{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:44:23Z","timestamp":1789901063110,"version":"4.0.1"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,6,16]],"date-time":"2011-06-16T00:00:00Z","timestamp":1308182400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2011.54","type":"journal-article","created":{"date-parts":[[2011,6,16]],"date-time":"2011-06-16T21:45:51Z","timestamp":1308260751000},"page":"e173-e173","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Ocular neuroprotection by siRNA targeting caspase-2"],"prefix":"10.1038","volume":"2","author":[{"given":"Z","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Kalinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Almasieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Ashush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Slager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Brafman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Spivak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Mett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Shalom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Alpert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Di Polo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Feinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Logan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,6,16]]},"reference":[{"key":"BFcddis201154_CR1","doi-asserted-by":"publisher","first-page":"164","DOI":"10.2174\/157015908784533851","volume":"6","author":"KG Schmidt","year":"2008","unstructured":"Schmidt KG, Bergert H, Funk RH . Neurodegenerative diseases of the retina and potential for protection and recovery. Curr Neuropharmacol 2008; 6: 164\u2013178.","journal-title":"Curr Neuropharmacol"},{"key":"BFcddis201154_CR2","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1159\/000247591","volume":"43","author":"L Kisiswa","year":"2010","unstructured":"Kisiswa L, Dervan AG, Albon J, Morgan JE, Wride MA . Retinal ganglion cell death postponed: giving apoptosis a break? Ophthalmic Res 2010; 43: 61\u201378.","journal-title":"Ophthalmic Res"},{"key":"BFcddis201154_CR3","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.exer.2009.02.004","volume":"88","author":"EC Johnson","year":"2009","unstructured":"Johnson EC, Guo Y, Cepurna WO, Morrison JC . Neurotrophin roles in retinal ganglion cell survival: lessons from rat glaucoma models. Exp Eye Res 2009; 88: 808\u2013815.","journal-title":"Exp Eye Res"},{"key":"BFcddis201154_CR4","doi-asserted-by":"publisher","first-page":"4368","DOI":"10.1523\/JNEUROSCI.14-07-04368.1994","volume":"14","author":"M Berkelaar","year":"1994","unstructured":"Berkelaar M, Clarke DB, Wang YC, Bray GM, Aguayo AJ . Axotomy results in delayed death and apoptosis of retinal ganglion-cells in adult-rats. J Neurosci 1994; 14: 4368\u20134374.","journal-title":"J Neurosci"},{"key":"BFcddis201154_CR5","first-page":"489","volume":"37","author":"P PeinadoRamon","year":"1996","unstructured":"PeinadoRamon P, Salvador M, Villegasperez MP, Vidalsanz M . Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells \u2013 a quantitative in vivo study. Invest Ophthal Vis Sci 1996; 37: 489\u2013500.","journal-title":"Invest Ophthal Vis Sci"},{"key":"BFcddis201154_CR6","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1002\/neu.480240103","volume":"24","author":"MP Villegasperez","year":"1993","unstructured":"Villegasperez MP, Vidalsanz M, Rasminsky M, Bray GM, Aguayo AJ . Rapid and protracted phases of retinal ganglion-cell loss follow axotomy in the optic-nerve of adult-rats. J Neurobiol 1993; 24: 23\u201336.","journal-title":"J Neurobiol"},{"key":"BFcddis201154_CR7","doi-asserted-by":"publisher","first-page":"2751","DOI":"10.1046\/j.1460-9568.1998.00325.x","volume":"10","author":"S Isenmann","year":"1998","unstructured":"Isenmann S, Klocker N, Gravel C, Bahr M . Protection of axotomized retinal ganglion cells by adenovirally delivered BDNF in vivo. Eur J Neurosci 1998; 10: 2751\u20132756.","journal-title":"Eur J Neurosci"},{"key":"BFcddis201154_CR8","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1523\/JNEUROSCI.13-02-00455.1993","volume":"13","author":"S Thanos","year":"1993","unstructured":"Thanos S, Mey J, Wild M . Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro. J Neurosci 1993; 13: 455\u2013466.","journal-title":"J Neurosci"},{"key":"BFcddis201154_CR9","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/0006-8993(93)90695-J","volume":"602","author":"J Mey","year":"1993","unstructured":"Mey J, Thanos S . Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion-cells in adult-rats in vivo. Brain Res 1993; 602: 304\u2013317.","journal-title":"Brain Res"},{"key":"BFcddis201154_CR10","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/S0042-6989(97)00364-7","volume":"38","author":"PD Koeberle","year":"1998","unstructured":"Koeberle PD, Ball AK . Effects of GDNF on retinal ganglion cell survival following axotomy. Vision Res 1998; 38: 1505\u20131515.","journal-title":"Vision Res"},{"key":"BFcddis201154_CR11","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1096\/fasebj.10.11.8836043","volume":"10","author":"O LazarovSpiegler","year":"1996","unstructured":"LazarovSpiegler O, Solomon AS, ZeevBrann AB, Hirschberg DL, Lavie V, Schwartz M . Transplantation of activated macrophages overcomes central nervous system regrowth failure. FASEB J 1996; 10: 1296\u20131302.","journal-title":"FASEB J"},{"key":"BFcddis201154_CR12","doi-asserted-by":"publisher","first-page":"4186","DOI":"10.1523\/JNEUROSCI.16-13-04186.1996","volume":"16","author":"L Bonfanti","year":"1996","unstructured":"Bonfanti L, Strettoi E, Chierzi S, Cenni MC, Liu XH, Martinou JC et al. Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2. J Neurosci 1996; 16: 4186\u20134194.","journal-title":"J Neurosci"},{"key":"BFcddis201154_CR13","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/S0042-6989(97)00332-5","volume":"38","author":"S Chierzi","year":"1998","unstructured":"Chierzi S, Cenni MC, Maffei L, Pizzorusso T, Porciatti V, Ratto GM et al. Protection of retinal ganglion cells and preservation of function after optic nerve lesion in bcl-2 transgenic mice. Vision Res 1998; 38: 1537\u20131543.","journal-title":"Vision Res"},{"key":"BFcddis201154_CR14","first-page":"202","volume":"10","author":"P Kermer","year":"1998","unstructured":"Kermer P, Klocker N, Labes M, Bahr M . CPP32-like proteases are major mediators of apoptosis in axotomized retinal ganglion cells in vivo. Eur J Neurosci 1998; 10: 202.","journal-title":"Eur J Neurosci"},{"key":"BFcddis201154_CR15","doi-asserted-by":"publisher","first-page":"4656","DOI":"10.1523\/JNEUROSCI.18-12-04656.1998","volume":"18","author":"P Kermer","year":"1998","unstructured":"Kermer P, Klocker N, Labes M, Bahr M . Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo. J Neurosci 1998; 18: 4656\u20134662.","journal-title":"J Neurosci"},{"key":"BFcddis201154_CR16","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0169-328X(97)00170-8","volume":"48","author":"R Lucius","year":"1997","unstructured":"Lucius R, Sievers J . YVAD protect post-natal retinal ganglion cells against axotomy-induced but not free radical-induced axonal degeneration in vitro. Mol Brain Res 1997; 48: 181\u2013184.","journal-title":"Mol Brain Res"},{"key":"BFcddis201154_CR17","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/sj.cdd.4400989","volume":"9","author":"M Lamkanfi","year":"2002","unstructured":"Lamkanfi M, Declercq W, Kalai M, Saelens X, Vandenabeele P . Alice in caspase land. A phylogenetic analysis of caspases from worm to man. Cell Death Differ 2002; 9: 358\u2013361.","journal-title":"Cell Death Differ"},{"key":"BFcddis201154_CR18","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1126\/science.1074721","volume":"297","author":"P Lassus","year":"2002","unstructured":"Lassus P, Opitz-Araya X, Lazebnik Y . Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science 2002; 297: 1352\u20131354.","journal-title":"Science"},{"key":"BFcddis201154_CR19","doi-asserted-by":"publisher","first-page":"29803","DOI":"10.1074\/jbc.M204185200","volume":"277","author":"JD Robertson","year":"2002","unstructured":"Robertson JD, Enoksson M, Suomela M, Zhivotovsky B, Orrenius S . Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. J Biol Chem 2002; 277: 29803\u201329809.","journal-title":"J Biol Chem"},{"key":"BFcddis201154_CR20","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1126\/science.1076118","volume":"297","author":"S Kumar","year":"2002","unstructured":"Kumar S, Vaux DL . Apoptosis. A Cinderella caspase takes center stage. Science 2002; 297: 1290\u20131291.","journal-title":"Science"},{"key":"BFcddis201154_CR21","doi-asserted-by":"publisher","first-page":"3393","DOI":"10.1038\/sj.onc.1211005","volume":"27","author":"LH Ho","year":"2008","unstructured":"Ho LH, Read SH, Dorstyn L, Lambrusco L, Kumar S . Caspase-2 is required for cell death induced by cytoskeletal disruption. Oncogene 2008; 27: 3393\u20133404.","journal-title":"Oncogene"},{"key":"BFcddis201154_CR22","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/ncb1340","volume":"8","author":"S Tu","year":"2006","unstructured":"Tu S, McStay GP, Boucher LM, Mak T, Beere HM, Green DR . In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis. Nat Cell Biol 2006; 8: 72\u201377.","journal-title":"Nat Cell Biol"},{"key":"BFcddis201154_CR23","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1126\/science.1095432","volume":"304","author":"A Tinel","year":"2004","unstructured":"Tinel A, Tschopp J . The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science 2004; 304: 843\u2013846.","journal-title":"Science"},{"key":"BFcddis201154_CR24","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.cell.2008.03.037","volume":"133","author":"S Sidi","year":"2008","unstructured":"Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R et al. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 2008; 133: 864\u2013877.","journal-title":"Cell"},{"key":"BFcddis201154_CR25","doi-asserted-by":"publisher","first-page":"3943","DOI":"10.1128\/MCB.00013-08","volume":"28","author":"JP Upton","year":"2008","unstructured":"Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, Han D et al. Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol 2008; 28: 3943\u20133951.","journal-title":"Mol Cell Biol"},{"key":"BFcddis201154_CR26","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1046\/j.1365-2443.1996.00255.x","volume":"1","author":"NL Harvey","year":"1996","unstructured":"Harvey NL, Trapani JA, Fernandes-Alnemri T, Litwack G, Alnemri ES, Kumar S . Processing of the Nedd2 precursor by ICE-like proteases and granzyme B. Genes Cells 1996; 1: 673\u2013685.","journal-title":"Genes Cells"},{"key":"BFcddis201154_CR27","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1083\/jcb.200811105","volume":"185","author":"C Manzl","year":"2009","unstructured":"Manzl C, Krumschnabel G, Bock F, Sohm B, Labi V, Baumgartner F . Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol 2009; 185: 291\u2013303.","journal-title":"J Cell Biol"},{"key":"BFcddis201154_CR28","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/nrc2745","volume":"9","author":"S Kumar","year":"2009","unstructured":"Kumar S . Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more? Nat Rev Cancer 2009; 9: 897\u2013903.","journal-title":"Nat Rev Cancer"},{"key":"BFcddis201154_CR29","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/cdd.2008.170","volume":"16","author":"G Krumschnabel","year":"2009","unstructured":"Krumschnabel G, Sohm B, Bock F, Manzl C, Villunger A . The enigma of caspase-2: the laymen's view. Cell Death Differ 2009; 16: 195\u2013207.","journal-title":"Cell Death Differ"},{"key":"BFcddis201154_CR30","doi-asserted-by":"publisher","first-page":"35047","DOI":"10.1074\/jbc.M400708200","volume":"279","author":"KW Wagner","year":"2004","unstructured":"Wagner KW, Engels IH, Deveraux QL . Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway. J Biol Chem 2004; 279: 35047\u201335052.","journal-title":"J Biol Chem"},{"key":"BFcddis201154_CR31","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1182\/blood.V97.6.1835","volume":"97","author":"N Droin","year":"2001","unstructured":"Droin N, Bichat F, Rebe C, Wotawa A, Sordet O, Hammann A . Involvement of caspase-2 long isoform in Fas-mediated cell death of human leukemic cells. Blood 2001; 97: 1835\u20131844.","journal-title":"Blood"},{"key":"BFcddis201154_CR32","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/385086a0","volume":"385","author":"H Duan","year":"1997","unstructured":"Duan H, Dixit VM . RAIDD is a new \u2018death\u2019 adaptor molecule. Nature 1997; 385: 86\u201389.","journal-title":"Nature"},{"key":"BFcddis201154_CR33","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1182\/blood-2005-07-007096","volume":"108","author":"IN Lavrik","year":"2006","unstructured":"Lavrik IN, Golks A, Baumann S, Krammer PH . Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis. Blood 2006; 108: 559\u2013565.","journal-title":"Blood"},{"key":"BFcddis201154_CR34","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1038\/onc.2009.36","volume":"28","author":"M Olsson","year":"2009","unstructured":"Olsson M, Vakifahmetoglu H, Abruzzo PM, Hogstrand K, Grandien A, Zhivotovsky B . DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis. Oncogene 2009; 28: 1949\u20131959.","journal-title":"Oncogene"},{"key":"BFcddis201154_CR35","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1083\/jcb.200811105","volume":"185","author":"C Manzl","year":"2009","unstructured":"Manzl C, Krumschnabel G, Bock F, Sohm B, Labi V, Baumgartner F . Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol 2009; 185: 291\u2013303.","journal-title":"J Cell Biol"},{"key":"BFcddis201154_CR36","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1038\/sj.cdd.4401492","volume":"11","author":"BC Baliga","year":"2004","unstructured":"Baliga BC, Read SH, Kumar S . The biochemical mechanism of caspase-2 activation. Cell Death Differ 2004; 11: 1234\u20131241.","journal-title":"Cell Death Differ"},{"key":"BFcddis201154_CR37","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.molcel.2009.07.023","volume":"35","author":"L Bouchier-Hayes","year":"2009","unstructured":"Bouchier-Hayes L, Oberst A, McStay GP, Connell S, Tait SW, Dillon CP et al. Characterization of cytoplasmic caspase-2 activation by induced proximity. Mol Cell 2009; 35: 830\u2013840.","journal-title":"Mol Cell"},{"key":"BFcddis201154_CR38","doi-asserted-by":"publisher","first-page":"3393","DOI":"10.1038\/sj.onc.1211005","volume":"27","author":"LH Ho","year":"2008","unstructured":"Ho LH, Read SH, Dorstyn L, Lambrusco L, Kumar S . Caspase-2 is required for cell death induced by cytoskeletal disruption. Oncogene 2008; 27: 3393\u20133404.","journal-title":"Oncogene"},{"key":"BFcddis201154_CR39","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1523\/JNEUROSCI.20-04-01386.2000","volume":"20","author":"CM Troy","year":"2000","unstructured":"Troy CM, Rabacchi SA, Friedman WJ, Frappier TF, Brown K, Shelanski ML . Caspase-2 mediates neuronal cell death induced by beta-amyloid. J Neurosci 2000; 20: 1386\u20131392.","journal-title":"J Neurosci"},{"key":"BFcddis201154_CR40","doi-asserted-by":"publisher","first-page":"e42","DOI":"10.1126\/scisignal.138pe42","volume":"1","author":"CM Troy","year":"2008","unstructured":"Troy CM, Ribe EM . Caspase-2: vestigial remnant or master regulator? Sci Signal 2008; 1: e42.","journal-title":"Sci Signal"},{"key":"BFcddis201154_CR41","doi-asserted-by":"publisher","first-page":"16368","DOI":"10.1073\/pnas.0806222105","volume":"105","author":"K Niizuma","year":"2008","unstructured":"Niizuma K, Endo H, Nito C, Myer DJ, Kim GS, Chan PH . The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats. Proc Natl Acad Sci USA 2008; 105: 16368\u201316373.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis201154_CR42","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1046\/j.1471-4159.2001.00258.x","volume":"77","author":"M Singh","year":"2001","unstructured":"Singh M, Savitz SI, Hoque R, Gupta G, Roth S, Rosenbaum PS et al. Cell-specific caspase expression by different neuronal phenotypes in transient retinal ischemia. J Neurochem 2001; 77: 466\u2013475.","journal-title":"J Neurochem"},{"key":"BFcddis201154_CR43","first-page":"3006","volume":"40","author":"T Kurokawa","year":"1999","unstructured":"Kurokawa T, Katai N, Shibuki H, Kuroiwa S, Kurimoto Y, Nakayama C et al. BDNF diminishes caspase-2 but not c-Jun immunoreactivity of neurons in retinal ganglion cell layer after transient ischemia. Invest Ophthalmol Vis Sci 1999; 40: 3006\u20133011.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFcddis201154_CR44","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/BF02284793","volume":"25","author":"M Berry","year":"1996","unstructured":"Berry M, Carlile J, Hunter A . Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve. J Neurocytol 1996; 25: 147\u2013170.","journal-title":"J Neurocytol"},{"key":"BFcddis201154_CR45","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1023\/A:1007086004022","volume":"28","author":"M Berry","year":"1999","unstructured":"Berry M, Carlile J, Hunter A, Tsang W, Rosustrel P, Sievers J . Optic nerve regeneration after intravitreal peripheral nerve implants: trajectories of axons regrowing through the optic chiasm into the optic tracts. J Neurocytol 1999; 28: 721\u2013741.","journal-title":"J Neurocytol"},{"key":"BFcddis201154_CR46","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1093\/brain\/awl080","volume":"129","author":"Z Ahmed","year":"2006","unstructured":"Ahmed Z, Suggate EL, Brown ER, Dent RG, Armstrong SJ, Barrett LB et al. Schwann cell-derived factor-induced modulation of the NgR\/p75(NTR)\/EGFR axis disinhibits axon growth through CNS myelin in vivo and in vitro. Brain 2006; 129: 1517\u20131533.","journal-title":"Brain"},{"key":"BFcddis201154_CR47","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.mcn.2004.08.013","volume":"28","author":"Z Ahmed","year":"2005","unstructured":"Ahmed Z, Dent RG, Leadbeater WE, Smith C, Berry M, Logan A . Matrix metalloproteases: degradation of the inhibitory environment of the transected optic nerve and the scar by regenerating axons. Mol Cell Neurosci 2005; 28: 64\u201378.","journal-title":"Mol Cell Neurosci"},{"key":"BFcddis201154_CR48","doi-asserted-by":"publisher","first-page":"3102","DOI":"10.1093\/brain\/awp240","volume":"132","author":"MR Douglas","year":"2009","unstructured":"Douglas MR, Morrison KC, Jacques SJ, Leadbeater WE, Gonzalez AM, Berry M et al. Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth. Brain 2009; 132: 3102\u20133121.","journal-title":"Brain"},{"key":"BFcddis201154_CR49","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1093\/brain\/awh706","volume":"129","author":"A Logan","year":"2006","unstructured":"Logan A, Ahmed Z, Baird A, Gonzalez AM, Berry M . Neurotrophic factor synergy is required for neuronal survival and disinhibited axon regeneration after CNS injury. Brain 2006; 129: 490\u2013502.","journal-title":"Brain"},{"key":"BFcddis201154_CR50","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.jmb.2005.03.011","volume":"348","author":"S Schubert","year":"2005","unstructured":"Schubert S, Grunweller A, Erdmann VA, Kurreck J . Local RNA target structure influences siRNA efficacy: systematic analysis of intentionally designed binding regions. J Mol Biol 2005; 348: 883\u2013893.","journal-title":"J Mol Biol"},{"key":"BFcddis201154_CR51","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/BF02284793","volume":"25","author":"M Berry","year":"1996","unstructured":"Berry M, Carlile J, Hunter A . Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve. J Neurocytol 1996; 25: 147\u2013170.","journal-title":"J Neurocytol"},{"key":"BFcddis201154_CR52","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1023\/A:1007086004022","volume":"28","author":"M Berry","year":"1999","unstructured":"Berry M, Carlile J, Hunter A, Tsang W, Rosustrel P, Sievers J . Optic nerve regeneration after intravitreal peripheral nerve implants: trajectories of axons regrowing through the optic chiasm into the optic tracts. J Neurocytol 1999; 28: 721\u2013741.","journal-title":"J Neurocytol"},{"key":"BFcddis201154_CR53","first-page":"1050","volume":"14","author":"M Agudo","year":"2008","unstructured":"Agudo M, Perez-Marin MC, Lonngren U, Sobrado P, Conesa A, Canovas I et al. Time course profiling of the retinal transcriptome after optic nerve transection and optic nerve crush. Mol Vision 2008; 14: 1050\u20131063.","journal-title":"Mol Vision"},{"key":"BFcddis201154_CR54","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.jocn.2009.04.002","volume":"16","author":"NM Kerr","year":"2009","unstructured":"Kerr NM, Chew SS, Danesh-Meyer HV . Non-arteritic anterior ischaemic optic neuropathy: a review and update. J Clin Neurosci 2009; 16: 994\u20131000.","journal-title":"J Clin Neurosci"},{"key":"BFcddis201154_CR55","first-page":"183","volume":"259","author":"B Philips","year":"1995","unstructured":"Philips B, Dralands L, Missotten L . Non-arteritic anterior ischemic optic neuropathy and refraction. Bull Soc Belge Ophtalmol 1995; 259: 183\u2013187.","journal-title":"Bull Soc Belge Ophtalmol"},{"key":"BFcddis201154_CR56","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.mehy.2006.12.014","volume":"69","author":"A Verit","year":"2007","unstructured":"Verit A . Non-arteritic anterior ischemic optic neuropathy, PDE-5 inhibitors, and amiodarone: may there be a sex hormone effect for the eye? Med Hypotheses 2007; 69: 470\u2013471.","journal-title":"Med Hypotheses"},{"key":"BFcddis201154_CR57","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0306-4522(94)00627-H","volume":"67","author":"D Zhang","year":"1995","unstructured":"Zhang D, Sucher NJ, Lipton SA . Co-expression of AMPA\/kainate receptor-operated channels with high and low Ca2+ permeability in single rat retinal ganglion cells. Neuroscience 1995; 67: 177\u2013188.","journal-title":"Neuroscience"},{"key":"BFcddis201154_CR58","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1073\/pnas.91.5.1632","volume":"91","author":"S Mansour-Robaey","year":"1994","unstructured":"Mansour-Robaey S, Clarke DB, Wang YC, Bray GM, Aguayo AJ . Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells. Proc Natl Acad Sci USA 1994; 91: 1632\u20131636.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis201154_CR59","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1016\/S0042-6989(97)00341-6","volume":"38","author":"DB Clarke","year":"1998","unstructured":"Clarke DB, Bray GM, Aguayo AJ . Prolonged administration of NT-4\/5 fails to rescue most axotomized retinal ganglion cells in adult rats. Vision Res 1998; 38: 1517\u20131524.","journal-title":"Vision Res"},{"key":"BFcddis201154_CR60","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/0006-8993(93)90695-J","volume":"602","author":"J Mey","year":"1993","unstructured":"Mey J, Thanos S . Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion-cells in adult-rats in vivo. Brain Res 1993; 602: 304\u2013317.","journal-title":"Brain Res"},{"key":"BFcddis201154_CR61","doi-asserted-by":"publisher","first-page":"3978","DOI":"10.1073\/pnas.95.7.3978","volume":"95","author":"A Di Polo","year":"1998","unstructured":"Di Polo A, Aigner LJ, Dunn RJ, Bray GM, Aguayo AJ . Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Muller cells temporarily rescues injured retinal ganglion cells. Proc Natl Acad Sci USA 1998; 95: 3978\u20133983.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis201154_CR62","doi-asserted-by":"publisher","first-page":"3977","DOI":"10.1523\/JNEUROSCI.22-10-03977.2002","volume":"22","author":"P Cheng","year":"2002","unstructured":"Cheng P, Sapieha P, Kittlerova WW, Hauswirth P, Di Polo A . TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo. J Neurosci 2002; 22: 3977\u20133986.","journal-title":"J Neurosci"},{"key":"BFcddis201154_CR63","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1517\/14712598.4.7.1053","volume":"4","author":"TJ McFarland","year":"2004","unstructured":"McFarland TJ, Zhang Y, Appukuttan B, Stout JT . Gene therapy for proliferative ocular diseases. Expert Opin Biol Ther 2004; 4: 1053\u20131058.","journal-title":"Expert Opin Biol Ther"},{"key":"BFcddis201154_CR64","first-page":"3006","volume":"40","author":"T Kurokawa","year":"1999","unstructured":"Kurokawa T, Katai N, Shibuki H, Kuroiwa S, Kurimoto Y, Nakayama C et al. BDNF diminishes caspase-2 but not c-Jun immunoreactivity of neurons in retinal ganglion cell layer after transient ischemia. Invest Ophthalmol Vis Sci 1999; 40: 3006\u20133011.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFcddis201154_CR65","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nm0305-243","volume":"11","author":"E Check","year":"2005","unstructured":"Check E . A crucial test. Nat Med 2005; 11: 243\u2013244.","journal-title":"Nat Med"},{"key":"BFcddis201154_CR66","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/nature06765","volume":"452","author":"ME Kleinman","year":"2008","unstructured":"Kleinman ME, Yamada K, Takeda A, Chandrasekaran V, Nozaki M, Baffi JZ et al. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature 2008; 452: 591\u2013597.","journal-title":"Nature"},{"key":"BFcddis201154_CR67","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/ncb1038","volume":"5","author":"CA Sledz","year":"2003","unstructured":"Sledz CA, Holko M, de Veer MJ, Silverman RH, Williams BR . Activation of the interferon system by short-interfering RNAs. Nat Cell Biol 2003; 5: 834\u2013839.","journal-title":"Nat Cell Biol"},{"key":"BFcddis201154_CR68","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/ng1173","volume":"34","author":"AJ Bridge","year":"2003","unstructured":"Bridge AJ, Pebernard S, Ducraux A, Nicoulaz AL, Iggo R . Induction of an interferon response by RNAi vectors in mammalian cells. Nat Genet 2003; 34: 263\u2013264.","journal-title":"Nat Genet"},{"key":"BFcddis201154_CR69","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1261\/rna.2340906","volume":"12","author":"A Reynolds","year":"2006","unstructured":"Reynolds A, Anderson EM, Vermeulen A, Fedorov Y, Robinson K, Leake D et al. Induction of the interferon response by siRNA is cell type- and duplex length-dependent. RNA 2006; 12: 988\u2013993.","journal-title":"RNA"},{"key":"BFcddis201154_CR70","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1089\/oli.2009.0180","volume":"19","author":"M Robbins","year":"2009","unstructured":"Robbins M, Judge A, MacLachlan I . siRNA and innate immunity. Oligonucleotides 2009; 19: 89\u2013102.","journal-title":"Oligonucleotides"},{"key":"BFcddis201154_CR71","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.ymthe.2005.11.002","volume":"13","author":"AD Judge","year":"2006","unstructured":"Judge AD, Bola G, Lee AC, MacLachlan I . Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol Ther 2006; 13: 494\u2013505.","journal-title":"Mol Ther"},{"key":"BFcddis201154_CR72","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1093\/brain\/awh382","volume":"128","author":"P Lingor","year":"2005","unstructured":"Lingor P, Koeberle P, Kugler S, Bahr M . Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo. Brain 2005; 128: 550\u2013558.","journal-title":"Brain"},{"key":"BFcddis201154_CR73","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1038\/sj.gt.3302073","volume":"10","author":"PR Lowenstein","year":"2003","unstructured":"Lowenstein PR . Virology and immunology of gene therapy, or virology and immunology of high MOI infection with defective viruses. Gene Ther 2003; 10: 933\u2013934.","journal-title":"Gene Ther"},{"key":"BFcddis201154_CR74","doi-asserted-by":"publisher","first-page":"14883","DOI":"10.1073\/pnas.0406421101","volume":"101","author":"P Hamar","year":"2004","unstructured":"Hamar P, Song E, Kokeny G, Chen A, Ouyang N, Lieberman J . Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. Proc Natl Acad Sci USA 2004; 101: 14883\u201314888.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis201154_CR75","doi-asserted-by":"publisher","first-page":"3977","DOI":"10.1523\/JNEUROSCI.22-10-03977.2002","volume":"22","author":"L Cheng","year":"2002","unstructured":"Cheng L, Sapieha P, Kittlerova P, Hauswirth WW, Di Polo A . TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo. J Neurosci 2002; 22: 3977\u20133986.","journal-title":"J Neurosci"},{"key":"BFcddis201154_CR76","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1002\/med.20009","volume":"24","author":"HS Zhou","year":"2004","unstructured":"Zhou HS, Liu DP, Liang CC . Challenges and strategies: the immune responses in gene therapy. Med Res Rev 2004; 24: 748\u2013761.","journal-title":"Med Res Rev"},{"key":"BFcddis201154_CR77","doi-asserted-by":"publisher","first-page":"7","DOI":"10.2174\/1389201053167239","volume":"6","author":"AL Gomes dos Santos","year":"2005","unstructured":"Gomes dos Santos AL, Bochot A, Fattal E . Intraocular delivery of oligonucleotides. Curr Pharm Biotechnol 2005; 6: 7\u201315.","journal-title":"Curr Pharm Biotechnol"},{"key":"BFcddis201154_CR78","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1261\/rna.2258506","volume":"12","author":"PT Nelson","year":"2006","unstructured":"Nelson PT, Baldwin DA, Kloosterman WP, Kauppinen S, Plasterk RH, Mourelatos Z . RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain. RNA 2006; 12: 187\u2013191.","journal-title":"RNA"},{"key":"BFcddis201154_CR79","doi-asserted-by":"publisher","first-page":"e179","DOI":"10.1093\/nar\/gni178","volume":"33","author":"C Chen","year":"2005","unstructured":"Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT et al. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 2005; 33: e179.","journal-title":"Nucleic Acids Res"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis201154.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis201154","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis201154.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T23:52:13Z","timestamp":1672962733000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis201154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,16]]},"references-count":79,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,6]]}},"alternative-id":["BFcddis201154"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2011.54","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,16]]},"assertion":[{"value":"8 October 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Some of the authors (HK, HA, NS, AB, IS, IM, ES, EA and EF) are employees of a biopharmaceutical company (Quark Pharmaceuticals Inc.). The academic collaborators (AL and ADP laboratories) received funding from Quark and these funds were used towards project consumables, support staff salaries and attendance at symposia meetings. The study was designed and analysed with participation of the funding body. Nevertheless, none of this influenced the objectivity and integrity of the experiments and this publication.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}