{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:26:32Z","timestamp":1791203192803,"version":"4.2.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2012,1,13]],"date-time":"2012-01-13T00:00:00Z","timestamp":1326412800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1038\/cdd.2011.196","type":"journal-article","created":{"date-parts":[[2012,1,13]],"date-time":"2012-01-13T10:20:56Z","timestamp":1326450056000},"page":"1109-1116","source":"Crossref","is-referenced-by-count":24,"title":["ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease"],"prefix":"10.1038","volume":"19","author":[{"given":"J","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y K","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G S","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y J","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K Y","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K H","family":"Seong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M-K","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Picketts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N W","family":"Kowall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K S","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,1,13]]},"reference":[{"key":"BFcdd2011196_CR1","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","volume":"57","author":"JP Vonsattel","year":"1998","unstructured":"Vonsattel JP, DiFiglia M . Huntington disease. J Neuropathol Exp Neurol 1998; 57: 369\u2013384.","journal-title":"J Neuropathol Exp Neurol"},{"key":"BFcdd2011196_CR2","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","author":"The Huntington\u2019s Disease Collaborative Research Group.","year":"1993","unstructured":"The Huntington\u2019s Disease Collaborative Research Group. A nobel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. Cell 1993; 72: 971\u2013983.","journal-title":"Cell"},{"key":"BFcdd2011196_CR3","doi-asserted-by":"publisher","first-page":"6763","DOI":"10.1073\/pnas.100110097","volume":"97","author":"JS Steffan","year":"2000","unstructured":"Steffan JS, Kazantsev A, Spasic-Boskovic O, Greenwald M, Zhu YZ, Gohler H et al. The Huntington\u2019s disease protein interacts with p53 and CREB-binding protein and represses transcription. Proc Natl Acad Sci USA 2000; 97: 6763\u20136768.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2011196_CR4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0168-9525(03)00074-X","volume":"19","author":"KL Sugars","year":"2003","unstructured":"Sugars KL, Rubinsztein DC . Transcriptional abnormalities in Huntington disease. Trends Genet 2003; 19: 233\u2013238.","journal-title":"Trends Genet"},{"key":"BFcdd2011196_CR5","doi-asserted-by":"publisher","first-page":"19176","DOI":"10.1073\/pnas.0606373103","volume":"103","author":"H Ryu","year":"2006","unstructured":"Ryu H, Lee J, Hargerty SW, Soh BY, Mcalpin SE, Cormier KA et al. ESET\/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington\u2019s disease. Proc Natl Acad Sci USA 2006; 103: 19176\u201319181.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2011196_CR6","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/ncpneuro0199","volume":"2","author":"G Sadri-Vakili","year":"2006","unstructured":"Sadri-Vakili G, Cha JH . Mechanisms of disease: histone modifications in Huntington's disease. Nat Clin Pract Neurol 2006; 2: 330\u2013338.","journal-title":"Nat Clin Pract Neurol"},{"key":"BFcdd2011196_CR7","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.gde.2006.02.006","volume":"16","author":"PD Varga-Weisz","year":"2006","unstructured":"Varga-Weisz PD, Becker PB . Regulation of higher-order chromatin structures by nucleosome-remodelling factors. Curr Opin Genet Dev 2006; 16: 151\u2013156.","journal-title":"Curr Opin Genet Dev"},{"key":"BFcdd2011196_CR8","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/0092-8674(95)90287-2","volume":"80","author":"RJ Gibbons","year":"1995","unstructured":"Gibbons RJ, Picketts DJ, Villard L, Higgs DR . Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alphathalassemia (ATR-X syndrome). Cell 1995; 80: 837\u2013845.","journal-title":"Cell"},{"key":"BFcdd2011196_CR9","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1093\/hmg\/5.12.1899","volume":"5","author":"DJ Picketts","year":"1996","unstructured":"Picketts DJ, Higgs DR, Bachoo S, Blake DJ, Quarrell OW, Gibbons RJ . ATRX encodes a novel member of the SNF2 family of proteins: mutations point to a common mechanism underlying the ATR-X syndrome. Hum Mol Genet 1996; 5: 1899\u20131907.","journal-title":"Hum Mol Genet"},{"key":"BFcdd2011196_CR10","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/74191","volume":"24","author":"RJ Gibbons","year":"2000","unstructured":"Gibbons RJ, McDowell TL, Raman S, O\u2019Rourke DM, Garrick D, Ayyub H et al. Mutations in ATRX, encoding a SWI\/SNF-like protein, cause diverse changes in the pattern of DNA methylation. Nat Genet 2000; 24: 368\u2013371.","journal-title":"Nat Genet"},{"key":"BFcdd2011196_CR11","doi-asserted-by":"publisher","first-page":"e1001137","DOI":"10.1371\/journal.pgen.1001137","volume":"6","author":"C Baumann","year":"2010","unstructured":"Baumann C, Viveiros MM, De La Fuente R . Loss of maternal ATRX results in centromere instability and aneuploidy in the mammalian oocyte and pre-implantation embryo. PLoS Genet 2010; 6: e1001137.","journal-title":"PLoS Genet"},{"key":"BFcdd2011196_CR12","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1093\/hmg\/11.3.253","volume":"11","author":"NG Berube","year":"2002","unstructured":"Berube NG, Jagla M, Smeenk C, De Repentigny Y, Kothary R, Picketts DJ . Neurodevelopmental defects resulting from ATRX overexpression in transgenic mice. Hum Mol Genet 2002; 11: 253\u2013261.","journal-title":"Hum Mol Genet"},{"key":"BFcdd2011196_CR13","doi-asserted-by":"publisher","first-page":"3807","DOI":"10.1242\/jcs.01230","volume":"117","author":"AM Ishov","year":"2004","unstructured":"Ishov AM, Vladimirova OV, Maul GG . Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI\/SNF protein ATRX. J Cell Sci 2004; 117: 3807\u20133820.","journal-title":"J Cell Sci"},{"key":"BFcdd2011196_CR14","doi-asserted-by":"publisher","first-page":"20369","DOI":"10.1074\/jbc.M401321200","volume":"279","author":"J Tang","year":"2004","unstructured":"Tang J, Wu S, Liu H, Stratt R, Barak OG, Shiekhattar R et al. A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein. J Biol Chem 2004; 279: 20369\u201320377.","journal-title":"J Biol Chem"},{"key":"BFcdd2011196_CR15","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1073\/pnas.0608056104","volume":"104","author":"X Nan","year":"2007","unstructured":"Nan X, Hou J, Maclean A, Nasir J, Lafuente MJ, Shu MJ et al. Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. Proc Natl Acad Sci USA 2007; 104: 2709\u20132714.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2011196_CR16","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1172\/JCI200522329","volume":"115","author":"NG Berube","year":"2005","unstructured":"Berube NG, Mangelsdorf M, Jagla M, Vanderluit J, Garrick D, Gibbons RJ et al. The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis. J Clin Invest 2005; 115: 258\u2013267.","journal-title":"J Clin Invest"},{"key":"BFcdd2011196_CR17","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","volume":"87","author":"L Mangiarini","year":"1996","unstructured":"Mangiarini L, Sathasivam K, Seller K, Cozens B, Harper A, Hetherington C et al. Exon1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 1996; 87: 493\u2013506.","journal-title":"Cell"},{"key":"BFcdd2011196_CR18","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1093\/hmg\/9.19.2799","volume":"9","author":"F Trettel","year":"2000","unstructured":"Trettel F, Rigamonti D, Hilditch-Maguire P, Wheeler VC, Sharp AH, Persichetti F et al. Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells. Hum Mol Genet 2000; 9: 2799\u20132809.","journal-title":"Hum Mol Genet"},{"key":"BFcdd2011196_CR19","doi-asserted-by":"publisher","first-page":"13983","DOI":"10.1073\/pnas.96.24.13983","volume":"96","author":"TL McDowell","year":"1999","unstructured":"McDowell TL, Gibbons RJ, Sutherland H, O\u2019Rourke DM, Bickmore WA, Pombo A et al. Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes. Proc Natl Acad Sci USA 1999; 96: 13983\u201313988.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2011196_CR20","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/sj.ejhg.5201943","volume":"16","author":"NG Berube","year":"2008","unstructured":"Berube NG, Healy J, Medina CF, Wu S, Hodgson T, Jagla M et al. Patient mutations alter ATRX targeting to PML nuclear bodies. Eur J Hum Genet 2008; 16: 192\u2013201.","journal-title":"Eur J Hum Genet"},{"key":"BFcdd2011196_CR21","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1101\/gad.1087503","volume":"17","author":"JP Taylor","year":"2003","unstructured":"Taylor JP, Taye AA, Campbell C, Kazemi-Esfarjani P, Fischbeck KH, Min KT . Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein. Genes Dev 2003; 17: 1463\u20131468.","journal-title":"Genes Dev"},{"key":"BFcdd2011196_CR22","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1016\/j.febslet.2007.05.005","volume":"581","author":"NG Lee","year":"2007","unstructured":"Lee NG, Hong YK, Yu SY, Han SY, Geum D, Cho D . dXNP, a Drosophila homolog of XNP\/ATRX, induces apoptosis via Jun-N-terminal kinase activation. FEBS Lett 2007; 581: 2625\u20132632.","journal-title":"FEBS Lett"},{"key":"BFcdd2011196_CR23","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.bbrc.2009.04.112","volume":"384","author":"YK Hong","year":"2009","unstructured":"Hong YK, Lee NG, Lee MJ, Park MS, Choi MS, Suh YS et al. dXNP\/DATRX increases apoptosis via the JNK and dFOXO pathway in Drosophila neurons. Biochem Biophys Res Commun 2009; 384: 160\u2013166.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcdd2011196_CR24","doi-asserted-by":"publisher","first-page":"11023","DOI":"10.1073\/pnas.0504921102","volume":"102","author":"F Borovecki","year":"2005","unstructured":"Borovecki F, Lovrecic L, Zhou J, Jeong H, Then H, Rosas HD et al. Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease. Proc Natl Acad Sci USA 2005; 102: 11023\u201311028.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2011196_CR25","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1093\/hmg\/ddr107","volume":"20","author":"A Dhayalan","year":"2011","unstructured":"Dhayalan A, Tamas R, Bock I, Tattermusch A, Dimitrova E, Kudithipudi S et al. The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9. Hum Mol Genet 2011; 20: 2195\u20132120.","journal-title":"Hum Mol Genet"},{"key":"BFcdd2011196_CR26","doi-asserted-by":"publisher","first-page":"14030","DOI":"10.1074\/jbc.273.22.14030","volume":"273","author":"GV Mallo","year":"1998","unstructured":"Mallo GV, Soubeyran P, Lissitzky JC, Andr\u00e9 F, Farnarier C, Marvaldi J et al. Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells. J Biol Chem 1998; 273: 14030\u201314036.","journal-title":"J Biol Chem"},{"key":"BFcdd2011196_CR27","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1126\/science.287.5459.1837","volume":"287","author":"P Kazemi-Esfarjani","year":"2000","unstructured":"Kazemi-Esfarjani P, Benzer S . Genetic suppression of polyglutamine toxicity in Drosophila. Science 2000; 287: 1837\u20131840.","journal-title":"Science"},{"key":"BFcdd2011196_CR28","doi-asserted-by":"publisher","first-page":"13915","DOI":"10.1073\/pnas.0502878102","volume":"102","author":"H Ryu","year":"2005","unstructured":"Ryu H, Lee J, Impey S, Ratan RR, Ferrante RJ . Antioxidants modulate mitochondrial protein kinase A and increase CREB binding to D-Loop DNA of the mitochondrial genome in neurons. Proc Natl Acad Sci USA 2005; 102: 13915\u201313920.","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Cell Death & Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd2011196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2011196","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2011196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:00:36Z","timestamp":1684414836000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd2011196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,13]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["BFcdd2011196"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2011.196","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,13]]}}}