{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T17:10:29Z","timestamp":1779124229698,"version":"3.51.4"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T00:00:00Z","timestamp":1446163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1038\/cdd.2015.143","type":"journal-article","created":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T13:01:20Z","timestamp":1446210080000},"page":"695-706","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Cardiac Gab1 deletion leads to dilated cardiomyopathy associated with mitochondrial damage and cardiomyocyte apoptosis"],"prefix":"10.1038","volume":"23","author":[{"given":"J","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F Q","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Mastrangelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z G","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,10,30]]},"reference":[{"key":"BFcdd2015143_CR1","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1056\/NEJMra072139","volume":"358","author":"JA Hill","year":"2008","unstructured":"Hill JA, Olson EN . Cardiac plasticity. N Engl J Med 2008; 358: 1370\u20131380.","journal-title":"N Engl J Med"},{"key":"BFcdd2015143_CR2","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.1161\/CIRCULATIONAHA.110.942268","volume":"122","author":"I Kehat","year":"2010","unstructured":"Kehat I, Molkentin JD . Molecular pathways underlying cardiac remodeling during pathophysiological stimulation. Circulation 2010; 122: 2727\u20132735.","journal-title":"Circulation"},{"key":"BFcdd2015143_CR3","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1056\/NEJM199704173361603","volume":"336","author":"G Olivetti","year":"1997","unstructured":"Olivetti G, Abbi R, Quaini F, Kajstura J, Cheng W, Nitahara JA et al. Apoptosis in the failing human heart. N Engl J Med 1997; 336: 1131\u20131141.","journal-title":"N Engl J Med"},{"key":"BFcdd2015143_CR4","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0167-5273(01)00451-X","volume":"80","author":"O Akyurek","year":"2001","unstructured":"Akyurek O, Akyurek N, Sayin T, Dincer I, Berkalp B, Akyol G et al. Association between the severity of heart failure and the susceptibility of myocytes to apoptosis in patients with idiopathic dilated cardiomyopathy. Int J Cardiol 2001; 80: 29\u201336.","journal-title":"Int J Cardiol"},{"key":"BFcdd2015143_CR5","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1007\/s12265-010-9174-x","volume":"3","author":"GW Dorn 2nd","year":"2010","unstructured":"Dorn GW 2nd . Mitochondrial pruning by Nix and BNip3: an essential function for cardiac-expressed death factors. J Cardiovasc Transl Res 2010; 3: 374\u2013383.","journal-title":"J Cardiovasc Transl Res"},{"key":"BFcdd2015143_CR6","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1083\/jcb.201101100","volume":"194","author":"PA Harvey","year":"2011","unstructured":"Harvey PA, Leinwand LA . The cell biology of disease: cellular mechanisms of cardiomyopathy. J Cell Biol 2011; 194: 355\u2013365.","journal-title":"J Cell Biol"},{"key":"BFcdd2015143_CR7","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/S0962-8924(03)00002-3","volume":"13","author":"H Gu","year":"2003","unstructured":"Gu H, Neel BG . The \u2018gab\u2019 in signal transduction. Trends Cell Biol 2003; 13: 122\u2013130.","journal-title":"Trends Cell Biol"},{"key":"BFcdd2015143_CR8","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1161\/01.RES.0000085562.48906.4A","volume":"93","author":"Y Nakaoka","year":"2003","unstructured":"Nakaoka Y, Nishida K, Fujio Y, Izumi M, Terai K, Oshima Y et al. Activation of gp130 transduces hypertrophic signal through interaction of scaffolding\/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes. Circ Res 2003; 93: 221\u2013229.","journal-title":"Circ Res"},{"key":"BFcdd2015143_CR9","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1161\/01.RES.0000087333.88497.AE","volume":"93","author":"Y Wang","year":"2003","unstructured":"Wang Y . Fill a Gab(1) in cardiac hypertrophy signaling: search a missing link between gp130 and ERK5 in hypertrophic remodeling in heart. Circ Res 2003; 93: 186\u2013188.","journal-title":"Circ Res"},{"key":"BFcdd2015143_CR10","doi-asserted-by":"publisher","first-page":"12419","DOI":"10.1073\/pnas.94.23.12419","volume":"94","author":"M Holgado-Madruga","year":"1997","unstructured":"Holgado-Madruga M, Moscatello DK, Emlet DR, Dieterich R, Wong AJ . Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor. Proc Natl Acad Sci USA 1997; 94: 12419\u201312424.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2015143_CR11","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/384173a0","volume":"384","author":"KM Weidner","year":"1996","unstructured":"Weidner KM, Di Cesare S, Sachs M, Brinkmann V, Behrens J, Birchmeier W . Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 1996; 384: 173\u2013176.","journal-title":"Nature"},{"key":"BFcdd2015143_CR12","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/379560a0","volume":"379","author":"M Holgado-Madruga","year":"1996","unstructured":"Holgado-Madruga M, Emlet DR, Moscatello DK, Godwin AK, Wong AJ . A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature 1996; 379: 560\u2013564.","journal-title":"Nature"},{"key":"BFcdd2015143_CR13","doi-asserted-by":"publisher","first-page":"20167","DOI":"10.1074\/jbc.272.32.20167","volume":"272","author":"ED Fixman","year":"1997","unstructured":"Fixman ED, Holgado-Madruga M, Nguyen L, Kamikura DM, Fournier TM, Wong AJ et al. Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1. J Biol Chem 1997; 272: 20167\u201320172.","journal-title":"J Biol Chem"},{"key":"BFcdd2015143_CR14","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1083\/jcb.150.6.1375","volume":"150","author":"M Sachs","year":"2000","unstructured":"Sachs M, Brohmann H, Zechner D, Muller T, Hulsken J, Walther I et al. Essential role of Gab1 for signaling by the c-Met receptor in vivo. J Cell Biol 2000; 150: 1375\u20131384.","journal-title":"J Cell Biol"},{"key":"BFcdd2015143_CR15","doi-asserted-by":"publisher","first-page":"3695","DOI":"10.1128\/MCB.20.10.3695-3704.2000","volume":"20","author":"M Itoh","year":"2000","unstructured":"Itoh M, Yoshida Y, Nishida K, Narimatsu M, Hibi M, Hirano T . Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation. Mol Cell Biol 2000; 20: 3695\u20133704.","journal-title":"Mol Cell Biol"},{"key":"BFcdd2015143_CR16","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1161\/ATVBAHA.111.224493","volume":"31","author":"J Zhao","year":"2011","unstructured":"Zhao J, Wang W, Ha CH, Kim JY, Wong C, Redmond EM et al. Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis. Arterioscler Thromb Vasc Biol 2011; 31: 1016\u20131023.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BFcdd2015143_CR17","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1161\/CIRCRESAHA.110.232223","volume":"108","author":"W Shioyama","year":"2011","unstructured":"Shioyama W, Nakaoka Y, Higuchi K, Minami T, Taniyama Y, Nishida K et al. Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF\/c-met signaling. Circ Res 2011; 108: 664\u2013675.","journal-title":"Circ Res"},{"key":"BFcdd2015143_CR18","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1073\/pnas.1009395108","volume":"108","author":"Y Lu","year":"2011","unstructured":"Lu Y, Xiong Y, Huo Y, Han J, Yang X, Zhang R et al. Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway. Proc Natl Acad Sci USA 2011; 108: 2957\u20132962.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2015143_CR19","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1172\/JCI30651","volume":"117","author":"Y Nakaoka","year":"2007","unstructured":"Nakaoka Y, Nishida K, Narimatsu M, Kamiya A, Minami T, Sawa H et al. Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1\/ErbB signaling. J Clin Invest 2007; 117: 1771\u20131781.","journal-title":"J Clin Invest"},{"key":"BFcdd2015143_CR20","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s10741-012-9357-4","volume":"18","author":"S Pankuweit","year":"2013","unstructured":"Pankuweit S, Klingel K . Viral myocarditis: from experimental models to molecular diagnosis in patients. Heart Fail Rev 2013; 18: 683\u2013702.","journal-title":"Heart Fail Rev"},{"key":"BFcdd2015143_CR21","doi-asserted-by":"publisher","first-page":"H401","DOI":"10.1152\/ajpheart.00292.2008","volume":"295","author":"G Gao","year":"2008","unstructured":"Gao G, Zhang J, Si X, Wong J, Cheung C, McManus B et al. Proteasome inhibition attenuates coxsackievirus-induced myocardial damage in mice. Am J Physiol Heart Circ Physiol 2008; 295: H401\u2013H408.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFcdd2015143_CR22","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/nm1227","volume":"11","author":"EA Bard-Chapeau","year":"2005","unstructured":"Bard-Chapeau EA, Hevener AL, Long S, Zhang EE, Olefsky JM, Feng GS . Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nat Med 2005; 11: 567\u2013571.","journal-title":"Nat Med"},{"key":"BFcdd2015143_CR23","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1182\/blood.V93.6.1809.406k35_1809_1816","volume":"93","author":"K Nishida","year":"1999","unstructured":"Nishida K, Yoshida Y, Itoh M, Fukada T, Ohtani T, Shirogane T et al. Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. Blood 1999; 93: 1809\u20131816.","journal-title":"Blood"},{"key":"BFcdd2015143_CR24","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1128\/MCB.20.5.1526-1536.2000","volume":"20","author":"ZQ Shi","year":"2000","unstructured":"Shi ZQ, Yu DH, Park M, Marshall M, Feng GS . Molecular mechanism for the SHP-2 tyrosine phosphatase function in promoting growth factor stimulation of ERK activity. Mol Cell Biol 2000; 20: 1526\u20131536.","journal-title":"Mol Cell Biol"},{"key":"BFcdd2015143_CR25","doi-asserted-by":"publisher","first-page":"13842","DOI":"10.1074\/jbc.275.18.13842","volume":"275","author":"JM Cunnick","year":"2000","unstructured":"Cunnick JM, Dorsey JF, Munoz-Antonia T, Mei L, Wu J . Requirement of SHP2 binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor. J Biol Chem 2000; 275: 13842\u201313848.","journal-title":"J Biol Chem"},{"key":"BFcdd2015143_CR26","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1161\/01.RES.0000021127.83364.7D","volume":"90","author":"W Che","year":"2002","unstructured":"Che W, Lerner-Marmarosh N, Huang Q, Osawa M, Ohta S, Yoshizumi M et al. Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression. Circ Res 2002; 90: 1222\u20131230.","journal-title":"Circ Res"},{"key":"BFcdd2015143_CR27","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1038\/ncb1071","volume":"5","author":"MT Uhlik","year":"2003","unstructured":"Uhlik MT, Abell AN, Johnson NL, Sun W, Cuevas BD, Lobel-Rice KE et al. Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock. Nat Cell Biol 2003; 5: 1104\u20131110.","journal-title":"Nat Cell Biol"},{"key":"BFcdd2015143_CR28","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1161\/CIRCULATIONAHA.107.728865","volume":"117","author":"MI Kontaridis","year":"2008","unstructured":"Kontaridis MI, Yang W, Bence KK, Cullen D, Wang B, Bodyak N et al. Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase\/mitogen-activated protein kinase and RhoA signaling pathways. Circulation 2008; 117: 1423\u20131435.","journal-title":"Circulation"},{"key":"BFcdd2015143_CR29","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1161\/01.RES.0000168028.36081.e0","volume":"96","author":"M De Acetis","year":"2005","unstructured":"De Acetis M, Notte A, Accornero F, Selvetella G, Brancaccio M, Vecchione C et al. Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload. Circ Res 2005; 96: 1087\u20131094.","journal-title":"Circ Res"},{"key":"BFcdd2015143_CR30","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1101\/gad.1458906","volume":"20","author":"DE White","year":"2006","unstructured":"White DE, Coutu P, Shi YF, Tardif JC, Nattel S, St Arnaud R et al. Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure. Genes Dev 2006; 20: 2355\u20132360.","journal-title":"Genes Dev"},{"key":"BFcdd2015143_CR31","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/nm719","volume":"8","author":"MG Yussman","year":"2002","unstructured":"Yussman MG, Toyokawa T, Odley A, Lynch RA, Wu G, Colbert MC et al. Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy. Nat Med 2002; 8: 725\u2013730.","journal-title":"Nat Med"},{"key":"BFcdd2015143_CR32","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1161\/CIRCULATIONAHA.107.727073","volume":"117","author":"A Diwan","year":"2008","unstructured":"Diwan A, Wansapura J, Syed FM, Matkovich SJ, Lorenz JN, Dorn GW 2nd . Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation. Circulation 2008; 117: 396\u2013404.","journal-title":"Circulation"},{"key":"BFcdd2015143_CR33","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1101\/gad.13.15.1899","volume":"13","author":"A Gross","year":"1999","unstructured":"Gross A, McDonnell JM, Korsmeyer SJ . Bcl-2 family members and the mitochondria in apoptosis. Genes Dev 1999; 13: 1899\u20131911.","journal-title":"Genes Dev"},{"key":"BFcdd2015143_CR34","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1016\/j.cell.2006.06.010","volume":"125","author":"DC Chan","year":"2006","unstructured":"Chan DC . Mitochondria: dynamic organelles in disease, aging, and development. Cell 2006; 125: 1241\u20131252.","journal-title":"Cell"},{"key":"BFcdd2015143_CR35","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1172\/JCI24405","volume":"115","author":"JM Huss","year":"2005","unstructured":"Huss JM, Kelly DP . Mitochondrial energy metabolism in heart failure: a question of balance. J Clin Invest 2005; 115: 547\u2013555.","journal-title":"J Clin Invest"},{"key":"BFcdd2015143_CR36","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1002\/aja.1001500105","volume":"150","author":"HG Sachs","year":"1977","unstructured":"Sachs HG, Colgan JA, Lazarus ML . Ultrastructure of the aging myocardium: a morphometric approach. Am J Anat 1977; 150: 63\u201371.","journal-title":"Am J Anat"},{"key":"BFcdd2015143_CR37","doi-asserted-by":"publisher","first-page":"12929","DOI":"10.1073\/pnas.2134694100","volume":"100","author":"JJ Jacoby","year":"2003","unstructured":"Jacoby JJ, Kalinowski A, Liu MG, Zhang SS, Gao Q, Chai GX et al. Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age. Proc Natl Acad Sci USA 2003; 100: 12929\u201312934.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2015143_CR38","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1161\/CIRCRESAHA.111.246108","volume":"110","author":"D Dutta","year":"2012","unstructured":"Dutta D, Calvani R, Bernabei R, Leeuwenburgh C, Marzetti E . Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities. Circ Res 2012; 110: 1125\u20131138.","journal-title":"Circ Res"},{"key":"BFcdd2015143_CR39","doi-asserted-by":"publisher","first-page":"e002278","DOI":"10.1161\/JAHA.115.002278","volume":"4","author":"J Yoshioka","year":"2015","unstructured":"Yoshioka J . Thioredoxin Reductase 2 (Txnrd2) regulates mitochondrial integrity in the progression of age-related heart failure. J Am Heart Assoc 2015; 4: e002278.","journal-title":"J Am Heart Assoc"},{"key":"BFcdd2015143_CR40","doi-asserted-by":"crossref","unstructured":"Zhang D, Contu R, Latronico MV, Zhang J, Rizzi R, Catalucci D et al. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest 120: 2805\u20132816.","DOI":"10.1172\/JCI43008"},{"key":"BFcdd2015143_CR41","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1161\/CIRCRESAHA.109.198416","volume":"105","author":"N Koitabashi","year":"2009","unstructured":"Koitabashi N, Bedja D, Zaiman AL, Pinto YM, Zhang M, Gabrielson KL et al. Avoidance of transient cardiomyopathy in cardiomyocyte-targeted tamoxifen-induced mercremer gene deletion models. Circ Res 2009; 105: 12\u201315.","journal-title":"Circ Res"},{"key":"BFcdd2015143_CR42","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1242\/dmm.010447","volume":"6","author":"K Bersell","year":"2013","unstructured":"Bersell K, Choudhury S, Mollova M, Polizzotti BD, Ganapathy B, Walsh S et al. Moderate and high amounts of tamoxifen in alphamhc-mercremer mice induce a DNA damage response, leading to heart failure and death. Dis Model Mech 2013; 6: 1459\u20131469.","journal-title":"Dis Model Mech"},{"key":"BFcdd2015143_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0014-5793(02)02425-0","volume":"515","author":"Y Liu","year":"2002","unstructured":"Liu Y, Rohrschneider LR . The gift of gab. FEBS Lett 2002; 515: 1\u20137.","journal-title":"FEBS Lett"},{"key":"BFcdd2015143_CR44","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1161\/CIRCULATIONAHA.106.631093","volume":"115","author":"D Xiong","year":"2007","unstructured":"Xiong D, Yajima T, Lim BK, Stenbit A, Dublin A, Dalton ND et al. Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy. Circulation 2007; 115: 94\u2013102.","journal-title":"Circulation"},{"key":"BFcdd2015143_CR45","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1161\/CIRCULATIONAHA.111.082453","volume":"126","author":"F Dong","year":"2012","unstructured":"Dong F, Harvey J, Finan A, Weber K, Agarwal U, Penn MS . Myocardial CXCR4 expression is required for mesenchymal stem cell mediated repair following acute myocardial infarction. Circulation 2012; 126: 314\u2013324.","journal-title":"Circulation"},{"key":"BFcdd2015143_CR46","doi-asserted-by":"publisher","first-page":"e000457","DOI":"10.1161\/JAHA.113.000457","volume":"2","author":"AJ Perricone","year":"2013","unstructured":"Perricone AJ, Bivona BJ, Jackson FR, Vander Heide RS . Conditional knockout of myocyte focal adhesion kinase abrogates ischemic preconditioning in adult murine hearts. J Am Heart Assoc 2013; 2: e000457.","journal-title":"J Am Heart Assoc"},{"key":"BFcdd2015143_CR47","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/ng772","volume":"29","author":"M Tartaglia","year":"2001","unstructured":"Tartaglia M, Mehler EL, Goldberg R, Zampino G, Brunner HG, Kremer H et al. Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nat Genet 2001; 29: 465\u2013468.","journal-title":"Nat Genet"},{"key":"BFcdd2015143_CR48","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/nm1084","volume":"10","author":"T Araki","year":"2004","unstructured":"Araki T, Mohi MG, Ismat FA, Bronson RT, Williams IR, Kutok JL et al. Mouse model of noonan syndrome reveals cell type- and gene dosage-dependent effects of PTPN11 mutation. Nat Med 2004; 10: 849\u2013857.","journal-title":"Nat Med"},{"key":"BFcdd2015143_CR49","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/ng2078","volume":"39","author":"MA Razzaque","year":"2007","unstructured":"Razzaque MA, Nishizawa T, Komoike Y, Yagi H, Furutani M, Amo R et al. Germline gain-of-function mutations in RAF1 cause Noonan syndrome. Nat Genet 2007; 39: 1013\u20131017.","journal-title":"Nat Genet"},{"key":"BFcdd2015143_CR50","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1038\/ng2073","volume":"39","author":"B Pandit","year":"2007","unstructured":"Pandit B, Sarkozy A, Pennacchio LA, Carta C, Oishi K, Martinelli S et al. Gain-of-function RAF1 mutations cause Noonan and Leopard syndromes with hypertrophic cardiomyopathy. Nat Genet 2007; 39: 1007\u20131012.","journal-title":"Nat Genet"},{"key":"BFcdd2015143_CR51","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/ng.2963","volume":"46","author":"PS Dhandapany","year":"2014","unstructured":"Dhandapany PS, Razzaque MA, Muthusami U, Kunnoth S, Edwards JJ, Mulero-Navarro S et al. RAF1 mutations in childhood-onset dilated cardiomyopathy. Nat Genet 2014; 46: 635\u2013639.","journal-title":"Nat Genet"},{"key":"BFcdd2015143_CR52","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1128\/MCB.01661-08","volume":"29","author":"F Princen","year":"2009","unstructured":"Princen F, Bard E, Sheikh F, Zhang SS, Wang J, Zago WM et al. Deletion of SHP2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death. Mol Cell Biol 2009; 29: 378\u2013388.","journal-title":"Mol Cell Biol"},{"key":"BFcdd2015143_CR53","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1172\/JCI200420317","volume":"114","author":"O Yamaguchi","year":"2004","unstructured":"Yamaguchi O, Watanabe T, Nishida K, Kashiwase K, Higuchi Y, Takeda T et al. Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J Clin Invest 2004; 114: 937\u2013943.","journal-title":"J Clin Invest"},{"key":"BFcdd2015143_CR54","doi-asserted-by":"publisher","first-page":"6341","DOI":"10.1093\/emboj\/19.23.6341","volume":"19","author":"OF Bueno","year":"2000","unstructured":"Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R et al. The MEK1-ERK1\/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J 2000; 19: 6341\u20136350.","journal-title":"EMBO J"},{"key":"BFcdd2015143_CR55","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1161\/01.RES.0000038488.38975.1A","volume":"91","author":"OF Bueno","year":"2002","unstructured":"Bueno OF, Molkentin JD . Involvement of extracellular signal-regulated kinases 1\/2 in cardiac hypertrophy and cell death. Circ Res 2002; 91: 776\u2013781.","journal-title":"Circ Res"},{"key":"BFcdd2015143_CR56","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1161\/01.CIR.0000138190.50127.6A","volume":"110","author":"IS Harris","year":"2004","unstructured":"Harris IS, Zhang S, Treskov I, Kovacs A, Weinheimer C, Muslin AJ . Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload. Circulation 2004; 110: 718\u2013723.","journal-title":"Circulation"},{"key":"BFcdd2015143_CR57","doi-asserted-by":"publisher","first-page":"14074","DOI":"10.1073\/pnas.0610906104","volume":"104","author":"NH Purcell","year":"2007","unstructured":"Purcell NH, Wilkins BJ, York A, Saba-El-Leil MK, Meloche S, Robbins J et al. Genetic inhibition of cardiac ERK1\/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. Proc Natl Acad Sci USA 2007; 104: 14074\u201314079.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2015143_CR58","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/j.yjmcc.2003.10.001","volume":"35","author":"Q Liang","year":"2003","unstructured":"Liang Q, Molkentin JD . Redefining the roles of p38 and jnk signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models. J Mol Cell Cardiol 2003; 35: 1385\u20131394.","journal-title":"J Mol Cell Cardiol"},{"key":"BFcdd2015143_CR59","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1172\/JCI29576","volume":"117","author":"PS Peter","year":"2007","unstructured":"Peter PS, Brady JE, Yan L, Chen W, Engelhardt S, Wang Y et al. Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor. J Clin Invest 2007; 117: 1335\u20131343.","journal-title":"J Clin Invest"},{"key":"BFcdd2015143_CR60","doi-asserted-by":"publisher","first-page":"12283","DOI":"10.1073\/pnas.211086598","volume":"98","author":"P Liao","year":"2001","unstructured":"Liao P, Georgakopoulos D, Kovacs A, Zheng M, Lerner D, Pu H et al. The in vivo role of p38 map kinases in cardiac remodeling and restrictive cardiomyopathy. Proc Natl Acad Sci USA 2001; 98: 12283\u201312288.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2015143_CR61","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.tcm.2003.11.002","volume":"14","author":"BG Petrich","year":"2004","unstructured":"Petrich BG, Wang Y . Stress-activated map kinases in cardiac remodeling and heart failure; new insights from transgenic studies. Trends Cardiovasc Med 2004; 14: 50\u201355.","journal-title":"Trends Cardiovasc Med"},{"key":"BFcdd2015143_CR62","doi-asserted-by":"crossref","unstructured":"Abel ED, Doenst T . Mitochondrial adaptations to physiological vs pathological cardiac hypertrophy. Cardiovasc Res 90: 234\u2013242.","DOI":"10.1093\/cvr\/cvr015"},{"key":"BFcdd2015143_CR63","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/0092-8674(93)90509-O","volume":"74","author":"ZN Oltvai","year":"1993","unstructured":"Oltvai ZN, Milliman CL, Korsmeyer SJ . Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 609\u2013619.","journal-title":"Cell"},{"key":"BFcdd2015143_CR64","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1530\/EJE-11-0584","volume":"165","author":"SI Chisalita","year":"2011","unstructured":"Chisalita SI, Dahlstrom U, Arnqvist HJ, Alehagen U . Increased IGF1 levels in relation to heart failure and cardiovascular mortality in an elderly population: impact of ACE inhibitors. Eur J Endocrinol 2011; 165: 891\u2013898.","journal-title":"Eur J Endocrinol"},{"key":"BFcdd2015143_CR65","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1038\/nm.2961","volume":"18","author":"NR Sundaresan","year":"2012","unstructured":"Sundaresan NR, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V et al. The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Nat Med 2012; 18: 1643\u20131650.","journal-title":"Nat Med"},{"key":"BFcdd2015143_CR66","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.bbrc.2011.07.024","volume":"411","author":"G Goormachtigh","year":"2011","unstructured":"Goormachtigh G, Ji Z, Le Goff A, Fafeur V . Degradation of the GAB1 adaptor by the ubiquitin-proteasome pathway hampers HGF\/SF-MET signaling. Biochem Biophys Res Commun 2011; 411: 780\u2013785.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcdd2015143_CR67","doi-asserted-by":"publisher","first-page":"H1765","DOI":"10.1152\/ajpheart.00559.2011","volume":"301","author":"R Ram","year":"2011","unstructured":"Ram R, Mickelsen DM, Theodoropoulos C, Blaxall BC . New approaches in small animal echocardiography: imaging the sounds of silence. Am J Physiol Heart Circ Physiol 2011; 301: H1765\u2013H1780.","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd2015143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2015143","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2015143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:08:40Z","timestamp":1684415320000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd2015143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,30]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["BFcdd2015143"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2015.143","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,30]]},"assertion":[{"value":"18 March 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}