{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:53:32Z","timestamp":1762458812574},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T00:00:00Z","timestamp":1274918400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2010.24","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T10:38:09Z","timestamp":1274956689000},"page":"e45-e45","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Protein kinase C\u03b8 is required for cardiomyocyte survival and cardiac remodeling"],"prefix":"10.1038","volume":"1","author":[{"given":"R","family":"Paoletti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Maffei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Madaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Notte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Stanganello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Cifelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Carullo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Molinaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Lembo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Bouch\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,5,27]]},"reference":[{"key":"BFcddis201024_CR1","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.hfc.2005.03.006","volume":"1","author":"G Selvetella","year":"2005","unstructured":"Selvetella G, Lembo G . Mechanisms of cardiac hypertrophy. Heart Fail Clin 2005; 1: 263\u2013273.","journal-title":"Heart Fail Clin"},{"key":"BFcddis201024_CR2","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/0022-2828(90)90121-H","volume":"22","author":"PM Dunnmon","year":"1990","unstructured":"Dunnmon PM, Iwaki K, Henderson SA, Sen A, Chien KR . Phorbol esters induce immediate-early genes and activate cardiac gene transcription in neonatal rat myocardial cells. J Mol Cell Cardiol 1990; 22: 901\u2013910.","journal-title":"J Mol Cell Cardiol"},{"key":"BFcddis201024_CR3","doi-asserted-by":"publisher","first-page":"C319","DOI":"10.1152\/ajpcell.1992.263.2.C319","volume":"263","author":"SN Allo","year":"1992","unstructured":"Allo SN, Carl LL, Morgan HE . Acceleration of growth of cultured cardiomyocytes and translocation of protein kinase C. Am J Physiol 1992; 263: C319\u2013C325.","journal-title":"Am J Physiol"},{"key":"BFcddis201024_CR4","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1093\/cvr\/cvp001","volume":"82","author":"SS Palaniyandi","year":"2009","unstructured":"Palaniyandi SS, Sun L, Ferreira JC, Mochly-Rosen D . Protein kinase C in heart failure: a therapeutic target? Cardiovasc Res 2009; 82: 229\u2013239.","journal-title":"Cardiovasc Res"},{"key":"BFcddis201024_CR5","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1161\/01.CIR.103.1.140","volume":"103","author":"JN Muth","year":"2001","unstructured":"Muth JN, Bodi I, Lewis W, Varadi G, Schwartz A . A Ca(2+)-dependent transgenic model of cardiac hypertrophy: a role for protein kinase Calpha. Circulation 2001; 103: 140\u2013147.","journal-title":"Circulation"},{"key":"BFcddis201024_CR6","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1083\/jcb.200108062","volume":"156","author":"JC Braz","year":"2002","unstructured":"Braz JC, Bueno OF, De Windt LJ, Molkentin JD . PKC alpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1\/2 (ERK1\/2). J Cell Biol 2002; 156: 905\u2013919.","journal-title":"J Cell Biol"},{"key":"BFcddis201024_CR7","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nm1000","volume":"10","author":"JC Braz","year":"2004","unstructured":"Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R et al. PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med 2004; 10: 248\u2013254.","journal-title":"Nat Med"},{"key":"BFcddis201024_CR8","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1172\/JCI119755","volume":"100","author":"JC Bowman","year":"1997","unstructured":"Bowman JC, Steinberg SF, Jiang T, Geenen DL, Fishman GI, Buttrick PM . Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates. J Clin Invest 1997; 100: 2189\u20132195.","journal-title":"J Clin Invest"},{"key":"BFcddis201024_CR9","doi-asserted-by":"publisher","first-page":"H2264","DOI":"10.1152\/ajpheart.2001.280.5.H2264","volume":"280","author":"BB Roman","year":"2001","unstructured":"Roman BB, Geenen DL, Leitges M, Buttrick PM . PKC-beta is not necessary for cardiac hypertrophy. Am J Physiol Heart Circ Physiol 2001; 280: H2264\u2013H2270.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFcddis201024_CR10","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1161\/01.RES.86.12.1218","volume":"86","author":"Y Takeishi","year":"2000","unstructured":"Takeishi Y, Ping P, Bolli R, Kirkpatrick DL, Hoit BD, Walsh RA . Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy. Circ Res 2000; 86: 1218\u20131223.","journal-title":"Circ Res"},{"key":"BFcddis201024_CR11","first-page":"263","volume":"3","author":"S Manicassamy","year":"2006","unstructured":"Manicassamy S, Gupta S, Sun Z . Selective function of PKC-theta in T cells. Cell Mol Immunol 2006; 3: 263\u2013270.","journal-title":"Cell Mol Immunol"},{"key":"BFcddis201024_CR12","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.phrs.2007.04.009","volume":"55","author":"K Hayashi","year":"2007","unstructured":"Hayashi K, Altman A . Protein kinase C theta (PKCtheta): a key player in T cell life and death. Pharmacol Res 2007; 55: 537\u2013544.","journal-title":"Pharmacol Res"},{"key":"BFcddis201024_CR13","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1006\/dbio.1996.0292","volume":"180","author":"F Zappelli","year":"1996","unstructured":"Zappelli F, Willems D, Osada S, Ohno S, Wetsel WC, Molinaro M et al. The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis. Dev Biol 1996; 180: 156\u2013164.","journal-title":"Dev Biol"},{"key":"BFcddis201024_CR14","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1002\/jcp.10278","volume":"196","author":"C Serra","year":"2003","unstructured":"Serra C, Federici M, Buongiorno A, Senni MI, Morelli S, Segratella E et al. Transgenic mice with dominant negative PKC-theta in skeletal muscle: a new model of insulin resistance and obesity. J Cell Physiol 2003; 196: 89\u201397.","journal-title":"J Cell Physiol"},{"key":"BFcddis201024_CR15","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/jcp.20585","volume":"207","author":"M D\u2019Andrea","year":"2006","unstructured":"D\u2019Andrea M, Pisaniello A, Serra C, Senni MI, Castaldi L, Molinaro M et al. Protein kinase C theta co-operates with calcineurin in the activation of slow muscle genes in cultured myogenic cells. J Cell Physiol 2006; 207: 379\u2013388.","journal-title":"J Cell Physiol"},{"key":"BFcddis201024_CR16","doi-asserted-by":"publisher","first-page":"E84","DOI":"10.1152\/ajpendo.00178.2006","volume":"292","author":"Z Gao","year":"2007","unstructured":"Gao Z, Wang Z, Zhang X, Butler AA, Zuberi A, Gawronska-Kozak B et al. Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice. Am J Physiol Endocrinol Metab 2007; 292: E84\u2013E91.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFcddis201024_CR17","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1034\/j.1600-065X.2003.00018.x","volume":"192","author":"G Baier","year":"2003","unstructured":"Baier G . The PKC gene module: molecular biosystematics to resolve its T cell functions. Immunol Rev 2003; 192: 64\u201379.","journal-title":"Immunol Rev"},{"key":"BFcddis201024_CR18","doi-asserted-by":"publisher","first-page":"13571","DOI":"10.1074\/jbc.275.18.13571","volume":"275","author":"LJ De Windt","year":"2000","unstructured":"De Windt LJ, Lim HW, Haq S, Force T, Molkentin JD . Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. Cross-talk between cardiac hypertrophic signaling pathways. J Biol Chem 2000; 275: 13571\u201313579.","journal-title":"J Biol Chem"},{"key":"BFcddis201024_CR19","doi-asserted-by":"publisher","first-page":"8374","DOI":"10.1128\/MCB.24.19.8374-8385.2004","volume":"24","author":"RB Vega","year":"2004","unstructured":"Vega RB, Harrison BC, Meadows E, Roberts CR, Papst PJ, Olson EN et al. Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5. Mol Cell Biol 2004; 24: 8374\u20138385.","journal-title":"Mol Cell Biol"},{"key":"BFcddis201024_CR20","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.yjmcc.2004.11.004","volume":"38","author":"CP Baines","year":"2005","unstructured":"Baines CP, Molkentin JD . STRESS signaling pathways that modulate cardiac myocyte apoptosis. J Mol Cell Cardiol 2005; 38: 47\u201362.","journal-title":"J Mol Cell Cardiol"},{"key":"BFcddis201024_CR21","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1007\/s00424-003-1236-3","volume":"448","author":"L Li","year":"2004","unstructured":"Li L, Hessel M, van der Valk L, Bax M, van der Linden I, van der Laarse A . Partial and delayed release of troponin-I compared with the release of lactate dehydrogenase from necrotic cardiomyocytes. Pflugers Arch 2004; 448: 146\u2013152.","journal-title":"Pflugers Arch"},{"key":"BFcddis201024_CR22","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1161\/01.RES.86.11.1173","volume":"86","author":"D Mochly-Rosen","year":"2000","unstructured":"Mochly-Rosen D, Wu G, Hahn H, Osinska H, Liron T, Lorenz JN et al. Cardiotrophic effects of protein kinase C epsilon: analysis by in vivo modulation of PKCepsilon translocation. Circ Res 2000; 86: 1173\u20131179.","journal-title":"Circ Res"},{"key":"BFcddis201024_CR23","doi-asserted-by":"publisher","first-page":"3596","DOI":"10.1074\/jbc.M311459200","volume":"279","author":"MO Gray","year":"2004","unstructured":"Gray MO, Zhou HZ, Schafhalter-Zoppoth I, Zhu P, Mochly-Rosen D, Messing RO . Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon. J Biol Chem 2004; 279: 3596\u20133604.","journal-title":"J Biol Chem"},{"key":"BFcddis201024_CR24","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1161\/01.CIR.49.6.1088","volume":"49","author":"KL Peterson","year":"1974","unstructured":"Peterson KL, Skloven D, Ludbrook P, Uther JB, Ross Jr J . Comparison of isovolumic and ejection phase indices of myocardial performance in man. Circulation 1974; 49: 1088\u20131101.","journal-title":"Circulation"},{"key":"BFcddis201024_CR25","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1161\/01.RES.0000161999.86198.1e","volume":"96","author":"G Klein","year":"2005","unstructured":"Klein G, Schaefer A, Hilfiker-Kleiner D, Oppermann D, Shukla P, Quint A et al. Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKCepsilon. Circ Res 2005; 96: 748\u2013755.","journal-title":"Circ Res"},{"key":"BFcddis201024_CR26","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s10741-007-9034-1","volume":"12","author":"M Rajabi","year":"2007","unstructured":"Rajabi M, Kassiotis C, Razeghi P, Taegtmeyer H . Return to the fetal gene program protects the stressed heart: a strong hypothesis. Heart Fail Rev 2007; 12: 331\u2013343.","journal-title":"Heart Fail Rev"},{"key":"BFcddis201024_CR27","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1161\/hh2201.099434","volume":"89","author":"MC Heidkamp","year":"2001","unstructured":"Heidkamp MC, Bayer AL, Martin JL, Samarel AM . Differential activation of mitogen-activated protein kinase cascades and apoptosis by protein kinase C epsilon and delta in neonatal rat ventricular myocytes. Circ Res 2001; 89: 882\u2013890.","journal-title":"Circ Res"},{"key":"BFcddis201024_CR28","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s10741-007-9070-x","volume":"13","author":"M Movassagh","year":"2008","unstructured":"Movassagh M, Foo RS . Simplified apoptotic cascades. Heart Fail Rev 2008; 13: 111\u2013119.","journal-title":"Heart Fail Rev"},{"key":"BFcddis201024_CR29","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1161\/01.CIR.0000028818.33488.7B","volume":"106","author":"W Wang","year":"2002","unstructured":"Wang W, Schulze CJ, Suarez-Pinzon WL, Dyck JR, Sawicki G, Schulz R . Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury. Circulation 2002; 106: 1543\u20131549.","journal-title":"Circulation"},{"key":"BFcddis201024_CR30","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1161\/01.CIR.103.16.2035","volume":"103","author":"J Feng","year":"2001","unstructured":"Feng J, Schaus BJ, Fallavollita JA, Lee TC, Canty Jr JM . Preload induces troponin I degradation independently of myocardial ischemia. Circulation 2001; 103: 2035\u20132037.","journal-title":"Circulation"},{"key":"BFcddis201024_CR31","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.clinbiochem.2007.04.004","volume":"40","author":"EC Michielsen","year":"2007","unstructured":"Michielsen EC, Diris JH, Kleijnen VW, Wodzig WK, Van Dieijen-Visser MP . Investigation of release and degradation of cardiac troponin T in patients with acute myocardial infarction. Clin Biochem 2007; 40: 851\u2013855.","journal-title":"Clin Biochem"},{"key":"BFcddis201024_CR32","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S0092-8674(02)00861-9","volume":"110","author":"CL Zhang","year":"2002","unstructured":"Zhang CL, McKinsey TA, Chang S, Antos CL, Hill JA, Olson EN . Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell 2002; 110: 479\u2013488.","journal-title":"Cell"},{"key":"BFcddis201024_CR33","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1073\/pnas.0712265105","volume":"105","author":"J Fielitz","year":"2008","unstructured":"Fielitz J, Kim MS, Shelton JM, Qi X, Hill JA, Richardson JA et al. Requirement of protein kinase D1 for pathological cardiac remodeling. Proc Natl Acad Sci USA 2008; 105: 3059\u20133063.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis201024_CR34","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/35006090","volume":"404","author":"Z Sun","year":"2000","unstructured":"Sun Z, Arendt CW, Ellmeier W, Schaeffer EM, Sunshine MJ, Gandhi L et al. PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature 2000; 404: 402\u2013407.","journal-title":"Nature"},{"key":"BFcddis201024_CR35","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1096\/fj.06-7454com","volume":"21","author":"L Castaldi","year":"2007","unstructured":"Castaldi L, Serra C, Moretti F, Messina G, Paoletti R, Sampaolesi M et al. Bisperoxovanadium, a phospho-tyrosine phosphatase inhibitor, reprograms myogenic cells to acquire a pluripotent, circulating phenotype. FASEB J 2007; 21: 3573\u20133583.","journal-title":"FASEB J"},{"key":"BFcddis201024_CR36","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nm805","volume":"9","author":"M Brancaccio","year":"2003","unstructured":"Brancaccio M, Fratta L, Notte A, Hirsch E, Poulet R, Guazzone S et al. Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Nat Med 2003; 9: 68\u201375.","journal-title":"Nat Med"}],"container-title":["Cell Death & Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis201024.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis201024","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis201024.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:12:36Z","timestamp":1672963956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis201024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,27]]},"references-count":36,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2010,5]]}},"alternative-id":["BFcddis201024"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2010.24","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,27]]},"assertion":[{"value":"20 January 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}