{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:02:45Z","timestamp":1791201765627,"version":"4.2.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,9,14]],"date-time":"2012-09-14T00:00:00Z","timestamp":1347580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1038\/cdd.2012.122","type":"journal-article","created":{"date-parts":[[2012,9,14]],"date-time":"2012-09-14T09:20:09Z","timestamp":1347614409000},"page":"270-280","source":"Crossref","is-referenced-by-count":73,"title":["Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury"],"prefix":"10.1038","volume":"20","author":[{"given":"T","family":"Katome","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Namekata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Semba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Kittaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Ichijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Mitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,9,14]]},"reference":[{"key":"BFcdd2012122_CR1","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1002\/cne.902190309","volume":"219","author":"VH Perry","year":"1983","unstructured":"Perry VH, Henderson Z, Linden R . Postnatal changes in retinal ganglion cell and optic axon populations in the pigmented rat. J Comp Neurol 1983; 219: 356\u2013368.","journal-title":"J Comp Neurol"},{"key":"BFcdd2012122_CR2","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1101\/gad.1504307","volume":"21","author":"T Harada","year":"2007","unstructured":"Harada T, Harada C, Parada LF . Molecular regulation of visual system development: more than meets the eye. Genes Dev 2007; 21: 367\u2013378.","journal-title":"Genes Dev"},{"key":"BFcdd2012122_CR3","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/0039-6257(94)90145-7","volume":"38","author":"KD Steinsapir","year":"1994","unstructured":"Steinsapir KD, Goldberg RA . Traumatic optic neuropathy. Surv Ophthalmol 1994; 38: 487\u2013518.","journal-title":"Surv Ophthalmol"},{"key":"BFcdd2012122_CR4","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1038\/sj.eye.6701571","volume":"18","author":"N Sarkies","year":"2004","unstructured":"Sarkies N . Traumatic optic neuropathy. Eye 2004; 18: 1122\u20131125.","journal-title":"Eye"},{"key":"BFcdd2012122_CR5","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1016\/S0161-6420(99)00707-1","volume":"106","author":"LA Levin","year":"1999","unstructured":"Levin LA, Beck RW, Joseph MP, Seiff S, Kraker R . The treatment of traumatic optic neuropathy: the International Optic Nerve Trauma Study. Ophthalmology 1999; 106: 1268\u20131277.","journal-title":"Ophthalmology"},{"key":"BFcdd2012122_CR6","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/ncomms1190","volume":"2","author":"C Harada","year":"2011","unstructured":"Harada C, Guo X, Namekata K, Kimura A, Nakamura K, Tanaka K et al. Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration. Nat Commun 2011; 2: 189.","journal-title":"Nat Commun"},{"key":"BFcdd2012122_CR7","doi-asserted-by":"publisher","first-page":"7586","DOI":"10.1073\/pnas.0914514107","volume":"107","author":"K Namekata","year":"2010","unstructured":"Namekata K, Harada C, Taya C, Guo X, Kimura H, Parada LF et al. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex. Proc Natl Acad Sci USA 2010; 107: 7586\u20137591.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2012122_CR8","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1523\/JNEUROSCI.4884-11.2012","volume":"32","author":"K Namekata","year":"2012","unstructured":"Namekata K, Harada C, Guo X, Kimura A, Kittaka D, Watanabe H et al. Dock3 stimulates axonal outgrowth via GSK-3\u03b2-mediated microtubule assembly. J Neurosci 2012; 32: 264\u2013274.","journal-title":"J Neurosci"},{"key":"BFcdd2012122_CR9","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/S1044-7431(03)00228-8","volume":"24","author":"PS Sapieha","year":"2003","unstructured":"Sapieha PS, Peltier M, Rendahl KG, Manning WC, Di Polo A . Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury. Mol Cell Neurosci 2003; 24: 656\u2013672.","journal-title":"Mol Cell Neurosci"},{"key":"BFcdd2012122_CR10","doi-asserted-by":"publisher","first-page":"5037","DOI":"10.1523\/JNEUROSCI.20-13-05037.2000","volume":"20","author":"M Kikuchi","year":"2000","unstructured":"Kikuchi M, Tenneti L, Lipton SA . Role of p38 mitogen-activated protein kinase in axotomy-induced apoptosis of rat retinal ganglion cells. J Neurosci 2000; 20: 5037\u20135044.","journal-title":"J Neurosci"},{"key":"BFcdd2012122_CR11","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.niox.2010.06.001","volume":"23","author":"GC Brown","year":"2010","unstructured":"Brown GC . Nitric oxide and neuronal death. Nitric Oxide 2010; 23: 153\u2013165.","journal-title":"Nitric Oxide"},{"key":"BFcdd2012122_CR12","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1101\/gad.1640108","volume":"22","author":"H Nishitoh","year":"2008","unstructured":"Nishitoh H, Kadowaki H, Nagai A, Maruyama T, Yokota T, Fukutomi H et al. ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1. Genes Dev 2008; 22: 1451\u20131464.","journal-title":"Genes Dev"},{"key":"BFcdd2012122_CR13","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1038\/cdd.2010.62","volume":"17","author":"C Harada","year":"2010","unstructured":"Harada C, Namekata K, Guo X, Yoshida H, Mitamura Y, Matsumoto Y et al. ASK1 deficiency attenuates neural cell death in GLAST-deficient mice, a model of normal tension glaucoma. Cell Death Differ 2010; 17: 1751\u20131759.","journal-title":"Cell Death Differ"},{"key":"BFcdd2012122_CR14","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1089\/ars.2005.7.472","volume":"7","author":"A Matsuzawa","year":"2005","unstructured":"Matsuzawa A, Ichijo H . Stress-responsive protein kinases in redox-regulated apoptosis signaling. Antioxid Redox Signal 2005; 7: 472\u2013481.","journal-title":"Antioxid Redox Signal"},{"key":"BFcdd2012122_CR15","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1002\/emmm.201000103","volume":"2","author":"X Guo","year":"2010","unstructured":"Guo X, Harada C, Namekata K, Matsuzawa A, Camps M, Ji H et al. Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol Med 2010; 2: 504\u2013515.","journal-title":"EMBO Mol Med"},{"key":"BFcdd2012122_CR16","doi-asserted-by":"publisher","first-page":"261","DOI":"10.2353\/ajpath.2006.050765","volume":"168","author":"C Harada","year":"2006","unstructured":"Harada C, Nakamura K, Namekata K, Okumura A, Mitamura Y, Iizuka Y et al. Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo. Am J Pathol 2006; 168: 261\u2013269.","journal-title":"Am J Pathol"},{"key":"BFcdd2012122_CR17","doi-asserted-by":"publisher","first-page":"6504","DOI":"10.1167\/iovs.10-5551","volume":"51","author":"L Guo","year":"2010","unstructured":"Guo L, Normando EM, Nizari S, Lara D, Cordeiro MF . Tracking longitudinal retinal changes in experimental ocular hypertension using the cSLO and spectral domain-OCT. Invest Ophthalmol Vis Sci 2010; 51: 6504\u20136513.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFcdd2012122_CR18","doi-asserted-by":"publisher","first-page":"8754","DOI":"10.1167\/iovs.10-6654","volume":"52","author":"N Nakano","year":"2011","unstructured":"Nakano N, Ikeda HO, Hangai M, Muraoka Y, Toda Y, Kakizuka A et al. Longitudinal and simultaneous imaging of retinal ganglion cells and inner retinal layers in a mouse model of glaucoma induced by N-methyl-D-aspartate. Invest Ophthalmol Vis Sci 2011; 52: 8754\u20138762.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFcdd2012122_CR19","doi-asserted-by":"publisher","first-page":"9228","DOI":"10.1523\/JNEUROSCI.22-21-09228.2002","volume":"22","author":"T Harada","year":"2002","unstructured":"Harada T, Harada C, Kohsaka S, Wada E, Yoshida K, Ohno S et al. Microglia\u2013M\u00fcller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration. J Neurosci 2002; 22: 9228\u20139236.","journal-title":"J Neurosci"},{"key":"BFcdd2012122_CR20","doi-asserted-by":"publisher","first-page":"8514","DOI":"10.1073\/pnas.1432609100","volume":"100","author":"S Lehnardt","year":"2003","unstructured":"Lehnardt S, Massillon L, Follett P, Jensen FE, Ratan R, Rosenberg PA et al. Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc Natl Acad Sci USA 2003; 100: 8514\u20138519.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2012122_CR21","doi-asserted-by":"publisher","first-page":"28373","DOI":"10.1074\/jbc.272.45.28373","volume":"272","author":"J Da Silva","year":"1997","unstructured":"Da Silva J, Pierrat B, Mary JL, Lesslauer W . Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes. J Biol Chem 1997; 272: 28373\u201328380.","journal-title":"J Biol Chem"},{"key":"BFcdd2012122_CR22","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/j.1750-3639.2010.00445.x","volume":"21","author":"G Yang","year":"2011","unstructured":"Yang G, Meng Y, Li W, Yong Y, Fan Z, Ding H et al. Neuronal MCP-1 mediates microglia recruitment and neurodegeneration induced by the mild impairment of oxidative metabolism. Brain Pathol 2011; 21: 279\u2013297.","journal-title":"Brain Pathol"},{"key":"BFcdd2012122_CR23","doi-asserted-by":"publisher","first-page":"12633","DOI":"10.1523\/JNEUROSCI.2801-06.2006","volume":"26","author":"T Nakazawa","year":"2006","unstructured":"Nakazawa T, Nakazawa C, Matsubara A, Noda K, Hisatomi T, She H et al. Tumor necrosis factor-alpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma. J Neurosci 2006; 26: 12633\u201312641.","journal-title":"J Neurosci"},{"key":"BFcdd2012122_CR24","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.neuropharm.2009.11.010","volume":"58","author":"L Munoz","year":"2010","unstructured":"Munoz L, Ammit AJ . Targeting p38 MAPK pathway for the treatment of Alzheimer\u2019s disease. Neuropharmacology 2010; 58: 561\u2013568.","journal-title":"Neuropharmacology"},{"key":"BFcdd2012122_CR25","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/nn1701","volume":"9","author":"Y Yin","year":"2006","unstructured":"Yin Y, Henzl MT, Lorber B, Nakazawa T, Thomas TT, Jiang F et al. Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells. Nat Neurosci 2006; 9: 843\u2013852.","journal-title":"Nat Neurosci"},{"key":"BFcdd2012122_CR26","doi-asserted-by":"publisher","first-page":"15620","DOI":"10.1073\/pnas.232565399","volume":"99","author":"J Kipnis","year":"2002","unstructured":"Kipnis J, Mizrahi T, Hauben E, Shaked I, Shevach E, Schwartz M . Neuroprotective autoimmunity: naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system. Proc Natl Acad Sci USA 2002; 99: 15620\u201315625.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2012122_CR27","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0896-6273(00)81185-X","volume":"26","author":"T Harada","year":"2000","unstructured":"Harada T, Harada C, Nakayama N, Okuyama S, Yoshida K, Kohsaka S et al. Modification of glial\u2013neuronal cell interactions prevents photoreceptor apoptosis during light-induced retinal degeneration. Neuron 2000; 26: 533\u2013541.","journal-title":"Neuron"},{"key":"BFcdd2012122_CR28","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.preteyeres.2009.07.001","volume":"28","author":"A Bringmann","year":"2009","unstructured":"Bringmann A, Iandiev I, Pannicke T, Wurm A, Hollborn M, Wiedemann P et al. Cellular signaling and factors involved in M\u00fcller cell gliosis: neuroprotective and detrimental effects. Prog Retin Eye Res 2009; 28: 423\u2013451.","journal-title":"Prog Retin Eye Res"},{"key":"BFcdd2012122_CR29","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0301-0082(99)00012-X","volume":"59","author":"V Castagne","year":"1999","unstructured":"Castagne V, Gautschi M, Lefevre K, Posada A, Clarke PG . Relationships between neuronal death and the cellular redox status. Focus on the developing nervous system. Prog Neurobiol 1999; 59: 397\u2013423.","journal-title":"Prog Neurobiol"},{"key":"BFcdd2012122_CR30","doi-asserted-by":"publisher","first-page":"2696","DOI":"10.1167\/iovs.10-6015","volume":"52","author":"X Guo","year":"2011","unstructured":"Guo X, Harada C, Namekata K, Kimura A, Mitamura Y, Yoshida H et al. Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis. Invest Ophthalmol Vis Sci 2011; 52: 2696\u20132703.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFcdd2012122_CR31","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/gt.2008.126","volume":"16","author":"Y Munemasa","year":"2009","unstructured":"Munemasa Y, Ahn JH, Kwong JM, Caprioli J, Piri N . Redox proteins thioredoxin 1 and thioredoxin 2 support retinal ganglion cell survival in experimental glaucoma. Gene Therapy 2009; 16: 17\u201325.","journal-title":"Gene Therapy"},{"key":"BFcdd2012122_CR32","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1523\/JNEUROSCI.4866-04.2005","volume":"25","author":"M Tanito","year":"2005","unstructured":"Tanito M, Kwon YW, Kondo N, Bai J, Masutani H, Nakamura H et al. Cytoprotective effects of geranylgeranylacetone against retinal photooxidative damage. J Neurosci 2005; 25: 2396\u20132404.","journal-title":"J Neurosci"},{"key":"BFcdd2012122_CR33","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1111\/j.1471-4159.2011.07382.x","volume":"118","author":"M Almasieh","year":"2011","unstructured":"Almasieh M, Lieven CJ, Levin LA, Di Polo A . A cell-permeable phosphine\u2013borane complex delays retinal ganglion cell death after axonal injury through activation of the pro-survival extracellular signal-regulated kinases 1\/2 pathway. J Neurochem 2011; 118: 1075\u20131086.","journal-title":"J Neurochem"},{"key":"BFcdd2012122_CR34","doi-asserted-by":"publisher","first-page":"ra66","DOI":"10.1126\/scisignal.2000387","volume":"2","author":"K Yamazaki","year":"2009","unstructured":"Yamazaki K, Gohda J, Kanayama A, Miyamoto Y, Sakurai H, Yamamoto M et al. Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling. Sci Signal 2009; 2: ra66.","journal-title":"Sci Signal"},{"key":"BFcdd2012122_CR35","doi-asserted-by":"publisher","first-page":"7522","DOI":"10.1074\/jbc.M607177200","volume":"282","author":"K Takeda","year":"2007","unstructured":"Takeda K, Shimozono R, Noguchi T, Umeda T, Morimoto Y, Naguro I et al. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. J Biol Chem 2007; 282: 7522\u20137531.","journal-title":"J Biol Chem"},{"key":"BFcdd2012122_CR36","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.preteyeres.2006.10.002","volume":"26","author":"ME van Velthoven","year":"2007","unstructured":"van Velthoven ME, Faber DJ, Verbraak FD, van Leeuwen TG, de Smet MD . Recent developments in optical coherence tomography for imaging the retina. Prog Retin Eye Res 2007; 26: 57\u201377.","journal-title":"Prog Retin Eye Res"},{"key":"BFcdd2012122_CR37","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1378\/chest.10-1914","volume":"139","author":"KF Chung","year":"2011","unstructured":"Chung KF . p38 mitogen-activated protein kinase pathways in asthma and COPD. Chest 2011; 139: 1470\u20131479.","journal-title":"Chest"},{"key":"BFcdd2012122_CR38","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s00228-011-1193-2","volume":"68","author":"S Kumphune","year":"2012","unstructured":"Kumphune S, Chattipakorn S, Chattipakorn N . Role of p38 inhibition in cardiac ischemia\/reperfusion injury. Eur J Clin Pharmacol 2012; 68: 513\u2013524.","journal-title":"Eur J Clin Pharmacol"},{"key":"BFcdd2012122_CR39","doi-asserted-by":"publisher","first-page":"8726","DOI":"10.1523\/JNEUROSCI.2774-04.2004","volume":"24","author":"D Fischer","year":"2004","unstructured":"Fischer D, Petkova V, Thanos S, Benowitz LI . Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation. J Neurosci 2004; 24: 8726\u20138740.","journal-title":"J Neurosci"},{"key":"BFcdd2012122_CR40","doi-asserted-by":"publisher","first-page":"4663","DOI":"10.1073\/pnas.95.8.4663","volume":"95","author":"T Harada","year":"1998","unstructured":"Harada T, Harada C, Watanabe M, Inoue Y, Sakagawa T, Nakayama N et al. Functions of the two glutamate transporters GLAST and GLT-1 in the retina. Proc Natl Acad Sci USA 1998; 95: 4663\u20134666.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2012122_CR41","doi-asserted-by":"publisher","first-page":"3273","DOI":"10.1128\/MCB.02159-07","volume":"28","author":"K Namekata","year":"2008","unstructured":"Namekata K, Harada C, Kohyama K, Matsumoto Y, Harada T . Interleukin-1 stimulates glutamate uptake in glial cells by accelerating membrane trafficking of Na+\/K+-ATPase via actin depolymerization. Mol Cell Biol 2008; 28: 3273\u20133280.","journal-title":"Mol Cell Biol"},{"key":"BFcdd2012122_CR42","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.neures.2007.08.014","volume":"59","author":"X Guo","year":"2007","unstructured":"Guo X, Nakamura K, Kohyama K, Harada C, Behanna HA, Watterson DM et al. Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis. Neurosci Res 2007; 59: 457\u2013466.","journal-title":"Neurosci Res"}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd2012122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2012122","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2012122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:01:53Z","timestamp":1684414913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd2012122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,14]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["BFcdd2012122"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2012.122","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,14]]}}}