{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:07:49Z","timestamp":1791400069870,"version":"4.3.3"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T00:00:00Z","timestamp":1398384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1038\/cdd.2014.58","type":"journal-article","created":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T12:55:34Z","timestamp":1398430534000},"page":"1432-1441","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Dominant-negative function of the C-terminal fragments of NBR1 and SQSTM1 generated during enteroviral infection"],"prefix":"10.1038","volume":"21","author":[{"given":"J","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Fung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Piesik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,4,25]]},"reference":[{"key":"BFcdd201458_CR1","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1126\/science.290.5497.1717","volume":"290","author":"DJ Klionsky","year":"2000","unstructured":"Klionsky DJ, Emr SD . Autophagy as a regulated pathway of cellular degradation. Science 2000; 290: 1717\u20131721.","journal-title":"Science"},{"key":"BFcdd201458_CR2","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.4161\/auto.6826","volume":"4","author":"Y Ichimura","year":"2008","unstructured":"Ichimura Y, Kominami E, Tanaka K, Komatsu M . Selective turnover of p62\/A170\/SQSTM1 by autophagy. Autophagy 2008; 4: 1063\u20131066.","journal-title":"Autophagy"},{"key":"BFcdd201458_CR3","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.molcel.2009.01.020","volume":"33","author":"V Kirkin","year":"2009","unstructured":"Kirkin V, Lamark T, Sou YS, Bjorkoy G, Nunn JL, Bruun JA et al. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell 2009; 33: 505\u2013516.","journal-title":"Mol Cell"},{"key":"BFcdd201458_CR4","doi-asserted-by":"publisher","first-page":"279","DOI":"10.4161\/auto.7.3.14487","volume":"7","author":"T Johansen","year":"2011","unstructured":"Johansen T, Lamark T . Selective autophagy mediated by autophagic adapter proteins. Autophagy 2011; 7: 279\u2013296.","journal-title":"Autophagy"},{"key":"BFcdd201458_CR5","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.ceb.2011.03.003","volume":"23","author":"N Fujita","year":"2011","unstructured":"Fujita N, Yoshimori T . Ubiquitination-mediated autophagy against invading bacteria. Curr Opin Cell Biol 2011; 23: 492\u2013497.","journal-title":"Curr Opin Cell Biol"},{"key":"BFcdd201458_CR6","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1111\/j.1365-2443.2010.01433.x","volume":"15","author":"M Komatsu","year":"2010","unstructured":"Komatsu M, Ichimura Y . Selective autophagy regulates various cellular functions. Genes Cells 2010; 15: 923\u2013933.","journal-title":"Genes Cells"},{"key":"BFcdd201458_CR7","doi-asserted-by":"publisher","first-page":"H401","DOI":"10.1152\/ajpheart.00292.2008","volume":"295","author":"G Gao","year":"2008","unstructured":"Gao G, Zhang J, Si X, Wong J, Cheung C, McManus B et al. Proteasome inhibition attenuates coxsackievirus-induced myocardial damage in mice. Am J Physiol Heart Circ Physiol 2008; 295: H401\u2013H408.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFcdd201458_CR8","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1093\/cvr\/cvp225","volume":"85","author":"H Luo","year":"2010","unstructured":"Luo H, Wong J, Wong B . Protein degradation systems in viral myocarditis leading to dilated cardiomyopathy. Cardiovasc Res 2010; 85: 347\u2013356.","journal-title":"Cardiovasc Res"},{"key":"BFcdd201458_CR9","doi-asserted-by":"publisher","first-page":"e2585","DOI":"10.1371\/journal.pone.0002585","volume":"3","author":"X Si","year":"2008","unstructured":"Si X, Gao G, Wong J, Wang Y, Zhang J, Luo H . Ubiquitination is required for effective replication of coxsackievirus B3. PLoS One 2008; 3: e2585.","journal-title":"PLoS One"},{"key":"BFcdd201458_CR10","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s00430-003-0190-1","volume":"193","author":"K Klingel","year":"2004","unstructured":"Klingel K, Sauter M, Bock CT, Szalay G, Schnorr JJ, Kandolf R . Molecular pathology of inflammatory cardiomyopathy. Med Microbiol Immunol 2004; 193: 101\u2013107.","journal-title":"Med Microbiol Immunol"},{"key":"BFcdd201458_CR11","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.4161\/auto.26059","volume":"9","author":"J Shi","year":"2013","unstructured":"Shi J, Wong J, Piesik P, Fung G, Zhang J, Jagdeo J et al. Cleavage of sequestosome 1\/p62 by an enteroviral protease results in disrupted selective autophagy and impaired NFKB signaling. Autophagy 2013; 9: 1591\u20131603.","journal-title":"Autophagy"},{"key":"BFcdd201458_CR12","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.4161\/cc.8.13.8892","volume":"8","author":"T Lamark","year":"2009","unstructured":"Lamark T, Kirkin V, Dikic I, Johansen T . NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets. Cell Cycle 2009; 8: 1986\u20131990.","journal-title":"Cell Cycle"},{"key":"BFcdd201458_CR13","doi-asserted-by":"publisher","first-page":"341","DOI":"10.4161\/auto.7.3.14046","volume":"7","author":"M Cemma","year":"2011","unstructured":"Cemma M, Kim PK, Brumell JH . The ubiquitin-binding adaptor proteins p62\/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway. Autophagy 2011; 7: 341\u2013345.","journal-title":"Autophagy"},{"issue":"Pt 4","key":"BFcdd201458_CR14","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1242\/jcs.114819","volume":"126","author":"E Deosaran","year":"2013","unstructured":"Deosaran E, Larsen KB, Hua R, Sargent G, Wang Y, Kim S et al. NBR1 acts as an autophagy receptor for peroxisomes. J Cell Sci 2013; 126 (Pt 4): 939\u2013952.","journal-title":"J Cell Sci"},{"key":"BFcdd201458_CR15","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.cell.2007.10.035","volume":"131","author":"M Komatsu","year":"2007","unstructured":"Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 2007; 131: 1149\u20131163.","journal-title":"Cell"},{"key":"BFcdd201458_CR16","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0042-6822(03)00242-3","volume":"313","author":"CM Carthy","year":"2003","unstructured":"Carthy CM, Yanagawa B, Luo H, Granville DJ, Yang D, Cheung P et al. Bcl-2 and Bcl-xL overexpression inhibits cytochrome c release, activation of multiple caspases, and virus release following coxsackievirus B3 infection. Virology 2003; 313: 147\u2013157.","journal-title":"Virology"},{"key":"BFcdd201458_CR17","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1056\/NEJMra1106180","volume":"368","author":"MS Willis","year":"2013","unstructured":"Willis MS, Patterson C . Proteotoxicity and cardiac dysfunction\u2014Alzheimer\u2019s disease of the heart? N Engl J Med 2013; 368: 455\u2013464.","journal-title":"N Engl J Med"},{"key":"BFcdd201458_CR18","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nrm3496","volume":"14","author":"BH Toyama","year":"2013","unstructured":"Toyama BH, Hetzer MW . Protein homeostasis: live long, won\u2019t prosper. Nat Rev Mol Cell Biol 2013; 14: 55\u201361.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcdd201458_CR19","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4331\/wjbc.v1.i1.3","volume":"1","author":"WX Ding","year":"2010","unstructured":"Ding WX . Role of autophagy in liver physiology and pathophysiology. World J Biol Chem 2010; 1: 3\u201312.","journal-title":"World J Biol Chem"},{"key":"BFcdd201458_CR20","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.nbd.2012.12.008","volume":"52","author":"L Rue","year":"2013","unstructured":"Rue L, Lopez-Soop G, Gelpi E, Martinez-Vicente M, Alberch J, Perez-Navarro E . Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington\u2019s disease. Neurobiol Dis 2013; 52: 219\u2013228.","journal-title":"Neurobiol Dis"},{"key":"BFcdd201458_CR21","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.neulet.2012.06.026","volume":"522","author":"F Mori","year":"2012","unstructured":"Mori F, Tanji K, Odagiri S, Toyoshima Y, Yoshida M, Kakita A et al. Autophagy-related proteins (p62, NBR1 and LC3) in intranuclear inclusions in neurodegenerative diseases. Neurosci Lett 2012; 522: 134\u2013138.","journal-title":"Neurosci Lett"},{"key":"BFcdd201458_CR22","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s00401-012-0999-z","volume":"124","author":"F Mori","year":"2012","unstructured":"Mori F, Tanji K, Odagiri S, Toyoshima Y, Yoshida M, Ikeda T et al. Ubiquilin immunoreactivity in cytoplasmic and nuclear inclusions in synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease. Acta Neuropathol 2012; 124: 149\u2013151.","journal-title":"Acta Neuropathol"},{"key":"BFcdd201458_CR23","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s00401-012-0975-7","volume":"124","author":"S Odagiri","year":"2012","unstructured":"Odagiri S, Tanji K, Mori F, Kakita A, Takahashi H, Wakabayashi K . Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in alpha-synucleinopathy. Acta Neuropathol 2012; 124: 173\u2013186.","journal-title":"Acta Neuropathol"},{"key":"BFcdd201458_CR24","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1161\/CIRCRESAHA.109.208801","volume":"106","author":"MS Willis","year":"2010","unstructured":"Willis MS, Townley-Tilson WH, Kang EY, Homeister JW, Patterson C . Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease. Circ Res 2010; 106: 463\u2013478.","journal-title":"Circ Res"},{"key":"BFcdd201458_CR25","first-page":"9","volume":"52","author":"Q Zheng","year":"2010","unstructured":"Zheng Q, Wang X . Autophagy and the ubiquitin-proteasome system in cardiac dysfunction. Panminerva Med 2010; 52: 9\u201325.","journal-title":"Panminerva Med"},{"key":"BFcdd201458_CR26","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1161\/CIRCRESAHA.111.244707","volume":"109","author":"Q Zheng","year":"2011","unstructured":"Zheng Q, Su H, Ranek MJ, Wang X . Autophagy and p62 in cardiac proteinopathy. Circ Res 2011; 109: 296\u2013308.","journal-title":"Circ Res"},{"key":"BFcdd201458_CR27","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.molcel.2009.04.026","volume":"34","author":"V Kirkin","year":"2009","unstructured":"Kirkin V, McEwan DG, Novak I, Dikic I . A role for ubiquitin in selective autophagy. Mol Cell 2009; 34: 259\u2013269.","journal-title":"Mol Cell"},{"key":"BFcdd201458_CR28","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1083\/jcb.201009067","volume":"192","author":"E Itakura","year":"2011","unstructured":"Itakura E, Mizushima N . p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J Cell Biol 2011; 192: 17\u201327.","journal-title":"J Cell Biol"},{"key":"BFcdd201458_CR29","doi-asserted-by":"publisher","first-page":"34568","DOI":"10.1074\/jbc.M303221200","volume":"278","author":"T Lamark","year":"2003","unstructured":"Lamark T, Perander M, Outzen H, Kristiansen K, Overvatn A, Michaelsen E et al. Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. J Biol Chem 2003; 278: 34568\u201334581.","journal-title":"J Biol Chem"},{"key":"BFcdd201458_CR30","doi-asserted-by":"publisher","first-page":"12913","DOI":"10.1073\/pnas.0913058107","volume":"107","author":"CA Whitehouse","year":"2010","unstructured":"Whitehouse CA, Waters S, Marchbank K, Horner A, McGowan NW, Jovanovic JV et al. Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity. Proc Natl Acad Sci USA 2010; 107: 12913\u201312918.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201458_CR31","doi-asserted-by":"publisher","first-page":"8055","DOI":"10.1128\/MCB.24.18.8055-8068.2004","volume":"24","author":"ML Seibenhener","year":"2004","unstructured":"Seibenhener ML, Babu JR, Geetha T, Wong HC, Krishna NR, Wooten MW . Sequestosome 1\/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol Cell Biol 2004; 24: 8055\u20138068.","journal-title":"Mol Cell Biol"},{"key":"BFcdd201458_CR32","doi-asserted-by":"crossref","first-page":"19200","DOI":"10.1016\/S0021-9258(19)36499-3","volume":"268","author":"BJ Lamphear","year":"1993","unstructured":"Lamphear BJ, Yan R, Yang F, Waters D, Liebig HD, Klump H et al. Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human coxsackievirus and rhinovirus. J Biol Chem 1993; 268: 19200\u201319203.","journal-title":"J Biol Chem"},{"key":"BFcdd201458_CR33","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1128\/JVI.73.1.709-717.1999","volume":"73","author":"V Kerekatte","year":"1999","unstructured":"Kerekatte V, Keiper BD, Badorff C, Cai A, Knowlton KU, Rhoads RE . Cleavage of Poly(A)-binding protein by coxsackievirus 2A protease in vitro and in vivo: another mechanism for host protein synthesis shutoff? J Virol 1999; 73: 709\u2013717.","journal-title":"J Virol"},{"key":"BFcdd201458_CR34","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/cr.2011.114","volume":"22","author":"J Wong","year":"2012","unstructured":"Wong J, Zhang J, Yanagawa B, Luo Z, Yang X, Chang J et al. Cleavage of serum response factor mediated by enteroviral protease 2A contributes to impaired cardiac function. Cell Res 2012; 22: 360\u2013371.","journal-title":"Cell Res"},{"key":"BFcdd201458_CR35","doi-asserted-by":"publisher","first-page":"11191","DOI":"10.1074\/jbc.275.15.11191","volume":"275","author":"C Badorff","year":"2000","unstructured":"Badorff C, Berkely N, Mehrotra S, Talhouk JW, Rhoads RE, Knowlton KU . Enteroviral protease 2A directly cleaves dystrophin and is inhibited by a dystrophin-based substrate analogue. J Biol Chem 2000; 275: 11191\u201311197.","journal-title":"J Biol Chem"},{"key":"BFcdd201458_CR36","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1096\/fj.12-226498","volume":"27","author":"J Wong","year":"2013","unstructured":"Wong J, Si X, Angeles A, Zhang J, Shi J, Fung G et al. Cytoplasmic redistribution and cleavage of AUF1 during coxsackievirus infection enhance the stability of its viral genome. FASEB J 2013; 27: 2777\u20132787.","journal-title":"FASEB J"},{"key":"BFcdd201458_CR37","doi-asserted-by":"publisher","first-page":"e79546","DOI":"10.1371\/journal.pone.0079546","volume":"8","author":"G Fung","year":"2013","unstructured":"Fung G, Ng CS, Zhang J, Shi J, Wong J, Piesik P et al. Production of a dominant-negative fragment due to G3BP1 cleavage contributes to the disruption of mitochondria-associated protective stress granules during CVB3 infection. PLoS One 2013; 8: e79546.","journal-title":"PLoS One"},{"key":"BFcdd201458_CR38","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.1128\/JVI.02712-13","volume":"88","author":"Q Feng","year":"2014","unstructured":"Feng Q, Langereis MA, Lork M, Nguyen M, Hato SV, Lanke K et al. Enteroviruses 2Apro targets MDA5 and MAVS in infected cells. J Virol 2014; 88: 3369\u20133378.","journal-title":"J Virol"},{"key":"BFcdd201458_CR39","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.chom.2010.01.007","volume":"7","author":"A Orvedahl","year":"2010","unstructured":"Orvedahl A, MacPherson S, Sumpter R Jr, Talloczy Z, Zou Z, Levine B . Autophagy protects against Sindbis virus infection of the central nervous system. Cell Host Microbe 2010; 7: 115\u2013127.","journal-title":"Cell Host Microbe"},{"key":"BFcdd201458_CR40","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.febslet.2010.11.056","volume":"585","author":"J Zhang","year":"2011","unstructured":"Zhang J, Wong J, Gao G, Luo H . Tripeptidyl peptidase II serves as an alternative to impaired proteasome to maintain viral growth in the host cells. FEBS Lett 2011; 585: 261\u2013265.","journal-title":"FEBS Lett"},{"key":"BFcdd201458_CR41","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1128\/JVI.73.1.718-727.1999","volume":"73","author":"M Joachims","year":"1999","unstructured":"Joachims M, Van Breugel PC, Lloyd RE . Cleavage of poly(A)-binding protein by enterovirus proteases concurrent with inhibition of translation in vitro. J Virol 1999; 73: 718\u2013727.","journal-title":"J Virol"}],"container-title":["Cell Death & Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd201458.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201458","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201458.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:07:35Z","timestamp":1684415255000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd201458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,25]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["BFcdd201458"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2014.58","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,25]]},"assertion":[{"value":"21 November 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}