":"T Shimada","year":"2004","unstructured":"Shimada T, Hasegawa H, Yamazaki Y et al. FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Miner Res 2004; 19: 429\u2013435.","journal-title":"J Bone Miner Res"},{"key":"BFboneres20143_CR184","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1172\/JCI200419081","volume":"113","author":"T Shimada","year":"2004","unstructured":"Shimada T, Kakitani M, Yamazaki Y et al. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Inves 2004; 113: 561\u2013568.","journal-title":"J Clin Inves"},{"key":"BFboneres20143_CR185","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.molmed.2006.05.002","volume":"12","author":"MS Razzaque","year":"2006","unstructured":"Razzaque MS, Lanske B . Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice. Trends Mol Med 2006; 12: 298\u2013305.","journal-title":"Trends Mol Med"},{"key":"BFboneres20143_CR186","doi-asserted-by":"publisher","first-page":"3541","DOI":"10.1210\/jc.2011-1239","volume":"96","author":"EA Imel","year":"2011","unstructured":"Imel EA, Peacock M, Gray AK, Padgett LR, Hui SL, Econs MJ . Iron modifies plasma FGF23 differently in autosomal dominant hypophosphatemic rickets and healthy humans. J Clin Endocrinol Metab 2011; 96: 3541\u20133549.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFboneres20143_CR187","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1258\/000456307781646102","volume":"44","author":"BH Durham","year":"2007","unstructured":"Durham BH, Joseph F, Bailey LM, Fraser WD . The association of circulating ferritin with serum concentrations of fibroblast growth factor-23 measured by three commercial assays. Ann Clin Biochem 2007; 44: 463\u2013466.","journal-title":"Ann Clin Biochem"},{"key":"BFboneres20143_CR188","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/jbmr.2049","volume":"29","author":"EL Clinkenbeard","year":"2014","unstructured":"Clinkenbeard EL, Farrow EG, Summers LJ et al. Neonatal iron deficiency causes abnormal phosphate metabolism by elevating FGF23 in normal and ADHR mice. J Bone Miner Res 2014; 29: 361\u2013369","journal-title":"J Bone Miner Res"},{"key":"BFboneres20143_CR189","doi-asserted-by":"publisher","first-page":"E1146","DOI":"10.1073\/pnas.1110905108","volume":"108","author":"EG Farrow","year":"2011","unstructured":"Farrow EG, Yu X, Summers LJ et al. Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice. Proc Natl Acad Sci USA 2011; 108: E1146\u2013E1155.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFboneres20143_CR190","doi-asserted-by":"publisher","first-page":"4957","DOI":"10.1210\/jc.2002-021105","volume":"87","author":"Y Yamazaki","year":"2002","unstructured":"Yamazaki Y, Okazaki R, Shibata M et al. Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets\/osteomalacia. J Clin Endocrinol Metab 2002; 87: 4957\u20134960.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFboneres20143_CR191","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1056\/NEJM200307313490517","volume":"349","author":"S Fukumoto","year":"2003","unstructured":"Fukumoto S, Yamashita T . Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. N Engl J Med 2003; 349: 505\u2013506; author reply 505\u2013506.","journal-title":"N Engl J Med"},{"key":"BFboneres20143_CR192","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1093\/hmg\/6.2.165","volume":"6","author":"TM Strom","year":"1997","unstructured":"Strom TM, Francis F, Lorenz B et al. Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia. Hum Mol Genet 1997; 6: 165\u2013171.","journal-title":"Hum Mol Genet"},{"key":"BFboneres20143_CR193","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.matbio.2004.09.007","volume":"23","author":"D Sitara","year":"2004","unstructured":"Sitara D, Razzaque MS, Hesse M et al. Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol 2004; 23: 421\u2013432.","journal-title":"Matrix Biol"},{"key":"BFboneres20143_CR194","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1002\/jcb.24115","volume":"113","author":"C Owen","year":"2012","unstructured":"Owen C, Chen F, Flenniken AM et al. A novel Phex mutation in a new mouse model of hypophosphatemic rickets. J Cell Biochem 2012; 113: 2432\u20132441.","journal-title":"J Cell Biochem"},{"key":"BFboneres20143_CR195","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1096\/fj.10-177816","volume":"25","author":"A Martin","year":"2011","unstructured":"Martin A, Liu S, David V et al. Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling. FASEB J 2011; 25: 2551\u20132562.","journal-title":"FASEB J"},{"key":"BFboneres20143_CR196","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1038\/ng1905","volume":"38","author":"JQ Feng","year":"2006","unstructured":"Feng JQ, Ward LM, Liu S et al. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet 2006; 38: 1310\u20131315.","journal-title":"Nat Genet"},{"key":"BFboneres20143_CR197","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1038\/ng1868","volume":"38","author":"B Lorenz-Depiereux","year":"2006","unstructured":"Lorenz-Depiereux B, Bastepe M, Benet-Pages A et al. DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. Nat Genet 2006; 38: 1248\u20131250.","journal-title":"Nat Genet"},{"key":"BFboneres20143_CR198","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1046\/j.1523-1755.2003.00328.x","volume":"64","author":"T Larsson","year":"2003","unstructured":"Larsson T, Nisbeth U, Ljunggren O, Juppner H, Jonsson KB . Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers. Kidney Int 2003; 64: 2272\u20132279.","journal-title":"Kidney Int"},{"key":"BFboneres20143_CR199","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1002\/jbmr.516","volume":"27","author":"JR Stubbs","year":"2012","unstructured":"Stubbs JR, He N, Idiculla A et al. Longitudinal evaluation of FGF23 changes and mineral metabolism abnormalities in a mouse model of chronic kidney disease. J Bone Miner Res 2012; 27: 38\u201346.","journal-title":"J Bone Miner Res"},{"key":"BFboneres20143_CR200","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nm0411-428","volume":"17","author":"LD Quarles","year":"2011","unstructured":"Quarles LD . The bone and beyond: \u2018Dem bones\u2019 are made for more than walking. Nat Med 2011; 17: 428\u2013430.","journal-title":"Nat Med"},{"key":"BFboneres20143_CR201","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.atherosclerosis.2009.05.013","volume":"207","author":"MA Mirza","year":"2009","unstructured":"Mirza MA, Larsson A, Melhus H, Lind L, Larsson TE . Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population. Atherosclerosis 2009; 207: 546\u2013551.","journal-title":"Atherosclerosis"},{"key":"BFboneres20143_CR202","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1161\/CIRCULATIONAHA.108.844506","volume":"119","author":"OM Gutierrez","year":"2009","unstructured":"Gutierrez OM, Januzzi JL, Isakova T et al. Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease. Circulation 2009; 119: 2545\u20132552.","journal-title":"Circulation"},{"key":"BFboneres20143_CR203","doi-asserted-by":"publisher","first-page":"4393","DOI":"10.1172\/JCI46122","volume":"121","author":"C Faul","year":"2011","unstructured":"Faul C, Amaral AP, Oskouei B et al. FGF23 induces left ventricular hypertrophy. J Clin Invest 2011; 121: 4393\u20134408.","journal-title":"J Clin Invest"},{"key":"BFboneres20143_CR204","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.tem.2012.07.002","volume":"23","author":"N Bhattacharyya","year":"2012","unstructured":"Bhattacharyya N, Chong WH, Gafni RI, Collins MT . Fibroblast growth factor 23: state of the field and future directions. Trends Endocrinol Metab 2012; 23: 610\u2013618.","journal-title":"Trends Endocrinol Metab"},{"key":"BFboneres20143_CR205","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1242\/dev.117.1.13","volume":"117","author":"SL Mansour","year":"1993","unstructured":"Mansour SL, Goddard JM, Capecchi MR . Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. Development 1993; 117: 13\u201328.","journal-title":"Development"},{"key":"BFboneres20143_CR206","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1128\/MCB.20.6.2260-2268.2000","volume":"20","author":"DL Miller","year":"2000","unstructured":"Miller DL, Ortega S, Bashayan O, Basch R, Basilico C . Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice. Mol Cell Biol 2000; 20: 2260\u20132268.","journal-title":"Mol Cell Biol"},{"key":"BFboneres20143_CR207","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/0092-8674(94)90276-3","volume":"78","author":"JM Hebert","year":"1994","unstructured":"Hebert JM, Rosenquist T, Gotz J, Martin GR . FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. Cell 1994; 78: 1017\u20131025.","journal-title":"Cell"},{"key":"BFboneres20143_CR208","first-page":"639","volume":"41","author":"F Fiore","year":"1997","unstructured":"Fiore F, Planche J, Gibier P, Sebille A, deLapeyriere O, Birnbaum D . Apparent normal phenotype of Fgf6\u2212\/\u2212 mice. Int J Dev Biol 1997; 41: 639\u2013642.","journal-title":"Int J Dev Biol"},{"key":"BFboneres20143_CR209","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1101\/gad.10.2.165","volume":"10","author":"L Guo","year":"1996","unstructured":"Guo L, Degenstein L, Fuchs E . Keratinocyte growth factor is required for hair development but not for wound healing. Genes Dev 1996; 10: 165\u2013175.","journal-title":"Genes Dev"},{"key":"BFboneres20143_CR210","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1242\/dev.127.9.1833","volume":"127","author":"J Xu","year":"2000","unstructured":"Xu J, Liu Z, Ornitz DM . Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures. Development 2000; 127: 1833\u20131843.","journal-title":"Development"},{"key":"BFboneres20143_CR211","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1111\/j.1601-183X.2007.00357.x","volume":"7","author":"K Scearce-Levie","year":"2008","unstructured":"Scearce-Levie K, Roberson ED, Gerstein H et al. Abnormal social behaviors in mice lacking Fgf17. Genes Brain Behav 2008; 7: 344\u2013354.","journal-title":"Genes Brain Behav"},{"key":"BFboneres20143_CR212","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/nature09041","volume":"465","author":"A Terauchi","year":"2010","unstructured":"Terauchi A, Johnson-Venkatesh EM, Toth AB, Javed D, Sutton MA, Umemori H . Distinct FGFs promote differentiation of excitatory and inhibitory synapses. Nature 2010; 465: 783\u2013787.","journal-title":"Nature"},{"key":"BFboneres20143_CR213","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.neuron.2007.07.006","volume":"55","author":"M Goldfarb","year":"2007","unstructured":"Goldfarb M, Schoorlemmer J, Williams A et al. Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels. Neuron 2007; 55: 449\u2013463.","journal-title":"Neuron"},{"key":"BFboneres20143_CR214","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1016\/j.cell.2012.04.046","volume":"149","author":"QF Wu","year":"2012","unstructured":"Wu QF, Yang L, Li S et al. Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell 2012; 149: 1549\u20131564.","journal-title":"Cell"},{"key":"BFboneres20143_CR215","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0896-6273(02)00744-4","volume":"35","author":"Q Wang","year":"2002","unstructured":"Wang Q, Bardgett ME, Wong M et al. Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14. Neuron 2002; 35: 25\u201338.","journal-title":"Neuron"},{"key":"BFboneres20143_CR216","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.cmet.2005.09.001","volume":"2","author":"T Inagaki","year":"2005","unstructured":"Inagaki T, Choi M, Moschetta A et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005; 2: 217\u2013225.","journal-title":"Cell Metab"},{"key":"BFboneres20143_CR217","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1002\/dvdy.21726","volume":"237","author":"Y Hotta","year":"2008","unstructured":"Hotta Y, Sasaki S, Konishi M et al. Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart. Dev Dyn 2008; 237: 2947\u20132954.","journal-title":"Dev Dyn"},{"key":"BFboneres20143_CR218","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/j.devcel.2012.04.018","volume":"22","author":"H Barak","year":"2012","unstructured":"Barak H, Huh SH, Chen S et al. FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Dev Cell 2012; 22: 1191\u20131207.","journal-title":"Dev Cell"},{"key":"BFboneres20143_CR219","unstructured":"Velocigene. Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission 2008."},{"key":"BFboneres20143_CR220","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/j.1748-1716.2011.02385.x","volume":"204","author":"A Neve","year":"2012","unstructured":"Neve A, Corrado A, Cantatore FP . Osteocytes: central conductors of bone biology in normal and pathological conditions. Acta Physiol 2012; 204: 317\u2013330.","journal-title":"Acta Physiol"},{"key":"BFboneres20143_CR221","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1177\/0022034510363963","volume":"89","author":"C Galli","year":"2010","unstructured":"Galli C, Passeri G, Macaluso GM . Osteocytes and WNT: the mechanical control of bone formation. J Dent Res 2010; 89: 331\u2013343.","journal-title":"J Dent Res"},{"key":"BFboneres20143_CR222","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/nature10763","volume":"481","author":"G Karsenty","year":"2012","unstructured":"Karsenty G, Ferron M . The contribution of bone to whole-organism physiology. Nature 2012; 481: 314\u2013320.","journal-title":"Nature"},{"key":"BFboneres20143_CR223","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.crvi.2011.07.007","volume":"334","author":"G Karsenty","year":"2011","unstructured":"Karsenty G . Bone endocrine regulation of energy metabolism and male reproduction. C R Biol 2011; 334: 720\u2013724.","journal-title":"C R Biol"},{"key":"BFboneres20143_CR224","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/nature02041","volume":"425","author":"J Zhang","year":"2003","unstructured":"Zhang J, Niu C, Ye L et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003; 425: 836\u2013841.","journal-title":"Nature"},{"key":"BFboneres20143_CR225","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1053\/j.ajkd.2013.02.366","volume":"62","author":"S Sardiwal","year":"2013","unstructured":"Sardiwal S, Magnusson P, Goldsmith DJ, Lamb EJ . Bone alkaline phosphatase in CKD-mineral bone disorder. Am J Kidney Dis 2013; 62: 810\u2013822.","journal-title":"Am J Kidney Dis"},{"key":"BFboneres20143_CR226","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/j.0105-2896.2005.00334.x","volume":"208","author":"JA Clowes","year":"2005","unstructured":"Clowes JA, Riggs BL, Khosla S . The role of the immune system in the pathophysiology of osteoporosis. Immunol Rev 2005; 208: 207\u2013227.","journal-title":"Immunol Rev"},{"key":"BFboneres20143_CR227","doi-asserted-by":"publisher","first-page":"S147","DOI":"10.1301\/nr.2007.dec.S147-S151","volume":"65","author":"GR Mundy","year":"2007","unstructured":"Mundy GR . Osteoporosis and inflammation. Nutr Rev 2007; 65: S147\u2013S151.","journal-title":"Nutr Rev"},{"key":"BFboneres20143_CR228","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1242\/dev.124.14.2829","volume":"124","author":"BG Ciruna","year":"1997","unstructured":"Ciruna BG, Schwartz L, Harpal K, Yamaguchi TP, Rossant J . Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak. Development 1997; 124: 2829\u20132841.","journal-title":"Development"},{"key":"BFboneres20143_CR229","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/gene.10028","volume":"32","author":"X Xu","year":"2002","unstructured":"Xu X, Qiao W, Li C, Deng CX . Generation of Fgfr1 conditional knockout mice. Genesis 2002; 32: 85\u201386.","journal-title":"Genesis"},{"key":"BFboneres20143_CR230","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/S0896-6273(02)00824-3","volume":"35","author":"U Pirvola","year":"2002","unstructured":"Pirvola U, Ylikoski J, Trokovic R, Hebert JM, McConnell SK, Partanen J . FGFR1 is required for the development of the auditory sensory epithelium. Neuron 2002; 35: 671\u2013680.","journal-title":"Neuron"},{"key":"BFboneres20143_CR231","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1006\/exer.2000.0892","volume":"71","author":"B Rousseau","year":"2000","unstructured":"Rousseau B, Dubayle D, Sennlaub F et al. Neural and angiogenic defects in eyes of transgenic mice expressing a dominant-negative FGF receptor in the pigmented cells. Exp Eye Res 2000; 71: 395\u2013404.","journal-title":"Exp Eye Res"},{"key":"BFboneres20143_CR232","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1242\/dev.00940","volume":"131","author":"MK Hajihosseini","year":"2004","unstructured":"Hajihosseini MK, Lalioti MD, Arthaud S et al. Skeletal development is regulated by fibroblast growth factor receptor 1 signalling dynamics. Development 2004; 131: 325\u2013335.","journal-title":"Development"},{"key":"BFboneres20143_CR233","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1006\/dbio.2000.0144","volume":"231","author":"JM Revest","year":"2001","unstructured":"Revest JM, Spencer-Dene B, Kerr K et al. Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4. Dev Biol 2001; 231: 47\u201362.","journal-title":"Dev Biol"},{"key":"BFboneres20143_CR234","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1242\/dev.127.3.483","volume":"127","author":"L de Moerlooze","year":"2000","unstructured":"de Moerlooze L, Spencer-Dene B, Revest JM, Hajihosseini M, Rosewell I, Dickson C . An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal\u2013epithelial signalling during mouse organogenesis. Development 2000; 127: 483\u2013492.","journal-title":"Development"},{"key":"BFboneres20143_CR235","doi-asserted-by":"publisher","first-page":"3855","DOI":"10.1073\/pnas.071586898","volume":"98","author":"MK Hajihosseini","year":"2001","unstructured":"Hajihosseini MK, Wilson S, de Moerlooze L, Dickson C . A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert\/Pfeiffer-syndrome-like phenotypes. Proc Natl Acad Sci USA 2001; 98: 3855\u20133860.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFboneres20143_CR236","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1002\/dvdy.22314","volume":"239","author":"S Mai","year":"2010","unstructured":"Mai S, Wei K, Flenniken A et al. The missense mutation W290R in Fgfr2 causes developmental defects from aberrant IIIb and IIIc signaling. Dev Dyn 2010; 239: 1888\u20131900.","journal-title":"Dev Dyn"},{"key":"BFboneres20143_CR237","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1093\/hmg\/ddl100","volume":"15","author":"G Valverde-Franco","year":"2006","unstructured":"Valverde-Franco G, Binette JS, Li W et al. Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice. Hum Mol Genet. 2006; 15: 1783\u20131792.","journal-title":"Hum Mol Genet"},{"key":"BFboneres20143_CR238","doi-asserted-by":"publisher","first-page":"3937","DOI":"10.1073\/pnas.0700012104","volume":"104","author":"VP Eswarakumar","year":"2007","unstructured":"Eswarakumar VP, Schlessinger J . Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3. Proc Natl Acad Sci USA 2007; 104: 3937\u20133942.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFboneres20143_CR239","doi-asserted-by":"publisher","first-page":"327","DOI":"10.7150\/ijbs.6.327","volume":"6","author":"N Su","year":"2010","unstructured":"Su N, Xu X, Li C et al. Generation of Fgfr3 conditional knockout mice. Int J Biol 2010; 6: 327\u2013332.","journal-title":"Int J Biol"},{"key":"BFboneres20143_CR240","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1002\/dvdy.21790","volume":"238","author":"SR Twigg","year":"2009","unstructured":"Twigg SR, Healy C, Babbs C et al. Skeletal analysis of the Fgfr3(P244R) mouse, a genetic model for the Muenke craniosynostosis syndrome. Dev Dyn 2009; 238: 331\u2013342.","journal-title":"Dev Dyn"},{"key":"BFboneres20143_CR241","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.bbadis.2008.11.010","volume":"1792","author":"S Pannier","year":"2009","unstructured":"Pannier S, Couloigner V, Messaddeq N et al. Activating Fgfr3 Y367C mutation causes hearing loss and inner ear defect in a mouse model of chondrodysplasia. Biochim Biophys Acta 2009; 1792: 140\u2013147.","journal-title":"Biochim Biophys Acta"},{"key":"BFboneres20143_CR242","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1093\/hmg\/10.12.1255","volume":"10","author":"T Iwata","year":"2001","unstructured":"Iwata T, Li CL, Deng CX, Francomano CA . Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice. Hum Mol Genet 2001; 10: 1255\u20131264.","journal-title":"Hum Mol Genet"},{"key":"BFboneres20143_CR243","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/hmg\/9.2.249","volume":"9","author":"O Segev","year":"2000","unstructured":"Segev O, Chumakov I, Nevo Z et al. Restrained chondrocyte proliferation and maturation with abnormal growth plate vascularization and ossification in human FGFR-3(G380R) transgenic mice. Hum Mol Genet 2000; 9: 249\u2013258.","journal-title":"Hum Mol Genet"},{"key":"BFboneres20143_CR244","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1158\/0008-5472.CAN-09-3239","volume":"70","author":"N Seitzer","year":"2010","unstructured":"Seitzer N, Mayr T, Streit S, Ullrich A . A single nucleotide change in the mouse genome accelerates breast cancer progression. Cancer Res 2010; 70: 802\u2013812.","journal-title":"Cancer Res"},{"key":"BFboneres20143_CR245","doi-asserted-by":"publisher","first-page":"4213","DOI":"10.1093\/emboj\/17.15.4213","volume":"17","author":"R Dono","year":"1998","unstructured":"Dono R, Texido G, Dussel R, Ehmke H, Zeller R . Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice. EMBO J 1998; 17: 4213\u20134225.","journal-title":"EMBO J"},{"key":"BFboneres20143_CR246","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1161\/01.RES.0000127719.13255.81","volume":"94","author":"B Garmy-Susini","year":"2004","unstructured":"Garmy-Susini B, Delmas E, Gourdy P et al. Role of fibroblast growth factor-2 isoforms in the effect of estradiol on endothelial cell migration and proliferation. Circ Res 2004; 94: 1301\u20131309.","journal-title":"Circ Res"},{"key":"BFboneres20143_CR247","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1002\/dvdy.21835","volume":"238","author":"M Azhar","year":"2009","unstructured":"Azhar M, Yin M, Zhou M et al. Gene targeted ablation of high molecular weight fibroblast growth factor-2. Dev Dyn 2009; 238: 351\u2013357.","journal-title":"Dev Dyn"},{"key":"BFboneres20143_CR248","doi-asserted-by":"publisher","first-page":"6329","DOI":"10.1242\/dev.00881","volume":"130","author":"Y Alvarez","year":"2003","unstructured":"Alvarez Y, Alonso MT, Vendrell V et al. Requirements for FGF3 and FGF10 during inner ear formation. Development 2003; 130: 6329\u20136338.","journal-title":"Development"},{"key":"BFboneres20143_CR249","doi-asserted-by":"publisher","first-page":"E92","DOI":"10.1093\/nar\/28.21.e92","volume":"28","author":"M Holzenberger","year":"2000","unstructured":"Holzenberger M, Lenzner C, Leneuve P et al. Cre-mediated germline mosaicism: a method allowing rapid generation of several alleles of a target gene. Nucleic Acids Res 2000; 28: E92.","journal-title":"Nucleic Acids Res"},{"key":"BFboneres20143_CR250","doi-asserted-by":"publisher","first-page":"3615","DOI":"10.1242\/dev.006627","volume":"134","author":"EP Hatch","year":"2007","unstructured":"Hatch EP, Noyes CA, Wang X, Wright TJ, Mansour SL . Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium. Development 2007; 134: 3615\u20133625.","journal-title":"Development"},{"key":"BFboneres20143_CR251","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.ydbio.2010.02.016","volume":"340","author":"LD Urness","year":"2010","unstructured":"Urness LD, Paxton CN, Wang X, Schoenwolf GC, Mansour SL . FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a. Dev Biol 2010; 340: 595\u2013604.","journal-title":"Dev Biol"},{"key":"BFboneres20143_CR252","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1002\/(SICI)1097-0177(199806)212:2<242::AID-AJA8>3.0.CO;2-H","volume":"212","author":"MB Carlton","year":"1998","unstructured":"Carlton MB, Colledge WH, Evans MJ . Crouzon-like craniofacial dysmorphology in the mouse is caused by an insertional mutation at the Fgf3\/Fgf4 locus. Dev Dyn 1998; 212: 242\u2013249.","journal-title":"Dev Dyn"},{"key":"BFboneres20143_CR253","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.ydbio.2004.06.010","volume":"273","author":"U Pirvola","year":"2004","unstructured":"Pirvola U, Zhang X, Mantela J, Ornitz DM, Ylikoski J . Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions. Dev Biol 2004; 273: 350\u2013360.","journal-title":"Dev Biol"},{"key":"BFboneres20143_CR254","doi-asserted-by":"publisher","first-page":"11853","DOI":"10.1073\/pnas.1003317107","volume":"107","author":"B Behr","year":"2010","unstructured":"Behr B, Leucht P, Longaker MT, Quarto N . Fgf-9 is required for angiogenesis and osteogenesis in long bone repair. Proc Natl Acad Sci USA 2010; 107: 11853\u201311858.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFboneres20143_CR255","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s00335-001-2143-6","volume":"13","author":"H Murakami","year":"2002","unstructured":"Murakami H, Okawa A, Yoshida H, Nishikawa S, Moriya H, Koseki H . Elbow knee synostosis (Eks): a new mutation on mouse Chromosome 14. Mamm Genome 2002; 13: 341\u2013344.","journal-title":"Mamm Genome"},{"key":"BFboneres20143_CR256","doi-asserted-by":"publisher","first-page":"e23678","DOI":"10.1371\/journal.pone.0023678","volume":"6","author":"O Puk","year":"2011","unstructured":"Puk O, Moller G, Geerlof A et al. The pathologic effect of a novel neomorphic Fgf9(Y162C) allele is restricted to decreased vision and retarded lens growth. PLoS ONE 2011; 6: e23678.","journal-title":"PLoS ONE"},{"key":"BFboneres20143_CR257","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.bbrc.2004.07.198","volume":"322","author":"H Usui","year":"2004","unstructured":"Usui H, Shibayama M, Ohbayashi N, Konishi M, Takada S, Itoh N . Fgf18 is required for embryonic lung alveolar development. Biochem Biophys Res Commun 2004; 322: 887\u2013892.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFboneres20143_CR258","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1089\/ten.tea.2010.0719","volume":"17","author":"MT Longaker","year":"2011","unstructured":"Longaker MT, Behr B, Sorkin M, Manu A, Lehnhardt M, Quarto N . Fgf-18 is required for osteogenesis but not angiogenesis during long bone repair. Tissue Eng Part A 2011; 17: 2061\u20132069.","journal-title":"Tissue Eng Part A"},{"key":"BFboneres20143_CR259","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1038\/jid.2011.490","volume":"132","author":"M Kimura-Ueki","year":"2012","unstructured":"Kimura-Ueki M, Oda Y, Oki J et al. Hair cycle resting phase is regulated by cyclic epithelial FGF18 signaling. J Invest Dermatol 2012; 132: 1338\u20131345.","journal-title":"J Invest Dermatol"},{"key":"BFboneres20143_CR260","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1172\/JCI23606","volume":"115","author":"A Kharitonenkov","year":"2005","unstructured":"Kharitonenkov A, Shiyanova TL, Koester A et al. FGF-21 as a novel metabolic regulator. J Clin Invest 2005; 115: 1627\u20131635.","journal-title":"J Clin Invest"},{"key":"BFboneres20143_CR261","doi-asserted-by":"publisher","first-page":"e39436","DOI":"10.1371\/journal.pone.0039436","volume":"7","author":"M Jarosz","year":"2012","unstructured":"Jarosz M, Robbez-Masson L, Chioni AM, Cross B, Rosewell I, Grose R . Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis. PLoS ONE 2012; 7: e39436.","journal-title":"PLoS ONE"},{"key":"BFboneres20143_CR262","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.cytogfr.2005.01.001","volume":"16","author":"VP Eswarakumar","year":"2005","unstructured":"Eswarakumar VP, Lax I, Schlessinger J . Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev 2005; 16: 139\u2013149.","journal-title":"Cytokine Growth Factor Rev"},{"key":"BFboneres20143_CR263","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3109\/03008207.2012.753879","volume":"54","author":"A Raimann","year":"2013","unstructured":"Raimann A, Ertl DA, Helmreich M, Sagmeister S, Egerbacher M, Haeusler G . Fibroblast growth factor 23 and Klotho are present in the growth plate. Connect Tissue Res 2013; 54: 108\u2013117.","journal-title":"Connect Tissue Res"}],"container-title":["Bone Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/boneres20143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/boneres20143","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/boneres20143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T18:05:45Z","timestamp":1672941945000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/boneres20143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,29]]},"references-count":263,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,12,23]]}},"alternative-id":["BFboneres20143"],"URL":"https:\/\/doi.org\/10.1038\/boneres.2014.3","relation":{},"ISSN":["2095-6231"],"issn-type":[{"value":"2095-6231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,29]]},"assertion":[{"value":"9 November 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14003"}}