{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:25:50Z","timestamp":1790112350759,"version":"4.0.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2013,5,31]],"date-time":"2013-05-31T00:00:00Z","timestamp":1369958400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1038\/cdd.2013.44","type":"journal-article","created":{"date-parts":[[2013,5,31]],"date-time":"2013-05-31T09:00:17Z","timestamp":1369990817000},"page":"1089-1100","source":"Crossref","is-referenced-by-count":46,"title":["A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors"],"prefix":"10.1038","volume":"20","author":[{"given":"K","family":"Tilgner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Neganova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Moreno-Gimeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Y","family":"AL-Aama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Burks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Yung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Singhapol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Saretzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Gorbunova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Gennery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Przyborski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Stojkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Jeggo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,31]]},"reference":[{"key":"BFcdd201344_CR1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1042\/BJ20090942","volume":"423","author":"AJ Hartlerode","year":"2009","unstructured":"Hartlerode AJ, Scully R . Mechanisms of double-strand break repair in somatic mammalian cells. Biochem J 2009; 423: 157\u2013168.","journal-title":"Biochem J"},{"key":"BFcdd201344_CR2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0065-2660(08)60144-3","volume":"38","author":"PA Jeggo","year":"1998","unstructured":"Jeggo PA . DNA breakage and repair. Adv Genet 1998; 38: 185\u2013218.","journal-title":"Adv Genet"},{"key":"BFcdd201344_CR3","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1016\/j.dnarep.2010.09.014","volume":"9","author":"JT Holthausen","year":"2010","unstructured":"Holthausen JT, Wyman C, Kanaar R . Regulation of DNA strand exchange in homologous recombination. DNA Repair (Amst) 2010; 9: 1264\u20131272.","journal-title":"DNA Repair (Amst)"},{"key":"BFcdd201344_CR4","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/nrm1202","volume":"4","author":"MR Lieber","year":"2003","unstructured":"Lieber MR, Ma Y, Pannicke U, Schwarz K . Mechanism and regulation of human non-homologous DNA end-joining. Nat Rev Mol Cell Biol 2003; 4: 712\u2013720.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcdd201344_CR5","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/41358","volume":"388","author":"U Grawunder","year":"1997","unstructured":"Grawunder U, Grawunder U, Wilm M, Wu M, Kulesza P, Wilson TE et al. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature 1997; 388: 492\u2013495.","journal-title":"Nature"},{"key":"BFcdd201344_CR6","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.cell.2005.12.031","volume":"124","author":"P Ahnesorg","year":"2006","unstructured":"Ahnesorg P, Smith P, Jackson SP . XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell 2006; 124: 301\u2013313.","journal-title":"Cell"},{"key":"BFcdd201344_CR7","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.cell.2007.10.005","volume":"131","author":"A Nussenzweig","year":"2007","unstructured":"Nussenzweig A, Nussenzweig MC . A backup DNA repair pathway moves to the forefront. Cell 2007; 131: 223\u2013225.","journal-title":"Cell"},{"key":"BFcdd201344_CR8","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/nature08467","volume":"461","author":"SP Jackson","year":"2009","unstructured":"Jackson SP, Bartek J . The DNA-damage response in human biology and disease. Nature 2009; 461: 1071\u20131078.","journal-title":"Nature"},{"key":"BFcdd201344_CR9","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/j.dnarep.2004.03.025","volume":"3","author":"M O'Driscoll","year":"2004","unstructured":"O'Driscoll M, Gennery AR, Seidel J, Concannon P, Jeggo PA . An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome. DNA Repair (Amst) 2004; 3: 1227\u20131235.","journal-title":"DNA Repair (Amst)"},{"key":"BFcdd201344_CR10","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/24172","volume":"396","author":"KM Frank","year":"1998","unstructured":"Frank KM, Sekiguchi JM, Seidl KJ, Swat W, Rathbun GA, Cheng HL et al. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature 1998; 396: 173\u2013177.","journal-title":"Nature"},{"key":"BFcdd201344_CR11","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/S1097-2765(00)80264-6","volume":"5","author":"KM Frank","year":"2000","unstructured":"Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C et al. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell 2000; 5: 993\u20131002.","journal-title":"Mol Cell"},{"key":"BFcdd201344_CR12","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/S0092-8674(00)81714-6","volume":"95","author":"Y Gao","year":"1998","unstructured":"Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ et al. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell 1998; 95: 891\u2013902.","journal-title":"Cell"},{"key":"BFcdd201344_CR13","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/nature05875","volume":"447","author":"A Nijnik","year":"2007","unstructured":"Nijnik A, Woodbine L, Marchetti C, Dawson S, Lambe T, Liu C et al. DNA repair is limiting for haematopoietic stem cells during ageing. Nature 2007; 447: 686\u2013690.","journal-title":"Nature"},{"key":"BFcdd201344_CR14","doi-asserted-by":"publisher","first-page":"10088","DOI":"10.1523\/JNEUROSCI.1324-11.2011","volume":"31","author":"SA Gatz","year":"2011","unstructured":"Gatz SA, Ju L, Gruber R, Hoffmann E, Carr AM, Wang ZQ et al. Requirement for DNA ligase IV during embryonic neural development. J Neurosci 2011; 31: 10088\u201310100.","journal-title":"J Neurosci"},{"key":"BFcdd201344_CR15","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/S1097-2765(01)00408-7","volume":"8","author":"M O'Driscoll","year":"2001","unstructured":"O'Driscoll M, Cerosaletti KM, Girard PM, Dai Y, Stumm M, Kysela B et al. DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Mol Cell 2001; 8: 1175\u20131185.","journal-title":"Mol Cell"},{"key":"BFcdd201344_CR16","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/S0960-9822(99)80311-X","volume":"9","author":"E Riballo","year":"1999","unstructured":"Riballo E, Critchlow SE, Teo SH, Doherty AJ, Priestley A, Broughton B et al. Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient. Curr Biol 1999; 9: 699\u2013702.","journal-title":"Curr Biol"},{"key":"BFcdd201344_CR17","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1002\/ajmg.a.30869","volume":"137A","author":"TI Ben-Omran","year":"2005","unstructured":"Ben-Omran TI, Cerosaletti K, Concannon P, Weitzman S, Nezarati MM . A patient with mutations in DNA Ligase IV: clinical features and overlap with Nijmegen breakage syndrome. Am J Med Genet A 2005; 137A: 283\u2013287.","journal-title":"Am J Med Genet A"},{"key":"BFcdd201344_CR18","doi-asserted-by":"crossref","unstructured":"Chistiakov DA Ligase IV syndrome chapter 16: 175-183: Diseases of DNA repair, edited by S. I. Ahmad.","DOI":"10.1007\/978-1-4419-6448-9_16"},{"key":"BFcdd201344_CR19","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/nature05862","volume":"447","author":"DJ Rossi","year":"2007","unstructured":"Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL . Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 2007; 447: 725\u2013729.","journal-title":"Nature"},{"key":"BFcdd201344_CR20","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1083\/jcb.201009074","volume":"193","author":"S Zhang","year":"2011","unstructured":"Zhang S, Yajima H, Huynh H, Zheng J, Callen E, Chen HT et al. Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. J Cell Biol 2011; 193: 295\u2013305.","journal-title":"J Cell Biol"},{"key":"BFcdd201344_CR21","doi-asserted-by":"publisher","first-page":"e1000389","DOI":"10.1371\/journal.pgen.1000389","volume":"5","author":"D Lucas","year":"2009","unstructured":"Lucas D, Escudero B, Ligos JM, Segovia JC, Estrada JC, Terrados G et al. Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair. PLoS Genet 2009; 5: e1000389.","journal-title":"PLoS Genet"},{"key":"BFcdd201344_CR22","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1172\/JCI32743","volume":"119","author":"A Nijnik","year":"2009","unstructured":"Nijnik A, Dawson S, Crockford TL, Woodbine L, Visetnoi S, Bennett S et al. Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome. J Clin Invest 2009; 119: 1696\u20131705.","journal-title":"J Clin Invest"},{"key":"BFcdd201344_CR23","doi-asserted-by":"publisher","first-page":"3024","DOI":"10.1073\/pnas.0914865107","volume":"107","author":"F Rucci","year":"2010","unstructured":"Rucci F, Notarangelo LD, Fazeli A, Patrizi L, Hickernell T, Paganini T et al. Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome. Proc Natl Acad Sci USA 2010; 107: 3024\u20133029.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201344_CR24","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.stem.2010.06.014","volume":"7","author":"M Mohrin","year":"2010","unstructured":"Mohrin M, Bourke E, Alexander D, Warr MR, Barry-Holson K, Le Beau MM et al. Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. Cell Stem Cell 2010; 7: 174\u2013185.","journal-title":"Cell Stem Cell"},{"key":"BFcdd201344_CR25","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1634\/stemcells.22-6-962","volume":"22","author":"G Saretzki","year":"2004","unstructured":"Saretzki G, Armstrong L, Leake A, Lako M, von Zglinicki T . Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells. Stem Cells 2004; 22: 962\u2013971.","journal-title":"Stem Cells"},{"key":"BFcdd201344_CR26","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1634\/stemcells.2007-0628","volume":"26","author":"G Saretzki","year":"2008","unstructured":"Saretzki G, Walter T, Atkinson S, Passos JF, Bareth B, Keith WN et al. Downregulation of multiple stress defence mechanisms during differentiation of human embryonic stem cells. Stem Cells 2008; 26: 455\u2013464.","journal-title":"Stem Cells"},{"key":"BFcdd201344_CR27","doi-asserted-by":"publisher","first-page":"584","DOI":"10.18632\/aging.100336","volume":"3","author":"AN Bogomazova","year":"2011","unstructured":"Bogomazova AN, Lagarkova MA, Tskhovrebova LV, Shutova MV, Kiselev SL . Error-prone nonhomologous end joining repair operates in human pluripotent stem cells during late G2. Aging 2011; 3: 584\u2013596.","journal-title":"Aging"},{"key":"BFcdd201344_CR28","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.mrfmmm.2011.05.018","volume":"713","author":"J Fan","year":"2011","unstructured":"Fan J, Robert C, Jang YY, Liu H, Sharkis S, Baylin SB et al. Human induced pluripotent cells resemble embryonic stem cells demonstrating enhanced levels of DNA repair and efficacy of nonhomologous end-joining. Mutat Res 2011; 713: 8\u201317.","journal-title":"Mutat Res"},{"key":"BFcdd201344_CR29","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1136\/jmg.39.12.900","volume":"39","author":"PL Roddam","year":"2002","unstructured":"Roddam PL, Rollinson S, O'Driscoll M, Jeggo PA, Jack A, Morgan GJ . Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination. J Med Genet 2002; 39: 900\u2013905.","journal-title":"J Med Genet"},{"key":"BFcdd201344_CR30","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1038\/nature08287","volume":"460","author":"RM Mari\u00f3n","year":"2009","unstructured":"Mari\u00f3n RM, Strati K, Li H, Murga M, Blanco R, Ortega S et al. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 2009; 460: 1149\u20131153.","journal-title":"Nature"},{"key":"BFcdd201344_CR31","first-page":"2002","volume":"43","author":"A Seluanov","year":"2002","unstructured":"Seluanov A, Mao Z, Gorbunova V . Analysis of DNA double-strand break (DSB) repair in mammalian cells. J Vis Exp 2002; 43 pii 2002.","journal-title":"J Vis Exp"},{"key":"BFcdd201344_CR32","doi-asserted-by":"publisher","first-page":"3454","DOI":"10.1093\/nar\/gkf452","volume":"30","author":"F Delac\u00f4te","year":"2002","unstructured":"Delac\u00f4te F, Han M, Stamato TD, Jasin M, Lopez BS . An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells. Nuc Acids Res 2002; 30: 3454\u20133463.","journal-title":"Nuc Acids Res"},{"key":"BFcdd201344_CR33","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.1101\/gad.946401","volume":"15","author":"AJ Pierce","year":"2001","unstructured":"Pierce AJ, Hu P, Han M, Ellis N, Jasin M . Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev 2001; 15: 3237\u20133242.","journal-title":"Genes Dev"},{"key":"BFcdd201344_CR34","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.stem.2010.06.018","volume":"7","author":"M Ohgushi","year":"2010","unstructured":"Ohgushi M, Matsumura M, Eiraku M, Murakami K, Aramaki T, Nishiyama A et al. Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells. Cell Stem Cell 2010; 7: 225\u2013239.","journal-title":"Cell Stem Cell"},{"key":"BFcdd201344_CR35","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.stem.2010.06.017","volume":"7","author":"G Chen","year":"2010","unstructured":"Chen G, Hou Z, Gulbranson DR, Thomson JA . Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cells. Cell Stem Cell 2010; 7: 240\u2013248.","journal-title":"Cell Stem Cell"},{"key":"BFcdd201344_CR36","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1182\/blood-2006-09-047704","volume":"109","author":"M Kennedy","year":"2007","unstructured":"Kennedy M, D'Souza SL, Lynch-Kattman M, Schwantz S, Keller G . Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures. Blood 2007; 109: 2679\u20132687.","journal-title":"Blood"},{"key":"BFcdd201344_CR37","doi-asserted-by":"publisher","first-page":"4932","DOI":"10.1093\/hmg\/ddr431","volume":"20","author":"S Yung","year":"2011","unstructured":"Yung S, Ledran M, Moreno-Gimeno I, Conesa A, Montaner D, Dopazo J et al. Large-scale transcriptional profiling and functional assays reveal important roles for Rho-GTPase signalling and SCL during haematopoietic differentiation of human embryonic stem cells. Hum Mol Genet 2011; 20: 4932\u20134946.","journal-title":"Hum Mol Genet"},{"key":"BFcdd201344_CR38","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1038\/mt.2012.49","volume":"20","author":"PJ Real","year":"2012","unstructured":"Real PJ, Ligero G, Ayllon V, Ramos-Mejia V, Bueno C, Gutierrez-Aranda I et al. SCL\/TAL1 regulates hematopoietic specification from human embryonic stem cells. Mol Ther 2012; 20: 1443\u20131453.","journal-title":"Mol Ther"},{"key":"BFcdd201344_CR39","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1016\/j.dnarep.2008.05.005","volume":"7","author":"CA Ba\u00f1uelos","year":"2008","unstructured":"Ba\u00f1uelos CA, Ban\u00e1th JP, MacPhail SH, Zhao J, Eaves CA, O'Connor MD et al. Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks. DNA Repair (Amst) 2008; 7: 1471\u20131483.","journal-title":"DNA Repair (Amst)"},{"key":"BFcdd201344_CR40","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1002\/stem.307","volume":"28","author":"L Armstrong","year":"2010","unstructured":"Armstrong L, Tilgner K, Saretzki G, Atkinson SP, Stojkovic M, Moreno R et al. Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells. Stem Cells 2010; 28: 661\u2013673.","journal-title":"Stem Cells"},{"key":"BFcdd201344_CR41","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.stem.2010.07.017","volume":"7","author":"Y Mayshar","year":"2010","unstructured":"Mayshar Y, Ben-David U, Lavon N, Biancotti JC, Yakir B, Clark AT et al. Identification and classification of chromosomal aberrations in human induced pluripotent stem cells. Cell Stem Cell 2010; 7: 521\u2013531.","journal-title":"Cell Stem Cell"},{"key":"BFcdd201344_CR42","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1007\/s12033-010-9294-1","volume":"46","author":"AM Elliott","year":"2010","unstructured":"Elliott AM, Elliott KA, Kammesheidt A . High resolution array-CGH characterization of human stem cells using a stem cell focused microarray. Mol Biotech 2010; 46: 234\u2013242.","journal-title":"Mol Biotech"},{"key":"BFcdd201344_CR43","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.stem.2010.12.003","volume":"8","author":"LC Laurent","year":"2011","unstructured":"Laurent LC, Ulitsky I, Slavin I, Tran H, Schork A, Morey R et al. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell 2011; 8: 106\u2013118.","journal-title":"Cell Stem Cell"},{"key":"BFcdd201344_CR44","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1038\/nbt.2051","volume":"29","author":"K Amps","year":"2011","unstructured":"International Stem Cell Initiative Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H et al. Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotech 2011; 29: 1132\u20131144.","journal-title":"Nat Biotech"},{"key":"BFcdd201344_CR45","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/nbt.1890","volume":"29","author":"K Martins-Taylor","year":"2011","unstructured":"Martins-Taylor K, Nisler BS, Taapken SM, Compton T, Crandall L, Montgomery KD et al. Recurrent copy number variations in human induced pluripotent stem cells. Nat Biotech 2011; 29: 488\u2013491.","journal-title":"Nat Biotech"},{"key":"BFcdd201344_CR46","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1002\/stem.1308","volume":"31","author":"SK Yung","year":"2013","unstructured":"Yung SK, Tilgner K, Ledran MH, Habibollah S, Neganova I, Singhapol C et al. Human pluripotent stem cell models of Fanconi Anaemia deficiency reveal an important role for Fanconi Anaemia proteins in cellular reprogramming and survival of haematopoietic progenitors. Stem Cells 2013; 31: 1022\u20131029.","journal-title":"Stem Cells"},{"key":"BFcdd201344_CR47","doi-asserted-by":"publisher","first-page":"5449","DOI":"10.1182\/blood-2012-02-408674","volume":"119","author":"LU M\u00fcller","year":"2012","unstructured":"M\u00fcller LU, Milsom MD, Harris CE, Vyas R, Brumme KM, Parmar K et al. Overcoming reprogramming resistance of Fanconi anemia cells. Blood 2012; 119: 5449\u20135457.","journal-title":"Blood"},{"key":"BFcdd201344_CR48","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1634\/stemcells.22-5-790","volume":"22","author":"M Stojkovic","year":"2004","unstructured":"Stojkovic M, Lako M, Stojkovic P, Stewart R, Przyborski S, Armstrong L et al. Derivation of human embryonic stem cells from day-8 blastocysts recovered after three-step in vitro culture. Stem Cells 2004; 22: 790\u2013797.","journal-title":"Stem Cells"},{"key":"BFcdd201344_CR49","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/onc.2008.358","volume":"28","author":"I Neganova","year":"2008","unstructured":"Neganova I, Zhang X, Atkinson S, Lako M . Expression and functional analysis of G1 to S regulatory components reveals an important role for CDK2 in cell cycle regulation in human embryonic stem cells. Oncogene 2008; 28: 20\u201330.","journal-title":"Oncogene"},{"key":"BFcdd201344_CR50","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1002\/stem.1037","volume":"30","author":"CB Mellough","year":"2012","unstructured":"Mellough CB, Sernagor E, Moreno-Gimeno I, Steel DH, Lako M . Efficient stage-specific differentiation of human pluripotent stem cells toward retinal photoreceptor cells. Stem Cells 2012; 30: 673\u2013686.","journal-title":"Stem Cells"}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd201344.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201344","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201344.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:05:01Z","timestamp":1684415101000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd201344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,31]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["BFcdd201344"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2013.44","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,31]]}}}