{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:44:15Z","timestamp":1793033055760,"version":"4.5.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T00:00:00Z","timestamp":1464912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1038\/cdd.2016.28","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T10:38:18Z","timestamp":1464950298000},"page":"1394-1405","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":199,"title":["The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873"],"prefix":"10.1038","volume":"23","author":[{"given":"K","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C-Y","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L-Y","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y-H","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-N","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y-F","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P-F","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,3]]},"reference":[{"key":"BFcdd201628_CR1","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s10059-010-0066-3","volume":"29","author":"YS Cho","year":"2010","unstructured":"Cho YS, Park SY, Shin HS, Chan FK . Physiological consequences of programmed necrosis, an alternative form of cell demise. Mol Cells 2010; 29: 327\u2013332.","journal-title":"Mol Cells"},{"key":"BFcdd201628_CR2","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/sj.cdd.4402047","volume":"14","author":"M Lamkanfi","year":"2007","unstructured":"Lamkanfi M, Festjens N, Declercq W, Vanden Berghe T, Vandenabeele P . Caspases in cell survival, proliferation and differentiation. Cell Death Differ 2007; 14: 44\u201355.","journal-title":"Cell Death Differ"},{"key":"BFcdd201628_CR3","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/nature03317","volume":"434","author":"T Nakagawa","year":"2005","unstructured":"Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Yamagata H et al. Cyclophilin d-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature 2005; 434: 652\u2013658.","journal-title":"Nature"},{"key":"BFcdd201628_CR4","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1038\/nature03434","volume":"434","author":"CP Baines","year":"2005","unstructured":"Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA et al. Loss of cyclophilin d reveals a critical role for mitochondrial permeability transition in cell death. Nature 2005; 434: 658\u2013662.","journal-title":"Nature"},{"key":"BFcdd201628_CR5","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1007\/s00395-012-0270-8","volume":"107","author":"MI Oerlemans","year":"2012","unstructured":"Oerlemans MI, Liu J, Arslan F, den Ouden K, van Middelaar BJ, Doevendans PA et al. Inhibition of rip1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia-reperfusion in vivo. Basic Res Cardiol 2012; 107: 270.","journal-title":"Basic Res Cardiol"},{"key":"BFcdd201628_CR6","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0891-5849(92)90113-U","volume":"12","author":"JG Kingma Jr","year":"1992","unstructured":"Kingma JG Jr, Yellon DM . Inability of dimethylthiourea to limit tissue necrosis during acute myocardial infarction in rabbits. Free Radic Biol Med 1992; 12: 263\u2013270.","journal-title":"Free Radic Biol Med"},{"key":"BFcdd201628_CR7","first-page":"277","volume":"1","author":"P Lissoni","year":"1992","unstructured":"Lissoni P, Pelizzoni F, Mauri O, Perego M, Pittalis S, Barni S . Enhanced secretion of tumour necrosis factor in patients with myocardial infarction. Eur J Med 1992; 1: 277\u2013280.","journal-title":"Eur J Med"},{"key":"BFcdd201628_CR8","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1161\/01.CIR.97.14.1375","volume":"97","author":"D Bryant","year":"1998","unstructured":"Bryant D, Becker L, Richardson J, Shelton J, Franco F, Peshock R et al. Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha. Circulation 1998; 97: 1375\u20131381.","journal-title":"Circulation"},{"key":"BFcdd201628_CR9","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1161\/01.RES.85.9.856","volume":"85","author":"S Guerra","year":"1999","unstructured":"Guerra S, Leri A, Wang X, Finato N, Di Loreto C, Beltrami CA et al. Myocyte death in the failing human heart is gender dependent. Circ Res 1999; 85: 856\u2013866.","journal-title":"Circ Res"},{"key":"BFcdd201628_CR10","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1016\/j.cell.2009.05.037","volume":"137","author":"YS Cho","year":"2009","unstructured":"Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M et al. Phosphorylation-driven assembly of the rip1-rip3 complex regulates programmed necrosis and virus-induced inflammation. Cell 2009; 137: 1112\u20131123.","journal-title":"Cell"},{"key":"BFcdd201628_CR11","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1126\/science.1172308","volume":"325","author":"DW Zhang","year":"2009","unstructured":"Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC et al. Rip3, an energy metabolism regulator that switches tnf-induced cell death from apoptosis to necrosis. Science 2009; 325: 332\u2013336.","journal-title":"Science"},{"key":"BFcdd201628_CR12","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.cell.2009.05.021","volume":"137","author":"S He","year":"2009","unstructured":"He S, Wang L, Miao L, Wang T, Du F, Zhao L et al. Receptor interacting protein kinase-3 determines cellular necrotic response to tnf-alpha. Cell 2009; 137: 1100\u20131111.","journal-title":"Cell"},{"key":"BFcdd201628_CR13","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","volume":"148","author":"L Sun","year":"2012","unstructured":"Sun L, Wang H, Wang Z, He S, Chen S, Liao D et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of rip3 kinase. Cell 2012; 148: 213\u2013227.","journal-title":"Cell"},{"key":"BFcdd201628_CR14","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1093\/cvr\/cvu146","volume":"103","author":"M Luedde","year":"2014","unstructured":"Luedde M, Lutz M, Carter N, Sosna J, Jacoby C, Vucur M et al. Rip3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction. Cardiovasc Res 2014; 103: 206\u2013216.","journal-title":"Cardiovasc Res"},{"key":"BFcdd201628_CR15","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nature01957","volume":"425","author":"Y Lee","year":"2003","unstructured":"Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J et al. The nuclear rnase iii drosha initiates microrna processing. Nature 2003; 425: 415\u2013419.","journal-title":"Nature"},{"key":"BFcdd201628_CR16","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00395-010-0139-7","volume":"106","author":"K Ohtani","year":"2011","unstructured":"Ohtani K, Dimmeler S . Control of cardiovascular differentiation by micrornas. Basic Res Cardiol 2011; 106: 5\u201311.","journal-title":"Basic Res Cardiol"},{"key":"BFcdd201628_CR17","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1084\/jem.20101547","volume":"208","author":"L Qian","year":"2011","unstructured":"Qian L, Van Laake LW, Huang Y, Liu S, Wendland MF, Srivastava D . Mir-24 inhibits apoptosis and represses bim in mouse cardiomyocytes. J Exp Med 2011; 208: 549\u2013560.","journal-title":"J Exp Med"},{"key":"BFcdd201628_CR18","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1161\/CIRCULATIONAHA.110.964684","volume":"122","author":"X Wang","year":"2010","unstructured":"Wang X, Zhang X, Ren XP, Chen J, Liu H, Yang J et al. Microrna-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia\/reperfusion-induced cardiac injury. Circulation 2010; 122: 1308\u20131318.","journal-title":"Circulation"},{"key":"BFcdd201628_CR19","doi-asserted-by":"publisher","first-page":"20281","DOI":"10.1074\/jbc.M110.109207","volume":"285","author":"D Sayed","year":"2010","unstructured":"Sayed D, He M, Hong C, Gao S, Rane S, Yang Z et al. Microrna-21 is a downstream effector of akt that mediates its antiapoptotic effects via suppression of fas ligand. J Biol Chem 2010; 285: 20281\u201320290.","journal-title":"J Biol Chem"},{"key":"BFcdd201628_CR20","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s12265-010-9175-9","volume":"3","author":"P Li","year":"2010","unstructured":"Li P . Micrornas in cardiac apoptosis. J Cardiovasc Transl Res 2010; 3: 219\u2013224.","journal-title":"J Cardiovasc Transl Res"},{"key":"BFcdd201628_CR21","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nm0507-541","volume":"13","author":"M Basson","year":"2007","unstructured":"Basson M . Micrornas loom large in the heart. Nat Med 2007; 13: 541.","journal-title":"Nat Med"},{"key":"BFcdd201628_CR22","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.cell.2007.03.030","volume":"129","author":"Y Zhao","year":"2007","unstructured":"Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN et al. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking mirna-1-2. Cell 2007; 129: 303\u2013317.","journal-title":"Cell"},{"key":"BFcdd201628_CR23","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/nm1569","volume":"13","author":"B Yang","year":"2007","unstructured":"Yang B, Lin H, Xiao J, Lu Y, Luo X, Li B et al. The muscle-specific microrna mir-1 regulates cardiac arrhythmogenic potential by targeting gja1 and kcnj2. Nat Med 2007; 13: 486\u2013491.","journal-title":"Nat Med"},{"key":"BFcdd201628_CR24","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1161\/CIRCULATIONAHA.107.687947","volume":"116","author":"T Thum","year":"2007","unstructured":"Thum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW et al. Micrornas in the human heart: a clue to fetal gene reprogramming in heart failure. Circulation 2007; 116: 258\u2013267.","journal-title":"Circulation"},{"key":"BFcdd201628_CR25","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/447389a","volume":"447","author":"KR Chien","year":"2007","unstructured":"Chien KR . Molecular medicine: micrornas and the tell-tale heart. Nature 2007; 447: 389\u2013390.","journal-title":"Nature"},{"key":"BFcdd201628_CR26","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/nature08975","volume":"464","author":"RA Gupta","year":"2010","unstructured":"Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ et al. Long non-coding rna hotair reprograms chromatin state to promote cancer metastasis. Nature 2010; 464: 1071\u20131076.","journal-title":"Nature"},{"key":"BFcdd201628_CR27","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/nature09701","volume":"470","author":"C Gong","year":"2011","unstructured":"Gong C, Maquat LE . Lncrnas transactivate stau1-mediated mrna decay by duplexing with 3' utrs via alu elements. Nature 2011; 470: 284\u2013288.","journal-title":"Nature"},{"key":"BFcdd201628_CR28","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.molcel.2009.01.026","volume":"33","author":"CM Clemson","year":"2009","unstructured":"Clemson CM, Hutchinson JN, Sara SA, Ensminger AW, Fox AH, Chess A et al. An architectural role for a nuclear noncoding rna: Neat1 rna is essential for the structure of paraspeckles. Mol Cell 2009; 33: 717\u2013726.","journal-title":"Mol Cell"},{"key":"BFcdd201628_CR29","doi-asserted-by":"publisher","first-page":"3852","DOI":"10.1158\/0008-5472.CAN-10-4460","volume":"71","author":"D Khaitan","year":"2011","unstructured":"Khaitan D, Dinger ME, Mazar J, Crawford J, Smith MA, Mattick JS et al. The melanoma-upregulated long noncoding rna spry4-it1 modulates apoptosis and invasion. Cancer Res 2011; 71: 3852\u20133862.","journal-title":"Cancer Res"},{"key":"BFcdd201628_CR30","doi-asserted-by":"publisher","first-page":"5781","DOI":"10.1073\/pnas.0600745103","volume":"103","author":"MR Ginger","year":"2006","unstructured":"Ginger MR, Shore AN, Contreras A, Rijnkels M, Miller J, Gonzalez-Rimbau MF et al. A noncoding rna is a potential marker of cell fate during mammary gland development. Proc Natl Acad Sci USA 2006; 103: 5781\u20135786.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201628_CR31","doi-asserted-by":"publisher","first-page":"23651","DOI":"10.3390\/ijms161023651","volume":"16","author":"K Archer","year":"2015","unstructured":"Archer K, Broskova Z, Bayoumi AS, Teoh JP, Davila A, Tang Y et al. Long non-coding rnas as master regulators in cardiovascular diseases. Int J Mol Sci 2015; 16: 23651\u201323667.","journal-title":"Int J Mol Sci"},{"key":"BFcdd201628_CR32","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.yjmcc.2015.09.013","volume":"89","author":"S Ounzain","year":"2015","unstructured":"Ounzain S, Burdet F, Ibberson M, Pedrazzini T . Discovery and functional characterization of cardiovascular long noncoding rnas. J Mol Cell Cardiol 2015; 89: 17\u201326.","journal-title":"J Mol Cell Cardiol"},{"key":"BFcdd201628_CR33","doi-asserted-by":"publisher","first-page":"473","DOI":"10.2459\/JCM.0b013e32836499cd","volume":"16","author":"W Gao","year":"2015","unstructured":"Gao W, Wang ZM, Zhu M, Lian XQ, Zhao H, Zhao D et al. Altered long noncoding rna expression profiles in the myocardium of rats with ischemic heart failure. J Cardiovasc Med (Hagerstown, MD) 2015; 16: 473\u2013479.","journal-title":"J Cardiovasc Med (Hagerstown, MD)"},{"key":"BFcdd201628_CR34","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1051\/medsci\/20153108016","volume":"31","author":"F Pinet","year":"2015","unstructured":"Pinet F, Bauters C . Potential of non-coding rna as biomarkers in heart failure. Med Sci (Paris) 2015; 31: 770\u2013776.","journal-title":"Med Sci (Paris)"},{"key":"BFcdd201628_CR35","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0891-5849(96)00235-3","volume":"22","author":"AM Gardner","year":"1997","unstructured":"Gardner AM, Xu FH, Fady C, Jacoby FJ, Duffey DC, Tu Y et al. Apoptotic vs. nonapoptotic cytotoxicity induced by hydrogen peroxide. Free Radic Biol Med 1997; 22: 73\u201383.","journal-title":"Free Radic Biol Med"},{"key":"BFcdd201628_CR36","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1159\/000045282","volume":"81","author":"M Takeda","year":"1999","unstructured":"Takeda M, Shirato I, Kobayashi M, Endou H . Hydrogen peroxide induces necrosis, apoptosis, oncosis and apoptotic oncosis of mouse terminal proximal straight tubule cells. Nephron 1999; 81: 234\u2013238.","journal-title":"Nephron"},{"key":"BFcdd201628_CR37","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/sj.cdd.4401249","volume":"10","author":"A Troyano","year":"2003","unstructured":"Troyano A, Sancho P, Fernandez C, de Blas E, Bernardi P, Aller P . The selection between apoptosis and necrosis is differentially regulated in hydrogen peroxide-treated and glutathione-depleted human promonocytic cells. Cell Death Differ 2003; 10: 889\u2013898.","journal-title":"Cell Death Differ"},{"key":"BFcdd201628_CR38","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1146\/annurev.ph.52.030190.002415","volume":"52","author":"JM Downey","year":"1990","unstructured":"Downey JM . Free radicals and their involvement during long-term myocardial ischemia and reperfusion. Annu Rev Physiol 1990; 52: 487\u2013504.","journal-title":"Annu Rev Physiol"},{"key":"BFcdd201628_CR39","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.cell.2011.09.028","volume":"147","author":"M Cesana","year":"2011","unstructured":"Cesana M, Cacchiarelli D, Legnini I, Santini T, Sthandier O, Chinappi M et al. A long noncoding rna controls muscle differentiation by functioning as a competing endogenous rna. Cell 2011; 147: 358\u2013369.","journal-title":"Cell"},{"key":"BFcdd201628_CR40","doi-asserted-by":"publisher","first-page":"5366","DOI":"10.1093\/nar\/gkq285","volume":"38","author":"J Wang","year":"2010","unstructured":"Wang J, Liu X, Wu H, Ni P, Gu Z, Qiao Y et al. Creb up-regulates long non-coding rna, hulc expression through interaction with microrna-372 in liver cancer. Nucleic Acids Res 2010; 38: 5366\u20135383.","journal-title":"Nucleic Acids Res"},{"key":"BFcdd201628_CR41","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1126\/science.1187197","volume":"328","author":"D Cazalla","year":"2010","unstructured":"Cazalla D, Yario T, Steitz JA . Down-regulation of a host microrna by a herpesvirus saimiri noncoding rna. Science 2010; 328: 1563\u20131566.","journal-title":"Science"},{"key":"BFcdd201628_CR42","doi-asserted-by":"publisher","first-page":"28971","DOI":"10.1074\/jbc.M114.577429","volume":"289","author":"X Liu","year":"2014","unstructured":"Liu X, He F, Pang R, Zhao D, Qiu W, Shan K et al. Interleukin-17 (il-17)-induced microrna 873 (mir-873) contributes to the pathogenesis of experimental autoimmune encephalomyelitis by targeting a20 ubiquitin-editing enzyme. J Biol Chem 2014; 289: 28971\u201328986.","journal-title":"J Biol Chem"},{"key":"BFcdd201628_CR43","doi-asserted-by":"publisher","first-page":"e34490","DOI":"10.1371\/journal.pone.0034490","volume":"7","author":"S Rahman","year":"2012","unstructured":"Rahman S, Quann K, Pandya D, Singh S, Khan ZK, Jain P . Htlv-1 tax mediated downregulation of mirnas associated with chromatin remodeling factors in t cells with stably integrated viral promoter. PloS One 2012; 7: e34490.","journal-title":"PloS One"},{"key":"BFcdd201628_CR44","doi-asserted-by":"publisher","first-page":"e24248","DOI":"10.1371\/journal.pone.0024248","volume":"6","author":"RL Skalsky","year":"2011","unstructured":"Skalsky RL, Cullen BR . Reduced expression of brain-enriched micrornas in glioblastomas permits targeted regulation of a cell death gene. PloS One 2011; 6: e24248.","journal-title":"PloS One"},{"key":"BFcdd201628_CR45","doi-asserted-by":"publisher","first-page":"11748","DOI":"10.1523\/JNEUROSCI.1887-11.2011","volume":"31","author":"CP Morgan","year":"2011","unstructured":"Morgan CP, Bale TL . Early prenatal stress epigenetically programs dysmasculinization in second-generation offspring via the paternal lineage. J Neurosci 2011; 31: 11748\u201311755.","journal-title":"J Neurosci"},{"key":"BFcdd201628_CR46","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/82732","volume":"1","author":"N Holler","year":"2000","unstructured":"Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase rip as effector molecule. Nat Immunol 2000; 1: 489\u2013495.","journal-title":"Nat Immunol"},{"key":"BFcdd201628_CR47","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1084\/jem.187.9.1477","volume":"187","author":"D Vercammen","year":"1998","unstructured":"Vercammen D, Beyaert R, Denecker G, Goossens V, Van Loo G, Declercq W et al. Inhibition of caspases increases the sensitivity of l929 cells to necrosis mediated by tumor necrosis factor. J Exp Med 1998; 187: 1477\u20131485.","journal-title":"J Exp Med"},{"key":"BFcdd201628_CR48","doi-asserted-by":"publisher","first-page":"e1004","DOI":"10.1038\/cddis.2013.531","volume":"5","author":"Q Remijsen","year":"2014","unstructured":"Remijsen Q, Goossens V, Grootjans S, Van den Haute C, Vanlangenakker N, Dondelinger Y et al. Depletion of ripk3 or mlkl blocks tnf-driven necroptosis and switches towards a delayed ripk1 kinase-dependent apoptosis. Cell Death Dis 2014; 5: e1004.","journal-title":"Cell Death Dis"},{"key":"BFcdd201628_CR49","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.ajpath.2011.05.046","volume":"179","author":"HA Eum","year":"2011","unstructured":"Eum HA, Vallabhaneni R, Wang Y, Loughran PA, Stolz DB, Billiar TR . Characterization of disc formation and tnfr1 translocation to mitochondria in tnf-alpha-treated hepatocytes. Am J Pathol 2011; 179: 1221\u20131229.","journal-title":"Am J Pathol"},{"key":"BFcdd201628_CR50","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1084\/jem.20011470","volume":"196","author":"N Cusson","year":"2002","unstructured":"Cusson N, Oikemus S, Kilpatrick ED, Cunningham L, Kelliher M . The death domain kinase rip protects thymocytes from tumor necrosis factor receptor type 2-induced cell death. J Exp Med 2002; 196: 15\u201326.","journal-title":"J Exp Med"},{"key":"BFcdd201628_CR51","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1111\/j.1582-4934.2009.00777.x","volume":"14","author":"AC Bellail","year":"2010","unstructured":"Bellail AC, Tse MC, Song JH, Phuphanich S, Olson JJ, Sun SY et al. Dr5-mediated disc controls caspase-8 cleavage and initiation of apoptosis in human glioblastomas. J Cell Mol Med 2010; 14: 1303\u20131317.","journal-title":"J Cell Mol Med"},{"key":"BFcdd201628_CR52","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.semcdb.2011.02.020","volume":"22","author":"C Kanduri","year":"2011","unstructured":"Kanduri C . Kcnq1ot1: a chromatin regulatory rna. Semin Cell Dev Biol 2011; 22: 343\u2013350.","journal-title":"Semin Cell Dev Biol"},{"key":"BFcdd201628_CR53","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/nature12785","volume":"505","author":"MS Kumar","year":"2014","unstructured":"Kumar MS, Armenteros-Monterroso E, East P, Chakravorty P, Matthews N, Winslow MM et al. Hmga2 functions as a competing endogenous rna to promote lung cancer progression. Nature 2014; 505: 212\u2013217.","journal-title":"Nature"},{"key":"BFcdd201628_CR54","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/nature04303","volume":"438","author":"J Krutzfeldt","year":"2005","unstructured":"Krutzfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, Manoharan M et al. Silencing of micrornas in vivo with 'antagomirs'. Nature 2005; 438: 685\u2013689.","journal-title":"Nature"},{"key":"BFcdd201628_CR55","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1038\/nm.2834","volume":"18","author":"EM Jimenez-Mateos","year":"2012","unstructured":"Jimenez-Mateos EM, Engel T, Merino-Serrais P, McKiernan RC, Tanaka K, Mouri G et al. Silencing microrna-134 produces neuroprotective and prolonged seizure-suppressive effects. Nat Med 2012; 18: 1087\u20131094.","journal-title":"Nat Med"},{"key":"BFcdd201628_CR56","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1038\/nprot.2008.145","volume":"3","author":"MD Horwich","year":"2008","unstructured":"Horwich MD, Zamore PD . Design and delivery of antisense oligonucleotides to block microrna function in cultured drosophila and human cells. Nat Protoc 2008; 3: 1537\u20131549.","journal-title":"Nat Protoc"},{"key":"BFcdd201628_CR57","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.cell.2005.10.043","volume":"124","author":"C-L Wei","year":"2006","unstructured":"Wei C-L, Wu Q, Vega VB, Chiu KP, Ng P, Zhang T et al. A global map of p53 transcription-factor binding sites in the human genome. Cell 2006; 124: 207\u2013219.","journal-title":"Cell"},{"key":"BFcdd201628_CR58","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1016\/j.cell.2012.05.014","volume":"149","author":"AV Vaseva","year":"2012","unstructured":"Vaseva AV, Marchenko ND, Ji K, Tsirka SE, Holzmann S, Moll UM . P53 opens the mitochondrial permeability transition pore to trigger necrosis. Cell 2012; 149: 1536\u20131548.","journal-title":"Cell"},{"key":"BFcdd201628_CR59","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1159\/000104152","volume":"20","author":"A Furukawa","year":"2007","unstructured":"Furukawa A, Tada-Oikawa S, Kawanishi S, Oikawa S . H2o2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of sirt1 by nad+ depletion. Cell Physiol Biochem 2007; 20: 45\u201354.","journal-title":"Cell Physiol Biochem"},{"key":"BFcdd201628_CR60","doi-asserted-by":"publisher","first-page":"25568","DOI":"10.1074\/jbc.M212574200","volume":"278","author":"Y-H Wang","year":"2003","unstructured":"Wang Y-H, Tsay Y-G, Tan BC-M, Lo W-Y, Lee S-C . Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305. J Biol Chem 2003; 278: 25568\u201325576.","journal-title":"J Biol Chem"},{"key":"BFcdd201628_CR61","doi-asserted-by":"publisher","first-page":"36194","DOI":"10.1074\/jbc.M104157200","volume":"276","author":"S Xie","year":"2001","unstructured":"Xie S, Wang Q, Wu H, Cogswell J, Lu L, Jhanwar-Uniyal M et al. Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3. J Biol Chem 2001; 276: 36194\u201336199.","journal-title":"J Biol Chem"},{"key":"BFcdd201628_CR62","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0169-328X(98)00339-8","volume":"65","author":"D Uberti","year":"1999","unstructured":"Uberti D, Yavin E, Gil S, Ayasola K-R, Goldfinger N, Rotter V . Hydrogen peroxide induces nuclear translocation of p53 and apoptosis in cells of oligodendroglia origin. Mol Brain Res 1999; 65: 167\u2013175.","journal-title":"Mol Brain Res"},{"key":"BFcdd201628_CR63","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s11010-007-9470-1","volume":"303","author":"X Long","year":"2007","unstructured":"Long X, Goldenthal MJ, Mar\u00edn-Garc\u00eda J . Oxidative stress enhances phosphorylation of p53 in neonatal rat cardiomyocytes. Mol Cell Biochem 2007; 303: 167\u2013174.","journal-title":"Mol Cell Biochem"},{"key":"BFcdd201628_CR64","doi-asserted-by":"publisher","first-page":"29730","DOI":"10.1074\/jbc.M805514200","volume":"283","author":"WQ Tan","year":"2008","unstructured":"Tan WQ, Wang K, Lv DY, Li PF . Foxo3a inhibits cardiomyocyte hypertrophy through transactivating catalase. J Biol Chem 2008; 283: 29730\u201329739.","journal-title":"J Biol Chem"},{"key":"BFcdd201628_CR65","doi-asserted-by":"publisher","first-page":"12103","DOI":"10.1073\/pnas.0811371106","volume":"106","author":"Z Lin","year":"2009","unstructured":"Lin Z, Murtaza I, Wang K, Jiao J, Gao J, Li PF . Mir-23a functions downstream of nfatc3 to regulate cardiac hypertrophy. Proc Natl Acad Sci USA 2009; 106: 12103\u201312108.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201628_CR66","doi-asserted-by":"publisher","first-page":"e179","DOI":"10.1093\/nar\/gni178","volume":"33","author":"C Chen","year":"2005","unstructured":"Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT et al. Real-time quantification of micrornas by stem-loop rt-pcr. Nucleic Acids Res 2005; 33: e179.","journal-title":"Nucleic Acids Res"},{"key":"BFcdd201628_CR67","doi-asserted-by":"publisher","first-page":"6027","DOI":"10.1093\/emboj\/18.21.6027","volume":"18","author":"PF Li","year":"1999","unstructured":"Li PF, Dietz R, von Harsdorf R . P53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by bcl-2. EMBO J 1999; 18: 6027\u20136036.","journal-title":"EMBO J"},{"key":"BFcdd201628_CR68","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/nm.2282","volume":"17","author":"JX Wang","year":"2011","unstructured":"Wang JX, Jiao JQ, Li Q, Long B, Wang K, Liu JP et al. Mir-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1. Nat Med 2011; 17: 71\u201378.","journal-title":"Nat Med"}],"container-title":["Cell Death & Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd201628.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201628","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201628.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T09:11:09Z","timestamp":1684401069000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd201628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,3]]},"references-count":68,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["BFcdd201628"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2016.28","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,3]]},"assertion":[{"value":"29 November 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}