{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:17:34Z","timestamp":1790497054600,"version":"4.1.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T00:00:00Z","timestamp":1498780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1038\/cdd.2017.95","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T10:57:48Z","timestamp":1498820268000},"page":"1694-1704","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":122,"title":["Germline BAP1 mutations induce a Warburg effect"],"prefix":"10.1038","volume":"24","author":[{"given":"Angela","family":"Bononi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haining","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Giorgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Patergnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxiang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Signorato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Pastorino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shafi","family":"Kuchay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1572-6571","authenticated-orcid":false,"given":"Giovanni","family":"Gaudino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey I","family":"Pass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Napolitano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7108-6508","authenticated-orcid":false,"given":"Paolo","family":"Pinton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,30]]},"reference":[{"key":"BFcdd201795_CR1","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1038\/ng.912","volume":"43","author":"JR Testa","year":"2011","unstructured":"Testa JR, Cheung M, Pei J, Below JE, Tan Y, Sementino E et al. Germline BAP1 mutations predispose to malignant mesothelioma. Nat Genet 2011; 43: 1022\u20131025.","journal-title":"Nat Genet"},{"key":"BFcdd201795_CR2","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/1479-5876-10-179","volume":"10","author":"M Carbone","year":"2012","unstructured":"Carbone M, Ferris LK, Baumann F, Napolitano A, Lum CA, Flores EG et al. BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs. J Transl Med 2012; 10: 179.","journal-title":"J Transl Med"},{"key":"BFcdd201795_CR3","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1038\/ng.910","volume":"43","author":"T Wiesner","year":"2011","unstructured":"Wiesner T, Obenauf AC, Murali R, Fried I, Griewank KG, Ulz P et al. Germline mutations in BAP1 predispose to melanocytic tumors. Nat Genet 2011; 43: 1018\u20131021.","journal-title":"Nat Genet"},{"key":"BFcdd201795_CR4","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.ajhg.2013.04.012","volume":"92","author":"T Popova","year":"2013","unstructured":"Popova T, Hebert L, Jacquemin V, Gad S, Caux-Moncoutier V, Dubois-d'Enghien C et al. Germline BAP1 mutations predispose to renal cell carcinomas. Am J Hum Genet 2013; 92: 974\u2013980.","journal-title":"Am J Hum Genet"},{"key":"BFcdd201795_CR5","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1158\/1541-7786.MCR-13-0111","volume":"11","author":"MN Farley","year":"2013","unstructured":"Farley MN, Schmidt LS, Mester JL, Pena-Llopis S, Pavia-Jimenez A, Christie A et al. A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma. Mol Cancer Res 2013; 11: 1061\u20131071.","journal-title":"Mol Cancer Res"},{"key":"BFcdd201795_CR6","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nrc3459","volume":"13","author":"M Carbone","year":"2013","unstructured":"Carbone M, Yang H, Pass HI, Krausz T, Testa JR, Gaudino G . BAP1 and cancer. Nat Rev Cancer 2013; 13: 153\u2013159.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd201795_CR7","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1093\/carcin\/bgu227","volume":"36","author":"F Baumann","year":"2015","unstructured":"Baumann F, Flores E, Napolitano A, Kanodia S, Taioli E, Pass H et al. Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival. Carcinogenesis 2015; 36: 76\u201381.","journal-title":"Carcinogenesis"},{"key":"BFcdd201795_CR8","doi-asserted-by":"publisher","first-page":"e1005633","DOI":"10.1371\/journal.pgen.1005633","volume":"11","author":"M Carbone","year":"2015","unstructured":"Carbone M, Flores EG, Emi M, Johnson TA, Tsunoda T, Behner D et al. Combined genetic and genealogic studies uncover a large BAP1 cancer syndrome kindred tracing back nine generations to a common ancestor from the 1700s. PLoS Genet 2015; 11: e1005633.","journal-title":"PLoS Genet"},{"key":"BFcdd201795_CR9","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s40364-015-0040-5","volume":"3","author":"S Klebe","year":"2015","unstructured":"Klebe S, Driml J, Nasu M, Pastorino S, Zangiabadi A, Henderson D et al. BAP1 hereditary cancer predisposition syndrome: a case report and review of literature. Biomark Res 2015; 3: 14.","journal-title":"Biomark Res"},{"key":"BFcdd201795_CR10","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nature08966","volume":"465","author":"JC Scheuermann","year":"2010","unstructured":"Scheuermann JC, de Ayala Alonso AG, Oktaba K, Ly-Hartig N, McGinty RK, Fraterman S et al. Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature 2010; 465: 243\u2013247.","journal-title":"Nature"},{"key":"BFcdd201795_CR11","doi-asserted-by":"publisher","first-page":"5071","DOI":"10.1128\/MCB.00396-10","volume":"30","author":"H Yu","year":"2010","unstructured":"Yu H, Mashtalir N, Daou S, Hammond-Martel I, Ross J, Sui G et al. The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. Mol Cell Biol 2010; 30: 5071\u20135085.","journal-title":"Mol Cell Biol"},{"key":"BFcdd201795_CR12","doi-asserted-by":"publisher","first-page":"5128","DOI":"10.1038\/ncomms6128","volume":"5","author":"HS Lee","year":"2014","unstructured":"Lee HS, Lee SA, Hur SK, Seo JW, Kwon J . Stabilization and targeting of INO80 to replication forks by BAP1 during normal DNA synthesis. Nat Commun 2014; 5: 5128.","journal-title":"Nat Commun"},{"key":"BFcdd201795_CR13","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1073\/pnas.1309085110","volume":"111","author":"H Yu","year":"2014","unstructured":"Yu H, Pak H, Hammond-Martel I, Ghram M, Rodrigue A, Daou S et al. Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair. Proc Natl Acad Sci USA 2014; 111: 285\u2013290.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201795_CR14","doi-asserted-by":"publisher","first-page":"4282","DOI":"10.1158\/0008-5472.CAN-13-3109","volume":"74","author":"IH Ismail","year":"2014","unstructured":"Ismail IH, Davidson R, Gagne JP, Xu ZZ, Poirier GG, Hendzel MJ . Germline mutations in BAP1 impair its function in DNA double-strand break repair. Cancer Res 2014; 74: 4282\u20134294.","journal-title":"Cancer Res"},{"key":"BFcdd201795_CR15","doi-asserted-by":"publisher","first-page":"6499","DOI":"10.1158\/0008-5472.CAN-14-0221","volume":"74","author":"R Zarrizi","year":"2014","unstructured":"Zarrizi R, Menard JA, Belting M, Massoumi R . Deubiquitination of gamma-tubulin by BAP1 prevents chromosome instability in breast cancer cells. Cancer Res 2014; 74: 6499\u20136508.","journal-title":"Cancer Res"},{"key":"BFcdd201795_CR16","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.canlet.2015.08.013","volume":"369","author":"J Peng","year":"2015","unstructured":"Peng J, Ma J, Li W, Mo R, Zhang P, Gao K et al. Stabilization of MCRS1 by BAP1 prevents chromosome instability in renal cell carcinoma. Cancer Lett 2015; 369: 167\u2013174.","journal-title":"Cancer Lett"},{"key":"BFcdd201795_CR17","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.cmet.2012.07.006","volume":"16","author":"HB Ruan","year":"2012","unstructured":"Ruan HB, Han X, Li MD, Singh JP, Qian K, Azarhoush S et al. O-GlcNAc transferase\/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1alpha stability. Cell Metab 2012; 16: 226\u2013237.","journal-title":"Cell Metab"},{"key":"BFcdd201795_CR18","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.celrep.2016.05.096","volume":"16","author":"JM Baughman","year":"2016","unstructured":"Baughman JM, Rose CM, Kolumam G, Webster JD, Wilkerson EM, Merrill AE et al. NeuCode proteomics reveals Bap1 regulation of metabolism. Cell Rep 2016; 16: 583\u2013595.","journal-title":"Cell Rep"},{"key":"BFcdd201795_CR19","unstructured":"Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M et al. BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation. Nature (in press; doi:10.1038\/nature22798)."},{"key":"BFcdd201795_CR20","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nrc2981","volume":"11","author":"RA Cairns","year":"2011","unstructured":"Cairns RA, Harris IS, Mak TW . Regulation of cancer cell metabolism. Nat Rev Cancer 2011; 11: 85\u201395.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd201795_CR21","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"O Warburg","year":"1956","unstructured":"Warburg O . On the origin of cancer cells. Science 1956; 123: 309\u2013314.","journal-title":"Science"},{"key":"BFcdd201795_CR22","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1038\/nrc1478","volume":"4","author":"RA Gatenby","year":"2004","unstructured":"Gatenby RA, Gillies RJ . Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004; 4: 891\u2013899.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd201795_CR23","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.cell.2008.08.021","volume":"134","author":"PP Hsu","year":"2008","unstructured":"Hsu PP, Sabatini DM . Cancer cell metabolism: Warburg and beyond. Cell 2008; 134: 703\u2013707.","journal-title":"Cell"},{"key":"BFcdd201795_CR24","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nrc3038","volume":"11","author":"WH Koppenol","year":"2011","unstructured":"Koppenol WH, Bounds PL, Dang CV . Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer 2011; 11: 325\u2013337.","journal-title":"Nat Rev Cancer"},{"key":"BFcdd201795_CR25","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA . Hallmarks of cancer: the next generation. Cell 2011; 144: 646\u2013674.","journal-title":"Cell"},{"key":"BFcdd201795_CR26","doi-asserted-by":"publisher","first-page":"e56884","DOI":"10.1371\/journal.pone.0056884","volume":"8","author":"MT Suchorolski","year":"2013","unstructured":"Suchorolski MT, Paulson TG, Sanchez CA, Hockenbery D, Reid BJ . Warburg and Crabtree effects in premalignant Barrett's esophagus cell lines with active mitochondria. PLoS ONE 2013; 8: e56884.","journal-title":"PLoS ONE"},{"key":"BFcdd201795_CR27","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/nature11862","volume":"493","author":"LA O'Neill","year":"2013","unstructured":"O'Neill LA, Hardie DG . Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature 2013; 493: 346\u2013355.","journal-title":"Nature"},{"key":"BFcdd201795_CR28","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.cmet.2011.11.013","volume":"15","author":"SK Biswas","year":"2012","unstructured":"Biswas SK, Mantovani A . Orchestration of metabolism by macrophages. Cell Metab 2012; 15: 432\u2013437.","journal-title":"Cell Metab"},{"key":"BFcdd201795_CR29","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1038\/nprot.2009.58","volume":"4","author":"N Zamboni","year":"2009","unstructured":"Zamboni N, Fendt SM, Ruhl M, Sauer U . (13)C-based metabolic flux analysis. Nat Protoc 2009; 4: 878\u2013892.","journal-title":"Nat Protoc"},{"key":"BFcdd201795_CR30","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.copbio.2015.02.003","volume":"34","author":"JM Buescher","year":"2015","unstructured":"Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB et al. A roadmap for interpreting (13)C metabolite labeling patterns from cells. Curr Opin Biotechnol 2015; 34: 189\u2013201.","journal-title":"Curr Opin Biotechnol"},{"key":"BFcdd201795_CR31","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1038\/sj.onc.1201861","volume":"16","author":"DE Jensen","year":"1998","unstructured":"Jensen DE, Proctor M, Marquis ST, Gardner HP, Ha SI, Chodosh LA et al. BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. Oncogene 1998; 16: 1097\u20131112.","journal-title":"Oncogene"},{"key":"BFcdd201795_CR32","doi-asserted-by":"publisher","first-page":"3576","DOI":"10.1021\/bi00228a031","volume":"30","author":"PC Hinkle","year":"1991","unstructured":"Hinkle PC, Kumar MA, Resetar A, Harris DL . Mechanistic stoichiometry of mitochondrial oxidative phosphorylation. Biochemistry 1991; 30: 3576\u20133582.","journal-title":"Biochemistry"},{"key":"BFcdd201795_CR33","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/ng.2323","volume":"44","author":"S Pena-Llopis","year":"2012","unstructured":"Pena-Llopis S, Vega-Rubin-de-Celis S, Liao A, Leng N, Pavia-Jimenez A, Wang S et al. BAP1 loss defines a new class of renal cell carcinoma. Nat Genet 2012; 44: 751\u2013759.","journal-title":"Nat Genet"},{"key":"BFcdd201795_CR34","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1126\/science.1194472","volume":"330","author":"JW Harbour","year":"2010","unstructured":"Harbour JW, Onken MD, Roberson ED, Duan S, Cao L, Worley LA et al. Frequent mutation of BAP1 in metastasizing uveal melanomas. Science 2010; 330: 1410\u20131413.","journal-title":"Science"},{"key":"BFcdd201795_CR35","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1111\/cas.12722","volume":"106","author":"T Mori","year":"2015","unstructured":"Mori T, Sumii M, Fujishima F, Ueno K, Emi M, Nagasaki M et al. Somatic alteration and depleted nuclear expression of BAP1 in human esophageal squamous cell carcinoma. Cancer Sci 2015; 106: 1118\u20131129.","journal-title":"Cancer Sci"},{"key":"BFcdd201795_CR36","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1038\/ng.2813","volume":"45","author":"Y Jiao","year":"2013","unstructured":"Jiao Y, Pawlik TM, Anders RA, Selaru FM, Streppel MM, Lucas DJ et al. Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas. Nat Genet 2013; 45: 1470\u20131473.","journal-title":"Nat Genet"},{"key":"BFcdd201795_CR37","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1097\/JTO.0000000000000471","volume":"10","author":"M Nasu","year":"2015","unstructured":"Nasu M, Emi M, Pastorino S, Tanji M, Powers A, Luk H et al. High incidence of somatic BAP1 alterations in sporadic malignant mesothelioma. J Thorac Oncol 2015; 10: 565\u2013576.","journal-title":"J Thorac Oncol"},{"key":"BFcdd201795_CR38","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1158\/0008-5472.CAN-14-1008","volume":"75","author":"G Guo","year":"2015","unstructured":"Guo G, Chmielecki J, Goparaju C, Heguy A, Dolgalev I, Carbone M et al. Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma. Cancer Res 2015; 75: 264\u2013269.","journal-title":"Cancer Res"},{"key":"BFcdd201795_CR39","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1097\/JTO.0000000000000436","volume":"10","author":"M Lo Iacono","year":"2015","unstructured":"Lo Iacono M, Monica V, Righi L, Grosso F, Libener R, Vatrano S et al. Targeted next-generation sequencing of cancer genes in advanced stage malignant pleural mesothelioma: a retrospective study. J Thorac Oncol 2015; 10: 492\u2013499.","journal-title":"J Thorac Oncol"},{"key":"BFcdd201795_CR40","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/ng.3520","volume":"48","author":"R Bueno","year":"2016","unstructured":"Bueno R, Stawiski EW, Goldstein LD, Durinck S, De Rienzo A, Modrusan Z et al. Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations. Nat Genet 2016; 48: 407\u2013416.","journal-title":"Nat Genet"},{"key":"BFcdd201795_CR41","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.juro.2015.07.113","volume":"195","author":"RW Joseph","year":"2016","unstructured":"Joseph RW, Kapur P, Serie DJ, Parasramka M, Ho TH, Cheville JC et al. Clear cell renal cell carcinoma subtypes identified by BAP1 and PBRM1 expression. J Urol 2016; 195: 180\u2013187.","journal-title":"J Urol"},{"key":"BFcdd201795_CR42","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1038\/ng.2806","volume":"45","author":"W Chan-On","year":"2013","unstructured":"Chan-On W, Nairismagi ML, Ong CK, Lim WK, Dima S, Pairojkul C et al. Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers. Nat Genet 2013; 45: 1474\u20131478.","journal-title":"Nat Genet"},{"key":"BFcdd201795_CR43","doi-asserted-by":"publisher","first-page":"7336","DOI":"10.1038\/srep07336","volume":"4","author":"Y Wang","year":"2014","unstructured":"Wang Y, Thomas A, Lau C, Rajan A, Zhu Y, Killian JK et al. Mutations of epigenetic regulatory genes are common in thymic carcinomas. Sci Rep 2014; 4: 7336.","journal-title":"Sci Rep"},{"key":"BFcdd201795_CR44","doi-asserted-by":"publisher","first-page":"13432","DOI":"10.1073\/pnas.1612074113","volume":"113","author":"Y Yoshikawa","year":"2016","unstructured":"Yoshikawa Y, Emi M, Hashimoto-Tamaoki T, Ohmuraya M, Sato A, Tsujimura T et al. High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma. Proc Natl Acad Sci USA 2016; 113: 13432\u201313437.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcdd201795_CR45","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/j.bbabio.2009.01.005","volume":"1787","author":"RM Denton","year":"2009","unstructured":"Denton RM . Regulation of mitochondrial dehydrogenases by calcium ions. Biochim Biophys Acta 2009; 1787: 1309\u20131316.","journal-title":"Biochim Biophys Acta"},{"key":"BFcdd201795_CR46","doi-asserted-by":"publisher","first-page":"e1600200","DOI":"10.1126\/sciadv.1600200","volume":"2","author":"RJ DeBerardinis","year":"2016","unstructured":"DeBerardinis RJ, Chandel NS . Fundamentals of cancer metabolism. Sci Adv 2016; 2: e1600200.","journal-title":"Sci Adv"},{"key":"BFcdd201795_CR47","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fimmu.2016.00052","volume":"7","author":"S Romero-Garcia","year":"2016","unstructured":"Romero-Garcia S, Moreno-Altamirano MM, Prado-Garcia H, Sanchez-Garcia FJ . Lactate contribution to the tumor microenvironment: mechanisms, effects on immune cells and therapeutic relevance. Front Immunol 2016; 7: 52.","journal-title":"Front Immunol"},{"key":"BFcdd201795_CR48","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1158\/0008-5472.CAN-10-2828","volume":"71","author":"F Vegran","year":"2011","unstructured":"Vegran F, Boidot R, Michiels C, Sonveaux P, Feron O . Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kappaB\/IL-8 pathway that drives tumor angiogenesis. Cancer Res 2011; 71: 2550\u20132560.","journal-title":"Cancer Res"},{"key":"BFcdd201795_CR49","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nature13490","volume":"513","author":"OR Colegio","year":"2014","unstructured":"Colegio OR, Chu NQ, Szabo AL, Chu T, Rhebergen AM, Jairam V et al. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature 2014; 513: 559\u2013563.","journal-title":"Nature"},{"key":"BFcdd201795_CR50","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1038\/onc.2015.243","volume":"35","author":"A Napolitano","year":"2016","unstructured":"Napolitano A, Pellegrini L, Dey A, Larson D, Tanji M, Flores EG et al. Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma. Oncogene 2016; 35: 1996\u20132002.","journal-title":"Oncogene"},{"key":"BFcdd201795_CR51","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1756-8722-7-38","volume":"7","author":"I Bononi","year":"2014","unstructured":"Bononi I, Perri P, Begnardi A, Martini A, Mazzoni E, Bosi S et al. Antibodies reacting with Simian Virus 40 capsid protein mimotopes in serum samples from patients affected by uveal melanoma. J Hematol Oncol 2014; 7: 38.","journal-title":"J Hematol Oncol"},{"key":"BFcdd201795_CR52","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1158\/1078-0432.CCR-13-1939","volume":"20","author":"Y Qiu","year":"2014","unstructured":"Qiu Y, Cai G, Zhou B, Li D, Zhao A, Xie G et al. A distinct metabolic signature of human colorectal cancer with prognostic potential. Clin Cancer Res 2014; 20: 2136\u20132146.","journal-title":"Clin Cancer Res"},{"key":"BFcdd201795_CR53","doi-asserted-by":"publisher","first-page":"8047","DOI":"10.3390\/ijms14048047","volume":"14","author":"Y Qiu","year":"2013","unstructured":"Qiu Y, Zhou B, Su M, Baxter S, Zheng X, Zhao X et al. Mass spectrometry-based quantitative metabolomics revealed a distinct lipid profile in breast cancer patients. Int J Mol Sci 2013; 14: 8047\u20138061.","journal-title":"Int J Mol Sci"},{"key":"BFcdd201795_CR54","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1007\/s00216-011-5556-4","volume":"402","author":"G Paglia","year":"2012","unstructured":"Paglia G, Hrafnsdottir S, Magnusdottir M, Fleming RM, Thorlacius S, Palsson BO et al. Monitoring metabolites consumption and secretion in cultured cells using ultra-performance liquid chromatography quadrupole-time of flight mass spectrometry (UPLC-Q-ToF-MS). Anal Bioanal Chem 2012; 402: 1183\u20131198.","journal-title":"Anal Bioanal Chem"}],"container-title":["Cell Death & Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cdd201795.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201795","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/cdd.2017.95","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/cdd201795.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T09:13:47Z","timestamp":1684401227000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cdd201795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,30]]},"references-count":54,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["BFcdd201795"],"URL":"https:\/\/doi.org\/10.1038\/cdd.2017.95","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,30]]},"assertion":[{"value":"2 December 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"MC has a pending patent applications on BAP1. MC provides consultation for mesothelioma diagnosis at no cost to patients and colleagues and for a fee to lawyers. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}