{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:00:29Z","timestamp":1792188029430,"version":"4.4.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T00:00:00Z","timestamp":1391731200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1038\/cdd.2014.9","type":"journal-article","created":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T15:24:12Z","timestamp":1391786652000},"page":"888-903","source":"Crossref","is-referenced-by-count":53,"title":["IRF4 is a novel mediator for neuronal survival in ischaemic stroke"],"prefix":"10.1038","volume":"21","author":[{"given":"S","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z-Z","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D-S","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y Y","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S-M","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L-H","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X-D","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D-P","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,7]]},"reference":[{"key":"BFcdd20149_CR1","first-page":"e6","volume":"127","author":"AS Go","year":"2013","unstructured":"Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB et al. Heart disease and stroke statistics\u20142013 update: a report from the American Heart Association. Circulation 2013; 127: e6\u20136e245.","journal-title":"Circulation"},{"key":"BFcdd20149_CR2","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1016\/S0140-6736(11)60516-3","volume":"377","author":"PM Rothwell","year":"2011","unstructured":"Rothwell PM, Algra A, Amarenco P . Medical treatment in acute and long-term secondary prevention after transient ischaemic attack and ischaemic stroke. Lancet 2011; 377: 1681\u20131692.","journal-title":"Lancet"},{"key":"BFcdd20149_CR3","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/S0140-6736(11)60325-5","volume":"377","author":"P Langhorne","year":"2011","unstructured":"Langhorne P, Bernhardt J, Kwakkel G . Stroke rehabilitation. Lancet 2011; 377: 1693\u20131702.","journal-title":"Lancet"},{"key":"BFcdd20149_CR4","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1161\/01.STR.0000258112.14918.24","volume":"38","author":"JH Rha","year":"2007","unstructured":"Rha JH, Saver JL . The impact of recanalization on ischemic stroke outcome: a meta-analysis. Stroke 2007; 38: 967\u2013973.","journal-title":"Stroke"},{"key":"BFcdd20149_CR5","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1002\/ana.20741","volume":"59","author":"VE O'Collins","year":"2006","unstructured":"O'Collins VE, Macleod MR, Donnan GA, Horky LL, van der Worp BH, Howells DW . 1,026 experimental treatments in acute stroke. Ann Neurol 2006; 59: 467\u2013477.","journal-title":"Ann Neurol"},{"key":"BFcdd20149_CR6","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1038\/nn.2953","volume":"14","author":"C Iadecola","year":"2011","unstructured":"Iadecola C, Anrather J . Stroke research at a crossroad: asking the brain for directions. Nat Neurosci 2011; 14: 1363\u20131368.","journal-title":"Nat Neurosci"},{"key":"BFcdd20149_CR7","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1523\/JNEUROSCI.4868-03.2004","volume":"24","author":"SH Chang","year":"2004","unstructured":"Chang SH, Poser S, Xia Z . A novel role for serum response factor in neuronal survival. J Neurosci 2004; 24: 2277\u20132285.","journal-title":"J Neurosci"},{"key":"BFcdd20149_CR8","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1146\/annurev.immunol.26.021607.090400","volume":"26","author":"T Tamura","year":"2008","unstructured":"Tamura T, Yanai H, Savitsky D, Taniguchi T . The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol 2008; 26: 535\u2013584.","journal-title":"Annu Rev Immunol"},{"key":"BFcdd20149_CR9","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1007\/s00395-012-0326-9","volume":"108","author":"J Lu","year":"2013","unstructured":"Lu J, Bian ZY, Zhang R, Zhang Y, Liu C, Yan L et al. Interferon regulatory factor 3 is a negative regulator of pathological cardiac hypertrophy. Basic Res Cardiol 2013; 108: 326.","journal-title":"Basic Res Cardiol"},{"key":"BFcdd20149_CR10","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1101\/gad.9.11.1377","volume":"9","author":"CF Eisenbeis","year":"1995","unstructured":"Eisenbeis CF, Singh H, U Storb . Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev 1995; 9: 1377\u20131387.","journal-title":"Genes Dev"},{"key":"BFcdd20149_CR11","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/hep.26368","volume":"58","author":"XA Wang","year":"2013","unstructured":"Wang XA, Zhang R, Jiang D, Deng W, Zhang S, Deng S et al. Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice. Hepatology 2013; 58: 603\u2013616.","journal-title":"Hepatology"},{"key":"BFcdd20149_CR12","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1161\/HYPERTENSIONAHA.113.02083","volume":"63","author":"DS Jiang","year":"2014","unstructured":"Jiang DS, Luo YX, Zhang R, Zhang XD, Chen HZ, Zhang Y et al. Interferon regulatory factor 9 protects against cardiac hypertrophy by targeting myocardin. Hypertension 2014; 63: 119\u2013127.","journal-title":"Hypertension"},{"key":"BFcdd20149_CR13","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1161\/HYPERTENSIONAHA.111.00614","volume":"61","author":"DS Jiang","year":"2013","unstructured":"Jiang DS, Bian ZY, Zhang Y, Zhang SM, Liu Y, Zhang R et al. Role of interferon regulatory factor 4 in the regulation of pathological cardiac hypertrophy. Hypertension 2013; 61: 1193\u20131202.","journal-title":"Hypertension"},{"key":"BFcdd20149_CR14","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1097\/PAI.0b013e3181cf1126","volume":"18","author":"G Gualco","year":"2010","unstructured":"Gualco G, Weiss LM, Bacchi CE . MUM1\/IRF4: a review. Appl Immunohistochem Mol Morphol 2010; 18: 301\u2013310.","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"BFcdd20149_CR15","doi-asserted-by":"publisher","first-page":"2954","DOI":"10.1158\/1078-0432.CCR-08-1845","volume":"15","author":"AL Shaffer","year":"2009","unstructured":"Shaffer AL, Emre NC, Romesser PB, Staudt LM . IRF4: immunity. malignancy! therapy. Clin Cancer Res 2009; 15: 2954\u20132961.","journal-title":"Clin Cancer Res"},{"key":"BFcdd20149_CR16","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/nature07064","volume":"454","author":"AL Shaffer","year":"2008","unstructured":"Shaffer AL, Emre NC, Lamy L, Ngo VN, Wright G, Xiao W et al. IRF4 addiction in multiple myeloma. Nature 2008; 454: 226\u2013231.","journal-title":"Nature"},{"key":"BFcdd20149_CR17","first-page":"2423","volume":"47","author":"O Engel","year":"2011","unstructured":"Engel O, Kolodziej S, Dirnagl U, Prinz V . Modeling stroke in mice\u2014middle cerebral artery occlusion with the filament model. J Vis Exp 2011; 47: 2423.","journal-title":"J Vis Exp"},{"key":"BFcdd20149_CR18","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1038\/nn.2951","volume":"14","author":"M Tymianski","year":"2011","unstructured":"Tymianski M . Emerging mechanisms of disrupted cellular signaling in brain ischemia. Nat Neurosci 2011; 14: 1369\u20131373.","journal-title":"Nat Neurosci"},{"key":"BFcdd20149_CR19","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1161\/01.STR.31.9.2212","volume":"31","author":"WR Schabitz","year":"2000","unstructured":"Schabitz WR, Sommer C, Zoder W, Kiessling M, Schwaninger M, Schwab S . Intravenous brain-derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia. Stroke 2000; 31: 2212\u20132217.","journal-title":"Stroke"},{"key":"BFcdd20149_CR20","doi-asserted-by":"publisher","first-page":"4905","DOI":"10.1002\/j.1460-2075.1995.tb00173.x","volume":"14","author":"R Treisman","year":"1995","unstructured":"Treisman R . Journey to the surface of the cell: Fos regulation and the SRE. EMBO J 1995; 14: 4905\u20134913.","journal-title":"EMBO J"},{"key":"BFcdd20149_CR21","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/nn1462","volume":"8","author":"N Ramanan","year":"2005","unstructured":"Ramanan N, Shen Y, Sarsfield S, Lemberger T, Sch\u00fctz G, Linden DJ et al. SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability. Nat Neurosci 2005; 8: 759\u2013767.","journal-title":"Nat Neurosci"},{"key":"BFcdd20149_CR22","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/S0169-328X(98)00039-4","volume":"56","author":"L McGahan","year":"1998","unstructured":"McGahan L, Hakim AM, Nakabeppu Y, Robertson GS . Ischemia-induced CA1 neuronal death is preceded by elevated FosB and Jun expression and reduced NGFI-A and JunB levels. Brain Res Mol Brain Res 1998; 56: 146\u2013161.","journal-title":"Brain Res Mol Brain Res"},{"key":"BFcdd20149_CR23","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/0092-8674(88)90244-9","volume":"55","author":"C Norman","year":"1988","unstructured":"Norman C, Runswick M, Pollock R, Treisman R . Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. Cell 1988; 55: 989\u20131003.","journal-title":"Cell"},{"key":"BFcdd20149_CR24","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.autrev.2012.08.011","volume":"11","author":"WD Xu","year":"2012","unstructured":"Xu WD, Pan HF, Ye DQ, Xu Y . Targeting IRF4 in autoimmune diseases. Autoimmun Rev 2012; 11: 918\u2013924.","journal-title":"Autoimmun Rev"},{"key":"BFcdd20149_CR25","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.cmet.2011.02.005","volume":"13","author":"J Eguchi","year":"2011","unstructured":"Eguchi J, Wang X, Yu S, Kershaw EE, Chiu PC, Dushay J et al. Transcriptional control of adipose lipid handling by IRF4. Cell Metab 2011; 13: 249\u2013259.","journal-title":"Cell Metab"},{"key":"BFcdd20149_CR26","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1084\/jem.191.8.1281","volume":"191","author":"RJ Grumont","year":"2000","unstructured":"Grumont RJ, Gerondakis S . Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: modulation of interferon-regulated gene expression by rel\/nuclear factor kappaB. J Exp Med 2000; 191: 1281\u20131292.","journal-title":"J Exp Med"},{"key":"BFcdd20149_CR27","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1038\/8432","volume":"5","author":"A Schneider","year":"1999","unstructured":"Schneider A, Martin-Villalba A, Weih F, Vogel J, Wirth T, Schwaninger M . NF-kappaB is activated and promotes cell death in focal cerebral ischemia. Nat Med 1999; 5: 554\u2013559.","journal-title":"Nat Med"},{"key":"BFcdd20149_CR28","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1084\/jem.190.12.1837","volume":"190","author":"S Gupta","year":"1999","unstructured":"Gupta S, Jiang M, Anthony A, Pernis AB . Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4. J Exp Med 1999; 190: 1837\u20131848.","journal-title":"J Exp Med"},{"key":"BFcdd20149_CR29","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.immuni.2006.07.009","volume":"25","author":"R Sciammas","year":"2006","unstructured":"Sciammas R, Shaffer AL, Schatz JH, Zhao H, Staudt LM, Singh H . Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity 2006; 25: 225\u2013236.","journal-title":"Immunity"},{"key":"BFcdd20149_CR30","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1089\/107999002753452737","volume":"22","author":"S Marecki","year":"2002","unstructured":"Marecki S, Fenton MJ . The role of IRF-4 in transcriptional regulation. J Interferon Cytokine Res 2002; 22: 121\u2013133.","journal-title":"J Interferon Cytokine Res"},{"key":"BFcdd20149_CR31","doi-asserted-by":"publisher","first-page":"3058","DOI":"10.1182\/blood-2002-09-2924","volume":"101","author":"SJ Gobin","year":"2003","unstructured":"Gobin SJ, Biesta P, Van den Elsen PJ . Regulation of human beta 2-microglobulin transactivation in hematopoietic cells. Blood 2003; 101: 3058\u20133064.","journal-title":"Blood"},{"key":"BFcdd20149_CR32","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1084\/jem.20011128","volume":"195","author":"J Rengarajan","year":"2002","unstructured":"Rengarajan J, Mowen KA, McBride KD, Smith ED, Singh H, Glimcher LH . Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J Exp Med 2002; 195: 1003\u20131012.","journal-title":"J Exp Med"},{"key":"BFcdd20149_CR33","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1111\/j.1460-9568.2012.08003.x","volume":"35","author":"C Rieker","year":"2012","unstructured":"Rieker C, Schober A, Bilbao A, Schutz G, Parkitna JR . Ablation of serum response factor in dopaminergic neurons exacerbates susceptibility towards MPTP-induced oxidative stress. Eur J Neurosci 2012; 35: 735\u2013741.","journal-title":"Eur J Neurosci"},{"key":"BFcdd20149_CR34","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1111\/j.1471-4159.2012.07818.x","volume":"122","author":"L Wang","year":"2012","unstructured":"Wang L, Lu Y, Deng S, Zhang Y, Yang L, Guan Y et al. SHPS-1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress. J Neurochem 2012; 122: 834\u2013843.","journal-title":"J Neurochem"},{"key":"BFcdd20149_CR35","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.expneurol.2013.01.022","volume":"247","author":"L Wang","year":"2013","unstructured":"Wang L, Lu Y, Zhang X, Zhang Y, Jiang D, Dong X et al. Mindin is a critical mediator of ischemic brain injury in an experimental stroke model. Exp Neurol 2013; 247: 506\u2013516.","journal-title":"Exp Neurol"},{"key":"BFcdd20149_CR36","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/jnc.12207","volume":"126","author":"L Wang","year":"2013","unstructured":"Wang L, Lu Y, Guan H, Jiang D, Guan Y, Zhang X et al. Tumor necrosis factor receptor-associated factor 5 is an essential mediator of ischemic brain infarction. J Neurochem 2013; 126: 400\u2013414.","journal-title":"J Neurochem"},{"key":"BFcdd20149_CR37","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.neuroscience.2012.06.010","volume":"220","author":"L Wang","year":"2012","unstructured":"Wang L, Deng S, Lu Y, Zhang Y, Yang L, Guan Y et al. Increased inflammation and brain injury after transient focal cerebral ischemia in activating transcription factor 3 knockout mice. Neuroscience 2012; 220: 100\u2013108.","journal-title":"Neuroscience"},{"key":"BFcdd20149_CR38","doi-asserted-by":"publisher","first-page":"2852","DOI":"10.1038\/ncomms3852","volume":"4","author":"YY Lu","year":"2013","unstructured":"Lu YY, Li ZZ, Jiang DS, Wang L, Zhang Y, Chen K et al. TRAF1 is a critical regulator of cerebral ischaemia-reperfusion injury and neuronal death. Nat Commun 2013; 4: 2852.","journal-title":"Nat Commun"},{"key":"BFcdd20149_CR39","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1161\/01.HYP.0000214867.35632.0e","volume":"47","author":"CF Xia","year":"2006","unstructured":"Xia CF, Smith RS Jr, Shen B, Yang ZR, Borlongan CV, Chao L et al. Postischemic brain injury is exacerbated in mice lacking the kinin B2 receptor. Hypertension 2006; 47: 752\u2013761.","journal-title":"Hypertension"}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd20149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd20149","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd20149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:07:55Z","timestamp":1684415275000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd20149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,7]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["BFcdd20149"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2014.9","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,7]]}}}