{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:37:18Z","timestamp":1790199438823,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T00:00:00Z","timestamp":1207872000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1038\/cdd.2008.36","type":"journal-article","created":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T09:11:02Z","timestamp":1207905062000},"page":"1255-1265","source":"Crossref","is-referenced-by-count":45,"title":["Oxygen-regulated protein-150 prevents calcium homeostasis deregulation and apoptosis induced by oxidized LDL in vascular cells"],"prefix":"10.1038","volume":"15","author":[{"given":"M","family":"Sanson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ingueneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Vindis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-C","family":"Thiers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Glock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Rousseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Sawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Bando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Mallat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Salvayre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"N\u00e8gre-Salvayre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,4,11]]},"reference":[{"key":"BFcdd200836_CR1","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/35025203","volume":"407","author":"AJ Lusis","year":"2000","unstructured":"Lusis AJ . Atherosclerosis. Nature 2000; 407: 233\u2013241.","journal-title":"Nature"},{"key":"BFcdd200836_CR2","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1056\/NEJM199901143400207","volume":"340","author":"R Ross","year":"1999","unstructured":"Ross R . Atherosclerosis--an inflammatory disease. N Engl J Med 1999; 340: 115\u2013126.","journal-title":"N Engl J Med"},{"key":"BFcdd200836_CR3","first-page":"697","volume":"9","author":"S Dimmeler","year":"1998","unstructured":"Dimmeler S, Hermann C, Zeiher AM . Apoptosis of endothelial cells. Contribution to the pathophysiology of atherosclerosis? Eur Cytokine Netw 1998; 9: 697\u2013698.","journal-title":"Eur Cytokine Netw"},{"key":"BFcdd200836_CR4","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1038\/sj.bjp.0703407","volume":"130","author":"Z Mallat","year":"2000","unstructured":"Mallat Z, Tedgui A . Apoptosis in the vasculature: mechanisms and functional importance. Br J Pharmacol 2000; 130: 947\u2013962.","journal-title":"Br J Pharmacol"},{"key":"BFcdd200836_CR5","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S1050-1738(01)00106-2","volume":"11","author":"SM Colles","year":"2001","unstructured":"Colles SM, Maxson JM, Carlson SG, Chisolm GM . Oxidized LDL-induced injury and apoptosis in atherosclerosis. Potential roles for oxysterols. Trends Cardiovasc Med 2001; 11: 131\u2013138.","journal-title":"Trends Cardiovasc Med"},{"key":"BFcdd200836_CR6","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S1388-1981(02)00343-8","volume":"1585","author":"R Salvayre","year":"2002","unstructured":"Salvayre R, Auge N, Benoist H, N\u00e8gre-Salvayre A . Oxidized low-density lipoprotein-induced apoptosis. Biochim Biophys Acta 2002; 1585: 213\u2013221.","journal-title":"Biochim Biophys Acta"},{"key":"BFcdd200836_CR7","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1096\/fasebj.8.13.7926374","volume":"8","author":"I Escargueil-Blanc","year":"1994","unstructured":"Escargueil-Blanc I, Salvayre R, N\u00e8gre-Salvayre A . Necrosis and apoptosis induced by oxidized low-density lipoproteins occur through two calcium-dependent pathways in lymphoblastoid cells. FASEB J 1994; 8: 1075\u20131080.","journal-title":"FASEB J"},{"key":"BFcdd200836_CR8","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1161\/01.ATV.0000154359.60886.33","volume":"25","author":"C Vindis","year":"2005","unstructured":"Vindis C, Elbaz M, Escargueil-Blanc I, Auge N, Heniquez A, Thiers JC et al. Two distinct calcium-dependent mitochondrial pathways are involved in oxidized LDL-induced apoptosis. Arterioscler Thromb Vasc Biol 2005; 25: 639\u2013645.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BFcdd200836_CR9","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1196\/annals.1299.127","volume":"1010","author":"C Napoli","year":"2003","unstructured":"Napoli C . Oxidation of LDL, atherogenesis, and apoptosis. Ann N Y Acad Sci 2003; 1010: 698\u2013709.","journal-title":"Ann N Y Acad Sci"},{"key":"BFcdd200836_CR10","doi-asserted-by":"publisher","first-page":"H568","DOI":"10.1152\/ajpcell.1998.275.2.C358","volume":"275","author":"D Li","year":"1998","unstructured":"Li D, Yang B, Mehta JL . Ox-LDL induces apoptosis in human coronary artery endothelial cells: role of PKC PTK, bcl-2, and Fas. Am J Physiol 1998; 275: H568\u2013H576.","journal-title":"Am J Physiol"},{"key":"BFcdd200836_CR11","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1172\/JCI3531","volume":"102","author":"M Sata","year":"1998","unstructured":"Sata M, Walsh K . Oxidized LDL activates fas-mediated endothelial cell apoptosis. J Clin Invest 1998; 102: 1682\u20131689.","journal-title":"J Clin Invest"},{"key":"BFcdd200836_CR12","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1161\/01.CIR.98.12.1153","volume":"98","author":"DH Walter","year":"1998","unstructured":"Walter DH, Haendeler J, Galle J, Zeiher AM, Dimmeler S . Cyclosporin A inhibits apoptosis of human endothelial cells by preventing release of cytochrome c from mitochondria. Circulation 1998; 98: 1153\u20131157.","journal-title":"Circulation"},{"key":"BFcdd200836_CR13","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1042\/bj20021955","volume":"374","author":"MI Porn-Ares","year":"2003","unstructured":"Porn-Ares MI, Saido TC, Andersson T, Ares MP . Oxidized low-density lipoprotein induces calpain-dependent cell death and ubiquitination of caspase 3 in HMEC-1 endothelial cells. Biochem J 2003; 374: 403\u2013411.","journal-title":"Biochem J"},{"key":"BFcdd200836_CR14","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1006\/bbrc.1996.5890","volume":"230","author":"J Ikeda","year":"1997","unstructured":"Ikeda J, Kaneda S, Kuwabara K, Ogawa S, Kobayashi T, Matsumoto M et al. Cloning and expression of cDNA encoding the human 150\u2009kDa oxygen-regulated protein, ORP150. Biochem Biophys Res Commun 1997; 230: 94\u201399.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcdd200836_CR15","doi-asserted-by":"publisher","first-page":"5025","DOI":"10.1074\/jbc.271.9.5025","volume":"271","author":"K Kuwabara","year":"1996","unstructured":"Kuwabara K, Matsumoto M, Ikeda J, Hori O, Ogawa S, Maeda Y et al. Purification and characterization of a novel stress protein, the 150-kDa oxygen-regulated protein (ORP150), from cultured rat astrocytes and its expression in ischemic mouse brain. J Biol Chem 1996; 271: 5025\u20135032.","journal-title":"J Biol Chem"},{"key":"BFcdd200836_CR16","doi-asserted-by":"publisher","first-page":"6397","DOI":"10.1074\/jbc.274.10.6397","volume":"274","author":"K Ozawa","year":"1999","unstructured":"Ozawa K, Kuwabara K, Tamatani M, Takatsuji K, Tsukamoto Y, Kaneda S et al. 150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death. J Biol Chem 1999; 274: 6397\u20136404.","journal-title":"J Biol Chem"},{"key":"BFcdd200836_CR17","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1096\/fj.03-1161fje","volume":"18","author":"Y Bando","year":"2004","unstructured":"Bando Y, Tsukamoto Y, Katayama T, Ozawa K, Kitao Y, Hori O et al. ORP150\/HSP12A protects renal tubular epithelium from ischemia-induced cell death. FASEB J 2004; 18: 1401\u20131403.","journal-title":"FASEB J"},{"key":"BFcdd200836_CR18","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/85463","volume":"7","author":"M Tamatani","year":"2001","unstructured":"Tamatani M, Matsuyama T, Yamaguchi A, Mitsuda N, Tsukamoto Y, Taniguchi M et al. ORP150 protects against hypoxia\/ischemia-induced neuronal death. Nat Med 2001; 7: 317\u2013323.","journal-title":"Nat Med"},{"key":"BFcdd200836_CR19","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1172\/JCI12978","volume":"108","author":"Y Kitao","year":"2001","unstructured":"Kitao Y, Ozawa K, Miyazaki M, Tamatani M, Kobayashi T, Yanagi H et al. Expression of the endoplasmic reticulum molecular chaperone (ORP150) rescues hippocampal neurons from glutamate toxicity. J Clin Invest 2001; 108: 1439\u20131450.","journal-title":"J Clin Invest"},{"key":"BFcdd200836_CR20","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1097\/00004647-200208000-00009","volume":"22","author":"M Miyazaki","year":"2002","unstructured":"Miyazaki M, Ozawa K, Hori O, Kitao Y, Matsushita K, Ogawa S et al. Expression of 150-kd oxygen-regulated protein in the hippocampus suppresses delayed neuronal cell death. J Cereb Blood Flow Metab 2002; 22: 979\u2013987.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFcdd200836_CR21","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.yjmcc.2005.01.001","volume":"38","author":"AN Aleshin","year":"2005","unstructured":"Aleshin AN, Sawa Y, Kitagawa-Sakakida S, Bando Y, Ono M, Memon IA et al. 150-kDa oxygen-regulated protein attenuates myocardial ischemia-reperfusion injury in rat heart. J Mol Cell Cardiol 2005; 38: 517\u2013525.","journal-title":"J Mol Cell Cardiol"},{"key":"BFcdd200836_CR22","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1292\/jvms.64.177","volume":"64","author":"T Kobayashi","year":"2002","unstructured":"Kobayashi T, Yura T, Yanagi H . The increment of anti-ORP150 autoantibody in initial stages of atheroma in high-fat diet fed mice. J Vet Med Sci 2002; 64: 177\u2013180.","journal-title":"J Vet Med Sci"},{"key":"BFcdd200836_CR23","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1172\/JCI118994","volume":"98","author":"Y Tsukamoto","year":"1996","unstructured":"Tsukamoto Y, Kuwabara K, Hirota S, Ikeda J, Stern D, Yanagi H et al. 150-kD oxygen-regulated protein is expressed in human atherosclerotic plaques and allows mononuclear phagocytes to withstand cellular stress on exposure to hypoxia and modified low-density lipoprotein. J Clin Invest 1996; 98: 1930\u20131941.","journal-title":"J Clin Invest"},{"key":"BFcdd200836_CR24","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.freeradbiomed.2004.10.028","volume":"38","author":"C Maziere","year":"2005","unstructured":"Maziere C, Morliere P, Massy Z, Kamel S, Louandre C, Conte MA et al. Oxidized low-density lipoprotein elicits an intracellular calcium rise and increases the binding activity of the transcription factor NFAT. Free Radic Biol Med 2005; 38: 472\u2013480.","journal-title":"Free Radic Biol Med"},{"key":"BFcdd200836_CR25","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/nrm1150","volume":"4","author":"S Orrenius","year":"2003","unstructured":"Orrenius S, Zhivotovsky B, Nicotera P . Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol 2003; 4: 552\u2013565.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcdd200836_CR26","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1124\/mol.106.027698","volume":"71","author":"T Namba","year":"2007","unstructured":"Namba T, Hoshino T, Tanaka K, Tsutsumi S, Ishihara T, Mima S et al. Upregulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells. Mol Pharmacol 2007; 71: 860\u2013870.","journal-title":"Mol Pharmacol"},{"key":"BFcdd200836_CR27","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/S0039-6060(96)80307-2","volume":"120","author":"KE Wells","year":"1996","unstructured":"Wells KE, Alexander JJ, Miguel R . Calcium-dependent second-messenger regulation of low-density lipoprotein oxidation by human aortic smooth muscle cells. Surgery 1996; 120: 337\u2013344.","journal-title":"Surgery"},{"key":"BFcdd200836_CR28","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1523\/JNEUROSCI.4029-03.2004","volume":"24","author":"Y Kitao","year":"2004","unstructured":"Kitao Y, Hashimoto K, Matsuyama T, Iso H, Tamatani T, Hori O et al. ORP150\/HSP12A regulates Purkinje cell survival: a role for endoplasmic reticulum stress in cerebellar development. J Neurosci 2004; 24: 1486\u20131496.","journal-title":"J Neurosci"},{"key":"BFcdd200836_CR29","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/ncb1035","volume":"5","author":"B Feng","year":"2003","unstructured":"Feng B, Yao PM, Li Y, Devlin CM, Zhang D, Harding HP et al. The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat Cell Biol 2003; 5: 781\u2013792.","journal-title":"Nat Cell Biol"},{"key":"BFcdd200836_CR30","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1083\/jcb.200502078","volume":"171","author":"T Devries-Seimon","year":"2005","unstructured":"Devries-Seimon T, Li Y, Yao PM, Stone E, Wang Y, Davis RJ et al. Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J Cell Biol 2005; 171: 61\u201373.","journal-title":"J Cell Biol"},{"key":"BFcdd200836_CR31","doi-asserted-by":"publisher","first-page":"10703","DOI":"10.1128\/MCB.24.24.10703-10717.2004","volume":"24","author":"E Pedruzzi","year":"2004","unstructured":"Pedruzzi E, Guichard C, Ollivier V, Driss F, Fay M, Prunet C et al. NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells. Mol Cell Biol 2004; 24: 10703\u201310717.","journal-title":"Mol Cell Biol"},{"key":"BFcdd200836_CR32","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.1016\/0006-2952(92)90683-A","volume":"44","author":"A N\u00e8gre-Salvayre","year":"1992","unstructured":"N\u00e8gre-Salvayre A, Fitoussi G, Troly M, Salvayre R . Comparative cytoprotective effect of dihydropyridine calcium channel blockers against the toxicity of oxidized low-density lipoprotein for cultured lymphoid cells. Biochem Pharmacol 1992; 44: 2379\u20132386.","journal-title":"Biochem Pharmacol"},{"key":"BFcdd200836_CR33","doi-asserted-by":"publisher","first-page":"R933","DOI":"10.1016\/j.cub.2004.10.019","volume":"14","author":"CJ Hanson","year":"2004","unstructured":"Hanson CJ, Bootman MD, Roderick HL . Cell signalling: IP3 receptors channel calcium into cell death. Curr Biol 2004; 14: R933\u2013R935.","journal-title":"Curr Biol"},{"key":"BFcdd200836_CR34","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1080\/10739680600930347","volume":"13","author":"C Tiruppathi","year":"2006","unstructured":"Tiruppathi C, Ahmmed GU, Vogel SM, Malik AB . Ca2+ signaling, TRP channels, and endothelial permeability. Microcirculation 2006; 13: 693\u2013708.","journal-title":"Microcirculation"},{"key":"BFcdd200836_CR35","doi-asserted-by":"publisher","first-page":"30873","DOI":"10.1074\/jbc.272.49.30873","volume":"272","author":"JP Lievremont","year":"1997","unstructured":"Lievremont JP, Rizzuto R, Hendershot L, Meldolesi J . BiP, a major chaperone protein of the endoplasmic reticulum lumen, plays a direct and important role in the storage of the rapidly exchanging pool of Ca2+. J Biol Chem 1997; 272: 30873\u201330879.","journal-title":"J Biol Chem"},{"key":"BFcdd200836_CR36","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1046\/j.1460-9568.2003.02818.x","volume":"18","author":"Y Bando","year":"2003","unstructured":"Bando Y, Katayama T, Kasai K, Taniguchi M, Tamatani M, Tohyama M . GRP94 (94\u2009kDa glucose-regulated protein) suppresses ischemic neuronal cell death against ischemia\/reperfusion injury. Eur J Neurosci 2003; 18: 829\u2013840.","journal-title":"Eur J Neurosci"},{"key":"BFcdd200836_CR37","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1247\/csf.20.133","volume":"20","author":"AF Naved","year":"1995","unstructured":"Naved AF, Ozawa M, Yu S, Miyauchi T, Muramatsu H, Muramatsu T . CBP-140, a novel endoplasmic reticulum resident Ca(2+)-binding protein with a carboxy-terminal NDEL sequence showed partial homology with 70-kDa heat shock protein (hsp70). Cell Struct Funct 1995; 20: 133\u2013141.","journal-title":"Cell Struct Funct"},{"key":"BFcdd200836_CR38","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1083\/jcb.200608073","volume":"175","author":"G Szabadkai","year":"2006","unstructured":"Szabadkai G, Bianchi K, Varnai P, De Stefani D, Wieckowski MR, Cavagna D et al. Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels. J Cell Biol 2006; 175: 901\u2013911.","journal-title":"J Cell Biol"},{"key":"BFcdd200836_CR39","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1172\/JCI114271","volume":"84","author":"S Yla-Herttuala","year":"1989","unstructured":"Yla-Herttuala S, Palinski W, Rosenfeld ME, Parthasarathy S, Carew TE, Butler S et al. Evidence for the presence of oxidatively modified low-density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin Invest 1989; 84: 1086\u20131095.","journal-title":"J Clin Invest"},{"key":"BFcdd200836_CR40","doi-asserted-by":"publisher","first-page":"C1172","DOI":"10.1152\/ajpcell.2000.278.6.C1172","volume":"278","author":"Y Bando","year":"2000","unstructured":"Bando Y, Ogawa S, Yamauchi A, Kuwabara K, Ozawa K, Hori O et al. 150-kDa oxygen-regulated protein (ORP150) functions as a novel molecular chaperone in MDCK cells. Am J Physiol Cell Physiol 2000; 278: C1172\u2013C1182.","journal-title":"Am J Physiol Cell Physiol"}],"container-title":["Cell Death & Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd200836.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd200836","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd200836.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:44:18Z","timestamp":1684417458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd200836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,11]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["BFcdd200836"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2008.36","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,11]]}}}