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Here we examined growth of the axial skeletons of TSK and wild-type(B6) mice during their period of rapid growth. The whole bodies of mice, 4\u201312 weeks of age, were scanned after sacrifice, by micro-computed tomography (microCT). We reconstructed three-dimensional models of the spine and ribs, and measured vertebral body heights and rib lengths using the Mac-based image-processing software \u201cOsiriX\u201d. Although the TSK mice were smaller than the B6 mice at 4 weeks, they experienced an early growth spurt and by 8 weeks the height, but not the width, of the vertebral body was significantly greater in the TSK mice than the B6 mice. Measurement of the angles of scoliotic and kyphotic curves post-mortem in the mice was problematic, hence we measured changes that develop in skeletal elements in these disorders. As a marker of kyphosis, we measured anterior wedging of the vertebral bodies; as a marker for scoliosis we measured asymmetries in rib length. We found, unlike in the B6 mice where the pattern was diffuse, wedging in TSK mice was directly related to spinal level and peaked steeply at the thoracolumbar junction. There was also significant asymmetry in length of the ribs in the TSK mice, but not in the B6 mice. The TSK mice thus appear to exhibit spinal deformities seen in MFS and could be a useful model for gaining understanding of the mechanisms of development of scoliosis and kyphosis in this disorder.<\/jats:p>","DOI":"10.1038\/boneres.2016.53","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T15:29:11Z","timestamp":1487690951000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Development of spinal deformities in the tight-skin mouse"],"prefix":"10.1038","volume":"5","author":[{"given":"Bing","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill PG","family":"Urban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"BFboneres201653_CR1","doi-asserted-by":"publisher","first-page":"E611","DOI":"10.1097\/BRS.0000000000001330","volume":"41","author":"EM Clark","year":"2016","unstructured":"Clark EM, Tobias JH, Fairbank J . The impact of small spinal curves in adolescents who have not presented to secondary care: A Population-Based Cohort Study. Spine (Phila Pa 1976) 2016; 41: E611\u2013E617.","journal-title":"Spine (Phila Pa 1976)"},{"key":"BFboneres201653_CR2","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1097\/01.blo.0000198725.54891.73","volume":"443","author":"JE Lonstein","year":"2006","unstructured":"Lonstein JE . Scoliosis: surgical versus nonsurgical treatment. Clin Orthop Relat Res 2006; 443: 248\u2013259.","journal-title":"Clin Orthop Relat Res"},{"key":"BFboneres201653_CR3","doi-asserted-by":"publisher","first-page":"322","DOI":"10.3171\/2015.3.PEDS14649","volume":"16","author":"HT Vigneswaran","year":"2015","unstructured":"Vigneswaran HT, Grabel ZJ, Eberson CP et al. Surgical treatment of adolescent idiopathic scoliosis in the United States from 1997 to 2012: an analysis of 20,346 patients. 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