{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:40:35Z","timestamp":1790253635152,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T00:00:00Z","timestamp":1360886400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1038\/cdd.2012.168","type":"journal-article","created":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T09:59:52Z","timestamp":1360922392000},"page":"659-668","source":"Crossref","is-referenced-by-count":98,"title":["Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model"],"prefix":"10.1038","volume":"20","author":[{"given":"N","family":"Sanchez-Macedo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Faubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Elia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E J","family":"Rushing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Tsuchihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Bungard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S L","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R G","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T W","family":"Mak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Zaugg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,2,15]]},"reference":[{"key":"BFcdd2012168_CR1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/nrc704","volume":"2","author":"AL Harris","year":"2002","unstructured":"Harris AL . Hypoxia--a key regulatory factor in tumour growth. Nat Rev Cancer 2002; 2: 38\u201347.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd2012168_CR2","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nrc1367","volume":"4","author":"JM Brown","year":"2004","unstructured":"Brown JM, Wilson WR . Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 2004; 4: 437\u2013447.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd2012168_CR3","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.ceb.2006.10.005","volume":"18","author":"RJ Shaw","year":"2006","unstructured":"Shaw RJ . Glucose metabolism and cancer. Curr Opin Cell Biol 2006; 18: 598\u2013608.","journal-title":"Curr Opin Cell Biol"},{"key":"BFcdd2012168_CR4","doi-asserted-by":"publisher","first-page":"R287","DOI":"10.1677\/ERC-10-0106","volume":"17","author":"JF Barger","year":"2010","unstructured":"Barger JF, Plas DR . Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis. Endocr Relat Cancer 2010; 17: R287\u2013R304.","journal-title":"Endocr Relat Cancer"},{"key":"BFcdd2012168_CR5","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/nrc2222","volume":"7","author":"JA Menendez","year":"2007","unstructured":"Menendez JA, Lupu R . Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 2007; 7: 763\u2013777.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd2012168_CR6","doi-asserted-by":"publisher","first-page":"551","DOI":"10.2217\/fon.10.11","volume":"6","author":"R Flavin","year":"2010","unstructured":"Flavin R, Peluso S, Nguyen PL, Loda M . Fatty acid synthase as a potential therapeutic target in cancer. Future Oncol 2010; 6: 551\u2013562.","journal-title":"Future Oncol"},{"key":"BFcdd2012168_CR7","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1101\/gad.1987211","volume":"25","author":"K Zaugg","year":"2011","unstructured":"Zaugg K, Yao Y, Reilly PT, Kannan K, Kiarash R, Mason J et al. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev 2011; 25: 1041\u20131051.","journal-title":"Genes Dev"},{"key":"BFcdd2012168_CR8","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1111\/j.1471-4159.2008.05255.x","volume":"105","author":"MJ Wolfgang","year":"2008","unstructured":"Wolfgang MJ, Cha SH, Millington DS, Cline G, Shulman GI, Suwa A et al. Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight. J Neurochem 2008; 105: 1550\u20131559.","journal-title":"J Neurochem"},{"key":"BFcdd2012168_CR9","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1146\/annurev.nutr.25.050304.092532","volume":"26","author":"MJ Wolfgang","year":"2006","unstructured":"Wolfgang MJ, Lane MD . Control of energy homeostasis: role of enzymes and intermediates of fatty acid metabolism in the central nervous system. Annu Rev Nutr 2006; 26: 23\u201344.","journal-title":"Annu Rev Nutr"},{"key":"BFcdd2012168_CR10","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/j.1471-4159.2011.07312.x","volume":"118","author":"AA Reamy","year":"2011","unstructured":"Reamy AA, Wolfgang MJ . Carnitine palmitoyltransferase-1c gain-of-function in the brain results in postnatal microencephaly. J Neurochem 2011; 118: 388\u2013398.","journal-title":"J Neurochem"},{"key":"BFcdd2012168_CR11","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nrm3311","volume":"13","author":"DG Hardie","year":"2012","unstructured":"Hardie DG, Ross FA, Hawley SA . AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 2012; 13: 251\u2013262.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcdd2012168_CR12","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1101\/gad.17420111","volume":"25","author":"DG Hardie","year":"2011","unstructured":"Hardie DG . AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev 2011; 25: 1895\u20131908.","journal-title":"Genes Dev"},{"key":"BFcdd2012168_CR13","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.molcel.2005.03.027","volume":"18","author":"RG Jones","year":"2005","unstructured":"Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell 2005; 18: 283\u2013293.","journal-title":"Mol Cell"},{"key":"BFcdd2012168_CR14","doi-asserted-by":"publisher","first-page":"6878","DOI":"10.1074\/jbc.M707965200","volume":"283","author":"AY Sierra","year":"2008","unstructured":"Sierra AY, Gratacos E, Carrasco P, Clotet J, Urena J, Serra D et al. CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity. J Biol Chem 2008; 283: 6878\u20136885.","journal-title":"J Biol Chem"},{"key":"BFcdd2012168_CR15","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1006\/jmbi.1995.0349","volume":"249","author":"DS Prestridge","year":"1995","unstructured":"Prestridge DS . Predicting Pol II promoter sequences using transcription factor binding sites. J Mol Biol 1995; 249: 923\u2013932.","journal-title":"J Mol Biol"},{"key":"BFcdd2012168_CR16","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1093\/bioinformatics\/15.7.622","volume":"15","author":"T Tsunoda","year":"1999","unstructured":"Tsunoda T, Takagi T . Estimating transcription factor bindability on DNA. Bioinformatics 1999; 15: 622\u2013630.","journal-title":"Bioinformatics"},{"key":"BFcdd2012168_CR17","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1126\/science.1191241","volume":"329","author":"D Bungard","year":"2010","unstructured":"Bungard D, Fuerth BJ, Zeng PY, Faubert B, Maas NL, Viollet B et al. Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science 2010; 329: 1201\u20131205.","journal-title":"Science"},{"key":"BFcdd2012168_CR18","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/79075","volume":"26","author":"KM Reilly","year":"2000","unstructured":"Reilly KM, Loisel DA, Bronson RT, McLaughlin ME, Jacks T . Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat Genet 2000; 26: 109\u2013113.","journal-title":"Nat Genet"},{"key":"BFcdd2012168_CR19","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1126\/science.286.5447.2176","volume":"286","author":"KS Vogel","year":"1999","unstructured":"Vogel KS, Klesse LJ, Velasco-Miguel S, Meyers K, Rushing EJ, Parada LF . Mouse tumor model for neurofibromatosis type 1. Science 1999; 286: 2176\u20132179.","journal-title":"Science"},{"key":"BFcdd2012168_CR20","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.ccr.2011.12.027","volume":"21","author":"J Buchstaller","year":"2012","unstructured":"Buchstaller J, McKeever PE, Morrison SJ . Tumorigenic cells are common in mouse MPNSTs but their frequency depends upon tumor genotype and assay conditions. Cancer Cell 2012; 21: 240\u2013252.","journal-title":"Cancer Cell"},{"key":"BFcdd2012168_CR21","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.1126\/science.286.5447.2172","volume":"286","author":"K Cichowski","year":"1999","unstructured":"Cichowski K, Shih TS, Schmitt E, Santiago S, Reilly K, McLaughlin ME et al. Mouse models of tumor development in neurofibromatosis type 1. Science 1999; 286: 2172\u20132176.","journal-title":"Science"},{"key":"BFcdd2012168_CR22","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1006\/geno.2002.6845","volume":"80","author":"N Price","year":"2002","unstructured":"Price N, van der Leij F, Jackson V, Corstorphine C, Thomson R, Sorensen A et al. A novel brain-expressed protein related to carnitine palmitoyltransferase I. Genomics 2002; 80: 433\u2013442.","journal-title":"Genomics"},{"key":"BFcdd2012168_CR23","doi-asserted-by":"publisher","first-page":"21224","DOI":"10.1074\/jbc.M111.337493","volume":"287","author":"P Carrasco","year":"2012","unstructured":"Carrasco P, Sahun I, McDonald J, Ramirez S, Jacas J, Gratacos E et al. Ceramide Levels Regulated by Carnitine Palmitoyltransferase 1C Control Dendritic Spine Maturation and Cognition. J Biol Chem 2012; 287: 21224\u201321232.","journal-title":"J Biol Chem"},{"key":"BFcdd2012168_CR24","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/35042675","volume":"408","author":"B Vogelstein","year":"2000","unstructured":"Vogelstein B, Lane D, Levine AJ . Surfing the p53 network. Nature 2000; 408: 307\u2013310.","journal-title":"Nature"},{"key":"BFcdd2012168_CR25","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1038\/sj.onc.1210263","volume":"26","author":"HF Horn","year":"2007","unstructured":"Horn HF, Vousden KH . Coping with stress: multiple ways to activate p53. Oncogene 2007; 26: 1306\u20131316.","journal-title":"Oncogene"},{"key":"BFcdd2012168_CR26","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1128\/MCB.21.4.1297-1310.2001","volume":"21","author":"C Koumenis","year":"2001","unstructured":"Koumenis C, Alarcon R, Hammond E, Sutphin P, Hoffman W, Murphy M et al. Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Mol Cell Biol 2001; 21: 1297\u20131310.","journal-title":"Mol Cell Biol"},{"key":"BFcdd2012168_CR27","doi-asserted-by":"publisher","first-page":"6264","DOI":"10.1128\/MCB.14.9.6264","volume":"14","author":"TG Graeber","year":"1994","unstructured":"Graeber TG, Peterson JF, Tsai M, Monica K, Fornace AJ, Giaccia AJ . Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol Cell Biol 1994; 14: 6264\u20136277.","journal-title":"Mol Cell Biol"},{"key":"BFcdd2012168_CR28","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/nature03098","volume":"432","author":"SW Lowe","year":"2004","unstructured":"Lowe SW, Cepero E, Evan G . Intrinsic tumour suppression. Nature 2004; 432: 307\u2013315.","journal-title":"Nature"},{"key":"BFcdd2012168_CR29","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/nrc2715","volume":"9","author":"KH Vousden","year":"2009","unstructured":"Vousden KH, Ryan KM . p53 and metabolism. Nat Rev Cancer 2009; 9: 691\u2013700.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd2012168_CR30","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1126\/science.1126863","volume":"312","author":"S Matoba","year":"2006","unstructured":"Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O et al. p53 regulates mitochondrial respiration. Science 2006; 312: 1650\u20131653.","journal-title":"Science"},{"key":"BFcdd2012168_CR31","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.cell.2006.05.036","volume":"126","author":"K Bensaad","year":"2006","unstructured":"Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R et al. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 2006; 126: 107\u2013120.","journal-title":"Cell"},{"key":"BFcdd2012168_CR32","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1101\/gad.1756509","volume":"23","author":"RG Jones","year":"2009","unstructured":"Jones RG, Thompson CB . Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev 2009; 23: 537\u2013548.","journal-title":"Genes Dev"},{"key":"BFcdd2012168_CR33","doi-asserted-by":"publisher","first-page":"37372","DOI":"10.1074\/jbc.M608372200","volume":"281","author":"RJ Deberardinis","year":"2006","unstructured":"Deberardinis RJ, Lum JJ, Thompson CB . Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth. J Biol Chem 2006; 281: 37372\u201337380.","journal-title":"J Biol Chem"},{"issue":"Pt 1","key":"BFcdd2012168_CR34","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1113\/jphysiol.2006.108944","volume":"574","author":"DG Hardie","year":"2006","unstructured":"Hardie DG, Hawley SA, Scott JW . AMP-activated protein kinase--development of the energy sensor concept. J Physiol 2006; 574 (Pt 1): 7\u201315.","journal-title":"J Physiol"},{"key":"BFcdd2012168_CR35","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.mam.2004.06.004","volume":"25","author":"JP Bonnefont","year":"2004","unstructured":"Bonnefont JP, Djouadi F, Prip-Buus C, Gobin S, Munnich A, Bastin J . Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects. Mol Aspects Med 2004; 25: 495\u2013520.","journal-title":"Mol Aspects Med"},{"key":"BFcdd2012168_CR36","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1111\/j.1742-4658.2010.07978.x","volume":"278","author":"MJ Wolfgang","year":"2011","unstructured":"Wolfgang MJ, Lane MD . Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity. FEBS J 2011; 278: 552\u2013558.","journal-title":"FEBS J"},{"key":"BFcdd2012168_CR37","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nature11066","volume":"485","author":"SM Jeon","year":"2012","unstructured":"Jeon SM, Chandel NS, Hay N . AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature 2012; 485: 661\u2013665.","journal-title":"Nature"},{"key":"BFcdd2012168_CR38","doi-asserted-by":"publisher","first-page":"6685","DOI":"10.1158\/0008-5472.CAN-04-4223","volume":"65","author":"K Tsuchihara","year":"2005","unstructured":"Tsuchihara K, Lapin V, Bakal C, Okada H, Brown L, Hirota-Tsuchihara M et al. Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. Cancer Res 2005; 65: 6685\u20136691.","journal-title":"Cancer Res"},{"key":"BFcdd2012168_CR39","doi-asserted-by":"publisher","first-page":"2648","DOI":"10.1101\/gad.1144003","volume":"17","author":"KW Henry","year":"2003","unstructured":"Henry KW, Wyce A, Lo WS, Duggan LJ, Emre NC, Kao CF et al. Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev 2003; 17: 2648\u20132663.","journal-title":"Genes Dev"},{"key":"BFcdd2012168_CR40","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1182\/blood.V97.1.250","volume":"97","author":"BF Skinnider","year":"2001","unstructured":"Skinnider BF, Elia AJ, Gascoyne RD, Trumper LH, von Bonin F, Kapp U et al. Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood 2001; 97: 250\u2013255.","journal-title":"Blood"},{"key":"BFcdd2012168_CR41","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/ng0393-241","volume":"3","author":"CC Hui","year":"1993","unstructured":"Hui CC, Joyner AL . A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat Genet 1993; 3: 241\u2013246.","journal-title":"Nat Genet"}],"container-title":["Cell Death & Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd2012168.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2012168","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2012168.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:02:15Z","timestamp":1684414935000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd2012168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,15]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["BFcdd2012168"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2012.168","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,15]]}}}