{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:39:52Z","timestamp":1783658392023,"version":"3.55.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1038\/cdd.2015.105","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T12:02:01Z","timestamp":1437739321000},"page":"347-357","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["RNASET2 is required for ROS propagation during oxidative stress-mediated cell death"],"prefix":"10.1038","volume":"23","author":[{"given":"G","family":"Caputa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A E G","family":"Criado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D S","family":"Ory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J G","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J E","family":"Schaffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,24]]},"reference":[{"key":"BFcdd2015105_CR1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1172\/JCI200422422","volume":"114","author":"JD Browning","year":"2004","unstructured":"Browning JD, Horton JD . Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 2004; 114: 147\u2013152.","journal-title":"J Clin Invest"},{"key":"BFcdd2015105_CR2","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1172\/JCI10583","volume":"106","author":"GI Shulman","year":"2000","unstructured":"Shulman GI . Cellular mechanisms of insulin resistance. J Clin Invest 2000; 106: 171\u2013176.","journal-title":"J Clin Invest"},{"issue":"Suppl 1","key":"BFcdd2015105_CR3","doi-asserted-by":"publisher","first-page":"S119","DOI":"10.2337\/diabetes.53.2007.S119","volume":"53","author":"RP Robertson","year":"2004","unstructured":"Robertson RP, Harmon J, Tran PO, Poitout V . Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 2004; 53 (Suppl 1): S119\u2013S124.","journal-title":"Diabetes"},{"key":"BFcdd2015105_CR4","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.cmet.2012.04.006","volume":"15","author":"IJ Goldberg","year":"2012","unstructured":"Goldberg IJ, Trent CM, Schulze PC . Lipid metabolism and toxicity in the heart. Cell Metab 2012; 15: 805\u2013812.","journal-title":"Cell Metab"},{"key":"BFcdd2015105_CR5","doi-asserted-by":"publisher","first-page":"977","DOI":"10.2337\/diabetes.51.4.977","volume":"51","author":"AK Busch","year":"2002","unstructured":"Busch AK, Cordery D, Denyer GS, Biden TJ . Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function. Diabetes 2002; 51: 977\u2013987.","journal-title":"Diabetes"},{"key":"BFcdd2015105_CR6","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.2337\/db13-1383","volume":"63","author":"M Cnop","year":"2014","unstructured":"Cnop M, Abdulkarim B, Bottu G, Cunha DA, Igoillo-Esteve M, Masini M et al. RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate. Diabetes 2014; 63: 1978\u20131993.","journal-title":"Diabetes"},{"key":"BFcdd2015105_CR7","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.2337\/diabetes.54.6.1838","volume":"54","author":"JM Cacicedo","year":"2005","unstructured":"Cacicedo JM, Benjachareowong S, Chou E, Ruderman NB, Ido Y . Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide. Diabetes 2005; 54: 1838\u20131845.","journal-title":"Diabetes"},{"key":"BFcdd2015105_CR8","doi-asserted-by":"publisher","first-page":"991","DOI":"10.2337\/diabetes.52.4.991","volume":"52","author":"K Eitel","year":"2003","unstructured":"Eitel K, Staiger H, Rieger J, Mischak H, Brandhorst H, Brendel MD et al. Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. Diabetes 2003; 52: 991\u2013997.","journal-title":"Diabetes"},{"key":"BFcdd2015105_CR9","doi-asserted-by":"publisher","first-page":"39336","DOI":"10.1074\/jbc.M111.280420","volume":"286","author":"SC Cazanave","year":"2011","unstructured":"Cazanave SC, Mott JL, Bronk SF, Werneburg NW, Fingas CD, Meng XW et al. Death receptor 5 signaling promotes hepatocyte lipoapoptosis. J Biol Chem 2011; 286: 39336\u201339348.","journal-title":"J Biol Chem"},{"key":"BFcdd2015105_CR10","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1172\/JCI30565","volume":"117","author":"L Liu","year":"2007","unstructured":"Liu L, Zhang Y, Chen N, Shi X, Tsang B, Yu YH . Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. J Clin Invest 2007; 117: 1679\u20131689.","journal-title":"J Clin Invest"},{"key":"BFcdd2015105_CR11","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.2337\/db12-0927","volume":"62","author":"T Pulinilkunnil","year":"2013","unstructured":"Pulinilkunnil T, Kienesberger PC, Nagendran J, Waller TJ, Young ME, Kershaw EE et al. Myocardial adipose triglyceride lipase overexpression protects diabetic mice from the development of lipotoxic cardiomyopathy. Diabetes 2013; 62: 1464\u20131477.","journal-title":"Diabetes"},{"key":"BFcdd2015105_CR12","doi-asserted-by":"publisher","first-page":"38061","DOI":"10.1074\/jbc.M103689200","volume":"276","author":"DB Ostrander","year":"2001","unstructured":"Ostrander DB, Sparagna GC, Amoscato AA, McMillin JB, Dowhan W . Decreased cardiolipin synthesis corresponds with cytochrome c release in palmitate-induced cardiomyocyte apoptosis. J Biol Chem 2001; 276: 38061\u201338067.","journal-title":"J Biol Chem"},{"key":"BFcdd2015105_CR13","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.2337\/diabetes.50.8.1771","volume":"50","author":"M Cnop","year":"2001","unstructured":"Cnop M, Hannaert JC, Hoorens A, Eizirik DL, Pipeleers DG . Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes 2001; 50: 1771\u20131777.","journal-title":"Diabetes"},{"key":"BFcdd2015105_CR14","doi-asserted-by":"publisher","first-page":"3989","DOI":"10.1074\/jbc.M607627200","volume":"282","author":"M Cnop","year":"2007","unstructured":"Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z et al. Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. J Biol Chem 2007; 282: 3989\u20133997.","journal-title":"J Biol Chem"},{"key":"BFcdd2015105_CR15","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.2337\/diabetes.49.11.1939","volume":"49","author":"T Inoguchi","year":"2000","unstructured":"Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Imamura M et al. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C\u2014dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 2000; 49: 1939\u20131945.","journal-title":"Diabetes"},{"key":"BFcdd2015105_CR16","doi-asserted-by":"publisher","first-page":"29965","DOI":"10.1074\/jbc.M110.128694","volume":"285","author":"D Gao","year":"2010","unstructured":"Gao D, Nong S, Huang X, Lu Y, Zhao H, Lin Y et al. The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways. J Biol Chem 2010; 285: 29965\u201329973.","journal-title":"J Biol Chem"},{"key":"BFcdd2015105_CR17","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.devcel.2014.08.028","volume":"31","author":"W Yang","year":"2014","unstructured":"Yang W, Tanaka Y, Bundo M, Hirokawa N . Antioxidant signaling involving the microtubule motor KIF12 is an intracellular target of nutrition excess in beta cells. Dev Cell 2014; 31: 202\u2013214.","journal-title":"Dev Cell"},{"key":"BFcdd2015105_CR18","doi-asserted-by":"publisher","first-page":"14890","DOI":"10.1074\/jbc.M010286200","volume":"276","author":"LL Listenberger","year":"2001","unstructured":"Listenberger LL, Ory DS, Schaffer JE . Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem 2001; 276: 14890\u201314895.","journal-title":"J Biol Chem"},{"key":"BFcdd2015105_CR19","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.bbrc.2006.03.062","volume":"344","author":"Y Lee","year":"2006","unstructured":"Lee Y, Naseem RH, Park BH, Garry DJ, Richardson JA, Schaffer JE et al. Alpha-lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice. Biochem Biophys Res Commun 2006; 344: 446\u2013452.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcdd2015105_CR20","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/35008121","volume":"404","author":"T Nishikawa","year":"2000","unstructured":"Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000; 404: 787\u2013790.","journal-title":"Nature"},{"key":"BFcdd2015105_CR21","doi-asserted-by":"publisher","first-page":"3181","DOI":"10.2337\/db12-0559","volume":"61","author":"A Huang","year":"2012","unstructured":"Huang A, Yang YM, Yan C, Kaley G, Hintze TH, Sun D . Altered MAPK signaling in progressive deterioration of endothelial function in diabetic mice. Diabetes 2012; 61: 3181\u20133188.","journal-title":"Diabetes"},{"key":"BFcdd2015105_CR22","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cmet.2011.04.009","volume":"14","author":"CI Michel","year":"2011","unstructured":"Michel CI, Holley CL, Scruggs BS, Sidhu R, Brookheart RT, Listenberger LL et al. Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress. Cell Metab 2011; 14: 33\u201344.","journal-title":"Cell Metab"},{"key":"BFcdd2015105_CR23","doi-asserted-by":"publisher","first-page":"4092","DOI":"10.1128\/MCB.00022-12","volume":"32","author":"BS Scruggs","year":"2012","unstructured":"Scruggs BS, Michel CI, Ory DS, Schaffer JE . SmD3 regulates intronic noncoding RNA biogenesis. Mol Cell Biol 2012; 32: 4092\u20134103.","journal-title":"Mol Cell Biol"},{"key":"BFcdd2015105_CR24","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1091\/mbc.e05-08-0742","volume":"17","author":"NM Borradaile","year":"2006","unstructured":"Borradaile NM, Buhman KK, Listenberger LL, Magee CJ, Morimoto ET, Ory DS et al. A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death. Mol Biol Cell 2006; 17: 770\u2013778.","journal-title":"Mol Biol Cell"},{"key":"BFcdd2015105_CR25","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.tibs.2010.02.002","volume":"35","author":"N Luhtala","year":"2010","unstructured":"Luhtala N, Parker R . T2 Family ribonucleases: ancient enzymes with diverse roles. Trends Biochem Sci 2010; 35: 253\u2013259.","journal-title":"Trends Biochem Sci"},{"key":"BFcdd2015105_CR26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2307\/3870373","volume":"9","author":"AG McCubbin","year":"1997","unstructured":"McCubbin AG, Chung YY, Kao T . A mutant S3 RNase of petunia inflata lacking RNase activity has an allele-specific dominant negative effect on self-incompatibility interactions. Plant Cell 1997; 9: 85\u201395.","journal-title":"Plant Cell"},{"key":"BFcdd2015105_CR27","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1083\/jcb.200811119","volume":"185","author":"DM Thompson","year":"2009","unstructured":"Thompson DM, Parker R . The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae. J Cell Biol 2009; 185: 43\u201350.","journal-title":"J Cell Biol"},{"key":"BFcdd2015105_CR28","doi-asserted-by":"publisher","first-page":"e1022","DOI":"10.1038\/cddis.2013.539","volume":"5","author":"Q Wang","year":"2014","unstructured":"Wang Q, Jiang M, Wu J, Ma Y, Li T, Chen Q et al. Stress-induced RNASET2 overexpression mediates melanocyte apoptosis via the TRAF2 pathway in vitro. Cell Death Dis 2014; 5: e1022.","journal-title":"Cell Death Dis"},{"key":"BFcdd2015105_CR29","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1093\/oxfordjournals.jbchem.a124029","volume":"113","author":"K Ohgi","year":"1993","unstructured":"Ohgi K, Horiuchi H, Watanabe H, Iwama M, Takagi M, Irie M . Role of Asp51 and Glu105 in the enzymatic activity of a ribonuclease from Rhizopus niveus. J Biochem 1993; 113: 219\u2013224.","journal-title":"J Biochem"},{"key":"BFcdd2015105_CR30","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.abb.2006.02.022","volume":"449","author":"P Campomenosi","year":"2006","unstructured":"Campomenosi P, Salis S, Lindqvist C, Mariani D, Nordstrom T, Acquati F et al. Characterization of RNASET2, the first human member of the Rh\/T2\/S family of glycoproteins. Arch Biochem Biophys 2006; 449: 17\u201326.","journal-title":"Arch Biochem Biophys"},{"key":"BFcdd2015105_CR31","doi-asserted-by":"publisher","first-page":"7446","DOI":"10.1074\/jbc.M806209200","volume":"284","author":"RT Brookheart","year":"2009","unstructured":"Brookheart RT, Michel CI, Listenberger LL, Ory DS, Schaffer JE . The non-coding RNA gadd7 is a regulator of lipid-induced oxidative and endoplasmic reticulum stress. J Biol Chem 2009; 284: 7446\u20137454.","journal-title":"J Biol Chem"},{"key":"BFcdd2015105_CR32","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1073\/pnas.1009811107","volume":"108","author":"N Haud","year":"2011","unstructured":"Haud N, Kara F, Diekmann S, Henneke M, Willer JR, Hillwig MS et al. rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA. Proc Natl Acad Sci USA 2011; 108: 1099\u20131103.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2015105_CR33","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1177\/0148607111434963","volume":"36","author":"J Preiser","year":"2012","unstructured":"Preiser J . Oxidative stress. JPEN J Parenter Enteral Nutr 2012; 36: 147\u2013154.","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"BFcdd2015105_CR34","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1093\/toxsci\/kft116","volume":"134","author":"SH Mehdi","year":"2013","unstructured":"Mehdi SH, Qamar A . Paraquat-induced ultrastructural changes and DNA damage in the nervous system is mediated via oxidative-stress-induced cytotoxicity in Drosophila melanogaster. Toxicol Sci 2013; 134: 355\u2013365.","journal-title":"Toxicol Sci"},{"key":"BFcdd2015105_CR35","doi-asserted-by":"publisher","first-page":"e105444","DOI":"10.1371\/journal.pone.0105444","volume":"9","author":"L Ambrosio","year":"2014","unstructured":"Ambrosio L, Morriss S, Riaz A, Bailey R, Ding J, MacIntosh GC . Phylogenetic analyses and characterization of RNase X25 from Drosophila melanogaster suggest a conserved housekeeping role and additional functions for RNase T2 enzymes in protostomes. PLoS One 2014; 9: e105444.","journal-title":"PLoS One"},{"key":"BFcdd2015105_CR36","first-page":"2281","volume":"118","author":"JR Zhang","year":"2008","unstructured":"Zhang JR, Coleman T, Langmade SJ, Scherrer DE, Lane L, Lanier MH et al. Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking. J Clin Invest 2008; 118: 2281\u20132290.","journal-title":"J Clin Invest"},{"key":"BFcdd2015105_CR37","doi-asserted-by":"publisher","first-page":"56ra81","DOI":"10.1126\/scitranslmed.3001417","volume":"2","author":"FD Porter","year":"2010","unstructured":"Porter FD, Scherrer DE, Lanier MH, Langmade SJ, Molugu V, Gale SE et al. Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease. Sci Transl Med 2010; 2: 56ra81.","journal-title":"Sci Transl Med"},{"key":"BFcdd2015105_CR38","doi-asserted-by":"publisher","first-page":"11741","DOI":"10.1074\/jbc.M115.637413","volume":"290","author":"CL Holley","year":"2015","unstructured":"Holley CL, Li MW, Scruggs BS, Matkovich SJ, Ory DS, Schaffer JE . Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase. J Biol Chem 2015; 290: 11741\u201311748.","journal-title":"J Biol Chem"},{"key":"BFcdd2015105_CR39","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1073\/pnas.1013746108","volume":"108","author":"F Acquati","year":"2011","unstructured":"Acquati F, Bertilaccio S, Grimaldi A, Monti L, Cinquetti R, Bonetti P et al. Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase. Proc Natl Acad Sci USA 2011; 108: 1104\u20131109.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2015105_CR40","doi-asserted-by":"publisher","first-page":"33629","DOI":"10.1074\/jbc.M114.589556","volume":"289","author":"SE Brennan-Laun","year":"2014","unstructured":"Brennan-Laun SE, Li XL, Ezelle HJ, Venkataraman T, Blackshear PJ, Wilson GM et al. RNase L attenuates mitogen-stimulated gene expression via transcriptional and post-transcriptional mechanisms to limit the proliferative response. J Biol Chem 2014; 289: 33629\u201333643.","journal-title":"J Biol Chem"},{"key":"BFcdd2015105_CR41","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nature13468","volume":"513","author":"Q Zhang","year":"2014","unstructured":"Zhang Q, Siegel TN, Martins RM, Wang F, Cao J, Gao Q et al. Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria. Nature 2014; 513: 431\u2013435.","journal-title":"Nature"},{"key":"BFcdd2015105_CR42","doi-asserted-by":"publisher","first-page":"e1136","DOI":"10.1038\/cddis.2014.104","volume":"5","author":"O Fabre","year":"2014","unstructured":"Fabre O, Breuker C, Amouzou C, Salehzada T, Kitzmann M, Mercier J et al. Defects in TLR3 expression and RNase L activation lead to decreased MnSOD expression and insulin resistance in muscle cells of obese people. Cell Death Dis 2014; 5: e1136.","journal-title":"Cell Death Dis"},{"key":"BFcdd2015105_CR43","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.1021\/pr800135v","volume":"7","author":"DE Sleat","year":"2008","unstructured":"Sleat DE, Della Valle MC, Zheng H, Moore DF, Lobel P . The mannose 6-phosphate glycoprotein proteome. J Proteome Res 2008; 7: 3010\u20133021.","journal-title":"J Proteome Res"},{"key":"BFcdd2015105_CR44","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1038\/ncb1723","volume":"10","author":"C Kraft","year":"2008","unstructured":"Kraft C, Deplazes A, Sohrmann M, Peter M . Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p\/Bre5p ubiquitin protease. Nat Cell Biol 2008; 10: 602\u2013610.","journal-title":"Nat Cell Biol"},{"key":"BFcdd2015105_CR45","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.4161\/auto.24135","volume":"9","author":"J Zhu","year":"2013","unstructured":"Zhu J, Wang KZ, Chu CT . After the banquet: mitochondrial biogenesis, mitophagy, and cell survival. Autophagy 2013; 9: 1663\u20131676.","journal-title":"Autophagy"},{"key":"BFcdd2015105_CR46","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/boc.201100092","volume":"104","author":"L Vidalino","year":"2012","unstructured":"Vidalino L, Monti L, Haase A, Moro A, Acquati F, Taramelli R et al. Intracellular trafficking of RNASET2, a novel component of P-bodies. Biol Cell 2012; 104: 13\u201321.","journal-title":"Biol Cell"},{"key":"BFcdd2015105_CR47","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/ng.398","volume":"41","author":"M Henneke","year":"2009","unstructured":"Henneke M, Diekmann S, Ohlenbusch A, Kaiser J, Engelbrecht V, Kohlschutter A et al. RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection. Nat Genet 2009; 41: 773\u2013775.","journal-title":"Nat Genet"},{"key":"BFcdd2015105_CR48","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/nrm3025","volume":"12","author":"R Zoncu","year":"2011","unstructured":"Zoncu R, Efeyan A, Sabatini DM . mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12: 21\u201335.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcdd2015105_CR49","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/nrm3565","volume":"14","author":"C Settembre","year":"2013","unstructured":"Settembre C, Fraldi A, Medina DL, Ballabio A . Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat Rev Mol Cell Biol 2013; 14: 283\u2013296.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcdd2015105_CR50","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1194\/jlr.M500514-JLR200","volume":"47","author":"MR Richards","year":"2006","unstructured":"Richards MR, Harp JD, Ory DS, Schaffer JE . Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes. J Lipid Res 2006; 47: 665\u2013672.","journal-title":"J Lipid Res"},{"key":"BFcdd2015105_CR51","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/1756-0500-2-243","volume":"2","author":"P Holden","year":"2009","unstructured":"Holden P, Horton WA . Crude subcellular fractionation of cultured mammalian cell lines. BMC Res Notes 2009; 2: 243.","journal-title":"BMC Res Notes"},{"key":"BFcdd2015105_CR52","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","volume":"26","author":"R Re","year":"1999","unstructured":"Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C . Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 1999; 26: 1231\u20131237.","journal-title":"Free Radic Biol Med"}],"container-title":["Cell Death & Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd2015105.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2015105","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2015105.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:08:12Z","timestamp":1684415292000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd2015105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,24]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["BFcdd2015105"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2015.105","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,24]]},"assertion":[{"value":"26 February 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}