{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:17:49Z","timestamp":1791206269400,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T00:00:00Z","timestamp":1417132800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1038\/cdd.2014.191","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T12:58:31Z","timestamp":1417179511000},"page":"1012-1024","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["A novel RIPK4\u2013IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes"],"prefix":"10.1038","volume":"22","author":[{"given":"P","family":"De Groote","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H T","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Fransen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Tanghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Urwyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"De Craene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Leurs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Van Imschoot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"De Rycke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C J","family":"Gu\u00e9rin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Berx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Vandenabeele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Lippens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Vleminckx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Declercq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,28]]},"reference":[{"issue":"Part 2","key":"BFcdd2014191_CR1","first-page":"321","volume":"103","author":"AD Hoyes","year":"1968","unstructured":"Hoyes AD . Electron microscopy of the surface layer (periderm) of human foetal skin. J Anat 1968; 103 (Part 2): 321\u2013336.","journal-title":"J Anat"},{"key":"BFcdd2014191_CR2","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/1523-1747.ep12598029","volume":"65","author":"KA Holbrook","year":"1975","unstructured":"Holbrook KA, Odland GF . The fine structure of developing human epidermis: light, scanning, and transmission electron microscopy of the periderm. J Invest Dermatol 1975; 65: 16\u201338.","journal-title":"J Invest Dermatol"},{"key":"BFcdd2014191_CR3","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1016\/S0960-9822(02)01075-8","volume":"12","author":"P Holland","year":"2002","unstructured":"Holland P, Willis C, Kanaly S, Glaccum M, Warren A, Charrier K et al. RIP4 is an ankyrin repeat-containing kinase essential for keratinocyte differentiation. Curr Biol 2002; 12: 1424\u20131428.","journal-title":"Curr Biol"},{"key":"BFcdd2014191_CR4","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/jid.2009.223","volume":"130","author":"RB Rountree","year":"2010","unstructured":"Rountree RB, Willis CR, Dinh H, Blumberg H, Bailey K, Dean Jr C et al. RIP4 regulates epidermal differentiation and cutaneous inflammation. J Invest Dermatol 2010; 130: 102\u2013112.","journal-title":"J Invest Dermatol"},{"key":"BFcdd2014191_CR5","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/sj.jid.5700588","volume":"127","author":"S Adams","year":"2007","unstructured":"Adams S, Pankow S, Werner S, Munz B . Regulation of NF-kappaB activity and keratinocyte differentiation by the RIP4 protein: implications for cutaneous wound repair. J Invest Dermatol 2007; 127: 538\u2013544.","journal-title":"J Invest Dermatol"},{"key":"BFcdd2014191_CR6","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.tibs.2005.01.003","volume":"30","author":"E Meylan","year":"2005","unstructured":"Meylan E, Tschopp J . The RIP kinases: crucial integrators of cellular stress. Trends Biochem Sci 2005; 30: 151\u2013159.","journal-title":"Trends Biochem Sci"},{"key":"BFcdd2014191_CR7","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/cmi.2010.10","volume":"7","author":"D Zhang","year":"2010","unstructured":"Zhang D, Lin J, Han J . Receptor-interacting protein (RIP) kinase family. Cell Mol Immunol 2010; 7: 243\u2013249.","journal-title":"Cell Mol Immunol"},{"key":"BFcdd2014191_CR8","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ajhg.2011.11.013","volume":"90","author":"K Mitchell","year":"2012","unstructured":"Mitchell K, O'Sullivan J, Missero C, Blair E, Richardson R, Anderson B et al. Exome sequence identifies RIPK4 as the Bartsocas\u2013Papas syndrome locus. Am J Hum Genet 2012; 90: 69\u201375.","journal-title":"Am J Hum Genet"},{"key":"BFcdd2014191_CR9","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ajhg.2011.11.014","volume":"90","author":"E Kalay","year":"2012","unstructured":"Kalay E, Sezgin O, Chellappa V, Mutlu M, Morsy H, Kayserili H et al. Mutations in RIPK4 cause the autosomal-recessive form of popliteal pterygium syndrome. Am J Hum Genet 2012; 90: 76\u201385.","journal-title":"Am J Hum Genet"},{"key":"BFcdd2014191_CR10","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1038\/ng1903","volume":"38","author":"CR Ingraham","year":"2006","unstructured":"Ingraham CR, Kinoshita A, Kondo S, Yang B, Sajan S, Trout KJ et al. Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6). Nat Genet 2006; 38: 1335\u20131340.","journal-title":"Nat Genet"},{"key":"BFcdd2014191_CR11","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1038\/ng1894","volume":"38","author":"RJ Richardson","year":"2006","unstructured":"Richardson RJ, Dixon J, Malhotra S, Hardman MJ, Knowles L, Boot-Handford RP et al. Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch. Nat Genet 2006; 38: 1329\u20131334.","journal-title":"Nat Genet"},{"key":"BFcdd2014191_CR12","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/ng985","volume":"32","author":"S Kondo","year":"2002","unstructured":"Kondo S, Schutte BC, Richardson RJ, Bjork BC, Knight AS, Watanabe Y et al. Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. Nat Genet 2002; 32: 285\u2013289.","journal-title":"Nat Genet"},{"key":"BFcdd2014191_CR13","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/jid.2011.272","volume":"132","author":"LC Biggs","year":"2012","unstructured":"Biggs LC, Rhea L, Schutte BC, Dunnwald M . Interferon regulatory factor 6 is necessary, but not sufficient, for keratinocyte differentiation. J Invest Dermatol 2012; 132: 50\u201358.","journal-title":"J Invest Dermatol"},{"key":"BFcdd2014191_CR14","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1152\/physrev.00004.2010","volume":"91","author":"CM Niessen","year":"2011","unstructured":"Niessen CM, Leckband D, Yap AS . Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation. Physiol Rev 2011; 91: 691\u2013731.","journal-title":"Physiol Rev"},{"key":"BFcdd2014191_CR15","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1083\/jcb.143.2.469","volume":"143","author":"KM McGowan","year":"1998","unstructured":"McGowan KM, Coulombe PA . Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development. J Cell Biol 1998; 143: 469\u2013486.","journal-title":"J Cell Biol"},{"key":"BFcdd2014191_CR16","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0925-4773(00)00489-5","volume":"100","author":"S Mazzalupo","year":"2001","unstructured":"Mazzalupo S, Coulombe PA . A reporter transgene based on a human keratin 6 gene promoter is specifically expressed in the periderm of mouse embryos. Mech Dev 2001; 100: 65\u201369.","journal-title":"Mech Dev"},{"issue":"Part 3","key":"BFcdd2014191_CR17","first-page":"453","volume":"108","author":"DK Whittaker","year":"1971","unstructured":"Whittaker DK, Adams D . The surface layer of human foetal skin and oral mucosa: a study by scanning and transmission electron microscopy. J Anat 1971; 108 (Part 3): 453\u2013464.","journal-title":"J Anat"},{"key":"BFcdd2014191_CR18","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1242\/dev.125.8.1541","volume":"125","author":"MJ Hardman","year":"1998","unstructured":"Hardman MJ, Sisi P, Banbury DN, Byrne C . Patterned acquisition of skin barrier function during development. Development 1998; 125: 1541\u20131552.","journal-title":"Development"},{"key":"BFcdd2014191_CR19","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/S1074-7613(00)80194-6","volume":"12","author":"A Devin","year":"2000","unstructured":"Devin A, Cook A, Lin Y, Rodriguez Y, Kelliher M, Liu Z . The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation. Immunity 2000; 12: 419\u2013429.","journal-title":"Immunity"},{"key":"BFcdd2014191_CR20","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/S0960-9822(07)00352-1","volume":"8","author":"M Thome","year":"1998","unstructured":"Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C et al. Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. Curr Biol 1998; 8: 885\u2013888.","journal-title":"Curr Biol"},{"key":"BFcdd2014191_CR21","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1093\/embo-reports\/kvf236","volume":"3","author":"E Meylan","year":"2002","unstructured":"Meylan E, Martinon F, Thome M, Gschwendt M, Tschopp J . RIP4 (DIK\/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis. EMBO Rep 2002; 3: 1201\u20131208.","journal-title":"EMBO Rep"},{"key":"BFcdd2014191_CR22","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1126\/science.1232253","volume":"339","author":"X Huang","year":"2013","unstructured":"Huang X, McGann JC, Liu BY, Hannoush RN, Lill JR, Pham V et al. Phosphorylation of dishevelled by protein kinase RIPK4 regulates Wnt signaling. Science 2013; 339: 1441\u20131445.","journal-title":"Science"},{"key":"BFcdd2014191_CR23","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/0092-8674(94)90069-8","volume":"79","author":"J Heasman","year":"1994","unstructured":"Heasman J, Crawford A, Goldstone K, Garner-Hamrick P, Gumbiner B, McCrea P et al. Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos. Cell 1994; 79: 791\u2013803.","journal-title":"Cell"},{"key":"BFcdd2014191_CR24","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1126\/science.1079478","volume":"298","author":"R Keller","year":"2002","unstructured":"Keller R . Shaping the vertebrate body plan by polarized embryonic cell movements. Science 2002; 298: 1950\u20131954.","journal-title":"Science"},{"key":"BFcdd2014191_CR25","doi-asserted-by":"publisher","first-page":"R213","DOI":"10.1016\/j.cub.2005.03.016","volume":"15","author":"L Solnica-Krezel","year":"2005","unstructured":"Solnica-Krezel L . Conserved patterns of cell movements during vertebrate gastrulation. Curr Biol 2005; 15: R213\u2013R228.","journal-title":"Curr Biol"},{"key":"BFcdd2014191_CR26","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1046\/j.1432-0436.2003.710301.x","volume":"71","author":"R Keller","year":"2003","unstructured":"Keller R, Davidson LA, Shook DR . How we are shaped: the biomechanics of gastrulation. Differentiation 2003; 71: 171\u2013205.","journal-title":"Differentiation"},{"key":"BFcdd2014191_CR27","first-page":"201","volume":"60","author":"RE Keller","year":"1980","unstructured":"Keller RE . The cellular basis of epiboly: an SEM study of deep-cell rearrangement during gastrulation in Xenopus laevis. J Embryol Exp Morphol 1980; 60: 201\u2013234.","journal-title":"J Embryol Exp Morphol"},{"key":"BFcdd2014191_CR28","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.ydbio.2008.10.031","volume":"325","author":"JL Sabel","year":"2009","unstructured":"Sabel JL, d'Alencon C, O'Brien EK, Van Otterloo E, Lutz K, Cuykendall TN et al. Maternal interferon regulatory factor 6 is required for the differentiation of primary superficial epithelia in Danio and Xenopus embryos. Dev Biol 2009; 325: 249\u2013262.","journal-title":"Dev Biol"},{"key":"BFcdd2014191_CR29","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1002\/ajmg.a.33338","volume":"152A","author":"N Matsuzawa","year":"2010","unstructured":"Matsuzawa N, Kondo S, Shimozato K, Nagao T, Nakano M, Tsuda M et al. Two missense mutations of the IRF6 gene in two Japanese families with popliteal pterygium syndrome. Am J Med Genet A 2010; 152A: 2262\u20132267.","journal-title":"Am J Med Genet A"},{"key":"BFcdd2014191_CR30","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1136\/jmg.9.2.222","volume":"9","author":"CS Bartsocas","year":"1972","unstructured":"Bartsocas CS, Papas CV . Popliteal pterygium syndrome. Evidence for a severe autosomal recessive form. J Med Genet 1972; 9: 222\u2013226.","journal-title":"J Med Genet"},{"key":"BFcdd2014191_CR31","doi-asserted-by":"publisher","first-page":"2632","DOI":"10.1093\/hmg\/ddp201","volume":"18","author":"RJ Richardson","year":"2009","unstructured":"Richardson RJ, Dixon J, Jiang R, Dixon MJ . Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence. Hum Mol Genet 2009; 18: 2632\u20132642.","journal-title":"Hum Mol Genet"},{"key":"BFcdd2014191_CR32","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/35070605","volume":"410","author":"Y Hu","year":"2001","unstructured":"Hu Y, Baud V, Oga T, Kim KI, Yoshida K, Karin M . IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature 2001; 410: 710\u2013714.","journal-title":"Nature"},{"key":"BFcdd2014191_CR33","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1126\/science.284.5412.316","volume":"284","author":"Y Hu","year":"1999","unstructured":"Hu Y, Baud V, Delhase M, Zhang P, Deerinck T, Ellisman M et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science 1999; 284: 316\u2013320.","journal-title":"Science"},{"key":"BFcdd2014191_CR34","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1126\/science.284.5412.313","volume":"284","author":"K Takeda","year":"1999","unstructured":"Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T et al. Limb and skin abnormalities in mice lacking IKKalpha. Science 1999; 284: 313\u2013316.","journal-title":"Science"},{"key":"BFcdd2014191_CR35","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/ncb1560","volume":"9","author":"R Gareus","year":"2007","unstructured":"Gareus R, Huth M, Breiden B, Nenci A, Rosch N, Haase I et al. Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation. Nat Cell Biol 2007; 9: 461\u2013469.","journal-title":"Nat Cell Biol"},{"key":"BFcdd2014191_CR36","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/jid.2012.269","volume":"133","author":"G de la Garza","year":"2013","unstructured":"de la Garza G, Schleiffarth JR, Dunnwald M, Mankad A, Weirather JL, Bonde G et al. Interferon regulatory factor 6 promotes differentiation of the periderm by activating expression of grainyhead-like 3. J Invest Dermatol 2013; 133: 68\u201377.","journal-title":"J Invest Dermatol"},{"key":"BFcdd2014191_CR37","doi-asserted-by":"publisher","first-page":"31077","DOI":"10.1074\/jbc.M114.589382","volume":"289","author":"MQ Kwa","year":"2014","unstructured":"Kwa MQ, Huynh J, Aw J, Zhang L, Nguyen T, Reynolds EC et al. Receptor-interacting protein kinase 4 and interferon regulatory factor 6 function as a signaling axis to regulate keratinocyte differentiation. J Biol Chem 2014; 289: 31077\u201331087.","journal-title":"J Biol Chem"},{"key":"BFcdd2014191_CR38","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1172\/JCI40266","volume":"120","author":"HA Thomason","year":"2010","unstructured":"Thomason HA, Zhou H, Kouwenhoven EN, Dotto GP, Restivo G, Nguyen BC et al. Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice. J Clin Invest 2010; 120: 1561\u20131569.","journal-title":"J Clin Invest"},{"key":"BFcdd2014191_CR39","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1172\/JCI40267","volume":"120","author":"F Moretti","year":"2010","unstructured":"Moretti F, Marinari B, Lo Iacono N, Botti E, Giunta A, Spallone G et al. A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias. J Clin Invest 2010; 120: 1570\u20131577.","journal-title":"J Clin Invest"},{"key":"BFcdd2014191_CR40","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/978-94-007-4186-7_13","volume":"60","author":"R Winklbauer","year":"2012","unstructured":"Winklbauer R . Cadherin function during Xenopus gastrulation. Sub-cell Biochem 2012; 60: 301\u2013320.","journal-title":"Sub-cell Biochem"},{"key":"BFcdd2014191_CR41","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1083\/jcb.126.2.519","volume":"126","author":"WM Brieher","year":"1994","unstructured":"Brieher WM, Gumbiner BM . Regulation of C-cadherin function during activin induced morphogenesis of Xenopus animal caps. J Cell Biol 1994; 126: 519\u2013527.","journal-title":"J Cell Biol"},{"key":"BFcdd2014191_CR42","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/nrm1699","volume":"6","author":"BM Gumbiner","year":"2005","unstructured":"Gumbiner BM . Regulation of cadherin-mediated adhesion in morphogenesis. Nat Rev Mol Cell Biol 2005; 6: 622\u2013634.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcdd2014191_CR43","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/B978-0-12-394311-8.00002-9","volume":"116","author":"C Collinet","year":"2013","unstructured":"Collinet C, Lecuit T . Stability and dynamics of cell\u2013cell junctions. Progr Mol Biol Transl Sci 2013; 116: 25\u201347.","journal-title":"Progr Mol Biol Transl Sci"},{"key":"BFcdd2014191_CR44","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1242\/dev.128.18.3635","volume":"128","author":"M Marsden","year":"2001","unstructured":"Marsden M, DeSimone DW . Regulation of cell polarity, radial intercalation and epiboly in Xenopus: novel roles for integrin and fibronectin. Development 2001; 128: 3635\u20133647.","journal-title":"Development"},{"key":"BFcdd2014191_CR45","doi-asserted-by":"publisher","first-page":"4266","DOI":"10.1242\/dev.096073","volume":"140","author":"NI Petridou","year":"2013","unstructured":"Petridou NI, Stylianou P, Skourides PA . A dominant-negative provides new insights into FAK regulation and function in early embryonic morphogenesis. Development 2013; 140: 4266\u20134276.","journal-title":"Development"},{"key":"BFcdd2014191_CR46","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nrm2618","volume":"10","author":"SJ Arnold","year":"2009","unstructured":"Arnold SJ, Robertson EJ . Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo. Nat Rev Mol Cell Biol 2009; 10: 91\u2013103.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcdd2014191_CR47","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0092-8674(01)00336-1","volume":"105","author":"J Huelsken","year":"2001","unstructured":"Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W . Beta-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 2001; 105: 533\u2013545.","journal-title":"Cell"}],"container-title":["Cell Death & Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd2014191.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2014191","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2014191.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:06:36Z","timestamp":1684415196000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd2014191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,28]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["BFcdd2014191"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2014.191","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,28]]},"assertion":[{"value":"31 May 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}