{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:34:00Z","timestamp":1759091640652},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T00:00:00Z","timestamp":1345680000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2012.118","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T10:13:35Z","timestamp":1345716815000},"page":"e375-e375","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["PP2A-dependent control of transcriptionally active FOXO3a in CD8+ central memory lymphocyte survival requires p47phox"],"prefix":"10.1038","volume":"3","author":[{"given":"Q","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Sadiq-Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M","family":"Koontz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S H","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,8,23]]},"reference":[{"key":"BFcddis2012118_CR1","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/S1074-7613(00)80540-3","volume":"8","author":"DH Busch","year":"1998","unstructured":"Busch DH, Pilip IM, Vijh S, Pamer EG . Coordinate regulation of complex T cell populations responding to bacterial infection. Immunity 1998; 8: 353\u2013362.","journal-title":"Immunity"},{"key":"BFcddis2012118_CR2","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/44385","volume":"401","author":"F Sallusto","year":"1999","unstructured":"Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A . Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401: 708\u2013712.","journal-title":"Nature"},{"key":"BFcddis2012118_CR3","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s12026-008-8027-z","volume":"45","author":"TW Hand","year":"2009","unstructured":"Hand TW, Kaech SM . Intrinsic and extrinsic control of effector T cell survival and memory T cell development. Immunol Res 2009; 45: 46\u201361.","journal-title":"Immunol Res"},{"key":"BFcddis2012118_CR4","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/j.1600-065X.2010.00920.x","volume":"236","author":"S Kurtulus","year":"2010","unstructured":"Kurtulus S, Tripathi P, Opferman JT, Hildeman DA . Contracting the \u2018mus cells\u2019--does down-sizing suit us for diving into the memory pool? Immunol Rev 2010; 236: 54\u201367.","journal-title":"Immunol Rev"},{"key":"BFcddis2012118_CR5","doi-asserted-by":"publisher","first-page":"7681","DOI":"10.1073\/pnas.0402293101","volume":"101","author":"Y Zhu","year":"2004","unstructured":"Zhu Y, Swanson BJ, Wang M, Hildeman DA, Schaefer BC, Liu X et al. Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells. Proc Natl Acad Sci USA 2004; 101: 7681\u20137686.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2012118_CR6","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.coi.2007.05.005","volume":"19","author":"D Hildeman","year":"2007","unstructured":"Hildeman D, Jorgensen T, Kappler J, Marrack P . Apoptosis and the homeostatic control of immune responses. Curr Opin Immunol 2007; 19: 516\u2013521.","journal-title":"Curr Opin Immunol"},{"key":"BFcddis2012118_CR7","doi-asserted-by":"publisher","first-page":"18703","DOI":"10.1073\/pnas.0602919103","volume":"103","author":"L Sabbagh","year":"2006","unstructured":"Sabbagh L, Srokowski CC, Pulle G, Snell LM, Sedgmen BJ, Liu Y et al. A critical role for TNF receptor-associated factor 1 and Bim down-regulation in CD8 memory T cell survival. Proc Natl Acad Sci USA 2006; 103: 18703\u201318708.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2012118_CR8","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1084\/jem.20061681","volume":"204","author":"C Riou","year":"2007","unstructured":"Riou C, Yassine-Diab B, Van grevenynghe J, Somogyi R, Greller LD, Gagnon D et al. Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+ central memory T cells. J Exp Med 2007; 204: 79\u201391.","journal-title":"J Exp Med"},{"key":"BFcddis2012118_CR9","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3858\/emm.2009.41.4.058","volume":"41","author":"J El-Benna","year":"2009","unstructured":"El-Benna J, Dang PM, Gougerot-Pocidalo MA, Marie JC, Braut-Boucher F . p47phox, the phagocyte NADPH oxidase\/NOX2 organizer: structure, phosphorylation and implication in diseases. Exp Mol Med 2009; 41: 217\u2013225.","journal-title":"Exp Mol Med"},{"key":"BFcddis2012118_CR10","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/S0952-7915(03)00109-2","volume":"15","author":"PG Heyworth","year":"2003","unstructured":"Heyworth PG, Cross AR, Curnutte JT . Chronic granulomatous disease. Curr Opin Immunol 2003; 15: 578\u2013584.","journal-title":"Curr Opin Immunol"},{"issue":"Suppl 1","key":"BFcddis2012118_CR11","doi-asserted-by":"publisher","first-page":"S67","DOI":"10.1007\/s10875-007-9160-5","volume":"28","author":"SD Rosenzweig","year":"2008","unstructured":"Rosenzweig SD . Inflammatory manifestations in chronic granulomatous disease (CGD). J Clin Immunol 2008; 28 (Suppl 1): S67\u2013S72.","journal-title":"J Clin Immunol"},{"key":"BFcddis2012118_CR12","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s00281-008-0121-8","volume":"30","author":"MJ Stasia","year":"2008","unstructured":"Stasia MJ, Li XJ . Genetics and immunopathology of chronic granulomatous disease. Semin Immunopathol 2008; 30: 209\u2013235.","journal-title":"Semin Immunopathol"},{"key":"BFcddis2012118_CR13","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/ni1096","volume":"5","author":"SH Jackson","year":"2004","unstructured":"Jackson SH, Devadas S, Kwon J, Pinto LA, Williams MS . T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation. Nat Immunol 2004; 5: 818\u2013827.","journal-title":"Nat Immunol"},{"key":"BFcddis2012118_CR14","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/cdd.2008.129","volume":"16","author":"M Donaldson","year":"2009","unstructured":"Donaldson M, Antignani A, Milner J, Zhu N, Wood A, Cardwell-Miller L et al. p47phox-deficient immune microenvironment signals dysregulate naive T-cell apoptosis. Cell Death Differ 2009; 16: 125\u2013138.","journal-title":"Cell Death Differ"},{"key":"BFcddis2012118_CR15","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1084\/jem.182.3.751","volume":"182","author":"SH Jackson","year":"1995","unstructured":"Jackson SH, Gallin JI, Holland SM . The p47phox mouse knock-out model of chronic granulomatous disease. J Exp Med 1995; 182: 751\u2013758.","journal-title":"J Exp Med"},{"key":"BFcddis2012118_CR16","doi-asserted-by":"publisher","first-page":"3402","DOI":"10.4049\/jimmunol.166.5.3402","volume":"166","author":"C Pope","year":"2001","unstructured":"Pope C, Kim SK, Marzo A, Masopust D, Williams K, Jiang J et al. Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection. J Immunol 2001; 166: 3402\u20133409.","journal-title":"J Immunol"},{"key":"BFcddis2012118_CR17","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/ng0295-202","volume":"9","author":"JD Pollock","year":"1995","unstructured":"Pollock JD, Williams DA, Gifford MA, Li LL, Du X, Fisherman J et al. Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat Genet 1995; 9: 202\u2013209.","journal-title":"Nat Genet"},{"key":"BFcddis2012118_CR18","doi-asserted-by":"publisher","first-page":"5610","DOI":"10.1073\/pnas.0308054101","volume":"101","author":"KM Huster","year":"2004","unstructured":"Huster KM, Busch V, Schiemann M, Linkemann K, Kerksiek KM, Wagner H et al. Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets. Proc Natl Acad Sci USA 2004; 101: 5610\u20135615.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2012118_CR19","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.coi.2006.05.008","volume":"18","author":"KM Huster","year":"2006","unstructured":"Huster KM, Stemberger C, Busch DH . Protective immunity towards intracellular pathogens. Curr Opin Immunol 2006; 18: 458\u2013464.","journal-title":"Curr Opin Immunol"},{"key":"BFcddis2012118_CR20","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/nri1461","volume":"4","author":"EG Pamer","year":"2004","unstructured":"Pamer EG . Immune responses to Listeria monocytogenes. Nat Rev Immunol 2004; 4: 812\u2013823.","journal-title":"Nat Rev Immunol"},{"key":"BFcddis2012118_CR21","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/j.micinf.2007.05.008","volume":"9","author":"LA Zenewicz","year":"2007","unstructured":"Zenewicz LA, Shen H . Innate and adaptive immune responses to Listeria monocytogenes: a short overview. Microbes Infect 2007; 9: 1208\u20131215.","journal-title":"Microbes Infect"},{"key":"BFcddis2012118_CR22","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1093\/emboj\/17.2.384","volume":"17","author":"L O'Connor","year":"1998","unstructured":"O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J 1998; 17: 384\u2013395.","journal-title":"EMBO J"},{"key":"BFcddis2012118_CR23","doi-asserted-by":"publisher","first-page":"8837","DOI":"10.1074\/jbc.M311578200","volume":"279","author":"R Ley","year":"2004","unstructured":"Ley R, Ewings KE, Hadfield K, Howes E, Balmanno K, Cook SJ . Extracellular signal-regulated kinases 1\/2 are serum-stimulated \u2018Bim(EL) kinases\u2019 that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover. J Biol Chem 2004; 279: 8837\u20138847.","journal-title":"J Biol Chem"},{"key":"BFcddis2012118_CR24","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1038\/ni.1784","volume":"10","author":"SM Hedrick","year":"2009","unstructured":"Hedrick SM . The cunning little vixen: Foxo and the cycle of life and death. Nat Immunol 2009; 10: 1057\u20131063.","journal-title":"Nat Immunol"},{"key":"BFcddis2012118_CR25","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0092-8674(04)00302-2","volume":"117","author":"MC Hu","year":"2004","unstructured":"Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY et al. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 2004; 117: 225\u2013237.","journal-title":"Cell"},{"key":"BFcddis2012118_CR26","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/35008115","volume":"404","author":"RH Medema","year":"2000","unstructured":"Medema RH, Kops GJ, Bos JL, Burgering BM . AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 2000; 404: 782\u2013787.","journal-title":"Nature"},{"key":"BFcddis2012118_CR27","doi-asserted-by":"publisher","first-page":"13856","DOI":"10.1074\/jbc.272.21.13856","volume":"272","author":"B Favre","year":"1997","unstructured":"Favre B, Turowski P, Hemmings BA . Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin. J Biol Chem 1997; 272: 13856\u201313863.","journal-title":"J Biol Chem"},{"key":"BFcddis2012118_CR28","doi-asserted-by":"publisher","first-page":"5729","DOI":"10.4049\/jimmunol.1100102","volume":"186","author":"S Kurtulus","year":"2011","unstructured":"Kurtulus S, Tripathi P, Moreno-Fernandez ME, Sholl A, Katz JD, Grimes HL et al. Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim. J Immunol 2011; 186: 5729\u20135737.","journal-title":"J Immunol"},{"key":"BFcddis2012118_CR29","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/S1074-7613(00)80363-5","volume":"7","author":"R Endres","year":"1997","unstructured":"Endres R, Luz A, Schulze H, Neubauer H, Futterer A, Holland SM et al. Listeriosis in p47(phox-\/-) and TRp55-\/- mice: protection despite absence of ROI and susceptibility despite presence of RNI. Immunity 1997; 7: 419\u2013432.","journal-title":"Immunity"},{"key":"BFcddis2012118_CR30","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S1074-7613(00)80004-7","volume":"10","author":"MU Shiloh","year":"1999","unstructured":"Shiloh MU, MacMicking JD, Nicholson S, Brause JE, Potter S, Marino M et al. Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity 1999; 10: 29\u201338.","journal-title":"Immunity"},{"key":"BFcddis2012118_CR31","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1084\/jem.20082851","volume":"206","author":"D Purushothaman","year":"2009","unstructured":"Purushothaman D, Sarin A . Cytokine-dependent regulation of NADPH oxidase activity and the consequences for activated T cell homeostasis. J Exp Med 2009; 206: 1515\u20131523.","journal-title":"J Exp Med"},{"key":"BFcddis2012118_CR32","doi-asserted-by":"publisher","first-page":"4183","DOI":"10.4049\/jimmunol.0800795","volume":"182","author":"C Richter","year":"2009","unstructured":"Richter C, Juan MH, Will J, Brandes RP, Kalinke U, Akira S et al. Ncf1 provides a reactive oxygen species-independent negative feedback regulation of TLR9-induced IL-12p70 in murine dendritic cells. J Immunol 2009; 182: 4183\u20134191.","journal-title":"J Immunol"},{"key":"BFcddis2012118_CR33","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.immuni.2007.10.012","volume":"27","author":"C Stemberger","year":"2007","unstructured":"Stemberger C, Huster KM, Koffler M, Anderl F, Schiemann M, Wagner H et al. A single naive CD8+ T cell precursor can develop into diverse effector and memory subsets. Immunity 2007; 27: 985\u2013997.","journal-title":"Immunity"},{"key":"BFcddis2012118_CR34","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/S0955-0674(99)00074-5","volume":"12","author":"DM Virshup","year":"2000","unstructured":"Virshup DM . Protein phosphatase 2A: a panoply of enzymes. Curr Opin Cell Biol 2000; 12: 180\u2013185.","journal-title":"Curr Opin Cell Biol"},{"key":"BFcddis2012118_CR35","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1016\/j.cell.2006.11.033","volume":"127","author":"Y Xu","year":"2006","unstructured":"Xu Y, Xing Y, Chen Y, Chao Y, Lin Z, Fan E et al. Structure of the protein phosphatase 2A holoenzyme. Cell 2006; 127: 1239\u20131251.","journal-title":"Cell"},{"key":"BFcddis2012118_CR36","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1126\/science.1325671","volume":"257","author":"J Chen","year":"1992","unstructured":"Chen J, Martin BL, Brautigan DL . Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation. Science 1992; 257: 1261\u20131264.","journal-title":"Science"},{"key":"BFcddis2012118_CR37","doi-asserted-by":"publisher","first-page":"5682","DOI":"10.1093\/emboj\/19.21.5682","volume":"19","author":"T Tolstykh","year":"2000","unstructured":"Tolstykh T, Lee J, Vafai S, Stock JB . Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits. EMBO J 2000; 19: 5682\u20135691.","journal-title":"EMBO J"},{"key":"BFcddis2012118_CR38","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1016\/j.biocel.2008.10.029","volume":"41","author":"L Chen","year":"2009","unstructured":"Chen L, Liu L, Yin J, Luo Y, Huang S . Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway. Int J Biochem Cell Biol 2009; 41: 1284\u20131295.","journal-title":"Int J Biochem Cell Biol"},{"key":"BFcddis2012118_CR39","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1111\/j.1460-9568.2010.07301.x","volume":"32","author":"S Finnegan","year":"2010","unstructured":"Finnegan S, Mackey AM, Cotter TG . A stress survival response in retinal cells mediated through inhibition of the serine\/threonine phosphatase PP2A. Eur J Neurosci 2010; 32: 322\u2013334.","journal-title":"Eur J Neurosci"},{"key":"BFcddis2012118_CR40","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1091\/mbc.e09-09-0795","volume":"21","author":"A Singh","year":"2010","unstructured":"Singh A, Ye M, Bucur O, Zhu S, Tanya Santos M, Rabinovitz I et al. Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. Mol Biol Cell 2010; 21: 1140\u20131152.","journal-title":"Mol Biol Cell"},{"key":"BFcddis2012118_CR41","doi-asserted-by":"publisher","first-page":"27141","DOI":"10.1074\/jbc.M704391200","volume":"282","author":"FJ Barreyro","year":"2007","unstructured":"Barreyro FJ, Kobayashi S, Bronk SF, Werneburg NW, Malhi H, Gores GJ . Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis. J Biol Chem 2007; 282: 27141\u201327154.","journal-title":"J Biol Chem"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis2012118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis2012118","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2012118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T23:40:53Z","timestamp":1672962053000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis2012118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,23]]},"references-count":41,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2012,8]]}},"alternative-id":["BFcddis2012118"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2012.118","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,23]]},"assertion":[{"value":"12 January 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}