{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:23:08Z","timestamp":1791206588790,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,8,21]],"date-time":"2009-08-21T00:00:00Z","timestamp":1250812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1038\/cdd.2009.115","type":"journal-article","created":{"date-parts":[[2009,8,21]],"date-time":"2009-08-21T09:04:37Z","timestamp":1250845477000},"page":"145-157","source":"Crossref","is-referenced-by-count":112,"title":["Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells"],"prefix":"10.1038","volume":"17","author":[{"given":"S","family":"Romano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"D'Angelillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Pacelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Staibano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"De Luna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Bisogni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E-L","family":"Eskelinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Mascolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Cal\u00ec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Arra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M F","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,8,21]]},"reference":[{"key":"BFcdd2009115_CR1","first-page":"1","volume":"1","author":"LB Norris","year":"2008","unstructured":"Norris LB, Beam S . Multidisciplinary perspectives on melanoma treatment. Updates from the 44th Annual Meeting of the American Society of Clinical Oncology, The Oncology Nurse 2008; 1: 1\u20137.","journal-title":"Updates from the 44th Annual Meeting of the American Society of Clinical Oncology, The Oncology Nurse"},{"key":"BFcdd2009115_CR2","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/0360-3016(95)00214-8","volume":"33","author":"WC Dewey","year":"1995","unstructured":"Dewey WC, Ling CC, Meyn RE . Radiation-induced apoptosis: relevance to radiotherapy. Int J Radiat Oncol Biol Phys 1995; 33: 781\u2013796.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"BFcdd2009115_CR3","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1080\/09553009414551661","volume":"66","author":"SS Wallace","year":"1994","unstructured":"Wallace SS . DNA damages processed by base excision repair: biological consequences. Int J Radiat Biol 1994; 66: 579\u2013589.","journal-title":"Int J Radiat Biol"},{"key":"BFcdd2009115_CR4","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1038\/35037710","volume":"407","author":"MO Hengartner","year":"2000","unstructured":"Hengartner MO . The biochemistry of apoptosis. Nature 2000; 407: 770\u2013776.","journal-title":"Nature"},{"key":"BFcdd2009115_CR5","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.taap.2008.06.017","volume":"232","author":"A Elliott","year":"2008","unstructured":"Elliott A, Reiners Jr JJ . Suppression of autophagy enhances the cytotoxicity of the DNA-damaging aromatic amine p-anilinoaniline. Toxicol Appl Pharmacol 2008; 232: 169\u2013179.","journal-title":"Toxicol Appl Pharmacol"},{"key":"BFcdd2009115_CR6","doi-asserted-by":"publisher","first-page":"9220","DOI":"10.1128\/MCB.01453-06","volume":"26","author":"M Ogata","year":"2006","unstructured":"Ogata M, Hino S, Saito A, Morikawa K, Kondo S, Kanemoto S et al. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 2006; 26: 9220\u20139231.","journal-title":"Mol Cell Biol"},{"key":"BFcdd2009115_CR7","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S1937-6448(07)66005-5","volume":"266","author":"EL Eskelinen","year":"2008","unstructured":"Eskelinen EL . New insights into the mechanisms of macroautophagy in mammalian cells. Int Rev Cell Mol Biol 2008; 266: 207\u2013247. Review.","journal-title":"Int Rev Cell Mol Biol"},{"key":"BFcdd2009115_CR8","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/nrm1666","volume":"6","author":"EH Baehrecke","year":"2005","unstructured":"Baehrecke EH . Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol 2005; 6: 505\u2013510. Review.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcdd2009115_CR9","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1038\/nrc2254","volume":"7","author":"R Mathew","year":"2007","unstructured":"Mathew R, Karantza-Wadsworth V, White E . Role of autophagy in cancer. Nat Rev Cancer 2007; 7: 961\u2013967.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd2009115_CR10","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1016\/j.ejca.2004.08.017","volume":"40","author":"MF Romano","year":"2004","unstructured":"Romano MF, Avellino R, Petrella A, Bisogni R, Romano S, Venuta S . Rapamycin inhibits doxorubicin-induced NF-kappaB\/Rel nuclear activity and enhances the apoptosis of melanoma cells. Eur J Cancer 2004; 40: 2829\u20132836.","journal-title":"Eur J Cancer"},{"key":"BFcdd2009115_CR11","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1007\/s10495-008-0212-y","volume":"13","author":"GE Johnson","year":"2008","unstructured":"Johnson GE, Ivanov VN, Hei TK . Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival. Apoptosis 2008; 13: 790\u2013802.","journal-title":"Apoptosis"},{"key":"BFcdd2009115_CR12","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1158\/1535-7163.985.3.8","volume":"3","author":"A Munshi","year":"2004","unstructured":"Munshi A, Kurland JF, Nishikaw T, Chiao PJ, Andreeff M et al. Inhibition of constitutively activated nuclear factor-kappaB radiosensitizes human melanoma cells. Mol Cancer Ther 2004; 3: 985\u2013992.","journal-title":"Mol Cancer Ther"},{"key":"BFcdd2009115_CR13","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1146\/annurev.immunol.16.1.225","volume":"16","author":"S Ghosh","year":"1998","unstructured":"Ghosh S, May MJ, Kopp EB . NF-\u03baB and Rel proteins: evolutionarily conserved mediators of immune response. Annu Rev Immunol 1998; 16: 225\u2013260.","journal-title":"Annu Rev Immunol"},{"key":"BFcdd2009115_CR14","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","volume":"14","author":"AS Baldwin Jr","year":"1996","unstructured":"Baldwin Jr AS . The NF-\u03baB and I\u03baB proteins: new discoveries and insights. Annu Rev Immunol 1996; 14: 649\u2013681.","journal-title":"Annu Rev Immunol"},{"key":"BFcdd2009115_CR15","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/nrc780","volume":"2","author":"M Karin","year":"2002","unstructured":"Karin M, Cao X, Greten FR, Li Z-W . NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2002; 2: 301\u2013310.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd2009115_CR16","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/nrc2419","volume":"8","author":"M Baumann","year":"2008","unstructured":"Baumann M, Krause M, Hill R . Exploring the role of cancer stem cells in radioresistance. Nat Rev Cancer 2008; 8: 545\u2013554. Review.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd2009115_CR17","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3324\/haematol.12402","volume":"93","author":"S Romano","year":"2008","unstructured":"Romano S, Mallardo M, Chiurazzi F, Bisogni R, D'Angelillo A, Liuzzi R et al. The effect of FK506 on transforming growth factor beta signaling and apoptosis in chronic lymphocytic leukemia B cells. Haematologica 2008; 93: 75\u201384.","journal-title":"Haematologica"},{"key":"BFcdd2009115_CR18","first-page":"1529","volume":"57","author":"AY Chen","year":"1997","unstructured":"Chen AY, Okunieff P, Pommier Y, Mitchell JB . Mammalian DNA topoisomerase I mediates the enhancement of radiation cytotoxicity by camptothecin derivatives. Cancer Res 1997; 57: 1529\u20131536.","journal-title":"Cancer Res"},{"key":"BFcdd2009115_CR19","doi-asserted-by":"publisher","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","volume":"19","author":"Y Kabeya","year":"2000","unstructured":"Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19: 5720\u20135728.","journal-title":"EMBO J"},{"key":"BFcdd2009115_CR20","doi-asserted-by":"publisher","first-page":"10815","DOI":"10.1074\/jbc.273.18.10815","volume":"273","author":"JM Chandler","year":"1998","unstructured":"Chandler JM, Cohen GM, MacFarlane M . Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver. J Biol Chem 1998; 273: 10815\u201310818.","journal-title":"J Biol Chem"},{"key":"BFcdd2009115_CR21","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1016\/j.bcp.2006.07.015","volume":"72","author":"Y Habraken","year":"2006","unstructured":"Habraken Y, Piette J . NF-kappaB activation by double-strand breaks. Biochem Pharmacol 2006; 72: 1132\u20131141. Review.","journal-title":"Biochem Pharmacol"},{"key":"BFcdd2009115_CR22","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1128\/MCB.01396-08","volume":"29","author":"T Copetti","year":"2009","unstructured":"Copetti T, Bertoli C, Dalla E, Demarchi F, Schneider C . p65\/RelA modulates BECN1 transcription and autophagy. Mol Cell Biol 2009; 29: 2594\u20132608.","journal-title":"Mol Cell Biol"},{"key":"BFcdd2009115_CR23","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1038\/ncb1499","volume":"8","author":"H Kim","year":"2006","unstructured":"Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ et al. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nat Cell Biol 2006; 8: 1348\u20131358.","journal-title":"Nat Cell Biol"},{"key":"BFcdd2009115_CR24","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/nm0901-1028","volume":"7","author":"S Zhou","year":"2001","unstructured":"Zhou S, Schuetz JD, Bunting KD, Colapietro AM, Sampath J, Morris JJ et al. The ABC transporter Bcrp1\/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med 2001; 7: 1028\u20131034.","journal-title":"Nat Med"},{"key":"BFcdd2009115_CR25","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.ejca.2007.01.017","volume":"43","author":"E Monzani","year":"2007","unstructured":"Monzani E, Facchetti F, Galmozzi E, Corsini E, Benetti A, Cavazzin C et al. Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential. Eur J Cancer 2007; 43: 935\u2013946.","journal-title":"Eur J Cancer"},{"key":"BFcdd2009115_CR26","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1038\/jid.2008.226","volume":"128","author":"TL Hocker","year":"2008","unstructured":"Hocker TL, Singh MK, Tsao H . Melanoma genetics and therapeutic approaches in the 21st century: moving from the benchside to the bedside. J Invest Dermatol 2008; 128: 2575\u20132595.","journal-title":"J Invest Dermatol"},{"key":"BFcdd2009115_CR27","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1038\/nm.1887","volume":"14","author":"H Poeck","year":"2008","unstructured":"Poeck H, Besch R, Maihoefer C, Renn M, Tormo D, Morskaya SS . 5\u2032-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat Med 2008; 14: 1256\u20131263.","journal-title":"Nat Med"},{"key":"BFcdd2009115_CR28","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1073\/pnas.0231020100","volume":"100","author":"CR Sinars","year":"2003","unstructured":"Sinars CR, Cheung-Flynn J, Rimerman RA, Scammell JG, Smith DF, Clardy J . Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. Proc Natl Acad Sci USA 2003; 100: 868\u2013873.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2009115_CR29","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/ncb1086","volume":"6","author":"T Bouwmeester","year":"2004","unstructured":"Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K et al. A physical and functional map of the human TNF-alpha\/NF-kappaB signal transduction pathway. Nat Cell Biol 2004; 6: 97\u2013105.","journal-title":"Nat Cell Biol"},{"key":"BFcdd2009115_CR30","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/sj.gt.3302845","volume":"14","author":"U Naumann","year":"2007","unstructured":"Naumann U, B\u00e4hr O, Wolburg H, Altenberend S, Wick W, Liston P et al. Adenoviral expression of XIAP antisense RNA induces apoptosis in glioma cells and suppresses the growth of xenografts in nude mice. Gene Ther 2007; 14: 147\u2013161.","journal-title":"Gene Ther"},{"key":"BFcdd2009115_CR31","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.ccr.2008.02.015","volume":"13","author":"SE Zabierowski","year":"2008","unstructured":"Zabierowski SE, Herlyn M . Learning the ABCs of melanoma-initiating cells. Cancer Cell 2008; 13: 185\u2013187.","journal-title":"Cancer Cell"},{"key":"BFcdd2009115_CR32","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nature06489","volume":"451","author":"T Schatton","year":"2008","unstructured":"Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M et al. Identification of cells initiating human melanomas. Nature 2008; 451: 345\u2013349.","journal-title":"Nature"},{"key":"BFcdd2009115_CR33","doi-asserted-by":"publisher","first-page":"4395","DOI":"10.1128\/MCB.15.8.4395","volume":"15","author":"G Baughman","year":"1995","unstructured":"Baughman G, Wiederrecht GJ, Faith Campbell N, Martin MM, Bourgeois S . FKBP51, a novel T-cell specific immunophilin capable of calcineurin inhibition. Mol Cell Biol 1995; 15: 4395\u20134402.","journal-title":"Mol Cell Biol"},{"key":"BFcdd2009115_CR34","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1124\/mol.107.038687","volume":"72","author":"B Benassi","year":"2007","unstructured":"Benassi B, Zupi G, Biroccio A . Gamma-glutamylcysteine synthetase mediates the c-Myc-dependent response to antineoplastic agents in melanoma cells. Mol Pharmacol 2007; 72: 1015\u20131023.","journal-title":"Mol Pharmacol"},{"key":"BFcdd2009115_CR35","first-page":"5347","volume":"47","author":"PP Trotta","year":"1987","unstructured":"Trotta PP, Harrison Jr SD . Evaluation of the antitumor activity of recombinant human gamma-interferon employing human melanoma xenografts in athymic nude mice. Cancer Res 1987; 47: 5347\u20135353.","journal-title":"Cancer Res"},{"key":"BFcdd2009115_CR36","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1093\/jnci\/51.5.1417","volume":"51","author":"DJ Giard","year":"1973","unstructured":"Giard DJ, Aaronson SA, Todaro GJ, Arnstein P, Kersey JH, Dosik H et al. In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. J Natl Cancer Inst 1973; 51: 1417\u20131423.","journal-title":"J Natl Cancer Inst"},{"key":"BFcdd2009115_CR37","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1038\/nprot.2006.339","volume":"1","author":"NAP Franken","year":"2006","unstructured":"Franken NAP, Rodermond HM, Stap J, Haveman J, van Bree C . Clonogenic assay of cells in vitro. Nat Protoc 2006; 1: 2315\u20132319.","journal-title":"Nat Protoc"},{"key":"BFcdd2009115_CR38","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.humpath.2005.04.017","volume":"36","author":"S Staibano","year":"2005","unstructured":"Staibano S, Pepe S, Lo Muzio L, Somma P, Mascolo M, Argenziano G . Poly(adenosine diphosphate-ribose) polymerase 1 expression in malignant melanomas from photoexposed areas of the head and neck region. Hum Pathol 2005; 36: 724\u2013731.","journal-title":"Hum Pathol"}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd2009115.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2009115","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2009115.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T12:03:00Z","timestamp":1685102580000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd2009115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,21]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["BFcdd2009115"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2009.115","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,21]]}}}