{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:18:19Z","timestamp":1789816699772,"version":"4.0.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:00:00Z","timestamp":1429747200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1038\/cdd.2015.34","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T15:24:04Z","timestamp":1429889044000},"page":"1812-1823","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Chaperone-like protein p32 regulates ULK1 stability and autophagy"],"prefix":"10.1038","volume":"22","author":[{"given":"H","family":"Jiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G-Q","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L-m","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z-X","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y-C","family":"Liou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,4,23]]},"reference":[{"key":"BFcdd201534_CR1","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1128\/MCB.01101-09","volume":"30","author":"V Fogal","year":"2010","unstructured":"Fogal V, Richardson AD, Karmali PP, Scheffler IE, Smith JW, Ruoslahti E . Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation. Mol Cell Biol 2010; 30: 1303\u20131318.","journal-title":"Mol Cell Biol"},{"key":"BFcdd201534_CR2","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1099\/0022-1317-79-7-1677","volume":"79","author":"DA Matthews","year":"1998","unstructured":"Matthews DA, Russell WC . Adenovirus core protein V interacts with p32\u2014a protein which is associated with both the mitochondria and the nucleus. J Gen Virol 1998; 79: 1677\u20131685.","journal-title":"J Gen Virol"},{"key":"BFcdd201534_CR3","doi-asserted-by":"publisher","first-page":"3572","DOI":"10.1073\/pnas.96.7.3572","volume":"96","author":"J Jiang","year":"1999","unstructured":"Jiang J, Zhang Y, Krainer AR, Xu RM . Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein. Proc Natl Acad Sci USA 1999; 96: 3572\u20133577.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201534_CR4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s004180000191","volume":"114","author":"BJ Soltys","year":"2000","unstructured":"Soltys BJ, Kang D, Gupta RS . Localization of P32 protein (gC1q-R) in mitochondria and at specific extramitochondrial locations in normal tissues. Histochem Cell Biol 2000; 114: 245\u2013255.","journal-title":"Histochem Cell Biol"},{"key":"BFcdd201534_CR5","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1242\/jcs.114.11.2115","volume":"114","author":"HC van Leeuwen","year":"2001","unstructured":"van Leeuwen HC, O\u2019Hare P . Retargeting of the mitochondrial protein p32\/gC1Qr to a cytoplasmic compartment and the cell surface. J Cell Sci 2001; 114: 2115\u20132123.","journal-title":"J Cell Sci"},{"key":"BFcdd201534_CR6","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1054\/bjoc.2000.1330","volume":"83","author":"A Parle-McDermott","year":"2000","unstructured":"Parle-McDermott A, McWilliam P, Tighe O, Dunican D, Croke DT . Serial analysis of gene expression identifies putative metastasis-associated transcripts in colon tumour cell lines. Br J Cancer 2000; 83: 725\u2013728.","journal-title":"Br J Cancer"},{"key":"BFcdd201534_CR7","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1002\/ijc.20105","volume":"110","author":"DB Rubinstein","year":"2004","unstructured":"Rubinstein DB, Stortchevoi A, Boosalis M, Ashfaq R, Ghebrehiwet B, Peerschke EI et al. Receptor for the globular heads of C1q (gC1q-R, p33, hyaluronan-binding protein) is preferentially expressed by adenocarcinoma cells. Int J Cancer 2004; 110: 741\u2013750.","journal-title":"Int J Cancer"},{"key":"BFcdd201534_CR8","doi-asserted-by":"publisher","first-page":"7210","DOI":"10.1158\/0008-5472.CAN-07-6752","volume":"68","author":"V Fogal","year":"2008","unstructured":"Fogal V, Zhang L, Krajewski S, Ruoslahti E . Mitochondrial\/cell-surface protein p32\/gC1qR as a molecular target in tumor cells and tumor stroma. Cancer Res 2008; 68: 7210\u20137218.","journal-title":"Cancer Res"},{"key":"BFcdd201534_CR9","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1002\/jso.21329","volume":"100","author":"YB Chen","year":"2009","unstructured":"Chen YB, Jiang CT, Zhang GQ, Wang JS, Pang D . Increased expression of hyaluronic acid binding protein 1 is correlated with poor prognosis in patients with breast cancer. J Surg Oncol 2009; 100: 382\u2013386.","journal-title":"J Surg Oncol"},{"key":"BFcdd201534_CR10","doi-asserted-by":"publisher","first-page":"9717","DOI":"10.1093\/nar\/gks774","volume":"40","author":"M Yagi","year":"2012","unstructured":"Yagi M, Uchiumi T, Takazaki S, Okuno B, Nomura M, Yoshida S et al. p32\/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability. Nucleic Acids Res 2012; 40: 9717\u20139737.","journal-title":"Nucleic Acids Res"},{"key":"BFcdd201534_CR11","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1042\/BJ20121829","volume":"453","author":"M Hu","year":"2013","unstructured":"Hu M, Crawford SA, Henstridge DC, Ng IH, Boey EJ, Xu Y et al. p32 protein levels are integral to mitochondrial and endoplasmic reticulum morphology, cell metabolism and survival. Biochem J 2013; 453: 381\u2013391.","journal-title":"Biochem J"},{"key":"BFcdd201534_CR12","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/sj.cdd.4401418","volume":"11","author":"J Sunayama","year":"2004","unstructured":"Sunayama J, Ando Y, Itoh N, Tomiyama A, Sakurada K, Sugiyama A et al. Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32. Cell Death Differ 2004; 11: 771\u2013781.","journal-title":"Cell Death Differ"},{"key":"BFcdd201534_CR13","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.ccr.2008.04.002","volume":"13","author":"K Itahana","year":"2008","unstructured":"Itahana K, Zhang Y . Mitochondrial p32 is a critical mediator of ARF-induced apoptosis. Cancer Cell 2008; 13: 542\u2013553.","journal-title":"Cancer Cell"},{"key":"BFcdd201534_CR14","doi-asserted-by":"publisher","first-page":"24601","DOI":"10.1074\/jbc.M002964200","volume":"275","author":"P Storz","year":"2000","unstructured":"Storz P, Hausser A, Link G, Dedio J, Ghebrehiwet B, Pfizenmaier K et al. Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32. J Biol Chem 2000; 275: 24601\u201324607.","journal-title":"J Biol Chem"},{"key":"BFcdd201534_CR15","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1182\/blood-2008-02-137398","volume":"112","author":"M Kundu","year":"2008","unstructured":"Kundu M, Lindsten T, Yang CY, Wu J, Zhao F, Zhang J et al. Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood 2008; 112: 1493\u20131502.","journal-title":"Blood"},{"key":"BFcdd201534_CR16","doi-asserted-by":"publisher","first-page":"5842","DOI":"10.1073\/pnas.0701402104","volume":"104","author":"X Zhou","year":"2007","unstructured":"Zhou X, Babu JR, da Silva S, Shu Q, Graef IA, Oliver T et al. Unc-51-like kinase 1\/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons. Proc Natl Acad Sci USA 2007; 104: 5842\u20135847.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201534_CR17","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/ncb2708","volume":"15","author":"F Nazio","year":"2013","unstructured":"Nazio F, Strappazzon F, Antonioli M, Bielli P, Cianfanelli V, Bordi M et al. mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6. Nat Cell Biol 2013; 15: 406\u2013416.","journal-title":"Nat Cell Biol"},{"key":"BFcdd201534_CR18","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1126\/science.1196371","volume":"331","author":"DF Egan","year":"2011","unstructured":"Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011; 331: 456\u2013461.","journal-title":"Science"},{"key":"BFcdd201534_CR19","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/ncb2152","volume":"13","author":"J Kim","year":"2011","unstructured":"Kim J, Kundu M, Viollet B, Guan KL . AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011; 13: 132\u2013141.","journal-title":"Nat Cell Biol"},{"key":"BFcdd201534_CR20","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1161\/RES.0b013e3182194c29","volume":"108","author":"K Mao","year":"2011","unstructured":"Mao K, Klionsky DJ . AMPK activates autophagy by phosphorylating ULK1. Circ Res 2011; 108: 787\u2013788.","journal-title":"Circ Res"},{"key":"BFcdd201534_CR21","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.molcel.2011.06.018","volume":"43","author":"JH Joo","year":"2011","unstructured":"Joo JH, Dorsey FC, Joshi A, Hennessy-Walters KM, Rose KL, McCastlain K et al. Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Mol Cell 2011; 43: 572\u2013585.","journal-title":"Mol Cell"},{"key":"BFcdd201534_CR22","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1002\/embr.201438501","volume":"15","author":"W Wu","year":"2014","unstructured":"Wu W, Tian W, Hu Z, Chen G, Huang L, Li W et al. ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy. EMBO Rep 2014; 15: 566\u2013575.","journal-title":"EMBO Rep"},{"key":"BFcdd201534_CR23","doi-asserted-by":"publisher","first-page":"25464","DOI":"10.1074\/jbc.M703663200","volume":"282","author":"EY Chan","year":"2007","unstructured":"Chan EY, Kir S, Tooze SA . siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy. J Biol Chem 2007; 282: 25464\u201325474.","journal-title":"J Biol Chem"},{"key":"BFcdd201534_CR24","doi-asserted-by":"publisher","first-page":"e1000298","DOI":"10.1371\/journal.pbio.1000298","volume":"8","author":"DP Narendra","year":"2010","unstructured":"Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J et al. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 2010; 8: e1000298.","journal-title":"PLoS Biol"},{"key":"BFcdd201534_CR25","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0014-5793(02)03153-8","volume":"527","author":"DV Rozanov","year":"2002","unstructured":"Rozanov DV, Ghebrehiwet B, Ratnikov B, Monosov EZ, Deryugina EI, Strongin AY . The cytoplasmic tail peptide sequence of membrane type-1 matrix metalloproteinase (MT1-MMP) directly binds to gC1qR, a compartment-specific chaperone-like regulatory protein. FEBS Lett 2002; 527: 51\u201357.","journal-title":"FEBS Lett"},{"key":"BFcdd201534_CR26","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.cmet.2013.03.014","volume":"17","author":"S Melser","year":"2013","unstructured":"Melser S, Chatelain EH, Lavie J, Mahfouf W, Jose C, Obre E et al. Rheb regulates mitophagy induced by mitochondrial energetic status. Cell Metab 2013; 17: 719\u2013730.","journal-title":"Cell Metab"}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd201534.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201534","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201534.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:09:15Z","timestamp":1684415355000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd201534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,23]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["BFcdd201534"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2015.34","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,23]]},"assertion":[{"value":"4 November 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}