{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:07:50Z","timestamp":1791306470693,"version":"4.3.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T00:00:00Z","timestamp":1382054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1038\/cdd.2013.142","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T14:16:13Z","timestamp":1382105773000},"page":"278-289","source":"Crossref","is-referenced-by-count":27,"title":["Perturbation of Hoxb5 signaling in vagal and trunk neural crest cells causes apoptosis and neurocristopathies in mice"],"prefix":"10.1038","volume":"21","author":[{"given":"M K M","family":"Kam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M C H","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J J","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W W C","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E W Y","family":"Sat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P K H","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V C H","family":"Lui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,10,18]]},"reference":[{"key":"BFcdd2013142_CR1","volume-title":"The Neural Crest","author":"C Kalcheim","year":"1999","unstructured":"Kalcheim C, Le Douarin N . The Neural Crest. Cambridge University Press: Cambridge, UK, 1999."},{"key":"BFcdd2013142_CR2","doi-asserted-by":"publisher","first-page":"4637","DOI":"10.1242\/dev.01350","volume":"131","author":"NM Le Douarin","year":"2004","unstructured":"Le Douarin NM, Creuzet S, Couly G, Dupin E . Neural crest cell plasticity and its limits. Development 2004; 131: 4637\u20134650.","journal-title":"Development"},{"key":"BFcdd2013142_CR3","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nrm2428","volume":"9","author":"T Sauka-Spengler","year":"2008","unstructured":"Sauka-Spengler T, Bronner-Fraser M . A gene regulatory network orchestrates neural crest formation. Nat Rev Mol Cell Biol 2008; 9: 557\u2013568.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcdd2013142_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00441-005-0047-6","volume":"323","author":"RB Anderson","year":"2006","unstructured":"Anderson RB, Stewart AL, Young HM . Phenotypes of neural-crest-derived cells in vagal and sacral pathways. Cell Tissue Res 2006; 323: 11\u201325.","journal-title":"Cell Tissue Res"},{"key":"BFcdd2013142_CR5","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1242\/dev.125.21.4335","volume":"125","author":"AJ Burns","year":"1998","unstructured":"Burns AJ, Douarin NM . The sacral neural crest contributes neurons and glia to the post-umbilical gut: spatiotemporal analysis of the development of the enteric nervous system. Development 1998; 125: 4335\u20134347.","journal-title":"Development"},{"key":"BFcdd2013142_CR6","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1006\/dbio.2000.9886","volume":"227","author":"RP Kapur","year":"2000","unstructured":"Kapur RP . Colonization of the murine hindgut by sacral crest-derived neural precursors: experimental support for an evolutionarily conserved model. Dev Biol 2000; 227: 146\u2013155.","journal-title":"Dev Biol"},{"key":"BFcdd2013142_CR7","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/dvdy.20933","volume":"236","author":"N Nagy","year":"2007","unstructured":"Nagy N, Brewer KC, Mwizerwa O, Goldstein AM . Pelvic plexus contributes ganglion cells to the hindgut enteric nervous system. Dev Dyn 2007; 236: 73\u201383.","journal-title":"Dev Dyn"},{"key":"BFcdd2013142_CR8","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1242\/dev.111.4.857","volume":"111","author":"GN Serbedzija","year":"1991","unstructured":"Serbedzija GN, Burgan S, Fraser SE, Bronner-Fraser M . Vital dye labelling demonstrates a sacral neural crest contribution to the enteric nervous system of chick and mouse embryos. Development 1991; 111: 857\u2013866.","journal-title":"Development"},{"key":"BFcdd2013142_CR9","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1053\/j.gastro.2011.06.002","volume":"141","author":"X Wang","year":"2011","unstructured":"Wang X, Chan AK, Sham MH, Burns AJ, Chan WY . Analysis of the sacral neural crest cell contribution to the hindgut enteric nervous system in the mouse embryo. Gastroenterology 2011; 141: 992\u20131002 e1-6.","journal-title":"Gastroenterology"},{"key":"BFcdd2013142_CR10","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1007\/s10571-005-3971-9","volume":"25","author":"ZN Akin","year":"2005","unstructured":"Akin ZN, Nazarali AJ . Hox genes and their candidate downstream targets in the developing central nervous system. Cell Mol Neurobiol 2005; 25: 697\u2013741.","journal-title":"Cell Mol Neurobiol"},{"key":"BFcdd2013142_CR11","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1159\/000064943","volume":"24","author":"EM Carpenter","year":"2002","unstructured":"Carpenter EM . Hox genes and spinal cord development. Dev Neurosci 2002; 24: 24\u201334.","journal-title":"Dev Neurosci"},{"key":"BFcdd2013142_CR12","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/0168-9525(94)90132-5","volume":"10","author":"D Duboule","year":"1994","unstructured":"Duboule D, Morata G . Colinearity and functional hierarchy among genes of the homeotic complexes. Trends Genet 1994; 10: 358\u2013364.","journal-title":"Trends Genet"},{"key":"BFcdd2013142_CR13","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1387\/ijdb.113358ad","volume":"55","author":"AJ Durston","year":"2011","unstructured":"Durston AJ, Jansen HJ, In der Rieden P, Hooiveld MH . Hox collinearity\u2014a new perspective. Int J Dev Biol 2011; 55: 899\u2013908.","journal-title":"Int J Dev Biol"},{"key":"BFcdd2013142_CR14","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1126\/science.274.5290.1109","volume":"274","author":"A Lumsden","year":"1996","unstructured":"Lumsden A, Krumlauf R . Patterning the vertebrate neuraxis. Science 1996; 274: 1109\u20131115.","journal-title":"Science"},{"key":"BFcdd2013142_CR15","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/35039056","volume":"1","author":"PA Trainor","year":"2000","unstructured":"Trainor PA, Krumlauf R . Patterning the cranial neural crest: hindbrain segmentation and Hox gene plasticity. Nat Rev Neurosci 2000; 1: 116\u2013124.","journal-title":"Nat Rev Neurosci"},{"key":"BFcdd2013142_CR16","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/978-3-540-48002-0_3","volume":"30","author":"PA Trainor","year":"2000","unstructured":"Trainor PA, Manzanares M, Krumlauf R . Genetic interactions during hindbrain segmentation in the mouse embryo. Results Probl Cell Differ 2000; 30: 51\u201389.","journal-title":"Results Probl Cell Differ"},{"key":"BFcdd2013142_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/dvdy.10350","volume":"228","author":"M Fu","year":"2003","unstructured":"Fu M, Lui VC, Sham MH, Cheung AN, Tam PK . HOXB5 expression is spatially and temporarily regulated in human embryonic gut during neural crest cell colonization and differentiation of enteric neuroblasts. Dev Dyn 2003; 228: 1\u201310.","journal-title":"Dev Dyn"},{"issue":"Suppl","key":"BFcdd2013142_CR18","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0922-3371(88)90098-6","volume":"25","author":"BL Hogan","year":"1988","unstructured":"Hogan BL, Holland PW, Lumsden A . Expression of the homeobox gene, Hox 2.1, during mouse embryogenesis. Cell Differ Dev 1988; 25 (Suppl): 39\u201344.","journal-title":"Cell Differ Dev"},{"key":"BFcdd2013142_CR19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1242\/dev.102.1.159","volume":"102","author":"PW Holland","year":"1988","unstructured":"Holland PW, Hogan BL . Spatially restricted patterns of expression of the homeobox-containing gene Hox 2.1. during mouse embryogenesis. Development 1988; 102: 159\u2013174.","journal-title":"Development"},{"key":"BFcdd2013142_CR20","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1242\/dev.99.4.603","volume":"99","author":"R Krumlauf","year":"1987","unstructured":"Krumlauf R, Holland PW, McVey JH, Hogan BL . Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2.1. Development 1987; 99: 603\u2013617.","journal-title":"Development"},{"key":"BFcdd2013142_CR21","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/aja.1001950103","volume":"195","author":"SC Kuratani","year":"1992","unstructured":"Kuratani SC, Wall NA . Expression of Hox 2.1 protein in restricted populations of neural crest cells and pharyngeal ectoderm. Dev Dyn 1992; 195: 15\u201328.","journal-title":"Dev Dyn"},{"key":"BFcdd2013142_CR22","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1053\/j.gastro.2008.01.028","volume":"134","author":"VC Lui","year":"2008","unstructured":"Lui VC, Cheng WW, Leon TY, Lau DK, Garcia-Barcelo MM, Miao XP et al. Perturbation of hoxb5 signaling in vagal neural crests down-regulates ret leading to intestinal hypoganglionosis in mice. Gastroenterology 2008; 134: 1104\u20131115.","journal-title":"Gastroenterology"},{"key":"BFcdd2013142_CR23","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/S0016-5085(99)70284-2","volume":"117","author":"JE Pitera","year":"1999","unstructured":"Pitera JE, Smith VV, Thorogood P, Milla PJ . Coordinated expression of 3' hox genes during murine embryonal gut development: an enteric Hox code. Gastroenterology 1999; 117: 1339\u20131351.","journal-title":"Gastroenterology"},{"key":"BFcdd2013142_CR24","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/0925-4773(92)90073-S","volume":"37","author":"NA Wall","year":"1992","unstructured":"Wall NA, Jones CM, Hogan BL, Wright CV . Expression and modification of Hox 2.1 protein in mouse embryos. Mech Dev 1992; 37: 111\u2013120.","journal-title":"Mech Dev"},{"key":"BFcdd2013142_CR25","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1101\/gad.9.1.108","volume":"9","author":"DE Rancourt","year":"1995","unstructured":"Rancourt DE, Tsuzuki T, Capecchi MR . Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. Genes Dev 1995; 9: 108\u2013122.","journal-title":"Genes Dev"},{"key":"BFcdd2013142_CR26","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/S0960-9822(07)00562-3","volume":"8","author":"PS Danielian","year":"1998","unstructured":"Danielian PS, Muccino D, Rowitch DH, Michael SK, McMahon AP . Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol 1998; 8: 1323\u20131326.","journal-title":"Curr Biol"},{"key":"BFcdd2013142_CR27","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.devcel.2004.12.010","volume":"8","author":"M Cheung","year":"2005","unstructured":"Cheung M, Chaboissier MC, Mynett A, Hirst E, Schedl A, Briscoe J . The transcriptional control of trunk neural crest induction, survival, and delamination. Dev Cell 2005; 8: 179\u2013192.","journal-title":"Dev Cell"},{"key":"BFcdd2013142_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/jmg.2007.053959","volume":"45","author":"J Amiel","year":"2008","unstructured":"Amiel J, Sproat-Emison E, Garcia-Barcelo M, Lantieri F, Burzynski G, Borrego S et al. Hirschsprung disease, associated syndromes and genetics: a review. J Med Genet 2008; 45: 1\u201314.","journal-title":"J Med Genet"},{"key":"BFcdd2013142_CR29","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s00383-009-2402-2","volume":"25","author":"PK Tam","year":"2009","unstructured":"Tam PK, Garcia-Barcelo M . Genetic basis of Hirschsprung\u2019s disease. Pediatr Surg Int 2009; 25: 543\u2013558.","journal-title":"Pediatr Surg Int"},{"key":"BFcdd2013142_CR30","doi-asserted-by":"publisher","first-page":"9360","DOI":"10.1073\/pnas.1631288100","volume":"100","author":"Y Mori-Akiyama","year":"2003","unstructured":"Mori-Akiyama Y, Akiyama H, Rowitch DH, de Crombrugghe B . Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc Natl Acad Sci USA 2003; 100: 9360\u20139365.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2013142_CR31","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/ng0996-62","volume":"14","author":"S Morais da Silva","year":"1996","unstructured":"Morais da Silva S, Hacker A, Harley V, Goodfellow P, Swain A, Lovell-Badge R . Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds. Nat Genet 1996; 14: 62\u201368.","journal-title":"Nat Genet"},{"key":"BFcdd2013142_CR32","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/ng0195-15","volume":"9","author":"E Wright","year":"1995","unstructured":"Wright E, Hargrave MR, Christiansen J, Cooper L, Kun J, Evans T et al. The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos. Nat Genet 1995; 9: 15\u201320.","journal-title":"Nat Genet"},{"key":"BFcdd2013142_CR33","doi-asserted-by":"publisher","first-page":"622","DOI":"10.4161\/cam.4.4.13502","volume":"4","author":"C Ruhrberg","year":"2010","unstructured":"Ruhrberg C, Schwarz Q . In the beginning: generating neural crest cell diversity. Cell Adh Migr 2010; 4: 622\u2013630.","journal-title":"Cell Adh Migr"},{"key":"BFcdd2013142_CR34","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1242\/dev.128.20.3949","volume":"128","author":"C Paratore","year":"2001","unstructured":"Paratore C, Goerich DE, Suter U, Wegner M, Sommer L . Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signaling. Development 2001; 128: 3949\u20133961.","journal-title":"Development"},{"key":"BFcdd2013142_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s004390000328","volume":"107","author":"SB Potterf","year":"2000","unstructured":"Potterf SB, Furumura M, Dunn KJ, Arnheiter H, Pavan WJ . Transcription factor hierarchy in Waardenburg syndrome: regulation of MITF expression by SOX10 and PAX3. Hum Genet 2000; 107: 1\u20136.","journal-title":"Hum Genet"},{"key":"BFcdd2013142_CR36","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1006\/dbio.2001.0372","volume":"237","author":"SB Potterf","year":"2001","unstructured":"Potterf SB, Mollaaghababa R, Hou L, Southard-Smith EM, Hornyak TJ, Arnheiter H et al. Analysis of SOX10 function in neural crest-derived melanocyte development: SOX10-dependent transcriptional control of dopachrome tautomerase. Dev Biol 2001; 237: 245\u2013257.","journal-title":"Dev Biol"},{"key":"BFcdd2013142_CR37","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/ng0198-60","volume":"18","author":"EM Southard-Smith","year":"1998","unstructured":"Southard-Smith EM, Kos L, Pavan WJ . Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model. Nat Genet 1998; 18: 60\u201364.","journal-title":"Nat Genet"},{"key":"BFcdd2013142_CR38","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1055\/s-2008-1066521","volume":"6","author":"JP Bonnet","year":"1996","unstructured":"Bonnet JP, Till M, Edery P, Attie T, Lyonnet S . Waardenburg-Hirschsprung disease in two sisters: a possible clue to the genetics of this association? Eur J Pediatr Surg 1996; 6: 245\u2013248.","journal-title":"Eur J Pediatr Surg"},{"key":"BFcdd2013142_CR39","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s00383-003-1057-7","volume":"19","author":"F Toki","year":"2003","unstructured":"Toki F, Suzuki N, Inoue K, Suzuki M, Hirakata K, Nagai K et al. Intestinal aganglionosis associated with the Waardenburg syndrome: report of two cases and review of the literature. Pediatr Surg Int 2003; 19: 725\u2013728.","journal-title":"Pediatr Surg Int"},{"key":"BFcdd2013142_CR40","first-page":"236","volume":"21","author":"BJ Yoder","year":"2002","unstructured":"Yoder BJ, Prayson RA . Shah-Waardenburg syndrome and Dandy-Walker malformation: an autopsy report. Clin Neuropathol 2002; 21: 236\u2013240.","journal-title":"Clin Neuropathol"},{"key":"BFcdd2013142_CR41","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1002\/humu.21211","volume":"31","author":"V Pingault","year":"2010","unstructured":"Pingault V, Ente D, Dastot-Le Moal F, Goossens M, Marlin S, Bondurand N . Review and update of mutations causing Waardenburg syndrome. Hum Mutat 2010; 31: 391\u2013406.","journal-title":"Hum Mutat"},{"key":"BFcdd2013142_CR42","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1113\/jphysiol.2010.202820","volume":"589","author":"VP Zagorodnyuk","year":"2011","unstructured":"Zagorodnyuk VP, Kyloh M, Nicholas S, Peiris H, Brookes SJ, Chen BN et al. Loss of visceral pain following colorectal distension in an endothelin-3 deficient mouse model of Hirschsprung's disease. J Physiol 2011; 589: 1691\u20131706.","journal-title":"J Physiol"},{"key":"BFcdd2013142_CR43","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/5007","volume":"21","author":"P Soriano","year":"1999","unstructured":"Soriano P . Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 1999; 21: 70\u201371.","journal-title":"Nat Genet"},{"key":"BFcdd2013142_CR44","doi-asserted-by":"publisher","first-page":"6502","DOI":"10.1073\/pnas.0401711101","volume":"101","author":"H Akiyama","year":"2004","unstructured":"Akiyama H, Chaboissier MC, Behringer RR, Rowitch DH, Schedl A, Epstein JA et al. Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci USA 2004; 101: 6502\u20136507.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2013142_CR45","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0165-3806(00)00049-3","volume":"121","author":"Y Cheng","year":"2000","unstructured":"Cheng Y, Cheung M, Abu-Elmagd MM, Orme A, Scotting PJ . Chick sox10, a transcription factor expressed in both early neural crest cells and central nervous system. Brain Res Dev Brain Res 2000; 121: 233\u2013241.","journal-title":"Brain Res Dev Brain Res"},{"key":"BFcdd2013142_CR46","doi-asserted-by":"publisher","first-page":"e20815","DOI":"10.1371\/journal.pone.0020815","volume":"6","author":"J Zhu","year":"2011","unstructured":"Zhu J, Garcia-Barcelo MM, Tam PK, Lui VC . HOXB5 cooperates with NKX2-1 in the transcription of human RET. PLoS One 2011; 6: e20815.","journal-title":"PLoS One"},{"key":"BFcdd2013142_CR47","doi-asserted-by":"publisher","first-page":"5383","DOI":"10.1038\/sj.emboj.7601398","volume":"25","author":"W Liu","year":"2006","unstructured":"Liu W, Lagutin OV, Mende M, Streit A, Oliver G . Six3 activation of Pax6 expression is essential for mammalian lens induction and specification. EMBO J 2006; 25: 5383\u20135395.","journal-title":"EMBO J"},{"key":"BFcdd2013142_CR48","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/j.yexcr.2007.01.001","volume":"313","author":"S Piera-Velazquez","year":"2007","unstructured":"Piera-Velazquez S, Hawkins DF, Whitecavage MK, Colter DC, Stokes DG, Jimenez SA . Regulation of the human SOX9 promoter by Sp1 and CREB. Exp Cell Res 2007; 313: 1069\u20131079.","journal-title":"Exp Cell Res"},{"key":"BFcdd2013142_CR49","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0378-1119(91)90434-D","volume":"108","author":"H Niwa","year":"1991","unstructured":"Niwa H, Yamamura K, Miyazaki J . Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 1991; 108: 193\u2013199.","journal-title":"Gene"},{"key":"BFcdd2013142_CR50","doi-asserted-by":"publisher","first-page":"5681","DOI":"10.1242\/dev.00808","volume":"130","author":"M Cheung","year":"2003","unstructured":"Cheung M, Briscoe J . Neural crest development is regulated by the transcription factor Sox9. Development 2003; 130: 5681\u20135693.","journal-title":"Development"}],"container-title":["Cell Death & Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd2013142.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2013142","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2013142.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:03:45Z","timestamp":1684415025000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd2013142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,18]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["BFcdd2013142"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2013.142","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,18]]}}}