{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:37:18Z","timestamp":1776451038461,"version":"3.51.2"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1038\/cdd.2017.87","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T14:32:41Z","timestamp":1496413961000},"page":"1577-1587","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Hepatitis B virus X protein promotes CREB-mediated activation of miR-3188 and Notch signaling in hepatocellular carcinoma"],"prefix":"10.1038","volume":"24","author":[{"given":"Shao-jun","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-ling","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-fang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan C","family":"Jaoude","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-yao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,6,2]]},"reference":[{"key":"BFcdd201787_CR1","doi-asserted-by":"publisher","first-page":"e1261","DOI":"10.1053\/j.gastro.2012.03.007","volume":"142","author":"HB El-Serag","year":"2012","unstructured":"El-Serag HB . Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 2012; 142: e1261.","journal-title":"Gastroenterology"},{"key":"BFcdd201787_CR2","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/S0140-6736(81)90585-7","volume":"2","author":"RP Beasley","year":"1981","unstructured":"Beasley RP, Hwang LY, Lin CC, Chien CS . Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet 1981; 2: 1129\u20131133.","journal-title":"Lancet"},{"key":"BFcdd201787_CR3","doi-asserted-by":"publisher","first-page":"3643","DOI":"10.1200\/JCO.2011.36.2335","volume":"29","author":"YT Huang","year":"2011","unstructured":"Huang YT, Jen CL, Yang HI, Lee MH, Su J, Lu SN et al. Lifetime risk and sex difference of hepatocellular carcinoma among patients with chronic hepatitis B and C. J Clin Oncol 2011; 29: 3643\u20133650.","journal-title":"J Clin Oncol"},{"key":"BFcdd201787_CR4","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1002\/hep.20933","volume":"42","author":"J Bruix","year":"2005","unstructured":"Bruix J, Sherman M . Management of hepatocellular carcinoma. Hepatology 2005; 42: 1208\u20131236.","journal-title":"Hepatology"},{"key":"BFcdd201787_CR5","doi-asserted-by":"publisher","first-page":"e1631","DOI":"10.1016\/j.cgh.2013.04.043","volume":"11","author":"R Loomba","year":"2013","unstructured":"Loomba R, Liu J, Yang HI, Lee MH, Lu SN, Wang LY et al. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. Clin Gastroenterol Hepatol 2013; 11: e1631\u2013e1633.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"BFcdd201787_CR6","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1093\/ije\/31.5.1008","volume":"31","author":"MW Yu","year":"2002","unstructured":"Yu MW, Chang HC, Chen PJ, Liu CJ, Liaw YF, Lin SM et al. Increased risk for hepatitis B-related liver cirrhosis in relatives of patients with hepatocellular carcinoma in northern Taiwan. Int J Epidemiol 2002; 31: 1008\u20131015.","journal-title":"Int J Epidemiol"},{"key":"BFcdd201787_CR7","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.jhep.2008.08.016","volume":"50","author":"MM Hassan","year":"2009","unstructured":"Hassan MM, Spitz MR, Thomas MB, Curley SA, Patt YZ, Vauthey JN et al. The association of family history of liver cancer with hepatocellular carcinoma: a case-control study in the United States. J Hepatol 2009; 50: 334\u2013341.","journal-title":"J Hepatol"},{"key":"BFcdd201787_CR8","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jhep.2008.11.009","volume":"50","author":"ML Volk","year":"2009","unstructured":"Volk ML, Lok AS . Is family history of liver cancer a risk factor for hepatocellular carcinoma? J Hepatol 2009; 50: 247\u2013248.","journal-title":"J Hepatol"},{"key":"BFcdd201787_CR9","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/cdd.2014.136","volume":"22","author":"E Callegari","year":"2015","unstructured":"Callegari E, Gramantieri L, Domenicali M, D'Abundo L, Sabbioni S, Negrini M . MicroRNAs in liver cancer: a model for investigating pathogenesis and novel therapeutic approaches. Cell Death Differ 2015; 22: 46\u201357.","journal-title":"Cell Death Differ"},{"key":"BFcdd201787_CR10","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.7150\/thno.8715","volume":"4","author":"KL Xie","year":"2014","unstructured":"Xie KL, Zhang YG, Liu J, Zeng Y, Wu H . MicroRNAs associated with HBV infection and HBV-related HCC. Theranostics 2014; 4: 1176\u20131192.","journal-title":"Theranostics"},{"key":"BFcdd201787_CR11","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1016\/j.jhep.2010.09.023","volume":"54","author":"P Gao","year":"2011","unstructured":"Gao P, Wong CC, Tung EK, Lee JM, Wong CM, Ng IO . Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis. J Hepatol 2011; 54: 1177\u20131184.","journal-title":"J Hepatol"},{"key":"BFcdd201787_CR12","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/nrd4359","volume":"13","author":"Z Li","year":"2014","unstructured":"Li Z, Rana TM . Therapeutic targeting of microRNAs: current status and future challenges. Nat Rev Drug Discov 2014; 13: 622\u2013638.","journal-title":"Nat Rev Drug Discov"},{"key":"BFcdd201787_CR13","doi-asserted-by":"publisher","first-page":"e1670","DOI":"10.1038\/cddis.2015.46","volume":"6","author":"FY Liu","year":"2015","unstructured":"Liu FY, Zhou SJ, Deng YL, Zhang ZY, Zhang EL, Wu ZB et al. MiR-216b is involved in pathogenesis and progression of hepatocellular carcinoma through HBx-miR-216b-IGF2BP2 signaling pathway. Cell Death Dis 2015; 6: e1670.","journal-title":"Cell Death Dis"},{"key":"BFcdd201787_CR14","doi-asserted-by":"publisher","first-page":"4781","DOI":"10.1200\/JCO.2011.38.2697","volume":"29","author":"J Zhou","year":"2011","unstructured":"Zhou J, Yu L, Gao X, Hu J, Wang J, Dai Z et al. Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma. J Clin Oncol 2011; 29: 4781\u20134788.","journal-title":"J Clin Oncol"},{"key":"BFcdd201787_CR15","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1002\/hep.22749","volume":"49","author":"S Ura","year":"2009","unstructured":"Ura S, Honda M, Yamashita T, Ueda T, Takatori H, Nishino R et al. Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma. Hepatology 2009; 49: 1098\u20131112.","journal-title":"Hepatology"},{"key":"BFcdd201787_CR16","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1126\/science.1231143","volume":"339","author":"L Cong","year":"2013","unstructured":"Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N et al. Multiplex genome engineering using CRISPR\/Cas systems. Science 2013; 339: 819\u2013823.","journal-title":"Science"},{"key":"BFcdd201787_CR17","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/j.cell.2014.05.010","volume":"157","author":"PD Hsu","year":"2014","unstructured":"Hsu PD, Lander ES, Zhang F . Development and applications of CRISPR-Cas9 for genome engineering. Cell 2014; 157: 1262\u20131278.","journal-title":"Cell"},{"key":"BFcdd201787_CR18","doi-asserted-by":"publisher","first-page":"326042","DOI":"10.1155\/2015\/326042","volume":"2015","author":"W Jing","year":"2015","unstructured":"Jing W, Zhang X, Sun W, Hou X, Yao Z, Zhu Y . CRISPR\/CAS9-mediated genome editing of miRNA-155 inhibits proinflammatory cytokine production by RAW264.7 Cells. Biomed Res Int 2015; 2015: 326042.","journal-title":"Biomed Res Int"},{"key":"BFcdd201787_CR19","doi-asserted-by":"publisher","first-page":"22312","DOI":"10.1038\/srep22312","volume":"6","author":"H Chang","year":"2016","unstructured":"Chang H, Yi B, Ma R, Zhang X, Zhao H, Xi Y . CRISPR\/cas9, a novel genomic tool to knock down microRNA in vitro and in vivo. Sci Rep 2016; 6: 22312.","journal-title":"Sci Rep"},{"key":"BFcdd201787_CR20","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nature01957","volume":"425","author":"Y Lee","year":"2003","unstructured":"Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 2003; 425: 415\u2013419.","journal-title":"Nature"},{"key":"BFcdd201787_CR21","first-page":"630","volume":"123","author":"X Xu","year":"2013","unstructured":"Xu X, Fan Z, Kang L, Han J, Jiang C, Zheng X et al. Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis. J Clin Invest 2013; 123: 630\u2013645.","journal-title":"J Clin Invest"},{"key":"BFcdd201787_CR22","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jhep.2009.12.043","volume":"53","author":"Y Wang","year":"2010","unstructured":"Wang Y, Lu Y, Toh ST, Sung WK, Tan P, Chow P et al. Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3. J Hepatol 2010; 53: 57\u201366.","journal-title":"J Hepatol"},{"key":"BFcdd201787_CR23","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S1359-6101(00)00034-4","volume":"12","author":"J Diao","year":"2001","unstructured":"Diao J, Garces R, Richardson CD . X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesis. Cytokine Growth Factor Rev 2001; 12: 189\u2013205.","journal-title":"Cytokine Growth Factor Rev"},{"key":"BFcdd201787_CR24","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1002\/hep.21825","volume":"46","author":"LA Morford","year":"2007","unstructured":"Morford LA, Davis C, Jin L, Dobierzewska A, Peterson ML, Spear BT . The oncofetal gene glypican 3 is regulated in the postnatal liver by zinc fingers and homeoboxes 2 and in the regenerating liver by alpha-fetoprotein regulator 2. Hepatology 2007; 46: 1541\u20131547.","journal-title":"Hepatology"},{"key":"BFcdd201787_CR25","doi-asserted-by":"publisher","first-page":"e1552","DOI":"10.1053\/j.gastro.2012.02.049","volume":"142","author":"X Yue","year":"2012","unstructured":"Yue X, Zhang Z, Liang X, Gao L, Zhang X, Zhao D et al. Zinc fingers and homeoboxes 2 inhibits hepatocellular carcinoma cell proliferation and represses expression of Cyclins A and E. Gastroenterology 2012; 142: e1552.","journal-title":"Gastroenterology"},{"key":"BFcdd201787_CR26","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.18632\/oncotarget.2832","volume":"6","author":"H Ma","year":"2015","unstructured":"Ma H, Yue X, Gao L, Liang X, Yan W, Zhang Z et al. ZHX2 enhances the cytotoxicity of chemotherapeutic drugs in liver tumor cells by repressing MDR1 via interfering with NF-YA. Oncotarget 2015; 6: 1049\u20131063.","journal-title":"Oncotarget"},{"key":"BFcdd201787_CR27","doi-asserted-by":"publisher","first-page":"e0146696","DOI":"10.1371\/journal.pone.0146696","volume":"11","author":"P Kongkavitoon","year":"2016","unstructured":"Kongkavitoon P, Tangkijvanich P, Hirankarn N, Palaga T . Hepatitis B virus HBx activates Notch Signaling via Delta-Like 4\/Notch1 in hepatocellular carcinoma. PLoS ONE 2016; 11: e0146696.","journal-title":"PLoS ONE"}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd201787.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201787","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/cdd.2017.87","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201787.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:13:43Z","timestamp":1684415623000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd201787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,2]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["BFcdd201787"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2017.87","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,2]]},"assertion":[{"value":"14 January 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}