{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:09:58Z","timestamp":1790622598715,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T00:00:00Z","timestamp":1415318400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1038\/cdd.2014.183","type":"journal-article","created":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T14:07:08Z","timestamp":1414764428000},"page":"946-958","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":150,"title":["Oncogenic BRAF induces chronic ER stress condition resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma"],"prefix":"10.1038","volume":"22","author":[{"given":"M","family":"Corazzari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Rapino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Ciccosanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Giglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Antonioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Conti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G M","family":"Fimia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P E","family":"Lovat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Piacentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,7]]},"reference":[{"key":"BFcdd2014183_CR1","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/S0140-6736(05)70937-5","volume":"365","author":"JF Thompson","year":"2005","unstructured":"Thompson JF, Scolyer RA, Kefford RF . Cutaneous melanoma. Lancet 2005; 365: 687\u2013701.","journal-title":"Lancet"},{"key":"BFcdd2014183_CR2","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.det.2012.04.007","volume":"30","author":"CJ Cockerell","year":"2012","unstructured":"Cockerell CJ . The pathology of melanoma. Dermatol Clin 2012; 30: 445\u2013468.","journal-title":"Dermatol Clin"},{"key":"BFcdd2014183_CR3","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.semcancer.2013.07.001","volume":"23","author":"M Corazzari","year":"2013","unstructured":"Corazzari M, Fimia GM, Lovat P, Piacentini M . Why is autophagy important for melanoma? molecular mechanisms and therapeutic implications. Semin Cancer Biol 2013; 23: 337\u2013343.","journal-title":"Semin Cancer Biol"},{"key":"BFcdd2014183_CR4","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1200\/JCO.2006.06.0442","volume":"25","author":"LA Fecher","year":"2007","unstructured":"Fecher LA, Cummings SD, Keefe MJ, Alani RM . Toward a molecular classification of melanoma. J Clin Oncol 2007; 25: 1606\u20131620.","journal-title":"J Clin Oncol"},{"key":"BFcdd2014183_CR5","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/sj.bjc.6606030","volume":"104","author":"HT Arkenau","year":"2011","unstructured":"Arkenau HT, Kefford R, Long GV . Targeting BRAF for patients with melanoma. Br J Cancer 2011; 104: 392\u2013398.","journal-title":"Br J Cancer"},{"key":"BFcdd2014183_CR6","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/35051606","volume":"409","author":"MS Soengas","year":"2001","unstructured":"Soengas MS, Capodieci P, Polsky D, Mora J, Esteller M, Opitz-Araya X et al. Inactivation of the apoptosis effector apaf-1 in malignant melanoma. Nature 2001; 409: 207\u2013211.","journal-title":"Nature"},{"key":"BFcdd2014183_CR7","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1046\/j.0022-202X.2004.22243.x","volume":"122","author":"H Tsao","year":"2004","unstructured":"Tsao H, Goel V, Wu H, Yang G, Haluska FG . Genetic interaction between NRAS and BRAF mutations and PTEN\/MMAC1 inactivation in melanoma. J Invest Dermatol 2004; 122: 337\u2013341.","journal-title":"J Invest Dermatol"},{"key":"BFcdd2014183_CR8","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1097\/00008390-200510000-00005","volume":"15","author":"S Ilmonen","year":"2005","unstructured":"Ilmonen S, Hernberg M, Pyrhonen S, Tarkkanen J, Asko-Seljavaara S . Ki-67, bcl-2 and p53 expression in primary and metastatic melanoma. Melanoma Res 2005; 15: 375\u2013381.","journal-title":"Melanoma Res"},{"key":"BFcdd2014183_CR9","doi-asserted-by":"publisher","first-page":"4934","DOI":"10.1158\/1078-0432.CCR-07-0665","volume":"13","author":"YF Wang","year":"2007","unstructured":"Wang YF, Jiang CC, Kiejda KA, Gillespie S, Zhang XD, Hersey P . Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the bcl-2 family members PUMA, bim, and mcl-1. Clin Cancer Res 2007; 13: 4934\u20134942.","journal-title":"Clin Cancer Res"},{"key":"BFcdd2014183_CR10","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1111\/exd.12254","volume":"22","author":"CS McKee","year":"2013","unstructured":"McKee CS, Hill DS, Redfern CP, Armstrong JL, Lovat PE . Oncogenic BRAF signalling increases mcl-1 expression in cutaneous metastatic melanoma. Exp Dermatol 2013; 22: 767\u2013769.","journal-title":"Exp Dermatol"},{"key":"BFcdd2014183_CR11","doi-asserted-by":"publisher","first-page":"9750","DOI":"10.1158\/0008-5472.CAN-07-2047","volume":"67","author":"CC Jiang","year":"2007","unstructured":"Jiang CC, Chen LH, Gillespie S, Wang YF, Kiejda KA, Zhang XD et al. Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis. Cancer Res 2007; 67: 9750\u20139761.","journal-title":"Cancer Res"},{"key":"BFcdd2014183_CR12","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1158\/0008-5472.CAN-03-3433","volume":"64","author":"C Wellbrock","year":"2004","unstructured":"Wellbrock C, Ogilvie L, Hedley D, Karasarides M, Martin J, Niculescu-Duvaz D et al. V599EB-RAF is an oncogene in melanocytes. Cancer Res 2004; 64: 2338\u20132342.","journal-title":"Cancer Res"},{"key":"BFcdd2014183_CR13","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/bjc.2013.325","volume":"109","author":"S Martin","year":"2013","unstructured":"Martin S, Lamb HK, Brady C, Lefkove B, Bonner MY, Thompson P et al. Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78. Br J Cancer 2013; 109: 433\u2013443.","journal-title":"Br J Cancer"},{"key":"BFcdd2014183_CR14","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1056\/NEJMoa1210093","volume":"367","author":"KT Flaherty","year":"2012","unstructured":"Flaherty KT, Infante JR, Daud A, Gonzalez R, Kefford RF, Sosman J et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 2012; 367: 1694\u20131703.","journal-title":"N Engl J Med"},{"key":"BFcdd2014183_CR15","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1158\/1535-7163.MCT-10-0799","volume":"10","author":"ER Cantwell-Dorris","year":"2011","unstructured":"Cantwell-Dorris ER, O'Leary JJ, Sheils OM . BRAFV600E: Implications for carcinogenesis and molecular therapy. Mol Cancer Ther 2011; 10: 385\u2013394.","journal-title":"Mol Cancer Ther"},{"key":"BFcdd2014183_CR16","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1007\/s00018-011-0878-0","volume":"69","author":"AH Aguissa-Toure","year":"2012","unstructured":"Aguissa-Toure AH, Li G . Genetic alterations of PTEN in human melanoma. Cell Mol Life Sci 2012; 69: 1475\u20131491.","journal-title":"Cell Mol Life Sci"},{"key":"BFcdd2014183_CR17","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.hoc.2009.04.001","volume":"23","author":"N Dhomen","year":"2009","unstructured":"Dhomen N, Marais R . BRAF signaling and targeted therapies in melanoma. Hematol Oncol Clin North Am 2009; 23: 529\u2013545 ix.","journal-title":"Hematol Oncol Clin North Am"},{"key":"BFcdd2014183_CR18","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/j.1600-0560.2009.01359.x","volume":"37","author":"R Lazova","year":"2010","unstructured":"Lazova R, Klump V, Pawelek J . Autophagy in cutaneous malignant melanoma. J Cutan Pathol. 2010; 37: 256\u2013268.","journal-title":"J Cutan Pathol."},{"key":"BFcdd2014183_CR19","doi-asserted-by":"publisher","first-page":"3478","DOI":"10.1158\/1078-0432.CCR-10-2372","volume":"17","author":"XH Ma","year":"2011","unstructured":"Ma XH, Piao S, Wang D, McAfee QW, Nathanson KL, Lum JJ et al. Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma. Clin Cancer Res 2011; 17: 3478\u20133489.","journal-title":"Clin Cancer Res"},{"key":"BFcdd2014183_CR20","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.1158\/1078-0432.CCR-10-3003","volume":"17","author":"JL Armstrong","year":"2011","unstructured":"Armstrong JL, Corazzari M, Martin S, Pagliarini V, Falasca L, Hill DS et al. Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition. Clin Cancer Res 2011; 17: 2216\u20132226.","journal-title":"Clin Cancer Res"},{"key":"BFcdd2014183_CR21","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1007\/s00018-010-0284-z","volume":"67","author":"GM Fimia","year":"2010","unstructured":"Fimia GM, Piacentini M . Regulation of autophagy in mammals and its interplay with apoptosis. Cell Mol Life Sci 2010; 67: 1581\u20131588.","journal-title":"Cell Mol Life Sci"},{"key":"BFcdd2014183_CR22","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/nrc3262","volume":"12","author":"E White","year":"2012","unstructured":"White E . Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer 2012; 12: 401\u2013410.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd2014183_CR23","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/j.1755-148X.2008.00467.x","volume":"21","author":"P Hersey","year":"2008","unstructured":"Hersey P, Zhang XD . Adaptation to ER stress as a driver of malignancy and resistance to therapy in human melanoma. Pigment Cell Melanoma Res 2008; 21: 358\u2013367.","journal-title":"Pigment Cell Melanoma Res"},{"key":"BFcdd2014183_CR24","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.tcb.2003.11.001","volume":"14","author":"DT Rutkowski","year":"2004","unstructured":"Rutkowski DT, Kaufman RJ . A trip to the ER: Coping with stress. Trends Cell Biol 2004; 14: 20\u201328.","journal-title":"Trends Cell Biol"},{"key":"BFcdd2014183_CR25","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.pharmthera.2012.02.003","volume":"134","author":"AM Gorman","year":"2012","unstructured":"Gorman AM, Healy SJ, Jager R, Samali A . Stress management at the ER: Regulators of ER stress-induced apoptosis. Pharmacol Ther 2012; 134: 306\u2013316.","journal-title":"Pharmacol Ther"},{"key":"BFcdd2014183_CR26","doi-asserted-by":"publisher","first-page":"930509","DOI":"10.1155\/2010\/930509","volume":"2010","author":"T Verfaillie","year":"2010","unstructured":"Verfaillie T, Salazar M, Velasco G, Agostinis P . Linking ER stress to autophagy: Potential implications for cancer therapy. Int J Cell Biol 2010; 2010: 930509","journal-title":"Int J Cell Biol"},{"key":"BFcdd2014183_CR27","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1038\/nrc1505","volume":"4","author":"Y Ma","year":"2004","unstructured":"Ma Y, Hendershot LM . The role of the unfolded protein response in tumour development: Friend or foe? Nat Rev Cancer 2004; 4: 966\u2013977.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd2014183_CR28","doi-asserted-by":"publisher","first-page":"e374","DOI":"10.1371\/journal.pbio.0040374","volume":"4","author":"DT Rutkowski","year":"2006","unstructured":"Rutkowski DT, Arnold SM, Miller CN, Wu J, Li J, Gunnison KM et al. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol 2006; 4: e374.","journal-title":"PLoS Biol"},{"key":"BFcdd2014183_CR29","doi-asserted-by":"publisher","first-page":"e423","DOI":"10.1371\/journal.pbio.0040423","volume":"4","author":"S Bernales","year":"2006","unstructured":"Bernales S, McDonald KL, Walter P . Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol 2006; 4: e423.","journal-title":"PLoS Biol"},{"key":"BFcdd2014183_CR30","unstructured":"Corazzari M, Lovat PE . Harnessing autophagy for melanoma benefit. Cell Biol: Res Ther 2013; 2."},{"key":"BFcdd2014183_CR31","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1038\/jid.2010.26","volume":"130","author":"N Maddodi","year":"2010","unstructured":"Maddodi N, Huang W, Havighurst T, Kim K, Longley BJ, Setaluri V . Induction of autophagy and inhibition of melanoma growth in vitro and in vivo by hyperactivation of oncogenic BRAF. J Invest Dermatol 2010; 130: 1657\u20131667.","journal-title":"J Invest Dermatol"},{"key":"BFcdd2014183_CR32","doi-asserted-by":"publisher","first-page":"5363","DOI":"10.1158\/0008-5472.CAN-08-0035","volume":"68","author":"PE Lovat","year":"2008","unstructured":"Lovat PE, Corazzari M, Armstrong JL, Martin S, Pagliarini V, Hill D et al. Increasing melanoma cell death using inhibitors of protein disulfide isomerases to abrogate survival responses to endoplasmic reticulum stress. Cancer Res 2008; 68: 5363\u20135369.","journal-title":"Cancer Res"},{"key":"BFcdd2014183_CR33","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1038\/sj.bjc.6603672","volume":"96","author":"M Corazzari","year":"2007","unstructured":"Corazzari M, Lovat PE, Armstrong JL, Fimia GM, Hill DS, Birch-Machin M et al. Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: The role of stress proteins ERdj5 and ERp57. Br J Cancer 2007; 96: 1062\u20131071.","journal-title":"Br J Cancer"},{"key":"BFcdd2014183_CR34","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1172\/JCI70454","volume":"124","author":"XH Ma","year":"2014","unstructured":"Ma XH, Piao SF, Dey S, McAfee Q, Karakousis G, Villanueva J et al. Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma. J Clin Invest 2014; 124: 1406\u20131417.","journal-title":"J Clin Invest"},{"key":"BFcdd2014183_CR35","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1101\/gad.992302","volume":"16","author":"H Nishitoh","year":"2002","unstructured":"Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K et al. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev 2002; 16: 1345\u20131355.","journal-title":"Genes Dev"},{"key":"BFcdd2014183_CR36","doi-asserted-by":"publisher","first-page":"13681","DOI":"10.1073\/pnas.251194298","volume":"98","author":"BL Bennett","year":"2001","unstructured":"Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W et al. SP600125, an anthrapyrazolone inhibitor of jun N-terminal kinase. Proc Natl Acad Sci U S A 2001; 98: 13681\u201313686.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"BFcdd2014183_CR37","doi-asserted-by":"publisher","first-page":"3004","DOI":"10.1038\/onc.2013.256","volume":"33","author":"W He","year":"2013","unstructured":"He W, Wang Q, Srinivasan B, Xu J, Padilla MT, Li Z et al. A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy. Oncogene 2013; 33: 3004\u20133013.","journal-title":"Oncogene"},{"key":"BFcdd2014183_CR38","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.cell.2005.07.002","volume":"122","author":"S Pattingre","year":"2005","unstructured":"Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N et al. Bcl-2 antiapoptotic proteins inhibit beclin 1-dependent autophagy. Cell 2005; 122: 927\u2013939.","journal-title":"Cell"},{"key":"BFcdd2014183_CR39","doi-asserted-by":"publisher","first-page":"8469","DOI":"10.1128\/MCB.19.12.8469","volume":"19","author":"K Yamamoto","year":"1999","unstructured":"Yamamoto K, Ichijo H, Korsmeyer SJ . BCL-2 is phosphorylated and inactivated by an ASK1\/jun N-terminal protein kinase pathway normally activated at G(2)\/M. Mol Cell Biol 1999; 19: 8469\u20138478.","journal-title":"Mol Cell Biol"},{"key":"BFcdd2014183_CR40","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.4161\/auto.5.7.9508","volume":"5","author":"M Salazar","year":"2009","unstructured":"Salazar M, Carracedo A, Salanueva IJ, Hern\u00e1ndez-Tiedra S, Egia A, Lorente M et al. TRB3 links ER stress to autophagy in cannabinoid anti-tumoral action. Autophagy 2009; 5: 1048\u20131049.","journal-title":"Autophagy"},{"key":"BFcdd2014183_CR41","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1172\/JCI37948","volume":"119","author":"M Salazar","year":"2009","unstructured":"Salazar M, Carracedo A, Salanueva IJ, Hern\u00e1ndez-Tiedra S, Lorente M, Egia A et al. Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J Clin Invest 2009; 119: 1359\u20131372.","journal-title":"J Clin Invest"},{"key":"BFcdd2014183_CR42","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1111\/j.1755-148X.2008.00520.x","volume":"22","author":"Y Estrada","year":"2009","unstructured":"Estrada Y, Dong J, Ossowski L . Positive crosstalk between ERK and p38 in melanoma stimulates migration and in vivo proliferation. Pigment Cell Melanoma Res 2009; 22: 66\u201376.","journal-title":"Pigment Cell Melanoma Res"},{"key":"BFcdd2014183_CR43","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1158\/0008-5472.CAN-05-3092","volume":"66","author":"AC Ranganathan","year":"2006","unstructured":"Ranganathan AC, Zhang L, Adam AP, Aguirre-Ghiso JA . Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells. Cancer Res 2006; 66: 1702\u20131711.","journal-title":"Cancer Res"},{"key":"BFcdd2014183_CR44","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1126\/science.1128294","volume":"313","author":"U Ozcan","year":"2006","unstructured":"Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006; 313: 1137\u20131140.","journal-title":"Science"},{"key":"BFcdd2014183_CR45","first-page":"23","volume":"1","author":"M Corazzari","year":"2013","unstructured":"Corazzari M . ER stress & autophagy in cancer: Contenders or partners in crime? Int J Mol Biol Biochem 2013; 1: 23.","journal-title":"Int J Mol Biol Biochem"},{"key":"BFcdd2014183_CR46","doi-asserted-by":"publisher","first-page":"721","DOI":"10.4161\/cbt.5.7.3120","volume":"5","author":"AS Lee","year":"2006","unstructured":"Lee AS, Hendershot LM . ER stress and cancer. Cancer Biol Ther 2006; 5: 721\u2013722.","journal-title":"Cancer Biol Ther"},{"key":"BFcdd2014183_CR47","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.molcel.2009.04.026","volume":"34","author":"V Kirkin","year":"2009","unstructured":"Kirkin V, McEwan DG, Novak I, Dikic I . A role for ubiquitin in selective autophagy. Mol Cell 2009; 34: 259\u2013269.","journal-title":"Mol Cell"},{"key":"BFcdd2014183_CR48","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1126\/science.1208347","volume":"334","author":"M Michaud","year":"2011","unstructured":"Michaud M, Martins I, Sukkurwala AQ, Adjemian S, Ma Y, Pellegatti P et al. Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Science 2011; 334: 1573\u20131577.","journal-title":"Science"},{"key":"BFcdd2014183_CR49","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/nature12865","volume":"504","author":"MT Rosenfeldt","year":"2013","unstructured":"Rosenfeldt MT, O'Prey J, Morton JP, Nixon C, MacKay G, Mrowinska A et al. P53 status determines the role of autophagy in pancreatic tumour development. Nature 2013; 504: 296\u2013300.","journal-title":"Nature"},{"key":"BFcdd2014183_CR50","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1038\/cdd.2012.27","volume":"19","author":"V Pagliarini","year":"2012","unstructured":"Pagliarini V, Wirawan E, Romagnoli A, Ciccosanti F, Lisi G, Lippens S et al. PMC3422474; proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response. Cell Death Differ 2012; 19: 1495\u20131504.","journal-title":"Cell Death Differ"},{"key":"BFcdd2014183_CR51","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/0092-8674(94)90380-8","volume":"76","author":"B Derijard","year":"1994","unstructured":"Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T et al. JNK1: A protein kinase stimulated by UV light and ha-ras that binds and phosphorylates the c-jun activation domain. Cell 1994; 76: 1025\u20131037.","journal-title":"Cell"},{"key":"BFcdd2014183_CR52","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1074\/jbc.273.3.1741","volume":"273","author":"H Enslen","year":"1998","unstructured":"Enslen H, Raingeaud J, Davis RJ . Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J Biol Chem 1998; 273: 1741\u20131748.","journal-title":"J Biol Chem"},{"key":"BFcdd2014183_CR53","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1083\/jcb.201002100","volume":"191","author":"S Di Bartolomeo","year":"2010","unstructured":"Di Bartolomeo S, Corazzari M, Nazio F, Oliverio S, Lisi G, Antonioli M et al. The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy. J Cell Biol 2010; 191: 155\u2013168.","journal-title":"J Cell Biol"}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd2014183.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2014183","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2014183.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:06:32Z","timestamp":1684415192000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd2014183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,7]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["BFcdd2014183"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2014.183","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,7]]},"assertion":[{"value":"18 March 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}