{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:11:39Z","timestamp":1791389499370,"version":"4.3.3"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T00:00:00Z","timestamp":1478217600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1038\/cdd.2016.121","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T18:25:03Z","timestamp":1485887103000},"page":"276-287","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Autophagy regulates MAVS signaling activation in a phosphorylation-dependent manner in microglia"],"prefix":"10.1038","volume":"24","author":[{"given":"Jinbo","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baidong","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengqiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,4]]},"reference":[{"key":"BFcdd2016121_CR1","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/ni1243","volume":"6","author":"T Kawai","year":"2005","unstructured":"Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 2005; 6: 981\u2013988.","journal-title":"Nat Immunol"},{"key":"BFcdd2016121_CR2","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.cell.2005.08.012","volume":"122","author":"RB Seth","year":"2005","unstructured":"Seth RB, Sun L, Ea CK, Chen ZJ . Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 2005; 122: 669\u2013682.","journal-title":"Cell"},{"key":"BFcdd2016121_CR3","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.molcel.2005.08.014","volume":"19","author":"LG Xu","year":"2005","unstructured":"Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB . VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell 2005; 19: 727\u2013740.","journal-title":"Mol Cell"},{"key":"BFcdd2016121_CR4","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1126\/science.1185068","volume":"327","author":"J Rehwinkel","year":"2010","unstructured":"Rehwinkel J, Reis e Sousa C . RIGorous detection: exposing virus through RNA sensing. Science 2010; 327: 284\u2013286.","journal-title":"Science"},{"key":"BFcdd2016121_CR5","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.cell.2013.02.054","volume":"153","author":"N Subramanian","year":"2013","unstructured":"Subramanian N, Natarajan K, Clatworthy MR, Wang Z, Germain RN . The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell 2013; 153: 348\u2013361.","journal-title":"Cell"},{"key":"BFcdd2016121_CR6","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1126\/science.1167728","volume":"324","author":"S Nejentsev","year":"2009","unstructured":"Nejentsev S, Walker N, Riches D, Egholm M, Todd JA . Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 2009; 324: 387\u2013389.","journal-title":"Science"},{"key":"BFcdd2016121_CR7","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.immuni.2013.12.014","volume":"40","author":"M Funabiki","year":"2014","unstructured":"Funabiki M, Kato H, Miyachi Y, Toki H, Motegi H, Inoue M et al. Autoimmune disorders associated with gain of function of the intracellular sensor MDA5. Immunity 2014; 40: 199\u2013212.","journal-title":"Immunity"},{"key":"BFcdd2016121_CR8","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1038\/cr.2007.81","volume":"17","author":"Y Wang","year":"2007","unstructured":"Wang Y, Zhang HX, Sun YP, Liu ZX, Liu XS, Wang L et al. Rig-I\u2212\/\u2212 mice develop colitis associated with downregulation of G alpha i2. Cell Res 2007; 17: 858\u2013868.","journal-title":"Cell Res"},{"key":"BFcdd2016121_CR9","first-page":"127","volume":"140","author":"KJ Bryson","year":"2013","unstructured":"Bryson KJ, Ligertwood Y, Quigg-Nicol M, Dutia BM, Manson J, Nash AA . Influenza A virus infection contributes to Parkinson's disease by driving pathological CD4(+) T cell responses in the brain. Immunology 2013; 140: 127\u2013127.","journal-title":"Immunology"},{"key":"BFcdd2016121_CR10","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1002\/mds.25077","volume":"27","author":"MA Harris","year":"2012","unstructured":"Harris MA, Tsui JK, Marion SA, Shen H, Teschke K . Association of Parkinson's disease with infections and occupational exposure to possible vectors. Mov Disord 2012; 27: 1111\u20131117.","journal-title":"Mov Disord"},{"key":"BFcdd2016121_CR11","doi-asserted-by":"publisher","first-page":"14063","DOI":"10.1073\/pnas.0900096106","volume":"106","author":"H Jang","year":"2009","unstructured":"Jang H, Boltz D, Sturm-Ramirez K, Shepherd KR, Jiao Y, Webster R et al. Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration. Proc Natl Acad Sci USA 2009; 106: 14063\u201314068.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2016121_CR12","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1371\/journal.pone.0020495","volume":"6","author":"TT Rohn","year":"2011","unstructured":"Rohn TT, Catlin LW . Immunolocalization of influenza A virus and markers of inflammation in the human Parkinson's disease brain. Plos One 2011; 6: 5.","journal-title":"Plos One"},{"key":"BFcdd2016121_CR13","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1111\/j.1750-2659.2011.00232.x","volume":"5","author":"S Toovey","year":"2011","unstructured":"Toovey S, Jick SS, Meier CR . Parkinson's disease or Parkinson symptoms following seasonal influenza. Influenza Other Respir Viruses 2011; 5: 328\u2013333.","journal-title":"Influenza Other Respir Viruses"},{"key":"BFcdd2016121_CR14","doi-asserted-by":"publisher","first-page":"16091","DOI":"10.1523\/JNEUROSCI.2400-10.2010","volume":"30","author":"M Deleidi","year":"2010","unstructured":"Deleidi M, Hallett PJ, Koprich JB, Chung CY, Isacson O . The toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration. J Neurosci 2010; 30: 16091\u201316101.","journal-title":"J Neurosci"},{"key":"BFcdd2016121_CR15","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/j.bbi.2010.04.004","volume":"24","author":"R Field","year":"2010","unstructured":"Field R, Campion S, Warren C, Murray C, Cunningham C . Systemic challenge with the TLR3 agonist poly I:C induces amplified IFN alpha\/beta and IL-1 beta responses in the diseased brain and exacerbates chronic neurodegeneration. Brain Behav Immun 2010; 24: 996\u20131007.","journal-title":"Brain Behav Immun"},{"key":"BFcdd2016121_CR16","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/1742-2094-10-143","volume":"10","author":"S Tanaka","year":"2013","unstructured":"Tanaka S, Ishii A, Ohtaki H, Shioda S, Yoshida T, Numazawa S . Activation of microglia induces symptoms of Parkinson's disease in wild-type, but not in IL-1 knockout mice. J Neuroinflammation 2013; 10: 143.","journal-title":"J Neuroinflammation"},{"key":"BFcdd2016121_CR17","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/glia.22595","volume":"62","author":"A Borrajo","year":"2014","unstructured":"Borrajo A, Rodriguez-Perez AI, Diaz-Ruiz C, Guerra MJ, Labandeira-Garcia JL . Microglial TNF-alpha mediates enhancement of dopaminergic degeneration by brain angiotensin. Glia 2014; 62: 145\u2013157.","journal-title":"Glia"},{"key":"BFcdd2016121_CR18","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1038\/mt.2008.146","volume":"16","author":"MK McCoy","year":"2008","unstructured":"McCoy MK, Ruhn KA, Martinez TN, McAlpine FE, Blesch A, Tansey MG . Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats. Mol Ther 2008; 16: 1572\u20131579.","journal-title":"Mol Ther"},{"key":"BFcdd2016121_CR19","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/glia.440090305","volume":"9","author":"RB Banati","year":"1993","unstructured":"Banati RB, Gehrmann J, Czech C, Monning U, Jones LL, Konig G et al. Early and rapid de novo synthesis of Alzheimer beta A4-amyloid precursor protein (APP) in activated microglia. Glia 1993; 9: 199\u2013210.","journal-title":"Glia"},{"key":"BFcdd2016121_CR20","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1038\/srep01393","volume":"3","author":"C Noelker","year":"2013","unstructured":"Noelker C, Morel L, Lescot T, Osterloh A, Alvarez-Fischer D, Breloer M et al. Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease. Sci Rep 2013; 3: 1393.","journal-title":"Sci Rep"},{"key":"BFcdd2016121_CR21","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/0006-8993(95)01257-5","volume":"707","author":"C Schwab","year":"1996","unstructured":"Schwab C, Steele JC, McGeer PL . Neurofibrillary tangles of Guam parkinson-dementia are associated with reactive microglia and complement proteins. Brain Res 1996; 707: 196\u2013205.","journal-title":"Brain Res"},{"key":"BFcdd2016121_CR22","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.neuint.2006.07.014","volume":"50","author":"XJ Wang","year":"2007","unstructured":"Wang XJ, Yan ZQ, Lu GQ, Stuart S, Chen SD . Parkinson disease IgG and C5a-induced synergistic dopaminergic neurotoxicity: role of microglia. Neurochem Int 2007; 50: 39\u201350.","journal-title":"Neurochem Int"},{"key":"BFcdd2016121_CR23","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.1073\/pnas.0807694106","volume":"106","author":"MC Tal","year":"2009","unstructured":"Tal MC, Sasai M, Lee HK, Yordy B, Shadel GS, Iwasaki A . Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proc Natl Acad Sci USA 2009; 106: 2770\u20132775.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2016121_CR24","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/nature04723","volume":"441","author":"M Komatsu","year":"2006","unstructured":"Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006; 441: 880\u2013884.","journal-title":"Nature"},{"key":"BFcdd2016121_CR25","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/nature04724","volume":"441","author":"T Hara","year":"2006","unstructured":"Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006; 441: 885\u2013889.","journal-title":"Nature"},{"key":"BFcdd2016121_CR26","doi-asserted-by":"publisher","first-page":"7585","DOI":"10.1523\/JNEUROSCI.5809-11.2012","volume":"32","author":"LG Friedman","year":"2012","unstructured":"Friedman LG, Lachenmayer ML, Wang J, He L, Poulose SM, Komatsu M et al. Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of alpha-synuclein and LRRK2 in the brain. J Neurosci 2012; 32: 7585\u20137593.","journal-title":"J Neurosci"},{"key":"BFcdd2016121_CR27","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s11064-012-0909-8","volume":"38","author":"K Liu","year":"2013","unstructured":"Liu K, Shi N, Sun Y, Zhang T, Sun X . Therapeutic effects of rapamycin on MPTP-induced Parkinsonism in mice. Neurochem Res 2013; 38: 201\u2013207.","journal-title":"Neurochem Res"},{"key":"BFcdd2016121_CR28","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1189\/jlb.0608385","volume":"85","author":"BR Tambuyzer","year":"2009","unstructured":"Tambuyzer BR, Ponsaerts P, Nouwen EJ . Microglia: gatekeepers of central nervous system immunology. J Leukocyte Biol 2009; 85: 352\u2013370.","journal-title":"J Leukocyte Biol"},{"key":"BFcdd2016121_CR29","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.immuni.2012.03.025","volume":"36","author":"Y Lei","year":"2012","unstructured":"Lei Y, Wen H, Yu Y, Taxman DJ, Zhang L, Widman DG et al. The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity 2012; 36: 933\u2013946.","journal-title":"Immunity"},{"key":"BFcdd2016121_CR30","doi-asserted-by":"publisher","first-page":"14050","DOI":"10.1073\/pnas.0704014104","volume":"104","author":"N Jounai","year":"2007","unstructured":"Jounai N, Takeshita F, Kobiyama K, Sawano A, Miyawaki A, Xin KQ et al. The Atg5 Atg12 conjugate associates with innate antiviral immune responses. Proc Natl Acad Sci USA 2007; 104: 14050\u201314055.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd2016121_CR31","doi-asserted-by":"publisher","first-page":"24131","DOI":"10.1074\/jbc.M702824200","volume":"282","author":"S Pankiv","year":"2007","unstructured":"Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H et al. p62\/SQSTM1 binds directly to Atg8\/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007; 282: 24131\u201324145.","journal-title":"J Biol Chem"},{"key":"BFcdd2016121_CR32","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/j.febslet.2010.01.018","volume":"584","author":"NN Noda","year":"2010","unstructured":"Noda NN, Ohsumi Y, Inagaki F . Atg8-family interacting motif crucial for selective autophagy. FEBS Lett 2010; 584: 1379\u20131385.","journal-title":"FEBS Lett"},{"key":"BFcdd2016121_CR33","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/ncb2422","volume":"14","author":"L Liu","year":"2012","unstructured":"Liu L, Feng D, Chen G, Chen M, Zheng Q, Song P et al. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol 2012; 14: 177\u2013185.","journal-title":"Nat Cell Biol"},{"key":"BFcdd2016121_CR34","first-page":"S185","volume":"43","author":"DA Drechsel","year":"2007","unstructured":"Drechsel DA, Liang LP, Ryan KR, Patel M . Mitochondrial mechanisms of ROS production and oxidative stress by redox cycling herbicides implicated in Parkinson's disease. Free Radical Bio Med 2007; 43: S185\u2013S185.","journal-title":"Free Radical Bio Med"},{"key":"BFcdd2016121_CR35","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1016\/j.biopsych.2007.04.020","volume":"62","author":"SH Guo","year":"2007","unstructured":"Guo SH, Yan JQ, Yang TB, Yang XQ, Bezard E, Zhao BL . Protective effects of green tea polyphenols in the 6-OHDA rat model of Parkinson's disease through inhibition of ROS-NO pathway. Biol Psychiat 2007; 62: 1353\u20131362.","journal-title":"Biol Psychiat"},{"key":"BFcdd2016121_CR36","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1111\/j.1742-7843.2010.00612.x","volume":"107","author":"HG Kim","year":"2010","unstructured":"Kim HG, Ju MS, Kim DH, Hong J, Cho SH, Cho KH et al. Protective effects of chunghyuldan against ROS-mediated neuronal cell death in models of Parkinson's disease. Basic Clin Pharmacol Toxicol 2010; 107: 958\u2013964.","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"BFcdd2016121_CR37","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.febslet.2009.11.025","volume":"584","author":"T Song","year":"2009","unstructured":"Song T, Wei C, Zheng Z, Xu Y, Cheng X, Yuan Y et al. c-Abl tyrosine kinase interacts with MAVS and regulates innate immune response. FEBS Lett 2009; 584: 33\u201338.","journal-title":"FEBS Lett"},{"key":"BFcdd2016121_CR38","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.4161\/auto.29647","volume":"10","author":"MH Cho","year":"2014","unstructured":"Cho MH, Cho K, Kang HJ, Jeon EY, Kim HS, Kwon HJ et al. Autophagy in microglia degrades extracellular beta-amyloid fibrils and regulates the NLRP3 inflammasome. Autophagy 2014; 10: 1761\u20131775.","journal-title":"Autophagy"},{"key":"BFcdd2016121_CR39","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nature09782","volume":"469","author":"B Levine","year":"2011","unstructured":"Levine B, Mizushima N, Virgin HW . Autophagy in immunity and inflammation. Nature 2011; 469: 323\u2013335.","journal-title":"Nature"},{"key":"BFcdd2016121_CR40","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/ni.1726","volume":"10","author":"HW Virgin","year":"2009","unstructured":"Virgin HW, Levine B . Autophagy genes in immunity. Nat Immunol 2009; 10: 461\u2013470.","journal-title":"Nat Immunol"},{"key":"BFcdd2016121_CR41","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature09663","volume":"469","author":"R Zhou","year":"2011","unstructured":"Zhou R, Yazdi AS, Menu P, Tschopp J . A role for mitochondria in NLRP3 inflammasome activation. Nature 2011; 469: 221\u2013225.","journal-title":"Nature"},{"key":"BFcdd2016121_CR42","doi-asserted-by":"publisher","first-page":"20158","DOI":"10.1038\/srep20158","volume":"6","author":"J Cheng","year":"2016","unstructured":"Cheng J, Liao Y, Zhou L, Peng S, Chen H, Yuan Z . Amplified RLR signaling activation through an interferon-stimulated gene-endoplasmic reticulum stress-mitochondrial calcium uniporter protein loop. Sci Rep 2016; 6: 20158.","journal-title":"Sci Rep"},{"key":"BFcdd2016121_CR43","doi-asserted-by":"publisher","first-page":"20252","DOI":"10.1074\/jbc.M109.089912","volume":"285","author":"E Nistal-Villan","year":"2010","unstructured":"Nistal-Villan E, Gack MU, Martinez-Delgado G, Maharaj NP, Inn KS, Yang H et al. Negative role of RIG-I serine 8 phosphorylation in the regulation of interferon-beta production. J Biol Chem 2010; 285: 20252\u201320261.","journal-title":"J Biol Chem"},{"key":"BFcdd2016121_CR44","doi-asserted-by":"crossref","unstructured":"Liu S, Cai X, Wu J, Cong Q, Chen X, Li T et al. Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 2015.","DOI":"10.1126\/science.aaa2630"},{"key":"BFcdd2016121_CR45","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.cell.2014.11.047","volume":"160","author":"Y Yan","year":"2015","unstructured":"Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z et al. Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Cell 2015; 160: 62\u201373.","journal-title":"Cell"},{"key":"BFcdd2016121_CR46","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nature11729","volume":"493","author":"MT Heneka","year":"2012","unstructured":"Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A et al. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP\/PS1 mice. Nature 2012; 493: 674\u2013678.","journal-title":"Nature"},{"key":"BFcdd2016121_CR47","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s12031-011-9588-1","volume":"45","author":"SD Schlatterer","year":"2011","unstructured":"Schlatterer SD, Acker CM, Davies P . c-Abl in neurodegenerative disease. J Mol Neurosci 2011; 45: 445\u2013452.","journal-title":"J Mol Neurosci"},{"key":"BFcdd2016121_CR48","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.molcel.2014.08.013","volume":"56","author":"M Gonzalez-Zuniga","year":"2014","unstructured":"Gonzalez-Zuniga M, Contreras PS, Estrada LD, Chamorro D, Villagra A, Zanlungo S et al. c-Abl stabilizes HDAC2 levels by tyrosine phosphorylation repressing neuronal gene expression in Alzheimer's disease. Mol Cell 2014; 56: 163\u2013173.","journal-title":"Mol Cell"},{"key":"BFcdd2016121_CR49","doi-asserted-by":"publisher","first-page":"e65129","DOI":"10.1371\/journal.pone.0065129","volume":"8","author":"SZ Imam","year":"2013","unstructured":"Imam SZ, Trickler W, Kimura S, Binienda ZK, Paule MG, Slikker W Jr et al. Neuroprotective efficacy of a new brain-penetrating C-Abl inhibitor in a murine Parkinson's disease model. PLoS One 2013; 8: e65129.","journal-title":"PLoS One"},{"key":"BFcdd2016121_CR50","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1523\/JNEUROSCI.1833-10.2011","volume":"31","author":"SZ Imam","year":"2011","unstructured":"Imam SZ, Zhou Q, Yamamoto A, Valente AJ, Ali SF, Bains M et al. Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease. J Neurosci 2011; 31: 157\u2013163.","journal-title":"J Neurosci"},{"key":"BFcdd2016121_CR51","doi-asserted-by":"publisher","first-page":"4874","DOI":"10.1038\/srep04874","volume":"4","author":"SS Karuppagounder","year":"2014","unstructured":"Karuppagounder SS, Brahmachari S, Lee Y, Dawson VL, Dawson TM, Ko HS . The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease. Sci Rep 2014; 4: 4874.","journal-title":"Sci Rep"},{"key":"BFcdd2016121_CR52","doi-asserted-by":"publisher","first-page":"9611","DOI":"10.1523\/JNEUROSCI.0035-11.2011","volume":"31","author":"L Xiao","year":"2011","unstructured":"Xiao L, Chen D, Hu P, Wu J, Liu W, Zhao Y et al. The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death. J Neurosci 2011; 31: 9611\u20139619.","journal-title":"J Neurosci"},{"key":"BFcdd2016121_CR53","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/cdd.2015.135","volume":"23","author":"R Wu","year":"2016","unstructured":"Wu R, Chen H, Ma J, He Q, Huang Q, Liu Q et al. c-Abl-p38alpha signaling plays an important role in MPTP-induced neuronal death. Cell Death Differ 2016; 23: 542\u2013552.","journal-title":"Cell Death Differ"},{"key":"BFcdd2016121_CR54","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.immuni.2013.02.013","volume":"38","author":"P Mukherjee","year":"2013","unstructured":"Mukherjee P, Woods TA, Moore RA, Peterson KE . Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death. Immunity 2013; 38: 705\u2013716.","journal-title":"Immunity"},{"key":"BFcdd2016121_CR55","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.cell.2011.02.010","volume":"144","author":"JH Shin","year":"2011","unstructured":"Shin JH, Ko HS, Kang H, Lee Y, Lee YI, Pletinkova O et al. PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease. Cell 2011; 144: 689\u2013702.","journal-title":"Cell"},{"key":"BFcdd2016121_CR56","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1002\/glia.10274","volume":"44","author":"J Saura","year":"2003","unstructured":"Saura J, Tusell JM, Serratosa J . High-yield isolation of murine microglia by mild trypsinization. Glia 2003; 44: 183\u2013189.","journal-title":"Glia"},{"key":"BFcdd2016121_CR57","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1038\/onc.2013.88","volume":"33","author":"B Mao","year":"2014","unstructured":"Mao B, Hu F, Cheng J, Wang P, Xu M, Yuan F et al. SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma. Oncogene 2014; 33: 1468\u20131474.","journal-title":"Oncogene"},{"key":"BFcdd2016121_CR58","doi-asserted-by":"publisher","first-page":"3815","DOI":"10.1074\/jbc.M109.059675","volume":"285","author":"Z Yuan","year":"2010","unstructured":"Yuan Z, Kim D, Shu S, Wu J, Guo J, Xiao L et al. Phosphoinositide 3-kinase\/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120. J Biol Chem 2010; 285: 3815\u20133824.","journal-title":"J Biol Chem"}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd2016121.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2016121","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd2016121.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:10:09Z","timestamp":1684415409000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd2016121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,4]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["BFcdd2016121"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2016.121","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,4]]},"assertion":[{"value":"15 March 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}