{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:30:45Z","timestamp":1791405045092,"version":"4.3.3"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T00:00:00Z","timestamp":1343952000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1038\/cdd.2012.95","type":"journal-article","created":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T09:31:00Z","timestamp":1343986260000},"page":"77-85","source":"Crossref","is-referenced-by-count":95,"title":["Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency"],"prefix":"10.1038","volume":"20","author":[{"given":"D","family":"Ramonet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Perier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Recasens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Dehay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bov\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Scorrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,3]]},"reference":[{"key":"BFcdd201295_CR1","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","volume":"39","author":"W Dauer","year":"2003","unstructured":"Dauer W, Przedborski S . Parkinson\u2019s disease: mechanisms and models. Neuron 2003; 39: 889\u2013909.","journal-title":"Neuron"},{"key":"BFcdd201295_CR2","doi-asserted-by":"publisher","first-page":"2837","DOI":"10.1073\/pnas.051633998","volume":"98","author":"M Vila","year":"2001","unstructured":"Vila M, Jackson-Lewis V, Vukosavic S, Djaldetti R, Liberatore G, Offen D et al. Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson\u2019s disease. Proc Natl Acad Sci USA 2001; 98: 2837\u20132842.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201295_CR3","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/nrn1100","volume":"4","author":"M Vila","year":"2003","unstructured":"Vila M, Przedborski S . Targeting programmed cell death in neurodegenerative diseases. Nat Rev Neurosci 2003; 4: 365\u2013375.","journal-title":"Nat Rev Neurosci"},{"key":"BFcdd201295_CR4","doi-asserted-by":"publisher","first-page":"19126","DOI":"10.1073\/pnas.0508215102","volume":"102","author":"C Perier","year":"2005","unstructured":"Perier C, Tieu K, Guegan C, Caspersen C, Jackson-Lewis V, Carelli V et al. Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage. Proc Natl Acad Sci USA 2005; 102: 19126\u201319131.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201295_CR5","doi-asserted-by":"publisher","first-page":"8161","DOI":"10.1073\/pnas.0609874104","volume":"104","author":"C Perier","year":"2007","unstructured":"Perier C, Bove J, Wu DC, Dehay B, Choi DK, Jackson-Lewis V et al. Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson\u2019s disease. Proc Natl Acad Sci USA 2007; 104: 8161\u20138166.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201295_CR6","doi-asserted-by":"publisher","first-page":"10756","DOI":"10.1523\/JNEUROSCI.23-34-10756.2003","volume":"23","author":"TB Sherer","year":"2003","unstructured":"Sherer TB, Betarbet R, Testa CM, Seo BB, Richardson JR, Kim JH et al. Mechanism of toxicity in rotenone models of Parkinson\u2019s disease. J Neurosci 2003; 23: 10756\u201310764.","journal-title":"J Neurosci"},{"key":"BFcdd201295_CR7","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.neuron.2011.06.003","volume":"70","author":"EA Schon","year":"2011","unstructured":"Schon EA, Przedborski S . Mitochondria: the next (neurode)generation. Neuron 2011; 70: 1033\u20131053.","journal-title":"Neuron"},{"key":"BFcdd201295_CR8","doi-asserted-by":"publisher","first-page":"R169","DOI":"10.1093\/hmg\/ddp326","volume":"18","author":"H Chen","year":"2009","unstructured":"Chen H, Chan DC . Mitochondrial dynamics \u2013 fusion, fission, movement, and mitophagy \u2013 in neurodegenerative diseases. Hum Mol Genet 2009; 18: R169\u2013R176.","journal-title":"Hum Mol Genet"},{"key":"BFcdd201295_CR9","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.cell.2006.06.025","volume":"126","author":"C Frezza","year":"2006","unstructured":"Frezza C, Cipolat S, Martins DB, Micaroni M, Beznoussenko GV, Rudka T et al. OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell 2006; 126: 177\u2013189.","journal-title":"Cell"},{"key":"BFcdd201295_CR10","doi-asserted-by":"publisher","first-page":"5001","DOI":"10.1091\/mbc.e04-04-0294","volume":"15","author":"YJ Lee","year":"2004","unstructured":"Lee YJ, Jeong SY, Karbowski M, Smith CL, Youle RJ . Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol Biol Cell 2004; 15: 5001\u20135011.","journal-title":"Mol Biol Cell"},{"key":"BFcdd201295_CR11","doi-asserted-by":"publisher","first-page":"7743","DOI":"10.1074\/jbc.C200677200","volume":"278","author":"A Olichon","year":"2003","unstructured":"Olichon A, Baricault L, Gas N, Guillou E, Valette A, Belenguer P et al. Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J Biol Chem 2003; 278: 7743\u20137746.","journal-title":"J Biol Chem"},{"key":"BFcdd201295_CR12","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/79936","volume":"26","author":"C Delettre","year":"2000","unstructured":"Delettre C, Lenaers G, Griffoin JM, Gigarel N, Lorenzo C, Belenguer P et al. Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy. Nat Genet 2000; 26: 207\u2013210.","journal-title":"Nat Genet"},{"key":"BFcdd201295_CR13","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/ng1341","volume":"36","author":"S Zuchner","year":"2004","unstructured":"Zuchner S, Mersiyanova IV, Muglia M, Bissar-Tadmouri N, Rochelle J, Dadali EL et al. Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A. Nat Genet 2004; 36: 449\u2013451.","journal-title":"Nat Genet"},{"key":"BFcdd201295_CR14","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1006\/exnr.2000.7333","volume":"162","author":"PA Trimmer","year":"2000","unstructured":"Trimmer PA, Swerdlow RH, Parks JK, Keeney P, Bennett JP, Miller SW et al. Abnormal mitochondrial morphology in sporadic Parkinson\u2019s and Alzheimer\u2019s disease cybrid cell lines. Exp Neurol 2000; 162: 37\u201350.","journal-title":"Exp Neurol"},{"key":"BFcdd201295_CR15","doi-asserted-by":"publisher","first-page":"20710","DOI":"10.1074\/jbc.M110.213538","volume":"286","author":"K Nakamura","year":"2011","unstructured":"Nakamura K, Nemani VM, Azarbal F, Skibinski G, Levy JM, Egami K et al. Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein. J Biol Chem 2011; 286: 20710\u201320726.","journal-title":"J Biol Chem"},{"key":"BFcdd201295_CR16","doi-asserted-by":"publisher","first-page":"4772","DOI":"10.1074\/jbc.M110.167155","volume":"286","author":"A Jahani-Asl","year":"2011","unstructured":"Jahani-Asl A, Pilon-Larose K, Xu W, MacLaurin JG, Park DS, McBride HM et al. The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity. J Biol Chem 2011; 286: 4772\u20134782.","journal-title":"J Biol Chem"},{"key":"BFcdd201295_CR17","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/ana.22034","volume":"68","author":"C Perier","year":"2010","unstructured":"Perier C, Bove J, Dehay B, Jackson-Lewis V, Rabinovitch PS, Przedborski S et al. Apoptosis-inducing factor deficiency sensitizes dopaminergic neurons to parkinsonian neurotoxins. Ann Neurol 2010; 68: 184\u2013192.","journal-title":"Ann Neurol"},{"key":"BFcdd201295_CR18","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S1534-5807(01)00116-2","volume":"2","author":"L Scorrano","year":"2002","unstructured":"Scorrano L, Ashiya M, Buttle K, Weiler S, Oakes SA, Mannella CA et al. A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Developmental Cell 2002; 2: 55\u201367.","journal-title":"Developmental Cell"},{"key":"BFcdd201295_CR19","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.cell.2006.06.021","volume":"126","author":"S Cipolat","year":"2006","unstructured":"Cipolat S, Rudka T, Hartmann D, Costa V, Serneels L, Craessaerts K et al. Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell 2006; 126: 163\u2013175.","journal-title":"Cell"},{"key":"BFcdd201295_CR20","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/nprot.2006.342","volume":"2","author":"V Jackson-Lewis","year":"2007","unstructured":"Jackson-Lewis V, Przedborski S . Protocol for the MPTP mouse model of Parkinson\u2019s disease. Nat Protoc 2007; 2: 141\u2013151.","journal-title":"Nat Protoc"},{"key":"BFcdd201295_CR21","first-page":"25","volume":"12","author":"P Anglade","year":"1997","unstructured":"Anglade P, Vyas S, Javoy-Agid F, Herrero MT, Michel PP, Marquez J et al. Apoptosis and autophagy in nigral neurons of patients with Parkinson\u2019s disease. Histol Histopathol 1997; 12: 25\u201331.","journal-title":"Histol Histopathol"},{"key":"BFcdd201295_CR22","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/BF00691186","volume":"56","author":"S Sekiya","year":"1982","unstructured":"Sekiya S, Tanaka M, Hayashi S, Oyanagi S . Light- and electron-microscopic studies of intracytoplasmic acidophilic granules in the human locus ceruleus and substantia nigra. Acta Neuropathol 1982; 56: 78\u201380.","journal-title":"Acta Neuropathol"},{"key":"BFcdd201295_CR23","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1038\/nature04779","volume":"441","author":"IE Clark","year":"2006","unstructured":"Clark IE, Dodson MW, Jiang C, Cao JH, Huh JR, Seol JH et al. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 2006; 441: 1162\u20131166.","journal-title":"Nature"},{"key":"BFcdd201295_CR24","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1038\/nature04788","volume":"441","author":"J Park","year":"2006","unstructured":"Park J, Lee SB, Lee S, Kim Y, Song S, Kim S et al. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 2006; 441: 1157\u20131161.","journal-title":"Nature"},{"key":"BFcdd201295_CR25","doi-asserted-by":"publisher","first-page":"10793","DOI":"10.1073\/pnas.0602493103","volume":"103","author":"Y Yang","year":"2006","unstructured":"Yang Y, Gehrke S, Imai Y, Huang Z, Ouyang Y, Wang JW et al. Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci USA 2006; 103: 10793\u201310798.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201295_CR26","doi-asserted-by":"publisher","first-page":"4078","DOI":"10.1073\/pnas.0737556100","volume":"100","author":"JC Greene","year":"2003","unstructured":"Greene JC, Whitworth AJ, Kuo I, Andrews LA, Feany MB, Pallanck LJ . Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc Natl Acad Sci USA 2003; 100: 4078\u20134083.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201295_CR27","doi-asserted-by":"publisher","first-page":"8563","DOI":"10.1523\/JNEUROSCI.0218-07.2007","volume":"27","author":"C Wang","year":"2007","unstructured":"Wang C, Lu R, Ouyang X, Ho MW, Chia W, Yu F et al. Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities. J Neurosci 2007; 27: 8563\u20138570.","journal-title":"J Neurosci"},{"key":"BFcdd201295_CR28","doi-asserted-by":"publisher","first-page":"12413","DOI":"10.1523\/JNEUROSCI.0719-07.2007","volume":"27","author":"N Exner","year":"2007","unstructured":"Exner N, Treske B, Paquet D, Holmstrom K, Schiesling C, Gispert S et al. Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci 2007; 27: 12413\u201312418.","journal-title":"J Neurosci"},{"key":"BFcdd201295_CR29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1756-6606-4-17","volume":"4","author":"C Fernandes","year":"2011","unstructured":"Fernandes C, Rao Y . Genome-wide screen for modifiers of Parkinson\u2019s disease genes in Drosophila. Mol Brain 2011; 4: 17.","journal-title":"Mol Brain"},{"key":"BFcdd201295_CR30","doi-asserted-by":"publisher","first-page":"3900","DOI":"10.1038\/sj.emboj.7601253","volume":"25","author":"MJ Barsoum","year":"2006","unstructured":"Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Graber S et al. Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J 2006; 25: 3900\u20133911.","journal-title":"EMBO J"},{"key":"BFcdd201295_CR31","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/sj.cdd.4402087","volume":"14","author":"K Meuer","year":"2007","unstructured":"Meuer K, Suppanz IE, Lingor P, Planchamp V, Goricke B, Fichtner L et al. Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis. Cell Death Differ 2007; 14: 651\u2013661.","journal-title":"Cell Death Differ"},{"key":"BFcdd201295_CR32","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1016\/j.freeradbiomed.2008.03.009","volume":"44","author":"M Gomez-Lazaro","year":"2008","unstructured":"Gomez-Lazaro M, Bonekamp NA, Galindo MF, Jordan J, Schrader M . 6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells. Free Radic Biol Med 2008; 44: 1960\u20131969.","journal-title":"Free Radic Biol Med"},{"key":"BFcdd201295_CR33","doi-asserted-by":"publisher","first-page":"7212","DOI":"10.1523\/JNEUROSCI.0711-11.2011","volume":"31","author":"JS Kim-Han","year":"2011","unstructured":"Kim-Han JS, Antenor-Dorsey JA, O\u2019Malley KL . The Parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons. J Neurosci 2011; 31: 7212\u20137221.","journal-title":"J Neurosci"},{"key":"BFcdd201295_CR34","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.molcel.2008.08.002","volume":"31","author":"C Sheridan","year":"2008","unstructured":"Sheridan C, Delivani P, Cullen SP, Martin SJ . Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release. Mol Cell 2008; 31: 570\u2013585.","journal-title":"Mol Cell"},{"key":"BFcdd201295_CR35","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/emmm.201000102","volume":"2","author":"V Costa","year":"2010","unstructured":"Costa V, Giacomello M, Hudec R, Lopreiato R, Ermak G, Lim D et al. Mitochondrial fission and cristae disruption increase the response of cell models of Huntington\u2019s disease to apoptotic stimuli. EMBO Mol Med 2010; 2: 490\u2013503.","journal-title":"EMBO Mol Med"},{"key":"BFcdd201295_CR36","doi-asserted-by":"publisher","first-page":"22938","DOI":"10.1074\/jbc.M109.035774","volume":"284","author":"AK Lutz","year":"2009","unstructured":"Lutz AK, Exner N, Fett ME, Schlehe JS, Kloos K, Lammermann K et al. Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem 2009; 284: 22938\u201322951.","journal-title":"J Biol Chem"},{"key":"BFcdd201295_CR37","doi-asserted-by":"publisher","first-page":"11740","DOI":"10.1074\/jbc.M109.066662","volume":"285","author":"M Cui","year":"2010","unstructured":"Cui M, Tang X, Christian WV, Yoon Y, Tieu K . Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1. J Biol Chem 2010; 285: 11740\u201311752.","journal-title":"J Biol Chem"},{"key":"BFcdd201295_CR38","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1038\/sj.emboj.7600592","volume":"24","author":"M Germain","year":"2005","unstructured":"Germain M, Mathai JP, McBride HM, Shore GC . Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis. EMBO J 2005; 24: 1546\u20131556.","journal-title":"EMBO J"},{"key":"BFcdd201295_CR39","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1016\/j.yexcr.2009.04.016","volume":"315","author":"K Mopert","year":"2009","unstructured":"Mopert K, Hajek P, Frank S, Chen C, Kaufmann J, Santel A . Loss of Drp1 function alters OPA1 processing and changes mitochondrial membrane organization. Exp Cell Res 2009; 315: 2165\u20132180.","journal-title":"Exp Cell Res"},{"key":"BFcdd201295_CR40","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1093\/hmg\/ddr077","volume":"20","author":"G Shi","year":"2011","unstructured":"Shi G, Lee JR, Grimes DA, Racacho L, Ye D, Yang H et al. Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson\u2019s disease. Hum Mol Genet 2011; 20: 1966\u20131974.","journal-title":"Hum Mol Genet"},{"key":"BFcdd201295_CR41","doi-asserted-by":"publisher","first-page":"14503","DOI":"10.1073\/pnas.0803998105","volume":"105","author":"H Deng","year":"2008","unstructured":"Deng H, Dodson MW, Huang H, Guo M . The Parkinson\u2019s disease genes pink1 and parkin promote mitochondrial fission and\/or inhibit fusion in Drosophila. Proc Natl Acad Sci USA 2008; 105: 14503\u201314508.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201295_CR42","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1073\/pnas.0709336105","volume":"105","author":"AC Poole","year":"2008","unstructured":"Poole AC, Thomas RE, Andrews LA, McBride HM, Whitworth AJ, Pallanck LJ . The PINK1\/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci USA 2008; 105: 1638\u20131643.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201295_CR43","doi-asserted-by":"publisher","first-page":"e1000298","DOI":"10.1371\/journal.pbio.1000298","volume":"8","author":"DP Narendra","year":"2010","unstructured":"Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J et al. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 2010; 8: e1000298.","journal-title":"PLoS Biol"},{"key":"BFcdd201295_CR44","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.devcel.2011.06.017","volume":"21","author":"JC Martinou","year":"2011","unstructured":"Martinou JC, Youle RJ . Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell 2011; 21: 92\u2013101.","journal-title":"Dev Cell"}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd201295.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201295","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201295.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T03:34:49Z","timestamp":1714275289000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd201295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,3]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["BFcdd201295"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2012.95","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,3]]}}}