{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:29:54Z","timestamp":1790746194933,"version":"4.1.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T00:00:00Z","timestamp":1363910400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1038\/cdd.2013.21","type":"journal-article","created":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T10:05:35Z","timestamp":1363946735000},"page":"878-887","source":"Crossref","is-referenced-by-count":145,"title":["Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation"],"prefix":"10.1038","volume":"20","author":[{"given":"M","family":"Amir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Czaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,3,22]]},"reference":[{"key":"BFcdd201321_CR1","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1038\/nrm2529","volume":"9","author":"G Kroemer","year":"2008","unstructured":"Kroemer G, Levine B . Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol 2008; 9: 1004\u20131010.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcdd201321_CR2","first-page":"439","volume":"61","author":"S Paglin","year":"2001","unstructured":"Paglin S, Hollister T, Delohery T, Hackett N, McMahill M, Sphicas E et al. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 2001; 61: 439\u2013444.","journal-title":"Cancer Res"},{"key":"BFcdd201321_CR3","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1172\/JCI26185","volume":"116","author":"L Espert","year":"2006","unstructured":"Espert L, Denizot M, Grimaldi M, Robert-Hebmann V, Gay B, Varbanov M et al. Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. J Clin Invest 2006; 116: 2161\u20132172.","journal-title":"J Clin Invest"},{"key":"BFcdd201321_CR4","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1128\/MCB.25.3.1025-1040.2005","volume":"25","author":"P Boya","year":"2005","unstructured":"Boya P, Gonzalez-Polo RA, Casares N, Perfettini JL, Dessen P, Larochette N et al. Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 2005; 25: 1025\u20131040.","journal-title":"Mol Cell Biol"},{"key":"BFcdd201321_CR5","doi-asserted-by":"publisher","first-page":"29776","DOI":"10.1074\/jbc.M603783200","volume":"281","author":"A Hamacher-Brady","year":"2006","unstructured":"Hamacher-Brady A, Brady NR, Gottlieb RA . Enhancing macroautophagy protects against ischemia\/reperfusion injury in cardiac myocytes. J Biol Chem 2006; 281: 29776\u201329787.","journal-title":"J Biol Chem"},{"key":"BFcdd201321_CR6","doi-asserted-by":"publisher","first-page":"4702","DOI":"10.1074\/jbc.M609267200","volume":"282","author":"WX Ding","year":"2007","unstructured":"Ding WX, Ni HM, Gao W, Hou YF, Melan MA, Chen X et al. Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J Biol Chem 2007; 282: 4702\u20134710.","journal-title":"J Biol Chem"},{"key":"BFcdd201321_CR7","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1053\/j.gastro.2011.04.038","volume":"140","author":"MJ Czaja","year":"2011","unstructured":"Czaja MJ . Functions of autophagy in hepatic and pancreatic physiology and disease. Gastroenterology 2011; 140: 1895\u20131908.","journal-title":"Gastroenterology"},{"key":"BFcdd201321_CR8","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/978-3-642-00150-5_10","volume-title":"Signaling Pathways in Liver Diseases","author":"JM Schattenberg","year":"2010","unstructured":"Schattenberg JM, Czaja MJ . TNF and TNF receptors In: Dufour JF, Clavien P-A, (eds). Signaling Pathways in Liver Diseases 2nd edn. Springer-Verlag: Berlin, 2010 pp 161\u2013179."},{"key":"BFcdd201321_CR9","doi-asserted-by":"publisher","first-page":"C1058","DOI":"10.1152\/ajpcell.1998.275.4.C1058","volume":"275","author":"Y Xu","year":"1998","unstructured":"Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A et al. NF-\u03baB inactivation converts a hepatocyte cell line TNF-\u03b1 response from proliferation to apoptosis. Am J Physiol 1998; 275: C1058\u2013C1066.","journal-title":"Am J Physiol"},{"key":"BFcdd201321_CR10","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1053\/jhep.2002.32534","volume":"35","author":"H Liu","year":"2002","unstructured":"Liu H, Lo CR, Czaja MJ . NF-\u03baB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun. Hepatology 2002; 35: 772\u2013778.","journal-title":"Hepatology"},{"key":"BFcdd201321_CR11","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1096\/fj.03-0771fje","volume":"18","author":"RF Schwabe","year":"2004","unstructured":"Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ, Brenner DA . Differential requirement for c-Jun NH2-terminal kinase in TNF\u03b1- and Fas-mediated apoptosis in hepatocytes. FASEB J 2004; 18: 720\u2013722.","journal-title":"FASEB J"},{"key":"BFcdd201321_CR12","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1089\/ars.2010.3768","volume":"14","author":"I Kim","year":"2011","unstructured":"Kim I, Lemasters JJ . Mitophagy selectively degrades individual damaged mitochondria after photoirradiation. Antioxid Redox Signal 2011; 14: 1919\u20131928.","journal-title":"Antioxid Redox Signal"},{"key":"BFcdd201321_CR13","doi-asserted-by":"publisher","first-page":"R1202","DOI":"10.1152\/ajpregu.2000.278.5.R1202","volume":"278","author":"M Nowak","year":"2000","unstructured":"Nowak M, Gaines GC, Rosenberg J, Minter R, Bahjat FR, Rectenwald J et al. LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-\u03b1 and the TNF-p55 receptor. Am J Physiol Regul Integr Comp Physiol 2000; 278: R1202\u2013R1209.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFcdd201321_CR14","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1038\/nature03029","volume":"432","author":"A Kuma","year":"2004","unstructured":"Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T et al. The role of autophagy during the early neonatal starvation period. Nature 2004; 432: 1032\u20131036.","journal-title":"Nature"},{"key":"BFcdd201321_CR15","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1083\/jcb.200412022","volume":"169","author":"M Komatsu","year":"2005","unstructured":"Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 2005; 169: 425\u2013434.","journal-title":"J Cell Biol"},{"key":"BFcdd201321_CR16","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1038\/nature07976","volume":"458","author":"R Singh","year":"2009","unstructured":"Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M et al. Autophagy regulates lipid metabolism. Nature 2009; 458: 1131\u20131135.","journal-title":"Nature"},{"key":"BFcdd201321_CR17","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1126\/science.7660125","volume":"269","author":"R Kuhn","year":"1995","unstructured":"Kuhn R, Schwenk F, Aguet M, Rajewsky K . Inducible gene targeting in mice. Science 1995; 269: 1427\u20131429.","journal-title":"Science"},{"key":"BFcdd201321_CR18","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1002\/gene.20039","volume":"39","author":"M Schuler","year":"2004","unstructured":"Schuler M, Dierich A, Chambon P, Metzger D . Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse. Genesis 2004; 39: 167\u2013172.","journal-title":"Genesis"},{"key":"BFcdd201321_CR19","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/23730","volume":"400","author":"XM Yin","year":"1999","unstructured":"Yin XM, Wang K, Gross A, Zhao Y, Zinkel S, Klocke B et al. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 1999; 400: 886\u2013891.","journal-title":"Nature"},{"key":"BFcdd201321_CR20","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1002\/hep.23645","volume":"52","author":"Y Wang","year":"2010","unstructured":"Wang Y, Singh R, Xiang Y, Czaja MJ . Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress. Hepatology 2010; 52: 266\u2013277.","journal-title":"Hepatology"},{"key":"BFcdd201321_CR21","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.cell.2006.01.021","volume":"124","author":"L Chang","year":"2006","unstructured":"Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K et al. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIPL turnover. Cell 2006; 124: 601\u2013613.","journal-title":"Cell"},{"key":"BFcdd201321_CR22","doi-asserted-by":"publisher","first-page":"15258","DOI":"10.1074\/jbc.M512953200","volume":"281","author":"Y Wang","year":"2006","unstructured":"Wang Y, Singh R, Lefkowitch JH, Rigoli RM, Czaja MJ . Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway. J Biol Chem 2006; 281: 15258\u201315267.","journal-title":"J Biol Chem"},{"key":"BFcdd201321_CR23","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1053\/j.gastro.2008.12.064","volume":"136","author":"Y Kodama","year":"2009","unstructured":"Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y, Brenner DA . Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Gastroenterology 2009; 136: 1423\u20131434.","journal-title":"Gastroenterology"},{"key":"BFcdd201321_CR24","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1002\/hep.24324","volume":"53","author":"EH Carchman","year":"2011","unstructured":"Carchman EH, Rao J, Loughran PA, Rosengart MR, Zuckerbraun BS . Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection\/sepsis in mice. Hepatology 2011; 53: 2053\u20132062.","journal-title":"Hepatology"},{"key":"BFcdd201321_CR25","doi-asserted-by":"publisher","first-page":"629","DOI":"10.4161\/auto.7.6.15100","volume":"7","author":"J Haspel","year":"2011","unstructured":"Haspel J, Shaik RS, Ifedigbo E, Nakahira K, Dolinay T, Englert JA et al. Characterization of macroautophagic flux in vivo using a leupeptin-based assay. Autophagy 2011; 7: 629\u2013642.","journal-title":"Autophagy"},{"key":"BFcdd201321_CR26","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","volume":"149","author":"M Laplante","year":"2012","unstructured":"Laplante M, Sabatini DM . mTOR signaling in growth control and disease. Cell 2012; 149: 274\u2013293.","journal-title":"Cell"},{"key":"BFcdd201321_CR27","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1126\/science.1196371","volume":"331","author":"DF Egan","year":"2011","unstructured":"Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011; 331: 456\u2013461.","journal-title":"Science"},{"key":"BFcdd201321_CR28","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.cmet.2010.04.005","volume":"11","author":"L Yang","year":"2010","unstructured":"Yang L, Li P, Fu S, Calay ES, Hotamisligil GS . Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab 2010; 11: 467\u2013478.","journal-title":"Cell Metab"},{"key":"BFcdd201321_CR29","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1053\/j.gastro.2011.08.005","volume":"141","author":"JH Wang","year":"2011","unstructured":"Wang JH, Ahn IS, Fischer TD, Byeon JI, Dunn WA, Behrns KE et al. Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice. Gastroenterology 2011; 141: 2188\u20132199.","journal-title":"Gastroenterology"},{"key":"BFcdd201321_CR30","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/cdd.2011.78","volume":"19","author":"JR Kovacs","year":"2012","unstructured":"Kovacs JR, Li C, Yang Q, Li G, Garcia IG, Ju S et al. Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery. Cell Death Differ 2012; 19: 144\u2013152.","journal-title":"Cell Death Differ"},{"key":"BFcdd201321_CR31","doi-asserted-by":"publisher","first-page":"12455","DOI":"10.1074\/jbc.M111.309104","volume":"287","author":"M Young","year":"2012","unstructured":"Young M, Takahashi Y, Khan O, Park S, Hori T, Yun J et al. Autophagosomal membrane serves as a platform for an intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis. J Biol Chem 2012; 287: 12455\u201312468.","journal-title":"J Biol Chem"},{"key":"BFcdd201321_CR32","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1038\/cdd.2011.27","volume":"18","author":"MA Laussmann","year":"2011","unstructured":"Laussmann MA, Passante E, Dussmann H, Rauen JA, Wurstle ML, Delgado ME et al. Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8. Cell Death Differ 2011; 18: 1584\u20131597.","journal-title":"Cell Death Differ"},{"key":"BFcdd201321_CR33","doi-asserted-by":"publisher","first-page":"20722","DOI":"10.1074\/jbc.M413934200","volume":"280","author":"JO Pyo","year":"2005","unstructured":"Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN et al. Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem 2005; 280: 20722\u201320729.","journal-title":"J Biol Chem"},{"key":"BFcdd201321_CR34","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1091\/mbc.e04-10-0906","volume":"16","author":"J Thorburn","year":"2005","unstructured":"Thorburn J, Moore F, Rao A, Barclay WW, Thomas LR, Grant KW et al. Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells. Mol Biol Cell 2005; 16: 1189\u20131199.","journal-title":"Mol Biol Cell"},{"key":"BFcdd201321_CR35","doi-asserted-by":"publisher","first-page":"131","DOI":"10.4161\/auto.1.3.2017","volume":"1","author":"AM Cuervo","year":"2005","unstructured":"Cuervo AM, Bergamini E, Brunk UT, Droge W, Ffrench M, Terman A . Autophagy and aging: the importance of maintaining \u2018clean\u2019 cells. Autophagy 2005; 1: 131\u2013140.","journal-title":"Autophagy"},{"key":"BFcdd201321_CR36","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1053\/jhep.2003.50048","volume":"37","author":"Z Li","year":"2003","unstructured":"Li Z, Yang S, Lin H, Huang J, Watkins PA, Moser AB et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 2003; 37: 343\u2013350.","journal-title":"Hepatology"},{"key":"BFcdd201321_CR37","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nrneurol.2011.200","volume":"8","author":"H Harris","year":"2012","unstructured":"Harris H, Rubinsztein DC . Control of autophagy as a therapy for neurodegenerative disease. Nat Rev Neurol 2012; 8: 108\u2013117.","journal-title":"Nat Rev Neurol"},{"key":"BFcdd201321_CR38","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1126\/science.1190354","volume":"329","author":"T Hidvegi","year":"2010","unstructured":"Hidvegi T, Ewing M, Hale P, Dippold C, Beckett C, Kemp C et al. An autophagy-enhancing drug promotes degradation of mutant \u03b11-antitrypsin Z and reduces hepatic fibrosis. Science 2010; 329: 229\u2013232.","journal-title":"Science"},{"key":"BFcdd201321_CR39","first-page":"329","volume":"289","author":"D Metzger","year":"2005","unstructured":"Metzger D, Li M, Chambon P . Targeted somatic mutagenesis in the mouse epidermis. Methods Mol Biol 2005; 289: 329\u2013340.","journal-title":"Methods Mol Biol"},{"key":"BFcdd201321_CR40","doi-asserted-by":"publisher","first-page":"31089","DOI":"10.1074\/jbc.M404170200","volume":"279","author":"Y Wang","year":"2004","unstructured":"Wang Y, Schattenberg JM, Rigoli RM, Storz P, Czaja MJ . Hepatocyte resistance to oxidative stress is dependent on protein kinase C-mediated down-regulation of c-Jun\/AP-1. J Biol Chem 2004; 279: 31089\u201331097.","journal-title":"J Biol Chem"},{"key":"BFcdd201321_CR41","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/S0016-5085(98)70095-2","volume":"115","author":"Y Xu","year":"1998","unstructured":"Xu Y, Jones BE, Neufeld DS, Czaja MJ . Glutathione modulates rat and mouse hepatocyte sensitivity to tumor necrosis factor toxicity. Gastroenterology 1998; 115: 1229\u20131237.","journal-title":"Gastroenterology"},{"key":"BFcdd201321_CR42","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/mt.2010.279","volume":"19","author":"J Xie","year":"2011","unstructured":"Xie J, Xie Q, Zhang H, Ameres SL, Hung JH, Su Q et al. MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression. Mol Ther 2011; 19: 526\u2013535.","journal-title":"Mol Ther"}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd201321.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201321","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201321.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:04:48Z","timestamp":1684415088000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd201321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,22]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["BFcdd201321"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2013.21","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,22]]}}}