{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:42:07Z","timestamp":1791099727375,"version":"4.1.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T00:00:00Z","timestamp":1373587200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1038\/cdd.2013.76","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T10:18:05Z","timestamp":1373624285000},"page":"1485-1497","source":"Crossref","is-referenced-by-count":60,"title":["The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis"],"prefix":"10.1038","volume":"20","author":[{"given":"K","family":"Evangelou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bartkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kotsinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I S","family":"Pateras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Liontos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Velimezi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kosar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Liloglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I P","family":"Trougakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Dyrskjot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C L","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Papaioannou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Drosos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Papafotiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Hodny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Sosa-Pineda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X-R","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Klinakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"\u00d8rntoft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Lukas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bartek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V G","family":"Gorgoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,12]]},"reference":[{"key":"BFcdd201376_CR1","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1126\/science.1140735","volume":"319","author":"TD Halazonetis","year":"2008","unstructured":"Halazonetis TD, Gorgoulis VG, Bartek J . An oncogene-induced DNA damage model for cancer development. Science 2008; 319: 1352\u20131355.","journal-title":"Science"},{"key":"BFcdd201376_CR2","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nrm1987","volume":"7","author":"J Gil","year":"2006","unstructured":"Gil J, Peters G . Regulation of the INK4b\u2013ARF\u2013INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol 2006; 7: 667\u2013677.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcdd201376_CR3","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.ceb.2010.07.013","volume":"22","author":"VG Gorgoulis","year":"2010","unstructured":"Gorgoulis VG, Halazonetis TD . Oncogene-induced senescence: the bright and dark side of the response. Curr Opin Cell Biol 2010; 22: 816\u2013827.","journal-title":"Curr Opin Cell Biol"},{"key":"BFcdd201376_CR4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nrc2772","volume":"10","author":"M Collado","year":"2010","unstructured":"Collado M, Serrano M . Senescence in tumours: evidence from mice and humans. Nat Rev Cancer 2010; 10: 51\u201357.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd201376_CR5","doi-asserted-by":"publisher","first-page":"a001883","DOI":"10.1101\/cshperspect.a001883","volume":"1","author":"JT Zilfou","year":"2009","unstructured":"Zilfou JT, Lowe SW . Tumor suppressive functions of p53. Cold Spring Harb Perspect Biol 2009; 1: a001883.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"BFcdd201376_CR6","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/nrm2858","volume":"11","author":"S Negrini","year":"2010","unstructured":"Negrini S, Gorgoulis VG, Halazonetis TD . Genomic instability\u2014an evolving hallmark of cancer. Nat Rev Mol Cell Biol 2010; 11: 220\u2013228.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcdd201376_CR7","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/nature03482","volume":"434","author":"J Bartkova","year":"2005","unstructured":"Bartkova J, Horejs\u00ed Z, Koed K, Kr\u00e4mer A, Tort F, Zieger K et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005; 434: 864\u2013870.","journal-title":"Nature"},{"key":"BFcdd201376_CR8","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/nature03485","volume":"434","author":"VG Gorgoulis","year":"2005","unstructured":"Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005; 434: 907\u2013913.","journal-title":"Nature"},{"key":"BFcdd201376_CR9","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/nature05268","volume":"444","author":"J Bartkova","year":"2006","unstructured":"Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006; 444: 633\u2013637.","journal-title":"Nature"},{"key":"BFcdd201376_CR10","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/nature05327","volume":"444","author":"R Di Micco","year":"2006","unstructured":"Di Micco R, Fumagalli M, Cicalese A, Piccinin S, Gasparini P, Luise C et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 2006; 444: 638\u2013642.","journal-title":"Nature"},{"key":"BFcdd201376_CR11","doi-asserted-by":"publisher","first-page":"10899","DOI":"10.1158\/0008-5472.CAN-07-2837","volume":"67","author":"M Liontos","year":"2007","unstructured":"Liontos M, Koutsami M, Sideridou M, Evangelou K, Kletsas D, Levy B et al. Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Res 2007; 67: 10899\u201310909.","journal-title":"Cancer Res"},{"key":"BFcdd201376_CR12","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/S0959-437X(99)00038-6","volume":"10","author":"CJ Sherr","year":"2000","unstructured":"Sherr CJ, Weber JD . The ARF\/p53 pathway. Curr Opin Genet Dev 2000; 10: 94\u201399.","journal-title":"Curr Opin Genet Dev"},{"key":"BFcdd201376_CR13","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1002\/wdev.40","volume":"1","author":"CJ Sherr","year":"2012","unstructured":"Sherr CJ . Ink4-Arf locus in cancer and aging. Wiley Interdiscip Rev Dev Biol 2012; 1: 731\u2013741.","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"key":"BFcdd201376_CR14","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/35077232","volume":"411","author":"JH Hoeijmakers","year":"2001","unstructured":"Hoeijmakers JH . Genome maintenance mechanisms for preventing cancer. Nature 2001; 411: 366\u2013374.","journal-title":"Nature"},{"key":"BFcdd201376_CR15","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/nature08467","volume":"461","author":"SP Jackson","year":"2009","unstructured":"Jackson SP, Bartek J . The DNA-damage response in human biology and disease. Nature 2009; 461: 1071\u20131078.","journal-title":"Nature"},{"key":"BFcdd201376_CR16","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1038\/nrm2852","volume":"11","author":"D Branzei","year":"2010","unstructured":"Branzei D, Foiani M . Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol 2010; 11: 208\u2013219.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcdd201376_CR17","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.cell.2006.10.003","volume":"127","author":"WY Kim","year":"2006","unstructured":"Kim WY, Sharpless NE . The regulation of INK4\/ARF in cancer and aging. Cell 2006; 127: 265\u2013275.","journal-title":"Cell"},{"key":"BFcdd201376_CR18","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1172\/JCI30062","volume":"117","author":"L Mo","year":"2007","unstructured":"Mo L, Zheng X, Huang HY, Shapiro E, Lepor H, Cordon-Cardo C et al. Hyperactivation of Ha-ras oncogene, but not Ink4a\/Arf deficiency, triggers bladder tumorigenesis. J Clin Invest 2007; 117: 314\u2013325.","journal-title":"J Clin Invest"},{"key":"BFcdd201376_CR19","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nprot.2007.41","volume":"2","author":"S Wirtz","year":"2007","unstructured":"Wirtz S, Neufert C, Weigmann B, Neurath MF . Chemically induced mouse models of intestinal inflammation. Nat Protoc 2007; 2: 541\u2013546.","journal-title":"Nat Protoc"},{"key":"BFcdd201376_CR20","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.4161\/cbt.8.14.8983","volume":"8","author":"J Chen","year":"2009","unstructured":"Chen J, Huang XF . The signal pathways in azoxymethane-induced colon cancer and preventive implications. Cancer Biol Ther 2009; 8: 1313\u20131317.","journal-title":"Cancer Biol Ther"},{"key":"BFcdd201376_CR21","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/1098-2744(200007)28:3<139::AID-MC2>3.0.CO;2-V","volume":"28","author":"QS Wang","year":"2000","unstructured":"Wang QS, Papanikolaou A, Nambiar PR, Rosenberg DW . Differential expression of p16(INK4a) in azoxymethane-induced mouse colon tumorigenesis. Mol Carcinog 2000; 28: 139\u2013147.","journal-title":"Mol Carcinog"},{"key":"BFcdd201376_CR22","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1056\/NEJM199011013231802","volume":"323","author":"A Ekbom","year":"1990","unstructured":"Ekbom A, Helmick C, Zack M, Adami HO . Ulcerative colitis and colorectal cancer. N Engl J Med 1990; 323: 1228\u20131233.","journal-title":"N Engl J Med"},{"key":"BFcdd201376_CR23","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/mc.20581","volume":"49","author":"SC Borinstein","year":"2010","unstructured":"Borinstein SC, Conerly M, Dzieciatkowski S, Biswas S, Washington MK, Trobridge P et al. Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model. Mol Carcinog 2010; 49: 94\u2013103.","journal-title":"Mol Carcinog"},{"key":"BFcdd201376_CR24","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1093\/carcin\/bgi361","volume":"27","author":"DF Peng","year":"2006","unstructured":"Peng DF, Kanai Y, Sawada M, Ushijima S, Hiraoka N, Kitazawa S et al. DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas. Carcinogenesis 2006; 27: 1160\u20131168.","journal-title":"Carcinogenesis"},{"key":"BFcdd201376_CR25","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1126\/science.284.5415.770","volume":"284","author":"S Artavanis-Tsakonas","year":"1999","unstructured":"Artavanis-Tsakonas S, Rand MD, Lake RJ . Notch signaling: cell fate control and signal integration in development. Science 1999; 284: 770\u2013776.","journal-title":"Science"},{"key":"BFcdd201376_CR26","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/ng1099","volume":"33","author":"M Nicolas","year":"2003","unstructured":"Nicolas M, Wolfer A, Raj K, Kummer JA, Mill P, van Noort M et al. Notch1 functions as a tumor suppressor in mouse skin. Nat Genet 2003; 33: 416\u2013421.","journal-title":"Nat Genet"},{"key":"BFcdd201376_CR27","first-page":"3862","volume":"60","author":"S Sarkar","year":"2000","unstructured":"Sarkar S, J\u00fclicher KP, Burger MS, Della Valle V, Larsen CJ, Yeager TR et al. Different combinations of genetic\/epigenetic alterations inactivate the p53 and pRb pathways in invasive human bladder cancers. Cancer Res 2000; 60: 3862\u20133871.","journal-title":"Cancer Res"},{"key":"BFcdd201376_CR28","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1093\/nar\/gkm099","volume":"35","author":"F Vikhanskaya","year":"2007","unstructured":"Vikhanskaya F, Kei Lee M, Mazzoletti M, Broggini M, Sabapathy K . Cancer-derived p53 mutants suppress p53-target gene expression\u2014potential mechanism for gain of function of mutant p53. Nucleic Acids Res 2007; 35: 2093\u20132104.","journal-title":"Nucleic Acids Res"},{"key":"BFcdd201376_CR29","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1002\/ijc.21852","volume":"119","author":"WA Schulz","year":"2006","unstructured":"Schulz WA . Understanding urothelial carcinoma through cancer pathways. Int J Cancer 2006; 119: 1513\u20131518.","journal-title":"Int J Cancer"},{"key":"BFcdd201376_CR30","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1586\/era.09.102","volume":"9","author":"AA Makitie","year":"2009","unstructured":"Makitie AA, Monni O . Molecular profiling of laryngeal cancer. Expert Rev Anticancer Ther 2009; 9: 1251\u20131260.","journal-title":"Expert Rev Anticancer Ther"},{"key":"BFcdd201376_CR31","doi-asserted-by":"publisher","first-page":"210813","DOI":"10.1155\/2011\/210813","volume":"2011","author":"VR Yanofsky","year":"2011","unstructured":"Yanofsky VR, Mercer SE, Phelps RG . Histopathological variants of cutaneous squamous cell carcinoma. J Skin Cancer 2011; 2011: 210813.","journal-title":"J Skin Cancer"},{"key":"BFcdd201376_CR32","doi-asserted-by":"publisher","first-page":"643","DOI":"10.4161\/cc.4.5.1673","volume":"4","author":"TM R\u00fcnger","year":"2005","unstructured":"R\u00fcnger TM, Vergilis I, Sarkar P, DePinho RA, Sharpless NE . How disruption of cell cycle regulating genes might predispose to sun-induced skin cancer. Cell Cycle 2005; 4: 643\u2013645.","journal-title":"Cell Cycle"},{"key":"BFcdd201376_CR33","doi-asserted-by":"publisher","first-page":"9027","DOI":"10.1158\/0008-5472.CAN-04-3703","volume":"64","author":"RD Ramirez","year":"2004","unstructured":"Ramirez RD, Sheridan S, Girard L, Sato M, Kim Y, Pollack J et al. Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res 2004; 64: 9027\u20139034.","journal-title":"Cancer Res"},{"key":"BFcdd201376_CR34","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1158\/0008-5472.CAN-05-2521","volume":"66","author":"M Sato","year":"2006","unstructured":"Sato M, Vaughan MB, Girard L, Peyton M, Lee W, Shames DS et al. Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res 2006; 66: 2116\u20132128.","journal-title":"Cancer Res"},{"key":"BFcdd201376_CR35","doi-asserted-by":"publisher","first-page":"6457","DOI":"10.1128\/MCB.18.11.6457","volume":"18","author":"KD Robertson","year":"1998","unstructured":"Robertson KD, Jones PA . The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53. Mol Cell Biol 1998; 18: 6457\u20136473.","journal-title":"Mol Cell Biol"},{"key":"BFcdd201376_CR36","doi-asserted-by":"publisher","first-page":"3993","DOI":"10.1073\/pnas.96.7.3993","volume":"96","author":"K Inoue","year":"1999","unstructured":"Inoue K, Roussel MF, Sherr CJ . Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1. Proc Natl Acad Sci USA 1999; 96: 3993\u20133998.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201376_CR37","doi-asserted-by":"publisher","first-page":"127","DOI":"10.4161\/cc.2.2.293","volume":"2","author":"E Berkovich","year":"2003","unstructured":"Berkovich E, Lamed Y, Ginsberg D . E2F and Ras synergize in transcriptionally activating p14ARF expression. Cell Cycle 2003; 2: 127\u2013133.","journal-title":"Cell Cycle"},{"key":"BFcdd201376_CR38","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1016\/j.ejca.2005.08.005","volume":"41","author":"PK Tsantoulis","year":"2005","unstructured":"Tsantoulis PK, Gorgoulis VG . Involvement of E2F transcription factor family in cancer. Eur J Cancer 2005; 41: 2403\u20132414.","journal-title":"Eur J Cancer"},{"key":"BFcdd201376_CR39","doi-asserted-by":"publisher","first-page":"2697","DOI":"10.4161\/cc.6.21.4857","volume":"6","author":"AG del Arroyo","year":"2007","unstructured":"del Arroyo AG, El Messaoudi S, Clark PA, James M, Stott F, Bracken A et al. E2F-dependent induction of p14ARF during cell cycle re-entry in human T cells. Cell Cycle 2007; 6: 2697\u20132705.","journal-title":"Cell Cycle"},{"key":"BFcdd201376_CR40","doi-asserted-by":"publisher","first-page":"4329","DOI":"10.1038\/sj.onc.1210226","volume":"26","author":"K Inoue","year":"2007","unstructured":"Inoue K, Mallakin A, Frazier DP . Dmp1 and tumor suppression. Oncogene 2007; 26: 4329\u20134335.","journal-title":"Oncogene"},{"key":"BFcdd201376_CR41","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/25867","volume":"395","author":"S Bates","year":"1998","unstructured":"Bates S, Phillips AC, Clark PA, Stott F, Peters G, Ludwig RL et al. p14ARF links the tumour suppressors RB and p53. Nature 1998; 395: 124\u2013125.","journal-title":"Nature"},{"key":"BFcdd201376_CR42","doi-asserted-by":"publisher","first-page":"6279","DOI":"10.1158\/0008-5472.CAN-12-3869","volume":"72","author":"SI Nikolaev","year":"2012","unstructured":"Nikolaev SI, Sotiriou SK, Pateras IS, Santoni F, Sougioultzis S, Edgren H et al. A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas. Cancer Res 2012; 72: 6279\u20136689.","journal-title":"Cancer Res"},{"key":"BFcdd201376_CR43","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/nature11935","volume":"494","author":"RA Burrell","year":"2013","unstructured":"Burrell RA, McClelland SE, Endesfelder D, Groth P, Weller MC, Shaikh N et al. Replication stress links structural and numerical cancer chromosomal instability. Nature 2013; 494: 492\u2013496.","journal-title":"Nature"},{"key":"BFcdd201376_CR44","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nsmb.2220","volume":"19","author":"J Bartek","year":"2012","unstructured":"Bartek J, Mistrik M, Bartkova J . Thresholds of replication stress signaling in cancer development and treatment. Nat Struct Mol Biol 2012; 19: 5\u20137.","journal-title":"Nat Struct Mol Biol"},{"key":"BFcdd201376_CR45","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.molcel.2012.03.001","volume":"45","author":"R Bermejo","year":"2012","unstructured":"Bermejo R, Lai MS, Foiani M . Preventing replication stress to maintain genome stability: resolving conflicts between replication and transcription. Mol Cell 2012; 45: 710\u2013718.","journal-title":"Mol Cell"},{"key":"BFcdd201376_CR46","doi-asserted-by":"publisher","first-page":"5001","DOI":"10.1093\/emboj\/17.17.5001","volume":"17","author":"FJ Stott","year":"1998","unstructured":"Stott FJ, Bates S, James MC, McConnell BB, Starborg M, Brookes S et al. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J 1998; 17: 5001\u20135014.","journal-title":"EMBO J"},{"key":"BFcdd201376_CR47","doi-asserted-by":"publisher","first-page":"42851","DOI":"10.1074\/jbc.M103596200","volume":"276","author":"E Berkovich","year":"2001","unstructured":"Berkovich E, Ginsberg D . Ras induces elevation of E2F-1 mRNA levels. J Biol Chem 2001; 276: 42851\u201342856.","journal-title":"J Biol Chem"},{"key":"BFcdd201376_CR48","doi-asserted-by":"publisher","first-page":"113","DOI":"10.4161\/cc.2.2.337","volume":"2","author":"Y Haupt","year":"2003","unstructured":"Haupt Y . Certainly no ARF terthought: oncogenic cooperation in ARF induction a key step in tumor suppression. Cell Cycle 2003; 2: 113\u2013115.","journal-title":"Cell Cycle"},{"key":"BFcdd201376_CR49","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/ncb1567","volume":"9","author":"CJ Sarkisian","year":"2007","unstructured":"Sarkisian CJ, Keister BA, Stairs DB, Boxer RB, Moody SE, Chodosh LA . Dose-dependent oncogen-induced senescence in vivo and its evasion during mammary tumorigenesis. Nat Cell Biol 2007; 9: 493\u2013505.","journal-title":"Nat Cell Biol"},{"key":"BFcdd201376_CR50","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.ccr.2008.10.018","volume":"14","author":"DJ Murphy","year":"2008","unstructured":"Murphy DJ, Junttila MR, Pouyet L, Karnezis A, Shchors K, Bui DA et al. Distinct thresholds govern Myc\u2019s biological output in vivo. Cancer Cell 2008; 14: 447\u2013457.","journal-title":"Cancer Cell"},{"key":"BFcdd201376_CR51","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1002\/jcp.10147","volume":"193","author":"D Zhu","year":"2002","unstructured":"Zhu D, Xu G, Ghandhi S, Hubbard K . Modulation of the expression of p16INK4a and p14ARF by hnRNP A1 and A2 RNA binding proteins: Implications for cellular senescence. J Cell Physiol 2002; 193: 19\u201325.","journal-title":"J Cell Physiol"},{"key":"BFcdd201376_CR52","doi-asserted-by":"publisher","first-page":"e1864","DOI":"10.1371\/journal.pone.0001864","volume":"3","author":"A Lal","year":"2008","unstructured":"Lal A, Kim HH, Abdelmohsen K, Kuwano Y, Pullmann R Jr, Srikantan S et al. p16INK4a translation suppressed by miR-24. PLoS One 2008; 3: e1864.","journal-title":"PLoS One"},{"key":"BFcdd201376_CR53","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1046\/j.1365-2443.2003.00620.x","volume":"8","author":"H Iwasa","year":"2003","unstructured":"Iwasa H, Han J, Ishikawa F . Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells 2003; 8: 131\u2013144.","journal-title":"Genes Cells"},{"key":"BFcdd201376_CR54","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/ng1317","volume":"36","author":"DV Bulavin","year":"2004","unstructured":"Bulavin DV, Phillips C, Nannenga B, Timofeev O, Donehower LA, Anderson CW et al. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16Ink4a-p19 Arf pathway. Nat Genet 2004; 36: 343\u2013350.","journal-title":"Nat Genet"},{"key":"BFcdd201376_CR55","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/nm1388","volume":"12","author":"K Ito","year":"2006","unstructured":"Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K et al. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med 2006; 12: 446\u2013451.","journal-title":"Nat Med"},{"key":"BFcdd201376_CR56","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/35065000","volume":"410","author":"L Chang","year":"2001","unstructured":"Chang L, Karin M . Mammalian MAP kinase signaling cascades. Nature 2001; 410: 37\u201340.","journal-title":"Nature"},{"key":"BFcdd201376_CR57","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1038\/35059131","volume":"409","author":"N Ohtani","year":"2001","unstructured":"Ohtani N, Zebedee Z, Huot TJ, Stinson JA, Sugimoto M, Ohashi Y et al. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature 2001; 409: 1067\u20131070.","journal-title":"Nature"},{"key":"BFcdd201376_CR58","first-page":"73","volume":"1602","author":"S Ortega","year":"2002","unstructured":"Ortega S, Malumbres M, Barbacid M . Cyclin D-dependent kinases, INK4 inhibitors and cancer. BBA-Rev Cancer 2002; 1602: 73\u201387.","journal-title":"BBA-Rev Cancer"},{"key":"BFcdd201376_CR59","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/sj.onc.1201178","volume":"15","author":"F Zindy","year":"1997","unstructured":"Zindy F, Quelle DE, Roussel MF, Sherr CJ . Expression of the p16(INK4a) tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 1997; 15: 203\u2013211.","journal-title":"Oncogene"},{"key":"BFcdd201376_CR60","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1172\/JCI22475","volume":"114","author":"J Krishnamurthy","year":"2004","unstructured":"Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L et al. Ink4a\/Arf expression is a biomarker of aging. J Clin Invest 2004; 114: 1299\u20131307.","journal-title":"J Clin Invest"}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd201376.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201376","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201376.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T09:05:26Z","timestamp":1684400726000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd201376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,12]]},"references-count":60,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["BFcdd201376"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2013.76","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718031533.793488399","asserted-by":"object"}]},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,12]]}}}