{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:13:47Z","timestamp":1791087227329,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,8,13]],"date-time":"2010-08-13T00:00:00Z","timestamp":1281657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1038\/cdd.2010.99","type":"journal-article","created":{"date-parts":[[2010,8,13]],"date-time":"2010-08-13T09:06:57Z","timestamp":1281690417000},"page":"362-370","source":"Crossref","is-referenced-by-count":61,"title":["Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia\/lymphoma by translational suppression of c-FLIP expression"],"prefix":"10.1038","volume":"18","author":[{"given":"M","family":"Bleumink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"K\u00f6hler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Giaisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Proksch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P H","family":"Krammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Li-Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,8,13]]},"reference":[{"key":"BFcdd201099_CR1","doi-asserted-by":"publisher","first-page":"2950","DOI":"10.1038\/sj.onc.1207558","volume":"23","author":"KM Debatin","year":"2004","unstructured":"Debatin KM, Krammer PH . Death receptors in chemotherapy and cancer. Oncogene 2004; 23: 2950\u20132966.","journal-title":"Oncogene"},{"key":"BFcdd201099_CR2","doi-asserted-by":"publisher","first-page":"4812","DOI":"10.1038\/sj.onc.1209598","volume":"25","author":"L Galluzzi","year":"2006","unstructured":"Galluzzi L, Larochette N, Zamzami N, Kroemer G . Mitochondria as therapeutic targets for cancer chemotherapy. Oncogene 2006; 25: 4812\u20134830.","journal-title":"Oncogene"},{"key":"BFcdd201099_CR3","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/nrc2465","volume":"8","author":"RW Johnstone","year":"2008","unstructured":"Johnstone RW, Frew AJ, Smyth MJ . The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nat Rev Cancer 2008; 8: 782\u2013798.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd201099_CR4","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/nri2115","volume":"7","author":"PH Krammer","year":"2007","unstructured":"Krammer PH, Arnold R, Lavrik I . Life and death in peripheral T cells. Nat Rev Immunol 2007; 7: 532\u2013542.","journal-title":"Nat Rev Immunol"},{"key":"BFcdd201099_CR5","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/5517","volume":"5","author":"H Walczak","year":"1999","unstructured":"Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 1999; 5: 157\u2013163.","journal-title":"Nat Med"},{"key":"BFcdd201099_CR6","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/86397","volume":"7","author":"D Lawrence","year":"2001","unstructured":"Lawrence D, Shahrokh Z, Marsters S, Achilles K, Shih D, Mounho B et al. Differential hepatocyte toxicity of recombinant Apo2L\/TRAIL versions. Nat Med 2001; 7: 383\u2013385.","journal-title":"Nat Med"},{"key":"BFcdd201099_CR7","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1038\/sj.leu.2402131","volume":"15","author":"C Wuchter","year":"2001","unstructured":"Wuchter C, Krappmann D, Cai Z, Ruppert V, Scheidereit C, D\u00f6rken B et al. In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-kappa B activity. Leukemia 2001; 15: 921\u2013928.","journal-title":"Leukemia"},{"key":"BFcdd201099_CR8","doi-asserted-by":"publisher","first-page":"3842","DOI":"10.1038\/sj.onc.1206520","volume":"22","author":"H Ehrhardt","year":"2003","unstructured":"Ehrhardt H, Fulda S, Schmid I, Hiscott J, Debatin KM, Jeremias I . TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB. Oncogene 2003; 22: 3842\u20133852.","journal-title":"Oncogene"},{"key":"BFcdd201099_CR9","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/nrc2111","volume":"7","author":"M Matsuoka","year":"2007","unstructured":"Matsuoka M, Jeang K . Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat Rev Cancer 2007; 7: 270\u2013280.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd201099_CR10","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/j.1365-2141.2004.05289.x","volume":"128","author":"H Hasegawa","year":"2005","unstructured":"Hasegawa H, Yamada Y, Harasawa H, Tsuji T, Murata K, Sugahara K et al. Sensitivity of adult T-cell leukaemia lymphoma cells to tumour necrosis factor-related apoptosis-inducing ligand. Br J Haematol 2005; 128: 253\u2013265.","journal-title":"Br J Haematol"},{"key":"BFcdd201099_CR11","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1128\/JVI.79.3.1367-1378.2005","volume":"79","author":"T Matsuda","year":"2005","unstructured":"Matsuda T, Almasan A, Tomita M, Uchihara JN, Masuda M, Ohshiro K et al. Resistance to Apo2 ligand (Apo2L)\/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis and constitutive expression of Apo2L\/TRAIL in human T-cell leukemia virus type 1-infected T-cell lines. J Virol 2005; 79: 1367\u20131378.","journal-title":"J Virol"},{"key":"BFcdd201099_CR12","doi-asserted-by":"publisher","first-page":"3933","DOI":"10.1182\/blood-2005-06-2567","volume":"107","author":"A Krueger","year":"2006","unstructured":"Krueger A, Fas SC, Giaisi M, Bleumink M, Merling A, Stumpf C et al. HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP). Blood 2006; 107: 3933\u20133939.","journal-title":"Blood"},{"key":"BFcdd201099_CR13","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/j.1365-2443.2006.00927.x","volume":"11","author":"K Okamoto","year":"2006","unstructured":"Okamoto K, Fujisawa J, Reth M, Yonehara S . Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NF-kappaB. Genes Cells 2006; 11: 177\u2013191.","journal-title":"Genes Cells"},{"key":"BFcdd201099_CR14","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1182\/blood-2008-02-141382","volume":"112","author":"N Ueffing","year":"2008","unstructured":"Ueffing N, Schuster M, Keil E, Schulze-Osthoff K, Schmitz I . Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells. Blood 2008; 112: 690\u2013698.","journal-title":"Blood"},{"key":"BFcdd201099_CR15","doi-asserted-by":"publisher","first-page":"5299","DOI":"10.1128\/MCB.21.16.5299-5305.2001","volume":"21","author":"O Micheau","year":"2001","unstructured":"Micheau O, Lens S, Gaide O, Alevizopoulos K, Tschopp J . NF-kappaB signals induce the expression of c-FLIP. Mol Cell Biol 2001; 21: 5299\u20135305.","journal-title":"Mol Cell Biol"},{"key":"BFcdd201099_CR16","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1084\/jem.188.10.1795","volume":"188","author":"JH Yeh","year":"1998","unstructured":"Yeh JH, Hsu SC, Han SH, Lai MZ . Mitogen-activated protein kinase kinase antagonized fas-associated death domain protein-mediated apoptosis by induced FLICE-inhibitory protein expression. J Exp Med 1998; 188: 1795\u20131802.","journal-title":"J Exp Med"},{"key":"BFcdd201099_CR17","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1083\/jcb.152.3.633","volume":"152","author":"F Aoudjit","year":"2001","unstructured":"Aoudjit F, Vuori K . Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. J Cell Biol 2001; 152: 633\u2013643.","journal-title":"J Cell Biol"},{"key":"BFcdd201099_CR18","doi-asserted-by":"publisher","first-page":"21723","DOI":"10.1074\/jbc.M202224200","volume":"277","author":"W Wang","year":"2002","unstructured":"Wang W, Prince CZ, Mou Y, Pollman MJ . Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK\/MAPK activation. Resistance to Fas ligand-induced apoptosis. J Biol Chem 2002; 277: 21723\u201321729.","journal-title":"J Biol Chem"},{"key":"BFcdd201099_CR19","doi-asserted-by":"publisher","first-page":"6893","DOI":"10.1074\/jbc.C000569200","volume":"276","author":"DJ Panka","year":"2001","unstructured":"Panka DJ, Mano T, Suhara T, Walsh K, Mier JW . Phosphatidylinositol 3-kinase\/Akt activity regulates c-FLIP expression in tumor cells. J Biol Chem 2001; 276: 6893\u20136896.","journal-title":"J Biol Chem"},{"key":"BFcdd201099_CR20","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1111\/j.1349-7006.2003.tb01402.x","volume":"94","author":"SY Nam","year":"2003","unstructured":"Nam SY, Jung GA, Hur GC, Chung HY, Kim WH, Seol DW et al. Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers. Cancer Sci 2003; 94: 1066\u20131073.","journal-title":"Cancer Sci"},{"key":"BFcdd201099_CR21","doi-asserted-by":"publisher","first-page":"27345","DOI":"10.1074\/jbc.M504019200","volume":"280","author":"M Poukkula","year":"2005","unstructured":"Poukkula M, Kaunisto A, Hietakangas V, Denessiouk K, Katajam\u00e4ki T, Johnson MS et al. Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail. J Biol Chem 2005; 280: 27345\u201327355.","journal-title":"J Biol Chem"},{"key":"BFcdd201099_CR22","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.cell.2006.01.021","volume":"124","author":"L Chang","year":"2006","unstructured":"Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K et al. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 2006; 124: 601\u2013613.","journal-title":"Cell"},{"key":"BFcdd201099_CR23","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.molcel.2005.08.017","volume":"19","author":"M Gao","year":"2005","unstructured":"Gao M, Karin M . Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli. Mol Cell 2005; 19: 581\u2013593.","journal-title":"Mol Cell"},{"key":"BFcdd201099_CR24","doi-asserted-by":"publisher","first-page":"923","DOI":"10.2174\/1385272013375049","volume":"5","author":"P Proksch","year":"2001","unstructured":"Proksch P, Edrada RA, Ebel R, Bohnenstengel FI, Nugroho BW . Chemistry and biological activity of rocaglamide derivatives and related compounds in Aglaia species (Meliaceae). Cur Org Chem 2001; 5: 923\u2013938.","journal-title":"Cur Org Chem"},{"key":"BFcdd201099_CR25","doi-asserted-by":"publisher","first-page":"319","DOI":"10.2174\/187152006777698123","volume":"6","author":"S Kim","year":"2006","unstructured":"Kim S, Salim AA, Swanson SM, Kinghorn AD . Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy. Anticancer Agents Med Chem 2006; 6: 319\u2013345.","journal-title":"Anticancer Agents Med Chem"},{"key":"BFcdd201099_CR26","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1002\/ijc.22743","volume":"121","author":"JY Zhu","year":"2007","unstructured":"Zhu JY, Lavrik IN, Mahlknecht U, Giaisi M, Proksch P, Krammer PH et al. The tradition Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of MAPK activities. Int J Cancer 2007; 121: 839\u20131846.","journal-title":"Int J Cancer"},{"key":"BFcdd201099_CR27","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1038\/cdd.2009.42","volume":"16","author":"JY Zhu","year":"2009","unstructured":"Zhu JY, Giaisi M, K\u00f6hler R, M\u00fcller WW, M\u00fchleisen A, Proksch P et al. Rocaglamide sensitizes leukemic T cells to activation-induced cell death by differential regulation of CD95L and c-FLIP expression. Cell Death Differ 2009; 16: 1289\u20131299.","journal-title":"Cell Death Differ"},{"key":"BFcdd201099_CR28","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/0022-2836(66)90079-9","volume":"21","author":"SY Lin","year":"1966","unstructured":"Lin SY, Mosteller RD, Hardesty B . The mechanism of sodium fluoride and cycloheximide inhibition of hemoglobin biosynthesis in the cell-free reticulocyte system. J Mol Biol 1966; 21: 51\u201369.","journal-title":"J Mol Biol"},{"key":"BFcdd201099_CR29","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1146\/annurev.biochem.68.1.913","volume":"68","author":"AC Gingras","year":"1999","unstructured":"Gingras AC, Raught B, Sonenberg N . eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem 1999; 68: 913\u2013963.","journal-title":"Annu Rev Biochem"},{"key":"BFcdd201099_CR30","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1046\/j.1432-1327.1998.2530531.x","volume":"253","author":"M Kleijn","year":"1998","unstructured":"Kleijn M, Scheper GC, Voorma HO, Thomas AA . Regulation of translation initiation factors by signal transduction. Eur J Biochem 1998; 253: 531\u2013544.","journal-title":"Eur J Biochem"},{"key":"BFcdd201099_CR31","first-page":"362","volume":"21","author":"X Wang","year":"2006","unstructured":"Wang X, Proud CG . The mTOR pathway in the control of protein synthesis. Physiology (Bethesda) 2006; 21: 362\u2013369.","journal-title":"Physiology (Bethesda)"},{"key":"BFcdd201099_CR32","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/nrm2838","volume":"11","author":"RJ Jackson","year":"2010","unstructured":"Jackson RJ, Hellen CU, Pestova TV . The mechanism of eukaryotic translation initiation and principles of its regulation. Nat Rev Mol Cell Biol 2010; 11: 113\u2013127.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcdd201099_CR33","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1074\/jbc.M310069200","volume":"279","author":"K Wu","year":"2004","unstructured":"Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A et al. Protein profile of tax-associated complexes. J Biol Chem 2004; 279: 495\u2013508.","journal-title":"J Biol Chem"},{"key":"BFcdd201099_CR34","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1128\/MCB.10.1.413","volume":"10","author":"R Pozzatti","year":"1990","unstructured":"Pozzatti R, Vogel J, Jay G . The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells. Mol Cell Biol 1990; 10: 413\u2013417.","journal-title":"Mol Cell Biol"},{"key":"BFcdd201099_CR35","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s10495-008-0289-3","volume":"14","author":"N Vajente","year":"2009","unstructured":"Vajente N, Trevisan R, Saggioro D . HTLV-1 Tax protein cooperates with Ras in protecting cells from apoptosis. Apoptosis 2009; 14: 153\u2013163.","journal-title":"Apoptosis"},{"key":"BFcdd201099_CR36","unstructured":"Fricker N, Beaudouin J, Richter P, Eils R, Krammer PH, Inna NL . Model based dissection of CD95 signaling dynamics reveals both a pro- and anti-apoptotic role of c-FLIPL. J Cell Biol (in press)."}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd201099.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201099","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201099.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:59:34Z","timestamp":1684414774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd201099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,13]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["BFcdd201099"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2010.99","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,13]]}}}