{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:26:48Z","timestamp":1790904408951,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2010,10,21]],"date-time":"2010-10-21T00:00:00Z","timestamp":1287619200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2010.63","type":"journal-article","created":{"date-parts":[[2010,10,22]],"date-time":"2010-10-22T05:35:04Z","timestamp":1287725704000},"page":"e84-e84","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Apoptosis-inducing factor deficiency decreases the proliferation rate and protects the subventricular zone against ionizing radiation"],"prefix":"10.1038","volume":"1","author":[{"given":"K","family":"Osato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Ochiishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Osato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Swanpalmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Modjtahedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Kroemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H G","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Blomgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,10,21]]},"reference":[{"key":"BFcddis201063_CR1","volume-title":"Childhood cancer incidence and survival in Sweden 1984-2005","author":"G Gustafsson","year":"2007","unstructured":"Gustafsson G, Heyman M, Vernby \u00c5 . Childhood cancer incidence and survival in Sweden 1984-2005. Karolinska Institute: Stockholm, 2007."},{"key":"BFcddis201063_CR2","doi-asserted-by":"publisher","first-page":"3742","DOI":"10.1200\/JCO.2005.00.554","volume":"23","author":"G Gatta","year":"2005","unstructured":"Gatta G, Capocaccia R, Stiller C, Kaatsch P, Berrino F, Terenziani M . Childhood cancer survival trends in Europe: a EUROCARE Working Group study. J Clin Oncol 2005; 23: 3742\u20133751.","journal-title":"J Clin Oncol"},{"key":"BFcddis201063_CR3","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1016\/j.ejca.2006.05.006","volume":"42","author":"C Magnani","year":"2006","unstructured":"Magnani C, Pastore G, Coebergh JW, Viscomi S, Spix C, Steliarova-Foucher E . Trends in survival after childhood cancer in Europe, 1978-1997: report from the Automated Childhood Cancer Information System project (ACCIS). Eur J Cancer 2006; 42: 1981\u20132005.","journal-title":"Eur J Cancer"},{"key":"BFcddis201063_CR4","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.cppeds.2005.04.001","volume":"35","author":"AS Levy","year":"2005","unstructured":"Levy AS . Brain tumors in children: evaluation and management. Curr Probl Pediatr Adolesc Health Care 2005; 35: 230\u2013245.","journal-title":"Curr Probl Pediatr Adolesc Health Care"},{"key":"BFcddis201063_CR5","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1097\/00019052-200312000-00006","volume":"16","author":"NE Anderson","year":"2003","unstructured":"Anderson NE . Late complications in childhood central nervous system tumour survivors. Current Opinion in Neurology 2003; 16: 677\u2013683.","journal-title":"Current Opinion in Neurology"},{"key":"BFcddis201063_CR6","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/mpo.2950180410","volume":"18","author":"B Lannering","year":"1990","unstructured":"Lannering B, Marky I, Lundberg A, Olsson E . Long-term sequelae after pediatric brain tumors: their effect on disability and quality of life. Medical and Pediatric Oncology 1990; 18: 304\u2013310.","journal-title":"Medical and Pediatric Oncology"},{"key":"BFcddis201063_CR7","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1002\/1097-0142(19840501)53:9<1952::AID-CNCR2820530925>3.0.CO;2-X","volume":"53","author":"HW Chin","year":"1984","unstructured":"Chin HW, Maruyama Y . Age at treatment and long-term performance results in medulloblastoma. Cancer 1984; 53: 1952.","journal-title":"Cancer"},{"issue":"Suppl 7","key":"BFcddis201063_CR8","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1002\/1097-0142(19851001)56:7+<1841::AID-CNCR2820561325>3.0.CO;2-C","volume":"56","author":"PK Duffner","year":"1985","unstructured":"Duffner PK, Cohen ME, Thomas PR, Lansky SB . The long-term effects of cranial irradiation on the central nervous system. Cancer 1985; 56 (Suppl 7): 1841.","journal-title":"Cancer"},{"key":"BFcddis201063_CR9","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/1097-0142(19840701)54:1<135::AID-CNCR2820540127>3.0.CO;2-B","volume":"54","author":"FP Li","year":"1984","unstructured":"Li FP, Winston KR, Gimbrere K . Follow-up of children with brain tumors. Cancer 1984; 54: 135.","journal-title":"Cancer"},{"key":"BFcddis201063_CR10","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/mpo.2950150505","volume":"15","author":"RJ Packer","year":"1987","unstructured":"Packer RJ, Meadows AT, Rorke LB, Goldwein JL, D\u2019Angio G . Long-term sequelae of cancer treatment on the central nervous system in childhood. Medical and Pediatric Oncology 1987; 15: 241\u2013253.","journal-title":"Medical and Pediatric Oncology"},{"key":"BFcddis201063_CR11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1136\/bmj.328.7430.19","volume":"328","author":"P Hall","year":"2004","unstructured":"Hall P, Adami HO, Trichopoulos D, Pedersen NL, Lagiou P, Ekbom A et al. Effect of low doses of ionising radiation in infancy on cognitive function in adulthood: Swedish population based cohort study. Bmj 2004; 328: 19.","journal-title":"Bmj"},{"key":"BFcddis201063_CR12","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1002\/ana.410230608","volume":"23","author":"PK Duffner","year":"1988","unstructured":"Duffner PK, Cohen ME, Parker MS . Prospective intellectual testing in children with brain tumors. Ann Neurol 1988; 23: 575\u2013579.","journal-title":"Ann Neurol"},{"key":"BFcddis201063_CR13","doi-asserted-by":"publisher","first-page":"707","DOI":"10.3171\/jns.1989.70.5.0707","volume":"70","author":"RJ Packer","year":"1989","unstructured":"Packer RJ, Sutton LN, Atkins TE, Radcliffe J, Bunin GR, D\u2019Angio G et al. A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemotherapy: 2-year results. J Neurosurg 1989; 70: 707\u2013713.","journal-title":"J Neurosurg"},{"key":"BFcddis201063_CR14","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/j.1471-4159.2004.02894.x","volume":"92","author":"A Fukuda","year":"2005","unstructured":"Fukuda A, Fukuda H, Swanpalmer J, Hertzman S, Lannering B, Marky I et al. Age-dependent sensitivity of the developing brain to irradiation is correlated with the number and vulnerability of progenitor cells. J Neurochem 2005; 92: 569\u2013584.","journal-title":"J Neurochem"},{"key":"BFcddis201063_CR15","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1038\/sj.cdd.4401472","volume":"11","author":"H Fukuda","year":"2004","unstructured":"Fukuda H, Fukuda A, Zhu C, Korhonen L, Swanpalmer J, Hertzman S et al. Irradiation-induced progenitor cell death in the developing brain is resistant to erythropoietin treatment and caspase inhibition. Cell Death Differ 2004; 11: 1166\u20131178.","journal-title":"Cell Death Differ"},{"key":"BFcddis201063_CR16","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1126\/science.1088417","volume":"302","author":"ML Monje","year":"2003","unstructured":"Monje ML, Toda H, Palmer TD . Inflammatory blockade restores adult hippocampal neurogenesis. Science (New York, N.Y) 2003; 302: 1760\u20131765.","journal-title":"Science (New York, N.Y)"},{"key":"BFcddis201063_CR17","doi-asserted-by":"publisher","first-page":"20804","DOI":"10.1074\/jbc.M202387200","volume":"277","author":"PE Lonergan","year":"2002","unstructured":"Lonergan PE, Martin DS, Horrobin DF, Lynch MA . Neuroprotective effect of eicosapentaenoic acid in hippocampus of rats exposed to gamma-irradiation. J Biol Chem 2002; 277: 20804\u201320811.","journal-title":"J Biol Chem"},{"key":"BFcddis201063_CR18","doi-asserted-by":"publisher","first-page":"16052","DOI":"10.1073\/pnas.0407065101","volume":"101","author":"CL Limoli","year":"2004","unstructured":"Limoli CL, Rola R, Giedzinski E, Mantha S, Huang TT, Fike JR . Cell-density-dependent regulation of neural precursor cell function. Proc Natl Acad Sci USA 2004; 101: 16052\u201316057.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis201063_CR19","doi-asserted-by":"publisher","first-page":"14632","DOI":"10.1073\/pnas.0711128105","volume":"105","author":"AS Naylor","year":"2008","unstructured":"Naylor AS, Bull C, Nilsson MK, Zhu C, Bjork-Eriksson T, Eriksson PS et al. Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain. Proc Natl AcadSci USA 2008; 105: 14632\u201314637.","journal-title":"Proc Natl AcadSci USA"},{"key":"BFcddis201063_CR20","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/0896-6273(93)90281-U","volume":"11","author":"MB Luskin","year":"1993","unstructured":"Luskin MB . Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. Neuron 1993; 11: 173\u2013189.","journal-title":"Neuron"},{"key":"BFcddis201063_CR21","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1038\/3305","volume":"4","author":"PS Eriksson","year":"1998","unstructured":"Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn AM, Nordborg C, Peterson DA et al. Neurogenesis in the adult human hippocampus. Nat Med 1998; 4: 1313\u20131317.","journal-title":"Nat Med"},{"key":"BFcddis201063_CR22","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/6365","volume":"2","author":"E Gould","year":"1999","unstructured":"Gould E, Beylin A, Tanapat P, Reeves A, Shors TJ . Learning enhances adult neurogenesis in the hippocampal formation. Nat Neurosci 1999; 2: 260\u2013265.","journal-title":"Nat Neurosci"},{"key":"BFcddis201063_CR23","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0169-328X(99)00170-9","volume":"71","author":"W Peissner","year":"1999","unstructured":"Peissner W, Kocher M, Treuer H, Gillardon F . Ionizing radiation-induced apoptosis of proliferating stem cells in the dentate gyrus of the adult rat hippocampus. Brain Res Mol Brain Res 1999; 71: 61\u201368.","journal-title":"Brain Res Mol Brain Res"},{"key":"BFcddis201063_CR24","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/nm749","volume":"8","author":"ML Monje","year":"2002","unstructured":"Monje ML, Mizumatsu S, Fike JR, Palmer TD . Irradiation induces neural precursor-cell dysfunction. Nat Med 2002; 8: 955\u2013962.","journal-title":"Nat Med"},{"key":"BFcddis201063_CR25","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0306-4522(00)00151-2","volume":"99","author":"E Tada","year":"2000","unstructured":"Tada E, Parent JM, Lowenstein DH, Fike JR . X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats. Neuroscience 2000; 99: 33\u201341.","journal-title":"Neuroscience"},{"key":"BFcddis201063_CR26","doi-asserted-by":"publisher","first-page":"4508","DOI":"10.1523\/JNEUROSCI.19-11-04508.1999","volume":"19","author":"JM Parent","year":"1999","unstructured":"Parent JM, Tada E, Fike JR, Lowenstein DH . Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat. J Neurosci 1999; 19: 4508\u20134519.","journal-title":"J Neurosci"},{"key":"BFcddis201063_CR27","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1002\/ana.21214","volume":"62","author":"ML Monje","year":"2007","unstructured":"Monje ML, Vogel H, Masek M, Ligon KL, Fisher PG, Palmer TD . Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies. Ann Neurol 2007; 62: 515\u2013520.","journal-title":"Ann Neurol"},{"key":"BFcddis201063_CR28","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nrn2665","volume":"10","author":"L Galluzzi","year":"2009","unstructured":"Galluzzi L, Blomgren K, Kroemer G . Mitochondrial membrane permeabilization in neuronal injury. Nat Rev Neurosci 2009; 10: 481\u2013494.","journal-title":"Nat Rev Neurosci"},{"key":"BFcddis201063_CR29","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1007\/s10495-007-0754-4","volume":"12","author":"K Blomgren","year":"2007","unstructured":"Blomgren K, Leist M, Groc L . Pathological apoptosis in the developing brain. Apoptosis 2007; 12: 993\u20131010.","journal-title":"Apoptosis"},{"key":"BFcddis201063_CR30","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/nm1263","volume":"11","author":"G Kroemer","year":"2005","unstructured":"Kroemer G, Martin SJ . Caspase-independent cell death. Nat Med 2005; 11: 725\u2013730.","journal-title":"Nat Med"},{"key":"BFcddis201063_CR31","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/17135","volume":"397","author":"SA Susin","year":"1999","unstructured":"Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999; 397: 441\u2013446.","journal-title":"Nature"},{"key":"BFcddis201063_CR32","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/sj.cdd.4402053","volume":"14","author":"C Zhu","year":"2007","unstructured":"Zhu C, Wang X, Huang Z, Qiu L, Xu F, Vahsen N et al. Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia. Cell Death Differ 2007; 14: 775\u2013784.","journal-title":"Cell Death Differ"},{"key":"BFcddis201063_CR33","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.tcb.2006.03.008","volume":"16","author":"N Modjtahedi","year":"2006","unstructured":"Modjtahedi N, Giordanetto F, Madeo F, Kroemer G . Apoptosis-inducing factor: vital and lethal. Trends Cell Biol 2006; 16: 264\u2013272.","journal-title":"Trends Cell Biol"},{"key":"BFcddis201063_CR34","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/nature01034","volume":"419","author":"JA Klein","year":"2002","unstructured":"Klein JA, Longo-Guess CM, Rossmann MP, Seburn KL, Hurd RE, Frankel WN et al. The harlequin mouse mutation downregulates apoptosis-inducing factor. Nature 2002; 419: 367\u2013374.","journal-title":"Nature"},{"key":"BFcddis201063_CR35","doi-asserted-by":"publisher","first-page":"10963","DOI":"10.1523\/JNEUROSCI.3461-04.2004","volume":"24","author":"H Wang","year":"2004","unstructured":"Wang H, Yu SW, Koh DW, Lew J, Coombs C, Bowers W et al. Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. J Neurosci 2004; 24: 10963\u201310973.","journal-title":"J Neurosci"},{"key":"BFcddis201063_CR36","doi-asserted-by":"publisher","first-page":"10262","DOI":"10.1523\/JNEUROSCI.2818-05.2005","volume":"25","author":"C Culmsee","year":"2005","unstructured":"Culmsee C, Zhu C, Landshamer S, Becattini B, Wagner E, Pellecchia M et al. Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. J Neurosci 2005; 25: 10262\u201310272.","journal-title":"J Neurosci"},{"key":"BFcddis201063_CR37","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1523\/JNEUROSCI.4261-04.2005","volume":"25","author":"EC Cheung","year":"2005","unstructured":"Cheung EC, Melanson-Drapeau L, Cregan SP, Vanderluit JL, Ferguson KL, McIntosh WC et al. Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms. J Neurosci 2005; 25: 1324\u20131334.","journal-title":"J Neurosci"},{"key":"BFcddis201063_CR38","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.2353\/ajpath.2008.080168","volume":"173","author":"JE Slemmer","year":"2008","unstructured":"Slemmer JE, Zhu C, Landshamer S, Trabold R, Grohm J, Ardeshiri A et al. Causal role of apoptosis-inducing factor for neuronal cell death following traumatic brain injury. Am J Pathol 2008; 173: 1795\u20131805.","journal-title":"Am J Pathol"},{"key":"BFcddis201063_CR39","doi-asserted-by":"publisher","first-page":"3402","DOI":"10.1111\/j.1460-9568.2007.05948.x","volume":"26","author":"C Zhu","year":"2007","unstructured":"Zhu C, Xu F, Fukuda A, Wang X, Fukuda H, Korhonen L et al. X chromosome-linked inhibitor of apoptosis protein reduces oxidative stress after cerebral irradiation or hypoxia-ischemia through up-regulation of mitochondrial antioxidants. Eur J Neurosci 2007; 26: 3402\u20133410.","journal-title":"Eur J Neurosci"},{"key":"BFcddis201063_CR40","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1038\/sj.onc.1207279","volume":"23","author":"C Cande","year":"2004","unstructured":"Cande C, Vahsen N, Kouranti I, Schmitt E, Daugas E, Spahr C et al. AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis. Oncogene 2004; 23: 1514\u20131521.","journal-title":"Oncogene"},{"key":"BFcddis201063_CR41","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1084\/jem.20070193","volume":"204","author":"C Zhu","year":"2007","unstructured":"Zhu C, Wang X, Deinum J, Huang Z, Gao J, Modjtahedi N et al. Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia. J Exp Med 2007; 204: 1741\u20131748.","journal-title":"J Exp Med"},{"key":"BFcddis201063_CR42","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1111\/j.1471-4159.2005.03313.x","volume":"94","author":"A Fukuda","year":"2005","unstructured":"Fukuda A, Fukuda H, Jonsson M, Swanpalmer J, Hertzman S, Lannering B et al. Progenitor cell injury after irradiation to the developing brain can be modulated by mild hypothermia or hyperthermia. J Neurochem 2005; 94: 1604\u20131619.","journal-title":"J Neurochem"},{"key":"BFcddis201063_CR43","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1634\/stemcells.2008-0732","volume":"27","author":"NA Hellstr\u00f6m","year":"2009","unstructured":"Hellstr\u00f6m NA, Bj\u00f6rk-Eriksson T, Blomgren K, Kuhn HG . Differential recovery of neural stem cells in the subventricular zone and dentate gyrus after ionizing radiation. Stem Cells 2009; 27: 634\u2013641.","journal-title":"Stem Cells"},{"key":"BFcddis201063_CR44","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1002\/ana.10393","volume":"52","author":"JM Parent","year":"2002","unstructured":"Parent JM, Vexler ZS, Gong C, Derugin N, Ferriero DM . Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Ann Neurol 2002; 52: 802\u2013813.","journal-title":"Ann Neurol"},{"key":"BFcddis201063_CR45","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1667\/RR3112","volume":"161","author":"CL Limoli","year":"2004","unstructured":"Limoli CL, Giedzinski E, Rola R, Otsuka S, Palmer TD, Fike JR . Radiation response of neural precursor cells: linking cellular sensitivity to cell cycle checkpoints, apoptosis and oxidative stress. Radiation Research 2004; 161: 17\u201327.","journal-title":"Radiation Research"},{"key":"BFcddis201063_CR46","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1269\/jrr.45.319","volume":"45","author":"K Anzai","year":"2004","unstructured":"Anzai K, Furuse M, Yoshida A, Matsuyama A, Moritake T, Tsuboi K et al. In vivo radioprotection of mice by 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone; Radicut), a clinical drug. J Radiat Res (Tokyo) 2004; 45: 319\u2013323.","journal-title":"J Radiat Res (Tokyo)"},{"key":"BFcddis201063_CR47","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.neulet.2007.07.029","volume":"423","author":"J Ishii","year":"2007","unstructured":"Ishii J, Natsume A, Wakabayashi T, Takeuchi H, Hasegawa H, Kim SU et al. The free-radical scavenger edaravone restores the differentiation of human neural precursor cells after radiation-induced oxidative stress. Neurosci Lett 2007; 423: 225\u2013230.","journal-title":"Neurosci Lett"},{"key":"BFcddis201063_CR48","doi-asserted-by":"publisher","first-page":"6030","DOI":"10.4049\/jimmunol.174.10.6030","volume":"174","author":"J Colgan","year":"2005","unstructured":"Colgan J, Asmal M, Yu B, Luban J . Cyclophilin A-deficient mice are resistant to immunosuppression by cyclosporine. J Immunol 2005; 174: 6030\u20136038.","journal-title":"J Immunol"},{"key":"BFcddis201063_CR49","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1259\/0007-1285-62-740-679","volume":"62","author":"JF Fowler","year":"1989","unstructured":"Fowler JF . The linear-quadratic formula and progress in fractionated radiotherapy. Br J Radiol 1989; 62: 679\u2013694.","journal-title":"Br J Radiol"},{"key":"BFcddis201063_CR50","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1097\/01.LAB.0000075556.74231.A5","volume":"83","author":"FP Wachs","year":"2003","unstructured":"Wachs FP, Couillard-Despres S, Engelhardt M, Wilhelm D, Ploetz S, Vroemen M et al. High efficacy of clonal growth and expansion of adult neural stem cells. Lab Invest 2003; 83: 949\u2013962.","journal-title":"Lab Invest"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis201063.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis201063","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis201063.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:14:57Z","timestamp":1672964097000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis201063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,21]]},"references-count":50,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2010,10]]}},"alternative-id":["BFcddis201063"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2010.63","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,21]]},"assertion":[{"value":"26 May 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}