{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:21:25Z","timestamp":1780053685677,"version":"3.54.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T00:00:00Z","timestamp":1354147200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2012.169","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T11:11:16Z","timestamp":1354187476000},"page":"e433-e433","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Overexpression of Uromodulin-like1 accelerates follicle depletion and subsequent ovarian degeneration"],"prefix":"10.1038","volume":"3","author":[{"given":"W","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Jongwutiwes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Hourvitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H-C","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Rosenwaks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,11,29]]},"reference":[{"key":"BFcddis2012169_CR1","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1210\/jcem-65-6-1231","volume":"65","author":"SJ Richardson","year":"1987","unstructured":"Richardson SJ, Senikas V, Nelson JF . Follicular depletion during the menopausal transition: evidence for accelerated loss and ultimate exhaustion. J Clin Endocrinol Metab 1987; 65: 1231\u20131237.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFcddis2012169_CR2","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1093\/humupd\/8.2.141","volume":"8","author":"ER te Velde","year":"2002","unstructured":"te Velde ER, Pearson PL . The variability of female reproductive ageing. Hum Reprod Update 2002; 8: 141\u2013154.","journal-title":"Hum Reprod Update"},{"key":"BFcddis2012169_CR3","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ejogrb.2003.09.024","volume":"113","author":"D Nikolaou","year":"2004","unstructured":"Nikolaou D, Templeton A . Early ovarian ageing. Eur J Obstet Gynecol Reprod Biol 2004; 113: 126\u2013133.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"BFcddis2012169_CR4","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1189\/jlb.1202629","volume":"73","author":"BM Burgering","year":"2003","unstructured":"Burgering BM, Medema RH . Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB\/Akt is off duty. J Leukoc Biol 2003; 73: 689\u2013701.","journal-title":"J Leukoc Biol"},{"key":"BFcddis2012169_CR5","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1126\/science.1086336","volume":"301","author":"DH Castrillon","year":"2003","unstructured":"Castrillon DH, Miao L, Kollipara R, Horner JW, DePinho RA . Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 2003; 301: 215\u2013218.","journal-title":"Science"},{"key":"BFcddis2012169_CR6","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/383531a0","volume":"383","author":"J Dong","year":"1996","unstructured":"Dong J, Albertini DF, Nishimori K, Kumar TR, Lu N, Matzuk MM . Growth differentiation factor-9 is required during early ovarian folliculogenesis. Nature 1996; 383: 531\u2013535.","journal-title":"Nature"},{"key":"BFcddis2012169_CR7","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1210\/mend.15.6.0662","volume":"15","author":"C Yan","year":"2001","unstructured":"Yan C, Wang P, DeMayo J, DeMayo FJ, Elvin JA, Carino C et al. Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function. Mol Endocrinol 2001; 15: 854\u2013866.","journal-title":"Mol Endocrinol"},{"key":"BFcddis2012169_CR8","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/5985","volume":"21","author":"GI Perez","year":"1999","unstructured":"Perez GI, Robles R, Knudson CM, Flaws JA, Korsmeyer SJ, Tilly JL . Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency. Nat Genet 1999; 21: 200\u2013203.","journal-title":"Nat Genet"},{"key":"BFcddis2012169_CR9","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1006\/geno.2001.6639","volume":"78","author":"MT Davisson","year":"2001","unstructured":"Davisson MT, Bechtel LJ, Akeson EC, Fortna A, Slavov D, Gardiner K . Evolutionary breakpoints on human chromosome 21. Genomics 2001; 78: 99\u2013106.","journal-title":"Genomics"},{"key":"BFcddis2012169_CR10","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.bbrc.2004.05.094","volume":"319","author":"K Shibuya","year":"2004","unstructured":"Shibuya K, Nagamine K, Okui M, Ohsawa Y, Asakawa S, Minoshima S et al. Initial characterization of an uromodulin-like 1 gene on human chromosome 21q22.3. Biochem Biophys Res Commun 2004; 319: 1181\u20131189.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcddis2012169_CR11","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/eye.2008.152","volume":"23","author":"R Nishizaki","year":"2009","unstructured":"Nishizaki R, Ota M, Inoko H, Meguro A, Shiota T, Okada E et al. New susceptibility locus for high myopia is linked to the uromodulin-like 1 (UMODL1) gene region on chromosome 21q22.3. Eye 2009; 23: 222\u2013229.","journal-title":"Eye"},{"key":"BFcddis2012169_CR12","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/0197-4580(96)00008-5","volume":"17","author":"C Murphy","year":"1996","unstructured":"Murphy C, Jinich S . Olfactory dysfunction in Down's Syndrome. Neurobiol Aging 1996; 17: 631\u2013637.","journal-title":"Neurobiol Aging"},{"key":"BFcddis2012169_CR13","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.1111\/j.1460-9568.2005.04164.x","volume":"21","author":"E Di Schiavi","year":"2005","unstructured":"Di Schiavi E, Riano E, Heye B, Bazzicalupo P, Rugarli EI . UMODL1\/Olfactorin is an extracellular membrane-bound molecule with a restricted spatial expression in olfactory and vomeronasal neurons. Eur J Neurosci 2005; 21: 3291\u20133300.","journal-title":"Eur J Neurosci"},{"key":"BFcddis2012169_CR14","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.ygeno.2006.09.006","volume":"89","author":"LM Peters","year":"2007","unstructured":"Peters LM, Belyantseva IA, Lagziel A, Battey JF, Friedman TB, Morell RJ . Signatures from tissue-specific MPSS libraries identify transcripts preferentially expressed in the mouse inner ear. Genomics 2007; 89: 197\u2013206.","journal-title":"Genomics"},{"key":"BFcddis2012169_CR15","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.neuroscience.2008.07.071","volume":"156","author":"F Markopoulos","year":"2008","unstructured":"Markopoulos F, Neubauer FB, Berger T, Scotti AL . Reassembling a system from the sensor to cerebral representation: the olfactory system in vitro. Neuroscience 2008; 156: 1048\u20131063.","journal-title":"Neuroscience"},{"key":"BFcddis2012169_CR16","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.mcn.2010.07.013","volume":"45","author":"N Sammeta","year":"2010","unstructured":"Sammeta N, Hardin DL, McClintock TS . Uncx regulates proliferation of neural progenitor cells and neuronal survival in the olfactory epithelium. Mol Cell Neurosci 2010; 45: 398\u2013407.","journal-title":"Mol Cell Neurosci"},{"key":"BFcddis2012169_CR17","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1002\/dvdy.22300","volume":"239","author":"W Wang","year":"2010","unstructured":"Wang W, Ni L, Yu Q, Xiong J, Liu HC, Rosenwaks Z . Expression of the Lycat gene in the mouse cardiovascular and female reproductive systems. Dev Dyn 2010; 239: 1827\u20131837.","journal-title":"Dev Dyn"},{"key":"BFcddis2012169_CR18","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1210\/mend.13.6.0309","volume":"13","author":"JA Elvin","year":"1999","unstructured":"Elvin JA, Yan C, Wang P, Nishimori K, Matzuk MM . Molecular characterization of the follicle defects in the growth differentiation factor 9-deficient ovary. Mol Endocrinol 1999; 13: 1018\u20131034.","journal-title":"Mol Endocrinol"},{"key":"BFcddis2012169_CR19","first-page":"147","volume":"7","author":"T Singtripop","year":"1993","unstructured":"Singtripop T, Mori T, Shiraishi K, Park MK, Kawashima S . Age-related changes in gonadotropin, prolactin and growth hormone levels with reference to the development of uterine adenomyosis in female SHN mice. In Vivo 1993; 7: 147\u2013150.","journal-title":"In Vivo"},{"key":"BFcddis2012169_CR20","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S0531-5565(82)80005-3","volume":"17","author":"TA Parkening","year":"1982","unstructured":"Parkening TA, Collins TJ, Smith ER . Plasma and pituitary concentrations of luteinizing hormone, follicle-stimulating hormone and prolactin in aged, ovariectomized CD-1 and C57BL\/6 mice. Exp Gerontol 1982; 17: 437\u2013443.","journal-title":"Exp Gerontol"},{"key":"BFcddis2012169_CR21","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0378-5122(00)00194-8","volume":"38","author":"P van Zonneveld","year":"2001","unstructured":"van Zonneveld P, Scheffer GJ, Broekmans FJ, te Velde ER . Hormones and reproductive aging. Maturitas 2001; 38: 83\u201391 discussion 92-4.","journal-title":"Maturitas"},{"key":"BFcddis2012169_CR22","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1530\/jrf.0.0570031","volume":"57","author":"J Reynolds","year":"1979","unstructured":"Reynolds J, Keverne EB . The accessory olfactory system and its role in the pheromonally mediated suppression of oestrus in grouped mice. J Reprod Fertil 1979; 57: 31\u201335.","journal-title":"J Reprod Fertil"},{"key":"BFcddis2012169_CR23","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/ar.1152","volume":"265","author":"TD Smith","year":"2001","unstructured":"Smith TD, Siegel MI, Bhatnagar KP . Reappraisal of the vomeronasal system of catarrhine primates: ontogeny, morphology, functionality, and persisting questions. Anat Rec 2001; 265: 176\u2013192.","journal-title":"Anat Rec"},{"key":"BFcddis2012169_CR24","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1746-160X-5-5","volume":"5","author":"R Foltan","year":"2009","unstructured":"Foltan R, Sedy J . Behavioral changes of patients after orthognathic surgery develop on the basis of the loss of vomeronasal organ: a hypothesis. Head Face Med 2009; 5: 5.","journal-title":"Head Face Med"},{"key":"BFcddis2012169_CR25","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1095\/biolreprod22.4.873","volume":"22","author":"N Kaneko","year":"1980","unstructured":"Kaneko N, Debski EA, Wilson MC, Whitten WK . Puberty acceleration in mice. II. Evidence that the vomeronasal organ isa receptor for the primer pheromone in male mouse urine. Biol Reprod 1980; 22: 873\u2013878.","journal-title":"Biol Reprod"},{"key":"BFcddis2012169_CR26","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1530\/jrf.0.0590223","volume":"59","author":"JF Bellringer","year":"1980","unstructured":"Bellringer JF, Pratt HP, Keverne EB . Involvement of the vomeronasal organ and prolactin in pheromonal induction of delayed implantation in mice. J Reprod Fertil 1980; 59: 223\u2013228.","journal-title":"J Reprod Fertil"},{"key":"BFcddis2012169_CR27","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1126\/science.166.3906.753","volume":"166","author":"Y Nishizuka","year":"1969","unstructured":"Nishizuka Y, Sakakura T . Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice. Science 1969; 166: 753\u2013755.","journal-title":"Science"},{"key":"BFcddis2012169_CR28","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1210\/endo-108-6-2375","volume":"108","author":"SD Michael","year":"1981","unstructured":"Michael SD, Taguchi O, Nishizuka Y . Changes in hypophyseal hormones associated with accelerated aging and tumorigenesis of the ovaries in neonatally thymectomized mice. Endocrinology 1981; 108: 2375\u20132380.","journal-title":"Endocrinology"},{"key":"BFcddis2012169_CR29","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1111\/j.1651-2227.1967.tb15424.x","volume":"56","author":"ME Miller","year":"1967","unstructured":"Miller ME, Chatten J . Ovarian changes in ataxia telangiectasia. Acta Paediatr Scand 1967; 56: 559\u2013561.","journal-title":"Acta Paediatr Scand"},{"key":"BFcddis2012169_CR30","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.imbio.2009.06.012","volume":"215","author":"M Perisic","year":"2010","unstructured":"Perisic M, Arsenovic-Ranin N, Pilipovic I, Kosec D, Pesic V, Radojevic K et al. Role of ovarian hormones in age-associated thymic involution revisited. Immunobiology 2010; 215: 275\u2013293.","journal-title":"Immunobiology"},{"key":"BFcddis2012169_CR31","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1080\/009841000156484","volume":"60","author":"JG Forsberg","year":"2000","unstructured":"Forsberg JG . Neonatal estrogen treatment and its consequences for thymus development, serum level of autoantibodies to cardiolipin, and the delayed-type hypersensitivity response. J Toxicol Environ Health A 2000; 60: 185\u2013213.","journal-title":"J Toxicol Environ Health A"},{"key":"BFcddis2012169_CR32","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1210\/en.2007-1550","volume":"149","author":"HE McMahon","year":"2008","unstructured":"McMahon HE, Hashimoto O, Mellon PL, Shimasaki S . Oocyte-specific overexpression of mouse bone morphogenetic protein-15 leads to accelerated folliculogenesis and an early onset of acyclicity in transgenic mice. Endocrinology 2008; 149: 2807\u20132815.","journal-title":"Endocrinology"},{"key":"BFcddis2012169_CR33","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1210\/endo.140.6.6823","volume":"140","author":"DW Schomberg","year":"1999","unstructured":"Schomberg DW, Couse JF, Mukherjee A, Lubahn DB, Sar M, Mayo KE et al. Targeted disruption of the estrogen receptor-alpha gene in female mice: characterization of ovarian responses and phenotype in the adult. Endocrinology 1999; 140: 2733\u20132744.","journal-title":"Endocrinology"},{"key":"BFcddis2012169_CR34","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1242\/dev.00969","volume":"131","author":"D Schmidt","year":"2004","unstructured":"Schmidt D, Ovitt CE, Anlag K, Fehsenfeld S, Gredsted L, Treier AC et al. The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development 2004; 131: 933\u2013942.","journal-title":"Development"},{"key":"BFcddis2012169_CR35","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1242\/dev.125.4.621","volume":"125","author":"W Wang","year":"1998","unstructured":"Wang W, Van De Water T, Lufkin T . Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene. Development 1998; 125: 621\u2013634.","journal-title":"Development"},{"key":"BFcddis2012169_CR36","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0925-4773(96)00562-X","volume":"58","author":"W Wang","year":"1996","unstructured":"Wang W, Chen X, Xu H, Lufkin T . Msx3: a novel murine homologue of the Drosophila msh homeobox gene restricted to the dorsal embryonic central nervous system. Mech Dev 1996; 58: 203\u2013215.","journal-title":"Mech Dev"},{"key":"BFcddis2012169_CR37","unstructured":"Moore D, Chory J, Ribaudo RK . Isolation and purification of large DNA restriction fragments from agarose gels. Curr Protoc Immunol 2001, Chapter 10: Unit 10 5."},{"key":"BFcddis2012169_CR38","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1095\/biolreprod27.2.327","volume":"27","author":"JF Nelson","year":"1982","unstructured":"Nelson JF, Felicio LS, Randall PK, Sims C, Finch CE . A longitudinal study of estrous cyclicity in aging C57BL\/6J mice: I. Cycle frequency, length and vaginal cytology. Biol Reprod 1982; 27: 327\u2013339.","journal-title":"Biol Reprod"},{"key":"BFcddis2012169_CR39","doi-asserted-by":"crossref","first-page":"19517","DOI":"10.1016\/S0021-9258(17)45403-2","volume":"265","author":"A Salustri","year":"1990","unstructured":"Salustri A, Ulisse S, Yanagishita M, Hascall VC . Hyaluronic acid synthesis by mural granulosa cells and cumulus cells in vitro is selectively stimulated by a factor produced by oocytes and by transforming growth factor-beta. J Biol Chem 1990; 265: 19517\u201319523.","journal-title":"J Biol Chem"},{"key":"BFcddis2012169_CR40","doi-asserted-by":"publisher","first-page":"e012","DOI":"10.1621\/nrs.01012","volume":"1","author":"AL Bookout","year":"2003","unstructured":"Bookout AL, Mangelsdorf DJ . Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways. Nucl Recept Signal 2003; 1: e012.","journal-title":"Nucl Recept Signal"},{"key":"BFcddis2012169_CR41","doi-asserted-by":"publisher","first-page":"5789","DOI":"10.1210\/endo.140.12.7204","volume":"140","author":"AL Durlinger","year":"1999","unstructured":"Durlinger AL, Kramer P, Karels B, de Jong FH, Uilenbroek JT, Grootegoed JA et al. Control of primordial follicle recruitment by anti-Mullerian hormone in the mouse ovary. Endocrinology 1999; 140: 5789\u20135796.","journal-title":"Endocrinology"},{"key":"BFcddis2012169_CR42","volume-title":"Theory and practice of Histotechnology","author":"DCH Sheehan","year":"1980","unstructured":"Sheehan DCH, Barbara B . Theory and practice of Histotechnology. Battle Press, 1980."}],"container-title":["Cell Death & Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis2012169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis2012169","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2012169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T23:47:23Z","timestamp":1672962443000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis2012169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,29]]},"references-count":42,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11]]}},"alternative-id":["BFcddis2012169"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2012.169","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,29]]},"assertion":[{"value":"27 February 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}