{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:36:56Z","timestamp":1791113816726,"version":"4.1.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2010,4,30]],"date-time":"2010-04-30T00:00:00Z","timestamp":1272585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1038\/cdd.2010.43","type":"journal-article","created":{"date-parts":[[2010,4,30]],"date-time":"2010-04-30T05:09:43Z","timestamp":1272604183000},"page":"1655-1664","source":"Crossref","is-referenced-by-count":61,"title":["Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development"],"prefix":"10.1038","volume":"17","author":[{"given":"P N","family":"Kelly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M W","family":"Goschnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K A","family":"Fairfax","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D M","family":"Tarlinton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S A","family":"Kinkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Bouillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B T","family":"Kile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Strasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,4,30]]},"reference":[{"key":"BFcdd201043_CR1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1146\/annurev.biochem.69.1.217","volume":"69","author":"A Strasser","year":"2000","unstructured":"Strasser A, O'Connor L, Dixit VM . Apoptosis signaling. Ann Rev Biochem 2000; 69: 217\u2013245.","journal-title":"Ann Rev Biochem"},{"key":"BFcdd201043_CR2","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1038\/sj.onc.1210220","volume":"26","author":"JM Adams","year":"2007","unstructured":"Adams JM, Cory S . The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 2007; 26: 1324\u20131337.","journal-title":"Oncogene"},{"key":"BFcdd201043_CR3","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/S0092-8674(00)00187-2","volume":"103","author":"DCS Huang","year":"2000","unstructured":"Huang DCS, Strasser A . BH3-only proteins \u2013 essential initiators of apoptotic cell death. Cell 2000; 103: 839\u2013842.","journal-title":"Cell"},{"key":"BFcdd201043_CR4","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/nri1568","volume":"5","author":"A Strasser","year":"2005","unstructured":"Strasser A . The role of BH3-only proteins in the immune system. Nat Rev Immunol 2005; 5: 189\u2013200.","journal-title":"Nat Rev Immunol"},{"key":"BFcdd201043_CR5","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1126\/science.1059108","volume":"292","author":"MC Wei","year":"2001","unstructured":"Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 2001; 292: 727\u2013730.","journal-title":"Science"},{"key":"BFcdd201043_CR6","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1101\/gad.897601","volume":"15","author":"WX Zong","year":"2001","unstructured":"Zong WX, Lindsten T, Ross AJ, MacGregor GR, Thompson CB . BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev 2001; 15: 1481\u20131486.","journal-title":"Genes Dev"},{"key":"BFcdd201043_CR7","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S0092-8674(00)81382-3","volume":"87","author":"J Zha","year":"1996","unstructured":"Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ . Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not Bcl-xL . Cell 1996; 87: 619\u2013628.","journal-title":"Cell"},{"key":"BFcdd201043_CR8","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1126\/science.278.5338.687","volume":"278","author":"L del Peso","year":"1997","unstructured":"del Peso L, Gonz\u00e1lez-Garcia M, Page C, Herrera R, Nu\u00f1ez G . Interleukin-3\u2013induced phosphorylation of BAD through the protein kinase Akt. Science 1997; 278: 687\u2013689.","journal-title":"Science"},{"key":"BFcdd201043_CR9","doi-asserted-by":"publisher","first-page":"24101","DOI":"10.1074\/jbc.272.39.24101","volume":"272","author":"JP Zha","year":"1997","unstructured":"Zha JP, Harada H, Osipov K, Jockel J, Waksman G, Korsmeyer SJ . BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity. J Biol Chem 1997; 272: 24101\u201324104.","journal-title":"J Biol Chem"},{"key":"BFcdd201043_CR10","doi-asserted-by":"publisher","first-page":"9324","DOI":"10.1073\/pnas.1533446100","volume":"100","author":"AM Ranger","year":"2003","unstructured":"Ranger AM, Zha J, Harada H, Datta SR, Danial NN, Gilmore AP et al. Bad-deficient mice develop diffuse large B cell lymphoma. Proc Natl Acad Sci USA 2003; 100: 9324\u20139329.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201043_CR11","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1038\/nature01825","volume":"424","author":"NN Danial","year":"2003","unstructured":"Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, Ranger AM et al. BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 2003; 424: 952\u2013956.","journal-title":"Nature"},{"key":"BFcdd201043_CR12","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1182\/blood-2006-03-014209","volume":"108","author":"PG Ekert","year":"2006","unstructured":"Ekert PG, Jabbour AM, Manoharan A, Heraud JE, Yu J, Pakusch M et al. Cell death provoked by loss of Interleukin-3 signalling is independent of Bad, Bim, and PI3 Kinase, but depends in part on Puma. Blood 2006; 108: 1461\u20131468.","journal-title":"Blood"},{"key":"BFcdd201043_CR13","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/sj.cdd.4400998","volume":"9","author":"H Puthalakath","year":"2002","unstructured":"Puthalakath H, Strasser A . Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ 2002; 9: 505\u2013512.","journal-title":"Cell Death Differ"},{"key":"BFcdd201043_CR14","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1126\/science.286.5445.1735","volume":"286","author":"P Bouillet","year":"1999","unstructured":"Bouillet P, Metcalf D, Huang DCS, Tarlinton DM, Kay TWH, K\u00f6ntgen F et al. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 1999; 286: 1735\u20131738.","journal-title":"Science"},{"key":"BFcdd201043_CR15","doi-asserted-by":"publisher","first-page":"4131","DOI":"10.1182\/blood-2005-04-1595","volume":"106","author":"M Erlacher","year":"2005","unstructured":"Erlacher M, Michalak EM, Kelly PN, Labi V, Niederegger H, Coultas L et al. BH3-only proteins Puma and Bim are rate-limiting for \u03b3-radiation and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Blood 2005; 106: 4131\u20134138.","journal-title":"Blood"},{"key":"BFcdd201043_CR16","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.1084\/jem.20061552","volume":"203","author":"M Erlacher","year":"2006","unstructured":"Erlacher M, Laabi V, Manzl C, Bock G, Tzankov A, Haecker G et al. Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction. J Exp Med 2006; 203: 2939\u20132951.","journal-title":"J Exp Med"},{"key":"BFcdd201043_CR17","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1038\/415922a","volume":"415","author":"P Bouillet","year":"2002","unstructured":"Bouillet P, Purton JF, Godfrey DI, Zhang L-C, Coultas L, Puthalakath H et al. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 2002; 415: 922\u2013926.","journal-title":"Nature"},{"key":"BFcdd201043_CR18","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1084\/jem.20030411","volume":"198","author":"A Enders","year":"2003","unstructured":"Enders A, Bouillet P, Puthalakath H, Xu Y, Tarlinton DM, Strasser A . Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreative B cells. J Exp Med 2003; 198: 1119\u20131126.","journal-title":"J Exp Med"},{"key":"BFcdd201043_CR19","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/S1074-7613(02)00322-9","volume":"16","author":"DA Hildeman","year":"2002","unstructured":"Hildeman DA, Zhu Y, Mitchell TC, Bouillet P, Strasser A, Kappler J et al. Activated T cell death in vivo mediated by pro-apoptotic Bcl-2 family member, Bim. Immunity 2002; 16: 759\u2013767.","journal-title":"Immunity"},{"key":"BFcdd201043_CR20","doi-asserted-by":"publisher","first-page":"14175","DOI":"10.1073\/pnas.2336198100","volume":"100","author":"M Pellegrini","year":"2003","unstructured":"Pellegrini M, Belz G, Bouillet P, Strasser A . Shut down of an acute T cell immune response to viral infection is mediated by the pro-apoptotic Bcl-2 homology 3-only protein Bim. Proc Natl Acad Sci USA 2003; 100: 14175\u201314180.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201043_CR21","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.immuni.2007.12.017","volume":"28","author":"PD Hughes","year":"2008","unstructured":"Hughes PD, Belz GT, Fortner K, Budd RC, Strasser A, Bouillet P . Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity. Immunity 2008; 28: 197\u2013205.","journal-title":"Immunity"},{"key":"BFcdd201043_CR22","doi-asserted-by":"publisher","first-page":"6164","DOI":"10.1073\/pnas.0401471101","volume":"101","author":"A Egle","year":"2004","unstructured":"Egle A, Harris AW, Bouillet P, Cory S . Bim is a suppressor of Myc-induced mouse B cell leukemia. Proc Natl Acad Sci USA 2004; 101: 6164\u20136169.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201043_CR23","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/S1097-2765(00)00136-2","volume":"6","author":"T Lindsten","year":"2000","unstructured":"Lindsten T, Ross AJ, King A, Zong W, Rathmell JC, Shiels HA et al. The combined functions of proapoptotic Bcl-2 family members Bak and Bax are essential for normal development of multiple tissues. Mol Cell 2000; 6: 1389\u20131399.","journal-title":"Mol Cell"},{"key":"BFcdd201043_CR24","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1038\/ni834","volume":"3","author":"JC Rathmell","year":"2002","unstructured":"Rathmell JC, Lindsten T, Zong W-X, Cinalli RM, Thompson CB . Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat Immunol 2002; 3: 932\u2013939.","journal-title":"Nat Immunol"},{"key":"BFcdd201043_CR25","doi-asserted-by":"publisher","first-page":"14943","DOI":"10.1073\/pnas.96.26.14943","volume":"96","author":"S Ogilvy","year":"1999","unstructured":"Ogilvy S, Metcalf D, Print CG, Bath ML, Harris AW, Adams JM . Constitutive bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival. Proc Natl Acad Sci USA 1999; 96: 14943\u201314948.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201043_CR26","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1128\/MCB.24.4.1570-1581.2004","volume":"24","author":"L Coultas","year":"2004","unstructured":"Coultas L, Bouillet P, Stanley EG, Brodnicki TC, Adams JM, Strasser A . Proapoptotic BH3-only Bcl-2 family member Bik\/Blk\/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death. Mol Cell Biol 2004; 24: 1570\u20131581.","journal-title":"Mol Cell Biol"},{"key":"BFcdd201043_CR27","doi-asserted-by":"publisher","first-page":"3963","DOI":"10.1038\/sj.emboj.7600857","volume":"24","author":"L Coultas","year":"2005","unstructured":"Coultas L, Bouillet P, Loveland KL, Meachem S, Perlman H, Adams JM et al. Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis. Embo J 2005; 24: 3963\u20133973.","journal-title":"Embo J"},{"key":"BFcdd201043_CR28","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/S0002-9440(10)64557-9","volume":"157","author":"LA O'Reilly","year":"2000","unstructured":"O'Reilly LA, Cullen L, Visvader J, Lindeman G, Print C, Bath ML et al. The pro-apoptotic BH3-only protein Bim is expressed in hemopoietic, epithelial, neuronal and germ cells. Am J Pathol 2000; 157: 449\u2013461.","journal-title":"Am J Pathol"},{"key":"BFcdd201043_CR29","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1084\/jem.189.3.575","volume":"189","author":"C-L Mok","year":"1999","unstructured":"Mok C-L, Gil G, Williams O, Coles M, Taga S, Tolaini M et al. Bad can act as a key regulator of T cell apoptosis and T cell development. J Exp Med 1999; 189: 575\u2013586.","journal-title":"J Exp Med"},{"key":"BFcdd201043_CR30","doi-asserted-by":"publisher","first-page":"8661","DOI":"10.1073\/pnas.88.19.8661","volume":"88","author":"A Strasser","year":"1991","unstructured":"Strasser A, Whittingham S, Vaux DL, Bath ML, Adams JM, Cory S et al. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc Natl Acad Sci USA 1991; 88: 8661\u20138665.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201043_CR31","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/j.cell.2007.01.037","volume":"128","author":"KD Mason","year":"2007","unstructured":"Mason KD, Carpinelli MR, Fletcher JI, Collinge JE, Hilton AA, Ellis S et al. Programmed anuclear cell death delimits platelet life span. Cell 2007; 128: 1173\u20131186.","journal-title":"Cell"},{"key":"BFcdd201043_CR32","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s003350010242","volume":"12","author":"P Bouillet","year":"2001","unstructured":"Bouillet P, Zhang LC, Huang DC, Webb GC, Bottema CD, Shore P et al. Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim. Mammalian Genome 2001; 12: 163\u2013168.","journal-title":"Mammalian Genome"},{"key":"BFcdd201043_CR33","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/362849a0","volume":"362","author":"AR Clarke","year":"1993","unstructured":"Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML et al. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 1993; 362: 849\u2013852.","journal-title":"Nature"},{"key":"BFcdd201043_CR34","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/362847a0","volume":"362","author":"SW Lowe","year":"1993","unstructured":"Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T . p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 1993; 362: 847\u2013849.","journal-title":"Nature"},{"key":"BFcdd201043_CR35","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/0092-8674(94)90201-1","volume":"79","author":"A Strasser","year":"1994","unstructured":"Strasser A, Harris AW, Jacks T, Cory S . DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell 1994; 79: 329\u2013339.","journal-title":"Cell"},{"key":"BFcdd201043_CR36","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1126\/science.1090072","volume":"302","author":"A Villunger","year":"2003","unstructured":"Villunger A, Michalak EM, Coultas L, M\u00fcllauer F, B\u00f6ck G, Ausserlechner MJ et al. p53- and drug-induced apoptotic responses mediated by BH3-only proteins Puma and Noxa. Science 2003; 302: 1036\u20131038.","journal-title":"Science"},{"key":"BFcdd201043_CR37","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/S1535-6108(03)00244-7","volume":"4","author":"JR Jeffers","year":"2003","unstructured":"Jeffers JR, Parganas E, Lee Y, Yang C, Wang J, Brennan J et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 2003; 4: 321\u2013328.","journal-title":"Cancer Cell"},{"key":"BFcdd201043_CR38","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1038\/cdd.2008.16","volume":"15","author":"EM Michalak","year":"2008","unstructured":"Michalak EM, Villunger A, Adams JM, Strasser A . In several cell types the tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute. Cell Death Differ 2008; 15: 1019\u20131029.","journal-title":"Cell Death Differ"},{"key":"BFcdd201043_CR39","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/S1534-5807(02)00326-X","volume":"3","author":"SR Datta","year":"2002","unstructured":"Datta SR, Ranger AM, Lin MZ, Sturgill JF, Ma YC, Cowan CW et al. Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev Cell 2002; 3: 631\u2013643.","journal-title":"Dev Cell"},{"key":"BFcdd201043_CR40","doi-asserted-by":"publisher","first-page":"9071","DOI":"10.1128\/MCB.01025-06","volume":"26","author":"P Jiang","year":"2006","unstructured":"Jiang P, Du W, Heese K, Wu M . The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad\/p53 complex at the mitochondria to induce apoptosispoptosis. Mol Cell Biol 2006; 26: 9071\u20139082.","journal-title":"Mol Cell Biol"},{"key":"BFcdd201043_CR41","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/0092-8674(91)90362-3","volume":"67","author":"A Strasser","year":"1991","unstructured":"Strasser A, Harris AW, Cory S . Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 1991; 67: 889\u2013899.","journal-title":"Cell"},{"key":"BFcdd201043_CR42","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1006\/smim.1998.0158","volume":"11","author":"W van Ewijk","year":"1999","unstructured":"van Ewijk W, Wang B, Holl\u00e4nder G, Kawamoto H, Spanopoulou E, Itoi M et al. Thymic microenvironments, 3-D versus 2-D? Semin Immunol 1999; 11: 57\u201364.","journal-title":"Semin Immunol"},{"key":"BFcdd201043_CR43","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/nrc1735","volume":"5","author":"MH Barcellos-Hoff","year":"2005","unstructured":"Barcellos-Hoff MH, Park C, Wright EG . Radiation and the microenvironment - tumorigenesis and therapy. Nat Rev Cancer 2005; 5: 867\u2013875.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd201043_CR44","first-page":"185","volume":"13","author":"HS Kaplan","year":"1952","unstructured":"Kaplan HS, Brown MB . A quantitative dose-response study of lymphoid-tumor development in irradiated C57 black mice. J Natl Cancer Institute 1952; 13: 185\u2013208.","journal-title":"J Natl Cancer Institute"},{"key":"BFcdd201043_CR45","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1038\/sj.onc.1208300","volume":"24","author":"H Tagawa","year":"2005","unstructured":"Tagawa H, Karnan S, Suzuki R, Matsuo K, Zhang X, Ota A et al. Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM. Oncogene 2005; 24: 1348\u20131358.","journal-title":"Oncogene"},{"key":"BFcdd201043_CR46","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/sj.cdd.4401782","volume":"13","author":"I Sturm","year":"2006","unstructured":"Sturm I, Stephan C, Gillissen B, Siebert R, Janz M, Radetzki S et al. Loss of the tissue-specific proapoptotic BH3-only protein Nbk\/Bik is a unifying feature of renal cell carcinoma. Cell Death Differ 2006; 13: 619\u2013627.","journal-title":"Cell Death Differ"},{"key":"BFcdd201043_CR47","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/ng0994-66","volume":"8","author":"CJ Kemp","year":"1994","unstructured":"Kemp CJ, Wheldon T, Balmain A . p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nat Genet 1994; 8: 66\u201369.","journal-title":"Nat Genet"},{"key":"BFcdd201043_CR48","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/S0960-9822(00)00728-4","volume":"10","author":"PF Dijkers","year":"2000","unstructured":"Dijkers PF, Medema RH, Lammers JJ, Koenderman L, Coffer PJ . Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol 2000; 10: 1201\u20131204.","journal-title":"Curr Biol"},{"key":"BFcdd201043_CR49","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1038\/sj.cdd.4401688","volume":"12","author":"R Ley","year":"2005","unstructured":"Ley R, Ewings KE, Hadfield K, Cook SJ . Regulatory phosphorylation of Bim: sorting out the ERK from the JNK. Cell Death Differ 2005; 12: 1008\u20131014.","journal-title":"Cell Death Differ"},{"key":"BFcdd201043_CR50","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0092-8674(00)80405-5","volume":"91","author":"SR Datta","year":"1997","unstructured":"Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997; 91: 231\u2013241.","journal-title":"Cell"},{"key":"BFcdd201043_CR51","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.molcel.2004.12.030","volume":"17","author":"L Chen","year":"2005","unstructured":"Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG et al. Differential targeting of pro-survival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 2005; 17: 393\u2013403.","journal-title":"Mol Cell"},{"key":"BFcdd201043_CR52","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.molcel.2005.02.003","volume":"17","author":"T Kuwana","year":"2005","unstructured":"Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR et al. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell 2005; 17: 525\u2013535.","journal-title":"Mol Cell"},{"key":"BFcdd201043_CR53","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1101\/gad.1304105","volume":"19","author":"SN Willis","year":"2005","unstructured":"Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI et al. Pro-apoptotic Bak is sequestered by Mc1-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 2005; 19: 1294\u20131305.","journal-title":"Genes Dev"},{"key":"BFcdd201043_CR54","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0092-8674(93)80065-M","volume":"75","author":"DJ Veis","year":"1993","unstructured":"Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ . Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 1993; 75: 229\u2013240.","journal-title":"Cell"},{"key":"BFcdd201043_CR55","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nature02067","volume":"426","author":"JT Opferman","year":"2003","unstructured":"Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ . Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature 2003; 426: 671\u2013676.","journal-title":"Nature"},{"key":"BFcdd201043_CR56","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1084\/jem.183.2.381","volume":"183","author":"DAM Grillot","year":"1996","unstructured":"Grillot DAM, Merino R, Pena JC, Fanslow WC, Finkelman FD, Thompson CB et al. bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice. J Exp Med 1996; 183: 381\u2013391.","journal-title":"J Exp Med"},{"key":"BFcdd201043_CR57","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/mc.2940140105","volume":"14","author":"LA Donehower","year":"1995","unstructured":"Donehower LA, Harvey M, Vogel H, McArthur MJ, Montgomery Jr CA, Park SH et al. Effects of genetic background on tumorigenesis in p53-deficient mice. Mol Carcinog 1995; 14: 16\u201322.","journal-title":"Mol Carcinog"},{"key":"BFcdd201043_CR58","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1038\/sj.cdd.4402081","volume":"14","author":"H Zhang","year":"2007","unstructured":"Zhang H, Nimmer PM, Tahir SK, Chen J, Fryer RM, Hahn KR et al. Bcl-2 family proteins are essential for platelet survival. Cell Death Differ 2007; 14: 943\u2013951.","journal-title":"Cell Death Differ"},{"key":"BFcdd201043_CR59","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/nature03579","volume":"435","author":"T Oltersdorf","year":"2005","unstructured":"Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005; 435: 677\u2013681.","journal-title":"Nature"},{"key":"BFcdd201043_CR60","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/s00018-009-0198-9","volume":"67","author":"MV Catani","year":"2010","unstructured":"Catani MV, Gasperi V, Evangelista D, Finazzi Agro A, Avigliano L, Maccarrone M . Anandamide extends platelets survival through CB(1)-dependent Akt signaling. Cell Mol Life Sci 2010; 67: 601\u2013610.","journal-title":"Cell Mol Life Sci"},{"key":"BFcdd201043_CR61","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.ccr.2006.08.027","volume":"10","author":"MF van Delft","year":"2006","unstructured":"van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE et al. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak\/Bax if Mcl-1 is neutralized. Cancer Cell 2006; 10: 389\u2013399.","journal-title":"Cancer Cell"},{"key":"BFcdd201043_CR62","doi-asserted-by":"publisher","first-page":"E178","DOI":"10.1038\/35036427","volume":"2","author":"KH Vousden","year":"2000","unstructured":"Vousden KH, Vande Woude GF . The ins and outs of p53. Nat Cell Biol 2000; 2: E178\u2013E180.","journal-title":"Nat Cell Biol"},{"key":"BFcdd201043_CR63","first-page":"643","volume":"29","author":"JY Yang","year":"2006","unstructured":"Yang JY, Xia W, Hu MC . Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis. Int J Oncol 2006; 29: 643\u2013648.","journal-title":"Int J Oncol"},{"key":"BFcdd201043_CR64","doi-asserted-by":"publisher","first-page":"14907","DOI":"10.1073\/pnas.0606176103","volume":"103","author":"J Kuroda","year":"2006","unstructured":"Kuroda J, Puthalakath H, Cragg MS, Kelly PN, Bouillet P, Huang DC et al. Bim and Bad mediate imatinib-induced killing of Bcr\/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. Proc Natl Acad Sci USA 2006; 103: 14907\u201314912.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201043_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0960-9822(00)00002-6","volume":"4","author":"T Jacks","year":"1994","unstructured":"Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT et al. Tumor spectrum analysis in p53-mutant mice. Curr Biol 1994; 4: 1\u20137.","journal-title":"Curr Biol"},{"key":"BFcdd201043_CR66","doi-asserted-by":"publisher","first-page":"3978","DOI":"10.1182\/blood-2007-05-091306","volume":"110","author":"SF Fischer","year":"2007","unstructured":"Fischer SF, Bouillet P, O'Donnell K, Light A, Tarlinton DM, Strasser A . Pro-apoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody forming cells. Blood 2007; 110: 3978\u20133984.","journal-title":"Blood"}],"container-title":["Cell Death & Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd201043.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201043","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201043.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T08:59:07Z","timestamp":1684400347000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd201043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,30]]},"references-count":66,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["BFcdd201043"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2010.43","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,30]]}}}