{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:28:54Z","timestamp":1791106134300,"version":"4.1.0"},"reference-count":115,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T00:00:00Z","timestamp":1320883200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2011.112","type":"journal-article","created":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T11:03:00Z","timestamp":1320922980000},"page":"e228-e228","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":152,"title":["Neurodegenerative processes in Huntington's disease"],"prefix":"10.1038","volume":"2","author":[{"given":"D","family":"Bano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Zanetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Mende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Nicotera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,11,10]]},"reference":[{"key":"BFcddis2011112_CR1","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1056\/NEJM198611133152006","volume":"315","author":"JB Martin","year":"1986","unstructured":"Martin JB, Gusella JF . Huntington's disease. Pathogenesis and management. N Engl J Med 1986; 315: 1267\u20131276.","journal-title":"N Engl J Med"},{"key":"BFcddis2011112_CR2","doi-asserted-by":"publisher","first-page":"5733","DOI":"10.1073\/pnas.85.15.5733","volume":"85","author":"A Reiner","year":"1988","unstructured":"Reiner A, Albin RL, Anderson KD, D\u2019Amato CJ, Penney JB, Young AB . Differential loss of striatal projection neurons in Huntington disease. Proc Natl Acad Sci USA 1988; 85: 5733\u20135737.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2011112_CR3","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1212\/01.WNL.0000065888.88988.6E","volume":"60","author":"HD Rosas","year":"2003","unstructured":"Rosas HD, Koroshetz WJ, Chen YI, Skeuse C, Vangel M, Cudkowicz ME et al. Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis. Neurology 2003; 60: 1615\u20131620.","journal-title":"Neurology"},{"issue":"6","key":"BFcddis2011112_CR4","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","author":"M MACDONALD","year":"1993","unstructured":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. Cell 1993; 72: 971\u2013983.","journal-title":"Cell"},{"key":"BFcddis2011112_CR5","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/ng0893-398","volume":"4","author":"SE Andrew","year":"1993","unstructured":"Andrew SE, Goldberg YP, Kremer B, Telenius H, Theilmann J, Adam S et al. The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease. Nat Genet 1993; 4: 398\u2013403.","journal-title":"Nat Genet"},{"key":"BFcddis2011112_CR6","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1093\/hmg\/2.10.1713","volume":"2","author":"DC Rubinsztein","year":"1993","unstructured":"Rubinsztein DC, Barton DE, Davison BC, Ferguson-Smith MA . Analysis of the huntingtin gene reveals a trinucleotide-length polymorphism in the region of the gene that contains two CCG-rich stretches and a correlation between decreased age of onset of Huntington's disease and CAG repeat number. Hum Mol Genet 1993; 2: 1713\u20131715.","journal-title":"Hum Mol Genet"},{"key":"BFcddis2011112_CR7","doi-asserted-by":"publisher","first-page":"e3507","DOI":"10.1371\/journal.pone.0003507","volume":"3","author":"B Aranda-Orgilles","year":"2008","unstructured":"Aranda-Orgilles B, Aigner J, Kunath M, Lurz R, Schneider R, Schweiger S . Active transport of the ubiquitin ligase MID1 along the microtubules is regulated by protein phosphatase 2A. PLoS One 2008; 3: e3507.","journal-title":"PLoS One"},{"key":"BFcddis2011112_CR8","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1093\/hmg\/ddm217","volume":"16","author":"RS Atwal","year":"2007","unstructured":"Atwal RS, Xia J, Pinchev D, Taylor J, Epand RM, Truant R . Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity. Hum Mol Genet 2007; 16: 2600\u20132615.","journal-title":"Hum Mol Genet"},{"key":"BFcddis2011112_CR9","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/0896-6273(95)90346-1","volume":"14","author":"M DiFiglia","year":"1995","unstructured":"DiFiglia M, Sapp E, Chase K, Schwarz C, Meloni A, Young C et al. Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron 1995; 14: 1075\u20131081.","journal-title":"Neuron"},{"key":"BFcddis2011112_CR10","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/ng0595-104","volume":"10","author":"Y Trottier","year":"1995","unstructured":"Trottier Y, Devys D, Imbert G, Saudou F, An I, Lutz Y et al. Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form. Nat Genet 1995; 10: 104\u2013110.","journal-title":"Nat Genet"},{"key":"BFcddis2011112_CR11","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1152\/physrev.00041.2009","volume":"90","author":"C Zuccato","year":"2010","unstructured":"Zuccato C, Valenza M, Cattaneo E . Molecular mechanisms and potential therapeutical targets in Huntington's disease. Physiol Rev 2010; 90: 905\u2013981.","journal-title":"Physiol Rev"},{"key":"BFcddis2011112_CR12","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/ng1193-259","volume":"5","author":"TV Strong","year":"1993","unstructured":"Strong TV, Tagle DA, Valdes JM, Elmer LW, Boehm K, Swaroop M et al. Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues. Nat Genet 1993; 5: 259\u2013265.","journal-title":"Nat Genet"},{"key":"BFcddis2011112_CR13","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/0092-8674(95)90542-1","volume":"81","author":"J Nasir","year":"1995","unstructured":"Nasir J, Floresco SB, O\u2019Kusky JR, Diewert VM, Richman JM, Zeisler J et al. Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes. Cell 1995; 81: 811\u2013823.","journal-title":"Cell"},{"key":"BFcddis2011112_CR14","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/ng1095-155","volume":"11","author":"S Zeitlin","year":"1995","unstructured":"Zeitlin S, Liu JP, Chapman DL, Papaioannou VE, Efstratiadis A . Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue. Nat Genet 1995; 11: 155\u2013163.","journal-title":"Nat Genet"},{"key":"BFcddis2011112_CR15","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/81593","volume":"26","author":"I Dragatsis","year":"2000","unstructured":"Dragatsis I, Levine MS, Zeitlin S . Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice. Nat Genet 2000; 26: 300\u2013306.","journal-title":"Nat Genet"},{"key":"BFcddis2011112_CR16","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1046\/j.1471-4159.2003.01980.x","volume":"87","author":"Y Zhang","year":"2003","unstructured":"Zhang Y, Li M, Drozda M, Chen M, Ren S, Mejia Sanchez RO et al. Depletion of wild-type huntingtin in mouse models of neurologic diseases. J Neurochem 2003; 87: 101\u2013106.","journal-title":"J Neurochem"},{"key":"BFcddis2011112_CR17","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/S1534-5807(02)00188-0","volume":"2","author":"S Humbert","year":"2002","unstructured":"Humbert S, Bryson EA, Cordelieres FP, Connors NC, Datta SR, Finkbeiner S et al. The IGF-1\/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt. Dev Cell 2002; 2: 831\u2013837.","journal-title":"Dev Cell"},{"key":"BFcddis2011112_CR18","doi-asserted-by":"publisher","first-page":"5355","DOI":"10.1073\/pnas.91.12.5355","volume":"91","author":"MF Perutz","year":"1994","unstructured":"Perutz MF, Johnson T, Suzuki M, Finch JT . Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases. Proc Natl Acad Sci USA 1994; 91: 5355\u20135358.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2011112_CR19","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1093\/hmg\/ddi477","volume":"15","author":"EB Clabough","year":"2006","unstructured":"Clabough EB, Zeitlin SO . Deletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral\/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitro. Hum Mol Genet 2006; 15: 607\u2013623.","journal-title":"Hum Mol Genet"},{"key":"BFcddis2011112_CR20","doi-asserted-by":"publisher","first-page":"e1000838","DOI":"10.1371\/journal.pgen.1000838","volume":"6","author":"S Zheng","year":"2010","unstructured":"Zheng S, Clabough EB, Sarkar S, Futter M, Rubinsztein DC, Zeitlin SO . Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice. PLoS Genet 2010; 6: e1000838.","journal-title":"PLoS Genet"},{"key":"BFcddis2011112_CR21","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","volume":"277","author":"M DiFiglia","year":"1997","unstructured":"DiFiglia M, Sapp E, Chase KO, Davies SW, Bates GP, Vonsattel JP et al. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 1997; 277: 1990\u20131993.","journal-title":"Science"},{"key":"BFcddis2011112_CR22","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/ng0298-150","volume":"18","author":"D Martindale","year":"1998","unstructured":"Martindale D, Hackam A, Wieczorek A, Ellerby L, Wellington C, McCutcheon K et al. Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates. Nat Genet 1998; 18: 150\u2013154.","journal-title":"Nat Genet"},{"key":"BFcddis2011112_CR23","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0092-8674(00)81782-1","volume":"95","author":"F Saudou","year":"1998","unstructured":"Saudou F, Finkbeiner S, Devys D, Greenberg ME . Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell 1998; 95: 55\u201366.","journal-title":"Cell"},{"key":"BFcddis2011112_CR24","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/nsmb.1570","volume":"16","author":"AK Thakur","year":"2009","unstructured":"Thakur AK, Jayaraman M, Mishra R, Thakur M, Chellgren VM, Byeon IJ et al. Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism. Nat Struct Mol Biol 2009; 16: 380\u2013389.","journal-title":"Nat Struct Mol Biol"},{"key":"BFcddis2011112_CR25","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/sj.cdd.4402261","volume":"15","author":"T Zuchner","year":"2008","unstructured":"Zuchner T, Brundin P . Mutant huntingtin can paradoxically protect neurons from death. Cell Death Differ 2008; 15: 435\u2013442.","journal-title":"Cell Death Differ"},{"key":"BFcddis2011112_CR26","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","volume":"90","author":"SW Davies","year":"1997","unstructured":"Davies SW, Turmaine M, Cozens BA, DiFiglia M, Sharp AH, Ross CA et al. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 1997; 90: 537\u2013548.","journal-title":"Cell"},{"key":"BFcddis2011112_CR27","doi-asserted-by":"publisher","first-page":"11402","DOI":"10.1073\/pnas.0503634102","volume":"102","author":"EJ Slow","year":"2005","unstructured":"Slow EJ, Graham RK, Osmand AP, Devon RS, Lu G, Deng Y et al. Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions. Proc Natl Acad Sci USA 2005; 102: 11402\u201311407.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2011112_CR28","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1093\/hmg\/ddg169","volume":"12","author":"EJ Slow","year":"2003","unstructured":"Slow EJ, van Raamsdonk J, Rogers D, Coleman SH, Graham RK, Deng Y et al. Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Hum Mol Genet 2003; 12: 1555\u20131567.","journal-title":"Hum Mol Genet"},{"key":"BFcddis2011112_CR29","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0896-6273(00)80764-3","volume":"23","author":"JG Hodgson","year":"1999","unstructured":"Hodgson JG, Agopyan N, Gutekunst CA, Leavitt BR, LePiane F, Singaraja R et al. A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration. Neuron 1999; 23: 181\u2013192.","journal-title":"Neuron"},{"key":"BFcddis2011112_CR30","doi-asserted-by":"publisher","first-page":"e90","DOI":"10.1038\/cddis.2010.68","volume":"1","author":"D Ciavardelli","year":"2010","unstructured":"Ciavardelli D, Silvestri E, Viscovo AD, Bomba M, Gregorio DD, Moreno M et al. Alterations of brain and cerebellar proteomes linked to Abeta and tau pathology in a female triple-transgenic murine model of Alzheimer's disease. Cell Death Dis 2010; 1: e90.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR31","doi-asserted-by":"publisher","first-page":"e110","DOI":"10.1038\/cddis.2010.83","volume":"1","author":"MH Lee","year":"2010","unstructured":"Lee MH, Lin SR, Chang JY, Schultz L, Heath J, Hsu LJ et al. TGF-beta induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid beta plaques in Alzheimer's disease. Cell Death Dis 2010; 1: e110.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR32","doi-asserted-by":"publisher","first-page":"e100","DOI":"10.1038\/cddis.2010.74","volume":"1","author":"SN Sivananthan","year":"2010","unstructured":"Sivananthan SN, Lee AW, Goodyer CG, LeBlanc AC . Familial amyloid precursor protein mutants cause caspase-6-dependent but amyloid beta-peptide-independent neuronal degeneration in primary human neuron cultures. Cell Death Dis 2010; 1: e100.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR33","doi-asserted-by":"publisher","first-page":"e2","DOI":"10.1038\/cddis.2009.4","volume":"1","author":"TA Yacoubian","year":"2010","unstructured":"Yacoubian TA, Slone SR, Harrington AJ, Hamamichi S, Schieltz JM, Caldwell KA et al. Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease. Cell Death Dis 2010; 1: e2.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR34","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1083\/jcb.201005144","volume":"190","author":"PM Douglas","year":"2010","unstructured":"Douglas PM, Dillin A . Protein homeostasis and aging in neurodegeneration. J Cell Biol 2010; 190: 719\u2013729.","journal-title":"J Cell Biol"},{"key":"BFcddis2011112_CR35","doi-asserted-by":"publisher","first-page":"476","DOI":"10.2174\/138920309789351912","volume":"10","author":"AL McCormack","year":"2009","unstructured":"McCormack AL, Di Monte DA . Enhanced alpha-synuclein expression in human neurodegenerative diseases: pathogenetic and therapeutic implications. Curr Protein Pept Sci 2009; 10: 476\u2013482.","journal-title":"Curr Protein Pept Sci"},{"key":"BFcddis2011112_CR36","doi-asserted-by":"publisher","first-page":"4246","DOI":"10.1073\/pnas.0511256103","volume":"103","author":"RA Bodner","year":"2006","unstructured":"Bodner RA, Outeiro TF, Altmann S, Maxwell MM, Cho SH, Hyman BT et al. Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases. Proc Natl Acad Sci USA 2006; 103: 4246\u20134251.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2011112_CR37","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1001\/archneurol.2010.40","volume":"67","author":"D Krainc","year":"2010","unstructured":"Krainc D . Clearance of mutant proteins as a therapeutic target in neurodegenerative diseases. Arch Neurol 2010; 67: 388\u2013392.","journal-title":"Arch Neurol"},{"key":"BFcddis2011112_CR38","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1172\/JCI45364","volume":"121","author":"I Munoz-Sanjuan","year":"2011","unstructured":"Munoz-Sanjuan I, Bates GP . The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease. J Clin Invest 2011; 121: 476\u2013483.","journal-title":"J Clin Invest"},{"key":"BFcddis2011112_CR39","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/ng0896-442","volume":"13","author":"YP Goldberg","year":"1996","unstructured":"Goldberg YP, Nicholson DW, Rasper DM, Kalchman MA, Koide HB, Graham RK et al. Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nat Genet 1996; 13: 442\u2013449.","journal-title":"Nat Genet"},{"key":"BFcddis2011112_CR40","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/nrm1150","volume":"4","author":"S Orrenius","year":"2003","unstructured":"Orrenius S, Zhivotovsky B, Nicotera P . Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol 2003; 4: 552\u2013565.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcddis2011112_CR41","doi-asserted-by":"publisher","first-page":"7862","DOI":"10.1523\/JNEUROSCI.22-18-07862.2002","volume":"22","author":"CL Wellington","year":"2002","unstructured":"Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK et al. Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease. J Neurosci 2002; 22: 7862\u20137872.","journal-title":"J Neurosci"},{"key":"BFcddis2011112_CR42","doi-asserted-by":"publisher","first-page":"19831","DOI":"10.1074\/jbc.M001475200","volume":"275","author":"CL Wellington","year":"2000","unstructured":"Wellington CL, Singaraja R, Ellerby L, Savill J, Roy S, Leavitt B et al. Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells. J Biol Chem 2000; 275: 19831\u201319838.","journal-title":"J Biol Chem"},{"key":"BFcddis2011112_CR43","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1016\/j.cell.2006.04.026","volume":"125","author":"RK Graham","year":"2006","unstructured":"Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G et al. Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin. Cell 2006; 125: 1179\u20131191.","journal-title":"Cell"},{"key":"BFcddis2011112_CR44","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1152\/physrev.00029.2002","volume":"83","author":"DE Goll","year":"2003","unstructured":"Goll DE, Thompson VF, Li H, Wei W, Cong J . The calpain system. Physiol Rev 2003; 83: 731\u2013801.","journal-title":"Physiol Rev"},{"key":"BFcddis2011112_CR45","doi-asserted-by":"publisher","first-page":"4842","DOI":"10.1523\/JNEUROSCI.22-12-04842.2002","volume":"22","author":"J Gafni","year":"2002","unstructured":"Gafni J, Ellerby LM . Calpain activation in Huntington's disease. J Neurosci 2002; 22: 4842\u20134849.","journal-title":"J Neurosci"},{"key":"BFcddis2011112_CR46","doi-asserted-by":"publisher","first-page":"12725","DOI":"10.1523\/JNEUROSCI.4619-08.2008","volume":"28","author":"CM Cowan","year":"2008","unstructured":"Cowan CM, Fan MM, Fan J, Shehadeh J, Zhang LY, Graham RK et al. Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity. J Neurosci 2008; 28: 12725\u201312735.","journal-title":"J Neurosci"},{"key":"BFcddis2011112_CR47","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nchembio.79","volume":"4","author":"A Williams","year":"2008","unstructured":"Williams A, Sarkar S, Cuddon P, Ttofi EK, Saiki S, Siddiqi FH et al. Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat Chem Biol 2008; 4: 295\u2013305.","journal-title":"Nat Chem Biol"},{"key":"BFcddis2011112_CR48","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.neuron.2010.06.021","volume":"67","author":"JP Miller","year":"2010","unstructured":"Miller JP, Holcomb J, Al-Ramahi I, de Haro M, Gafni J, Zhang N et al. Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease. Neuron 2010; 67: 199\u2013212.","journal-title":"Neuron"},{"key":"BFcddis2011112_CR49","doi-asserted-by":"publisher","first-page":"e76","DOI":"10.1038\/cddis.2010.53","volume":"1","author":"N Heidari","year":"2010","unstructured":"Heidari N, Hicks MA, Harada H . GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy. Cell Death Dis 2010; 1: e76.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR50","doi-asserted-by":"publisher","first-page":"e72","DOI":"10.1038\/cddis.2010.50","volume":"1","author":"HL Bennett","year":"2010","unstructured":"Bennett HL, Fleming JT, O\u2019Prey J, Ryan KM, Leung HY . Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78\/BiP in prostate cancer cells. Cell Death Dis 2010; 1: e72.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR51","doi-asserted-by":"publisher","first-page":"e19","DOI":"10.1038\/cddis.2009.18","volume":"1","author":"RR Ruela-de-Sousa","year":"2010","unstructured":"Ruela-de-Sousa RR, Fuhler GM, Blom N, Ferreira CV, Aoyama H, Peppelenbosch MP . Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy. Cell Death Dis 2010; 1: e19.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR52","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1038\/cddis.2010.33","volume":"1","author":"Q Li","year":"2010","unstructured":"Li Q, Li H, Roughton K, Wang X, Kroemer G, Blomgren K et al. Lithium reduces apoptosis and autophagy after neonatal hypoxia-ischemia. Cell Death Dis 2010; 1: e56.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR53","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1038\/cdd.2010.115","volume":"17","author":"C Liang","year":"2010","unstructured":"Liang C . Negative regulation of autophagy. Cell Death Differ 2010; 17: 1807\u20131815.","journal-title":"Cell Death Differ"},{"key":"BFcddis2011112_CR54","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1038\/cdd.2009.33","volume":"16","author":"A Eisenberg-Lerner","year":"2009","unstructured":"Eisenberg-Lerner A, Bialik S, Simon HU, Kimchi A . Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ 2009; 16: 966\u2013975.","journal-title":"Cell Death Differ"},{"key":"BFcddis2011112_CR55","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1038\/cdd.2009.19","volume":"16","author":"Y Takahashi","year":"2009","unstructured":"Takahashi Y, Meyerkord CL, Wang HG . Bif-1\/endophilin B1: a candidate for crescent driving force in autophagy. Cell Death Differ 2009; 16: 947\u2013955.","journal-title":"Cell Death Differ"},{"key":"BFcddis2011112_CR56","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/cdd.2009.16","volume":"16","author":"J Zhang","year":"2009","unstructured":"Zhang J, Ney PA . Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ 2009; 16: 939\u2013946.","journal-title":"Cell Death Differ"},{"key":"BFcddis2011112_CR57","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/cdd.2008.131","volume":"16","author":"MC Maiuri","year":"2009","unstructured":"Maiuri MC, Tasdemir E, Criollo A, Morselli E, Vicencio JM, Carnuccio R et al. Control of autophagy by oncogenes and tumor suppressor genes. Cell Death Differ 2009; 16: 87\u201393.","journal-title":"Cell Death Differ"},{"key":"BFcddis2011112_CR58","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","volume":"132","author":"B Levine","year":"2008","unstructured":"Levine B, Kroemer G . Autophagy in the pathogenesis of disease. Cell 2008; 132: 27\u201342.","journal-title":"Cell"},{"key":"BFcddis2011112_CR59","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1038\/cdd.2009.54","volume":"16","author":"T Noda","year":"2009","unstructured":"Noda T, Fujita N, Yoshimori T . The late stages of autophagy: how does the end begin? Cell Death Differ 2009; 16: 984\u2013990.","journal-title":"Cell Death Differ"},{"key":"BFcddis2011112_CR60","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1038\/cdd.2009.39","volume":"16","author":"A Longatti","year":"2009","unstructured":"Longatti A, Tooze SA . Vesicular trafficking and autophagosome formation. Cell Death Differ 2009; 16: 956\u2013965.","journal-title":"Cell Death Differ"},{"key":"BFcddis2011112_CR61","doi-asserted-by":"publisher","first-page":"e32","DOI":"10.1038\/cddis.2010.9","volume":"1","author":"L Deng","year":"2010","unstructured":"Deng L, Feng J, Broaddus RR . The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress. Cell Death Dis 2010; 1: e32.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR62","doi-asserted-by":"publisher","first-page":"e87","DOI":"10.1038\/cddis.2010.67","volume":"1","author":"ML Marino","year":"2010","unstructured":"Marino ML, Fais S, Djavaheri-Mergny M, Villa A, Meschini S, Lozupone F et al. Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells. Cell Death Dis 2010; 1: e87.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR63","doi-asserted-by":"publisher","first-page":"e14","DOI":"10.1038\/cddis.2009.12","volume":"1","author":"N Silver","year":"2010","unstructured":"Silver N, Proctor GB, Arno M, Carpenter GH . Activation of mTOR coincides with autophagy during ligation-induced atrophy in the rat submandibular gland. Cell Death Dis 2010; 1: e14.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR64","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/ng1362","volume":"36","author":"B Ravikumar","year":"2004","unstructured":"Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet 2004; 36: 585\u2013595.","journal-title":"Nat Genet"},{"key":"BFcddis2011112_CR65","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/cdd.2008.130","volume":"16","author":"A Orvedahl","year":"2009","unstructured":"Orvedahl A, Levine B . Eating the enemy within: autophagy in infectious diseases. Cell Death Differ 2009; 16: 57\u201369.","journal-title":"Cell Death Differ"},{"key":"BFcddis2011112_CR66","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0070-2153(06)76003-3","volume":"76","author":"A Williams","year":"2006","unstructured":"Williams A, Jahreiss L, Sarkar S, Saiki S, Menzies FM, Ravikumar B et al. Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications. Curr Top Dev Biol 2006; 76: 89\u2013101.","journal-title":"Curr Top Dev Biol"},{"key":"BFcddis2011112_CR67","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/cdd.2008.110","volume":"16","author":"S Sarkar","year":"2009","unstructured":"Sarkar S, Ravikumar B, Floto RA, Rubinsztein DC . Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ 2009; 16: 46\u201356.","journal-title":"Cell Death Differ"},{"key":"BFcddis2011112_CR68","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nature06639","volume":"451","author":"N Mizushima","year":"2008","unstructured":"Mizushima N, Levine B, Cuervo AM, Klionsky DJ . Autophagy fights disease through cellular self-digestion. Nature 2008; 451: 1069\u20131075.","journal-title":"Nature"},{"key":"BFcddis2011112_CR69","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/cdd.2008.126","volume":"16","author":"T Vellai","year":"2009","unstructured":"Vellai T . Autophagy genes and ageing. Cell Death Differ 2009; 16: 94\u2013102.","journal-title":"Cell Death Differ"},{"key":"BFcddis2011112_CR70","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/cdd.2008.120","volume":"16","author":"N Kourtis","year":"2009","unstructured":"Kourtis N, Tavernarakis N . Autophagy and cell death in model organisms. Cell Death Differ 2009; 16: 21\u201330.","journal-title":"Cell Death Differ"},{"key":"BFcddis2011112_CR71","doi-asserted-by":"publisher","first-page":"e18","DOI":"10.1038\/cddis.2009.16","volume":"1","author":"E Wirawan","year":"2010","unstructured":"Wirawan E, Vande Walle L, Kersse K, Cornelis S, Claerhout S, Vanoverberghe I et al. Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria. Cell Death Dis 2010; 1: e18.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR72","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.molcel.2010.09.023","volume":"40","author":"G Kroemer","year":"2010","unstructured":"Kroemer G, Marino G, Levine B . Autophagy and the integrated stress response. Mol Cell 2010; 40: 280\u2013293.","journal-title":"Mol Cell"},{"key":"BFcddis2011112_CR73","doi-asserted-by":"publisher","first-page":"e144","DOI":"10.1038\/cddis.2011.29","volume":"2","author":"R Russo","year":"2011","unstructured":"Russo R, Berliocchi L, Adornetto A, Varano GP, Cavaliere F, Nucci C et al. Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo. Cell Death Dis 2011; 2: e144.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR74","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1038\/ncb1482","volume":"8","author":"S Yousefi","year":"2006","unstructured":"Yousefi S, Perozzo R, Schmid I, Ziemiecki A, Schaffner T, Scapozza L et al. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol 2006; 8: 1124\u20131132.","journal-title":"Nat Cell Biol"},{"key":"BFcddis2011112_CR75","doi-asserted-by":"publisher","first-page":"61","DOI":"10.4161\/auto.6.1.10326","volume":"6","author":"HG Xia","year":"2010","unstructured":"Xia HG, Zhang L, Chen G, Zhang T, Liu J, Jin M et al. Control of basal autophagy by calpain1 mediated cleavage of ATG5. Autophagy 2010; 6: 61\u201366.","journal-title":"Autophagy"},{"key":"BFcddis2011112_CR76","doi-asserted-by":"publisher","first-page":"520","DOI":"10.4161\/auto.5.4.7768","volume":"5","author":"C He","year":"2009","unstructured":"He C, Bartholomew CR, Zhou W, Klionsky DJ . Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos. Autophagy 2009; 5: 520\u2013526.","journal-title":"Autophagy"},{"key":"BFcddis2011112_CR77","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/nn.2528","volume":"13","author":"M Martinez-Vicente","year":"2010","unstructured":"Martinez-Vicente M, Talloczy Z, Wong E, Tang G, Koga H, Kaushik S et al. Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nat Neurosci 2010; 13: 567\u2013576.","journal-title":"Nat Neurosci"},{"key":"BFcddis2011112_CR78","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/35099568","volume":"413","author":"JS Steffan","year":"2001","unstructured":"Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, Apostol BL et al. Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature 2001; 413: 739\u2013743.","journal-title":"Nature"},{"key":"BFcddis2011112_CR79","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.cell.2009.03.018","volume":"137","author":"H Jeong","year":"2009","unstructured":"Jeong H, Then F, Melia Jr TJ, Mazzulli JR, Cui L, Savas JN et al. Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell 2009; 137: 60\u201372.","journal-title":"Cell"},{"key":"BFcddis2011112_CR80","doi-asserted-by":"publisher","first-page":"3767","DOI":"10.1093\/hmg\/ddn273","volume":"17","author":"J Pallos","year":"2008","unstructured":"Pallos J, Bodai L, Lukacsovich T, Purcell JM, Steffan JS, Thompson LM et al. Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease. Hum Mol Genet 2008; 17: 3767\u20133775.","journal-title":"Hum Mol Genet"},{"key":"BFcddis2011112_CR81","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/nature01960","volume":"425","author":"KT Howitz","year":"2003","unstructured":"Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003; 425: 191\u2013196.","journal-title":"Nature"},{"key":"BFcddis2011112_CR82","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1038\/cddis.2009.8","volume":"1","author":"E Morselli","year":"2010","unstructured":"Morselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K et al. Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis 2010; 1: e10.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR83","doi-asserted-by":"publisher","first-page":"e12","DOI":"10.1038\/cddis.2009.17","volume":"1","author":"MV Blagosklonny","year":"2010","unstructured":"Blagosklonny MV . Linking calorie restriction to longevity through sirtuins and autophagy: any role for TOR. Cell Death Dis 2010; 1: e12.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR84","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nrm2101","volume":"8","author":"C Haass","year":"2007","unstructured":"Haass C, Selkoe DJ . Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 2007; 8: 101\u2013112.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcddis2011112_CR85","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1146\/annurev.neuro.26.010302.081142","volume":"26","author":"B Caughey","year":"2003","unstructured":"Caughey B, Lansbury PT . Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu Rev Neurosci 2003; 26: 267\u2013298.","journal-title":"Annu Rev Neurosci"},{"key":"BFcddis2011112_CR86","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1126\/science.1132814","volume":"314","author":"M Goedert","year":"2006","unstructured":"Goedert M, Spillantini MG . A century of Alzheimer's disease. Science 2006; 314: 777\u2013781.","journal-title":"Science"},{"key":"BFcddis2011112_CR87","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1126\/science.1124646","volume":"313","author":"E Cohen","year":"2006","unstructured":"Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A . Opposing activities protect against age-onset proteotoxicity. Science 2006; 313: 1604\u20131610.","journal-title":"Science"},{"key":"BFcddis2011112_CR88","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/j.cell.2009.11.014","volume":"139","author":"E Cohen","year":"2009","unstructured":"Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G et al. Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell 2009; 139: 1157\u20131169.","journal-title":"Cell"},{"key":"BFcddis2011112_CR89","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/nrn2474","volume":"9","author":"E Cohen","year":"2008","unstructured":"Cohen E, Dillin A . The insulin paradox: aging, proteotoxicity and neurodegeneration. Nat Rev Neurosci 2008; 9: 759\u2013767.","journal-title":"Nat Rev Neurosci"},{"key":"BFcddis2011112_CR90","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1007\/s12035-011-8164-6","volume":"43","author":"D Bano","year":"2011","unstructured":"Bano D, Agostini M, Melino G, Nicotera P . Ageing, neuronal connectivity and brain disorders: an unsolved ripple effect. Mol Neurobiol 2011; 43: 124\u2013130.","journal-title":"Mol Neurobiol"},{"key":"BFcddis2011112_CR91","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/366461a0","volume":"366","author":"C Kenyon","year":"1993","unstructured":"Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R . A C. elegans mutant that lives twice as long as wild type. Nature 1993; 366: 461\u2013464.","journal-title":"Nature"},{"key":"BFcddis2011112_CR92","doi-asserted-by":"publisher","first-page":"10417","DOI":"10.1073\/pnas.152161099","volume":"99","author":"JF Morley","year":"2002","unstructured":"Morley JF, Brignull HR, Weyers JJ, Morimoto RI . The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc Natl Acad Sci USA 2002; 99: 10417\u201310422.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2011112_CR93","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1126\/science.1083701","volume":"300","author":"AL Hsu","year":"2003","unstructured":"Hsu AL, Murphy CT, Kenyon C . Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 2003; 300: 1142\u20131145.","journal-title":"Science"},{"key":"BFcddis2011112_CR94","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1093\/hmg\/ddq026","volume":"19","author":"MA Pouladi","year":"2010","unstructured":"Pouladi MA, Xie Y, Skotte NH, Ehrnhoefer DE, Graham RK, Kim JE et al. Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression. Hum Mol Genet 2010; 19: 1528\u20131538.","journal-title":"Hum Mol Genet"},{"key":"BFcddis2011112_CR95","doi-asserted-by":"publisher","first-page":"e50","DOI":"10.1038\/cddis.2010.28","volume":"1","author":"GC Mitchell","year":"2010","unstructured":"Mitchell GC, Fillinger JL, Sittadjody S, Avila JL, Burd R, Limesand KH . IGF1 activates cell cycle arrest following irradiation by reducing binding of DeltaNp63 to the p21 promoter. Cell Death Dis 2010; 1: e50.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR96","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.cell.2010.07.020","volume":"142","author":"TJ van Ham","year":"2010","unstructured":"van Ham TJ, Holmberg MA, van der Goot AT, Teuling E, Garcia-Arencibia M, Kim HE et al. Identification of MOAG-4\/SERF as a regulator of age-related proteotoxicity. Cell 2010; 142: 601\u2013612.","journal-title":"Cell"},{"key":"BFcddis2011112_CR97","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1038\/sj.cdd.4402147","volume":"14","author":"M Giacomello","year":"2007","unstructured":"Giacomello M, Drago I, Pizzo P, Pozzan T . Mitochondrial Ca2+ as a key regulator of cell life and death. Cell Death Differ 2007; 14: 1267\u20131274.","journal-title":"Cell Death Differ"},{"key":"BFcddis2011112_CR98","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.cell.2004.11.003","volume":"119","author":"Z Li","year":"2004","unstructured":"Li Z, Okamoto K, Hayashi Y, Sheng M . The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell 2004; 119: 873\u2013887.","journal-title":"Cell"},{"key":"BFcddis2011112_CR99","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.ceca.2007.06.007","volume":"43","author":"KW Young","year":"2008","unstructured":"Young KW, Bampton ET, Pinon L, Bano D, Nicotera P . Mitochondrial Ca2+ signalling in hippocampal neurons. Cell Calcium 2008; 43: 296\u2013306.","journal-title":"Cell Calcium"},{"key":"BFcddis2011112_CR100","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/emmm.201000102","volume":"2","author":"V Costa","year":"2010","unstructured":"Costa V, Giacomello M, Hudec R, Lopreiato R, Ermak G, Lim D et al. Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli. EMBO Mol Med 2010; 2: 490\u2013503.","journal-title":"EMBO Mol Med"},{"key":"BFcddis2011112_CR101","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/nm.2313","volume":"17","author":"W Song","year":"2011","unstructured":"Song W, Chen J, Petrilli A, Liot G, Klinglmayr E, Zhou Y et al. Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity. Nat Med 2011; 17: 377\u2013382.","journal-title":"Nat Med"},{"key":"BFcddis2011112_CR102","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1038\/cddis.2009.6","volume":"1","author":"J Sassone","year":"2010","unstructured":"Sassone J, Colciago C, Marchi P, Ascardi C, Alberti L, Di Pardo A et al. Mutant Huntingtin induces activation of the Bcl-2\/adenovirus E1B 19-kDa interacting protein (BNip3). Cell Death Dis 2010; 1: e7.","journal-title":"Cell Death Dis"},{"issue":"2 Suppl","key":"BFcddis2011112_CR103","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1161\/01.STR.0000256294.46009.29","volume":"38","author":"D Bano","year":"2007","unstructured":"Bano D, Nicotera P . Ca2+ signals and neuronal death in brain ischemia. Stroke 2007; 38 (2 Suppl): 674\u2013676.","journal-title":"Stroke"},{"key":"BFcddis2011112_CR104","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/0896-6273(95)90186-8","volume":"15","author":"M Ankarcrona","year":"1995","unstructured":"Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA et al. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 1995; 15: 961\u2013973.","journal-title":"Neuron"},{"key":"BFcddis2011112_CR105","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.cell.2006.09.015","volume":"127","author":"L Cui","year":"2006","unstructured":"Cui L, Jeong H, Borovecki F, Parkhurst CN, Tanese N, Krainc D . Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell 2006; 127: 59\u201369.","journal-title":"Cell"},{"key":"BFcddis2011112_CR106","doi-asserted-by":"publisher","first-page":"e115","DOI":"10.1038\/cddis.2010.94","volume":"2","author":"S Zhu","year":"2011","unstructured":"Zhu S, Zhang Y, Bai G, Li H . Necrostatin-1 ameliorates symptoms in R6\/2 transgenic mouse model of Huntington's disease. Cell Death Dis 2011; 2: e115.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR107","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature09663","volume":"469","author":"R Zhou","year":"2011","unstructured":"Zhou R, Yazdi AS, Menu P, Tschopp J . A role for mitochondria in NLRP3 inflammasome activation. Nature 2011; 469: 221\u2013225.","journal-title":"Nature"},{"key":"BFcddis2011112_CR108","doi-asserted-by":"publisher","first-page":"e54","DOI":"10.1038\/cddis.2010.31","volume":"1","author":"A Ruiz","year":"2010","unstructured":"Ruiz A, Matute C, Alberdi E . Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes. Cell Death Dis 2010; 1: e54.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR109","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.cell.2010.02.016","volume":"140","author":"CK Glass","year":"2010","unstructured":"Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH . Mechanisms underlying inflammation in neurodegeneration. Cell 2010; 140: 918\u2013934.","journal-title":"Cell"},{"key":"BFcddis2011112_CR110","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1093\/jnen\/60.2.161","volume":"60","author":"E Sapp","year":"2001","unstructured":"Sapp E, Kegel KB, Aronin N, Hashikawa T, Uchiyama Y, Tohyama K et al. Early and progressive accumulation of reactive microglia in the Huntington disease brain. J Neuropathol Exp Neurol 2001; 60: 161\u2013172.","journal-title":"J Neuropathol Exp Neurol"},{"key":"BFcddis2011112_CR111","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1038\/cddis.2009.2","volume":"1","author":"JJ Rodriguez","year":"2010","unstructured":"Rodriguez JJ, Witton J, Olabarria M, Noristani HN, Verkhratsky A . Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease. Cell Death Dis 2010; 1: e1.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR112","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1083\/jcb.200508072","volume":"171","author":"JY Shin","year":"2005","unstructured":"Shin JY, Fang ZH, Yu ZX, Wang CE, Li SH, Li XJ . Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity. J Cell Biol 2005; 171: 1001\u20131012.","journal-title":"J Cell Biol"},{"key":"BFcddis2011112_CR113","doi-asserted-by":"publisher","first-page":"3277","DOI":"10.1523\/JNEUROSCI.0116-08.2008","volume":"28","author":"SY Chou","year":"2008","unstructured":"Chou SY, Weng JY, Lai HL, Liao F, Sun SH, Tu PH et al. Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5\/RANTES) by astrocytes. J Neurosci 2008; 28: 3277\u20133290.","journal-title":"J Neurosci"},{"key":"BFcddis2011112_CR114","doi-asserted-by":"publisher","first-page":"e33","DOI":"10.1038\/cddis.2010.10","volume":"1","author":"J Nicolai","year":"2010","unstructured":"Nicolai J, Burbassi S, Rubin J, Meucci O . CXCL12 inhibits expression of the NMDA receptor's NR2B subunit through a histone deacetylase-dependent pathway contributing to neuronal survival. Cell Death Dis 2010; 1: e33.","journal-title":"Cell Death Dis"},{"key":"BFcddis2011112_CR115","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.neuron.2009.09.035","volume":"64","author":"VW Yong","year":"2009","unstructured":"Yong VW, Rivest S . Taking advantage of the systemic immune system to cure brain diseases. Neuron 2009; 64: 55\u201360.","journal-title":"Neuron"}],"container-title":["Cell Death & Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis2011112.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis2011112","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2011112.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T23:49:30Z","timestamp":1672962570000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis2011112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,10]]},"references-count":115,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2011,11]]}},"alternative-id":["BFcddis2011112"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2011.112","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,10]]},"assertion":[{"value":"27 September 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2011","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2011","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}