{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:19:02Z","timestamp":1790900342594,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T00:00:00Z","timestamp":1393545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1038\/cdd.2014.26","type":"journal-article","created":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T15:55:19Z","timestamp":1393602919000},"page":"1071-1080","source":"Crossref","is-referenced-by-count":34,"title":["G0\/G1 switch gene 2 has a critical role in adipocyte differentiation"],"prefix":"10.1038","volume":"21","author":[{"given":"H","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T-H","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H J","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y J","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S J","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K-S","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S W","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-w","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,28]]},"reference":[{"key":"BFcdd201426_CR1","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/35007508","volume":"404","author":"PG Kopelman","year":"2000","unstructured":"Kopelman PG . Obesity as a medical problem. Nature 2000; 404: 635\u2013643.","journal-title":"Nature"},{"key":"BFcdd201426_CR2","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1152\/physrev.1998.78.3.783","volume":"78","author":"FM Gregoire","year":"1998","unstructured":"Gregoire FM, Smas CM, Sul HS . Understanding adipocyte differentiation. Physiol Rev 1998; 78: 783\u2013809.","journal-title":"Physiol Rev"},{"key":"BFcdd201426_CR3","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/S0092-8674(00)81359-8","volume":"87","author":"BM Spiegelman","year":"1996","unstructured":"Spiegelman BM, Flier JS . Adipogenesis and obesity: rounding out the big picture. Cell 1996; 87: 377\u2013389.","journal-title":"Cell"},{"key":"BFcdd201426_CR4","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1146\/annurev.cellbio.16.1.145","volume":"16","author":"ED Rosen","year":"2000","unstructured":"Rosen ED, Spiegelman BM . Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol 2000; 16: 145\u2013171.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"BFcdd201426_CR5","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0092-8674(75)90087-2","volume":"5","author":"H Green","year":"1975","unstructured":"Green H, Kehinde O . An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell 1975; 5: 19\u201327.","journal-title":"Cell"},{"key":"BFcdd201426_CR6","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1146\/annurev.bi.64.070195.002021","volume":"64","author":"OA MacDougald","year":"1995","unstructured":"MacDougald OA, Lane MD . Transcriptional regulation of gene expression during adipocyte differentiation. Annu Rev Biochem 1995; 64: 345\u2013373.","journal-title":"Annu Rev Biochem"},{"key":"BFcdd201426_CR7","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1073\/pnas.0137044100","volume":"100","author":"QQ Tang","year":"2003","unstructured":"Tang QQ, Otto TC, Lane MD . Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc Natl Acad Sci USA 2003; 100: 44\u201349.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201426_CR8","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/nrm2066","volume":"7","author":"ED Rosen","year":"2006","unstructured":"Rosen ED, MacDougald OA . Adipocyte differentiation from the inside out. Nat Rev 2006; 7: 885\u2013896.","journal-title":"Nat Rev"},{"key":"BFcdd201426_CR9","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1101\/gad.14.11.1293","volume":"14","author":"ED Rosen","year":"2000","unstructured":"Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM . Transcriptional regulation of adipogenesis. Genes Dev 2000; 14: 1293\u20131307.","journal-title":"Genes Dev"},{"key":"BFcdd201426_CR10","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S1097-2765(00)80306-8","volume":"3","author":"Z Wu","year":"1999","unstructured":"Wu Z, Rosen ED, Brun R, Hauser S, Adelmant G, Troy AE et al. Cross-regulation of C\/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol cell 1999; 3: 151\u2013158.","journal-title":"Mol cell"},{"key":"BFcdd201426_CR11","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nm1025","volume":"10","author":"RM Evans","year":"2004","unstructured":"Evans RM, Barish GD, Wang YX . PPARs and the complex journey to obesity. Nat Med 2004; 10: 355\u2013361.","journal-title":"Nat Med"},{"key":"BFcdd201426_CR12","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.cmet.2006.07.001","volume":"4","author":"SR Farmer","year":"2006","unstructured":"Farmer SR . Transcriptional control of adipocyte formation. Cell Metab 2006; 4: 263\u2013273.","journal-title":"Cell Metab"},{"key":"BFcdd201426_CR13","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/0092-8674(94)90006-X","volume":"79","author":"P Tontonoz","year":"1994","unstructured":"Tontonoz P, Hu E, Spiegelman BM . Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 1994; 79: 1147\u20131156.","journal-title":"Cell"},{"key":"BFcdd201426_CR14","doi-asserted-by":"publisher","first-page":"9766","DOI":"10.1073\/pnas.0503891102","volume":"102","author":"QQ Tang","year":"2005","unstructured":"Tang QQ, Gronborg M, Huang H, Kim JW, Otto TC, Pandey A et al. Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3beta is required for adipogenesis. Proc Natl Acad Sci USA 2005; 102: 9766\u20139771.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201426_CR15","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1073\/pnas.0337434100","volume":"100","author":"QQ Tang","year":"2003","unstructured":"Tang QQ, Otto TC, Lane MD . CCAAT\/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis. Proc Natl Acad Sci USA 2003; 100: 850\u2013855.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201426_CR16","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1089\/dna.1991.10.581","volume":"10","author":"L Russell","year":"1991","unstructured":"Russell L, Forsdyke DR . A human putative lymphocyte G0\/G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated. DNA Cell Biol 1991; 10: 581\u2013591.","journal-title":"DNA Cell Biol"},{"key":"BFcdd201426_CR17","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1042\/BJ20050636","volume":"392","author":"F Zandbergen","year":"2005","unstructured":"Zandbergen F, Mandard S, Escher P, Tan NS, Patsouris D, Jatkoe T et al. The G0\/G1 switch gene 2 is a novel PPAR target gene. Biochem J 2005; 392: 313\u2013324.","journal-title":"Biochem J"},{"key":"BFcdd201426_CR18","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.cmet.2010.02.003","volume":"11","author":"X Yang","year":"2010","unstructured":"Yang X, Lu X, Lombes M, Rha GB, Chi YI, Guerin TM et al. The G(0)\/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab 2010; 11: 194\u2013205.","journal-title":"Cell Metab"},{"key":"BFcdd201426_CR19","doi-asserted-by":"crossref","first-page":"30761","DOI":"10.1016\/S0021-9258(18)47344-9","volume":"269","author":"T Fernandes-Alnemri","year":"1994","unstructured":"Fernandes-Alnemri T, Litwack G, Alnemri ES . CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J Biol Chem 1994; 269: 30761\u201330764.","journal-title":"J Biol Chem"},{"key":"BFcdd201426_CR20","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1074\/jbc.274.4.2225","volume":"274","author":"DM Finucane","year":"1999","unstructured":"Finucane DM, Bossy-Wetzel E, Waterhouse NJ, Cotter TG, Green DR . Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL. J Biol Chem 1999; 274: 2225\u20132233.","journal-title":"J Biol Chem"},{"key":"BFcdd201426_CR21","doi-asserted-by":"publisher","first-page":"13656","DOI":"10.1073\/pnas.1203218109","volume":"109","author":"YJ Lee","year":"2012","unstructured":"Lee YJ, Ko EH, Kim JE, Kim E, Lee H, Choi H et al. Nuclear receptor PPARgamma-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis. Proc Natl Acad Sci USA 2012; 109: 13656\u201313661.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201426_CR22","first-page":"2405","volume":"61","author":"P Wang","year":"2004","unstructured":"Wang P, Mariman E, Keijer J, Bouwman F, Noben JP, Robben J et al. Profiling of the secreted proteins during 3T3-L1 adipocyte differentiation leads to the identification of novel adipokines. Cell Mol Life Sci 2004; 61: 2405\u20132417.","journal-title":"Cell Mol Life Sci"},{"key":"BFcdd201426_CR23","doi-asserted-by":"publisher","first-page":"36093","DOI":"10.1074\/jbc.M405346200","volume":"279","author":"I Tzameli","year":"2004","unstructured":"Tzameli I, Fang H, Ollero M, Shi H, Hamm JK, Kievit P et al. Regulated production of a peroxisome proliferator-activated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes. J Biol Chem 2004; 279: 36093\u201336102.","journal-title":"J Biol Chem"},{"key":"BFcdd201426_CR24","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev.nu.14.070194.000531","volume":"14","author":"P Cornelius","year":"1994","unstructured":"Cornelius P, MacDougald OA, Lane MD . Regulation of adipocyte development. Annu Rev Nutr 1994; 14: 99\u2013129.","journal-title":"Annu Rev Nutr"},{"key":"BFcdd201426_CR25","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.bbalip.2012.09.016","volume":"1831","author":"BL Heckmann","year":"2013","unstructured":"Heckmann BL, Zhang X, Xie X, Liu J . The G0\/G1 switch gene 2 (G0S2): regulating metabolism and beyond. Biochim Biophys Acta 2013; 1831: 276\u2013281.","journal-title":"Biochim Biophys Acta"},{"key":"BFcdd201426_CR26","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1146\/annurev-biochem-052110-115718","volume":"81","author":"QQ Tang","year":"2012","unstructured":"Tang QQ, Lane MD . Adipogenesis: from stem cell to adipocyte. Annu Rev Biochem 2012; 81: 715\u2013736.","journal-title":"Annu Rev Biochem"},{"key":"BFcdd201426_CR27","doi-asserted-by":"publisher","first-page":"9607","DOI":"10.1073\/pnas.0403100101","volume":"101","author":"QQ Tang","year":"2004","unstructured":"Tang QQ, Otto TC, Lane MD . Commitment of C3H10T1\/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci USA 2004; 101: 9607\u20139611.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201426_CR28","doi-asserted-by":"publisher","first-page":"e52474","DOI":"10.1371\/journal.pone.0052474","volume":"7","author":"H Lee","year":"2012","unstructured":"Lee H, Kim HJ, Lee YJ, Lee MY, Choi H, Kim JW . Kruppel-like factor KLF8 plays a critical role in adipocyte differentiation. PLoS One 2012; 7: e52474.","journal-title":"PLoS One"},{"key":"BFcdd201426_CR29","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1073\/pnas.0611137104","volume":"104","author":"JW Kim","year":"2007","unstructured":"Kim JW, Tang QQ, Li X, Lane MD . Effect of phosphorylation and S-S bond-induced dimerization on DNA binding and transcriptional activation by C\/EBPbeta. Proc Natl Acad Sci USA 2007; 104: 1800\u20131804.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201426_CR30","doi-asserted-by":"publisher","first-page":"10601","DOI":"10.1074\/jbc.M808742200","volume":"284","author":"H Lee","year":"2009","unstructured":"Lee H, Lee YJ, Choi H, Ko EH, Kim JW . Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion. J Biol Chem 2009; 284: 10601\u201310609.","journal-title":"J Biol Chem"}],"container-title":["Cell Death & Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd201426.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201426","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201426.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:07:07Z","timestamp":1684415227000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd201426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,28]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["BFcdd201426"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2014.26","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,28]]}}}