{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:23:50Z","timestamp":1782861830629,"version":"3.54.5"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2012.202","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T15:05:39Z","timestamp":1359039939000},"page":"e472-e472","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet"],"prefix":"10.1038","volume":"4","author":[{"given":"O V","family":"Leontieva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Paszkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z N","family":"Demidenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M V","family":"Blagosklonny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,1,24]]},"reference":[{"key":"BFcddis2012202_CR1","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/scientificamerican0112-32","volume":"306","author":"D Stipp","year":"2012","unstructured":"Stipp D . A new path to longevity. Sci Am 2012; 306: 32\u201339.","journal-title":"Sci Am"},{"key":"BFcddis2012202_CR2","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.cmet.2010.05.001","volume":"11","author":"P Kapahi","year":"2010","unstructured":"Kapahi P, Chen D, Rogers AN, Katewa SD, Li PW, Thomas EL et al. With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab 2010; 11: 453\u2013465.","journal-title":"Cell Metab"},{"key":"BFcddis2012202_CR3","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1111\/j.1474-9726.2010.00665.x","volume":"10","author":"M Kaeberlein","year":"2011","unstructured":"Kaeberlein M, Kennedy BK . Hot topics in aging research: protein translation and TOR signaling, 2010. Aging Cell 2011; 10: 185\u2013190.","journal-title":"Aging Cell"},{"key":"BFcddis2012202_CR4","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1101\/gad.1381406","volume":"20","author":"KaeberleinM Powers RWr,","year":"2006","unstructured":"Powers RWr, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S . Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev 2006; 20: 174\u2013184.","journal-title":"Genes Dev"},{"key":"BFcddis2012202_CR5","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.4161\/cc.9.10.11872","volume":"9","author":"MV Blagosklonny","year":"2010","unstructured":"Blagosklonny MV . Rapamycin and quasi-programmed aging: Four years later. Cell Cycle 2010; 9: 1859\u20131862.","journal-title":"Cell Cycle"},{"key":"BFcddis2012202_CR6","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.ajpath.2012.06.024","volume":"181","author":"MV Blagosklonny","year":"2012","unstructured":"Blagosklonny MV . Prospective treatment of age-related diseases by slowing down aging. Am J Pathol 2012; 181: 1142\u20131146.","journal-title":"Am J Pathol"},{"key":"BFcddis2012202_CR7","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.ceb.2011.09.003","volume":"23","author":"E Dazert","year":"2011","unstructured":"Dazert E, Hall MN . mTOR signaling in disease. Curr Opin Cell Biol 2011; 23: 744\u2013755.","journal-title":"Curr Opin Cell Biol"},{"key":"BFcddis2012202_CR8","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1042\/BST0390460","volume":"39","author":"I Bjedov","year":"2011","unstructured":"Bjedov I, Partridge L . A longer and healthier life with TOR down-regulation: genetics and drugs. Biochem Soc Trans 2011; 39: 460\u2013465.","journal-title":"Biochem Soc Trans"},{"key":"BFcddis2012202_CR9","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nature08221","volume":"460","author":"DE Harrison","year":"2009","unstructured":"Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K et al. Rapamycin fed late in life extends lifespan in genetically heterogenous mice. Nature 2009; 460: 392\u2013396.","journal-title":"Nature"},{"key":"BFcddis2012202_CR10","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1093\/gerona\/glq178","volume":"66","author":"RA Miller","year":"2011","unstructured":"Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 2011; 66: 191\u2013201.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"BFcddis2012202_CR11","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1111\/j.1474-9726.2012.00832.x","volume":"11","author":"JE Wilkinson","year":"2012","unstructured":"Wilkinson JE, Burmeister L, Brooks SV, Chan CC, Friedline S, Harrison DE et al. Rapamycin slows aging in mice. Aging Cell 2012; 11: 675\u2013682.","journal-title":"Aging Cell"},{"key":"BFcddis2012202_CR12","doi-asserted-by":"crossref","unstructured":"Spong A, Bartke A . Rapamycin slows aging in mice. Cell Cycle 2012: 11.","DOI":"10.4161\/cc.11.5.19607"},{"key":"BFcddis2012202_CR13","doi-asserted-by":"publisher","first-page":"4230","DOI":"10.4161\/cc.10.24.18486","volume":"10","author":"VN Anisimov","year":"2011","unstructured":"Anisimov VN, Zabezhinski MA, Popovich IG, Piskunova TS, Semenchenko AV, Tyndyk ML et al. Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice. Cell Cycle 2011; 10: 4230\u20134236.","journal-title":"Cell Cycle"},{"key":"BFcddis2012202_CR14","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.2353\/ajpath.2010.091050","volume":"176","author":"VN Anisimov","year":"2010","unstructured":"Anisimov VN, Zabezhinski MA, Popovich IG, Piskunova TS, Semenchenko AV, Tyndyk ML et al. Rapamycin extends maximal lifespan in cancer-prone mice. Am J Pathol 2010; 176: 2092\u20132097.","journal-title":"Am J Pathol"},{"key":"BFcddis2012202_CR15","doi-asserted-by":"publisher","first-page":"709","DOI":"10.18632\/aging.100498","volume":"4","author":"EA Komarova","year":"2012","unstructured":"Komarova EA, Antoch MP, Novototskaya LR, Chernova OB, Paszkiewicz G, Leontieva OV et al. Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+\/\u2212 mice. Aging (Albany NY) 2012; 4: 709\u2013714.","journal-title":"Aging (Albany NY)"},{"key":"BFcddis2012202_CR16","doi-asserted-by":"publisher","first-page":"715","DOI":"10.18632\/aging.100496","volume":"4","author":"M Comas","year":"2012","unstructured":"Comas M, Toshkov I, Kuropatwinski KK, Chernova OB, Polinsky A, Blagosklonny MV et al. New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-\/- mice by delaying carcinogenesis. Aging (Albany NY) 2012; 4: 715\u2013722.","journal-title":"Aging (Albany NY)"},{"key":"BFcddis2012202_CR17","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1254\/jphs.08215FP","volume":"109","author":"GR Chang","year":"2009","unstructured":"Chang GR, Chiu YS, Wu YY, Chen WY, Liao JW, Chao TH et al. Rapamycin protects against high fat diet-induced obesity in C57BL\/6J mice. J Pharmacol Sci 2009; 109: 496\u2013503.","journal-title":"J Pharmacol Sci"},{"key":"BFcddis2012202_CR18","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1126\/science.1215135","volume":"335","author":"DW Lamming","year":"2012","unstructured":"Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM et al. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 2012; 335: 1638\u20131643.","journal-title":"Science"},{"key":"BFcddis2012202_CR19","doi-asserted-by":"publisher","first-page":"945","DOI":"10.2337\/db07-0922","volume":"57","author":"M Fraenkel","year":"2008","unstructured":"Fraenkel M, Ketzinel-Gilad M, Ariav Y, Pappo O, Karaca M, Castel J et al. mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes. Diabetes 2008; 57: 945\u2013957.","journal-title":"Diabetes"},{"key":"BFcddis2012202_CR20","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1111\/j.1742-7843.2009.00427.x","volume":"105","author":"GR Chang","year":"2009","unstructured":"Chang GR, Wu YY, Chiu YS, Chen WY, Liao JW, Hsu HM et al. Long-term administration of rapamycin reduces adiposity, but impairs glucose tolerance in high-fat diet-fed KK\/HlJ mice. Basic Clin Pharmacol Toxicol 2009; 105: 188\u2013198.","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"BFcddis2012202_CR21","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1111\/j.1476-5381.2011.01716.x","volume":"165","author":"N Deblon","year":"2012","unstructured":"Deblon N, Bourgoin L, Veyrat-Durebex C, Peyrou M, Vinciguerra M, Caillon A et al. Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats. Br J Pharmacol 2012; 165: 2325\u20132340.","journal-title":"Br J Pharmacol"},{"key":"BFcddis2012202_CR22","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.2337\/db09-1324","volume":"59","author":"VP Houde","year":"2010","unstructured":"Houde VP, Brule S, Festuccia WT, Blanchard PG, Bellmann K, Deshaies Y et al. Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. Diabetes 2010; 59: 1338\u20131348.","journal-title":"Diabetes"},{"key":"BFcddis2012202_CR23","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s00109-011-0834-3","volume":"90","author":"SB Yang","year":"2011","unstructured":"Yang SB, Lee HY, Young DM, Tien AC, Rowson-Baldwin A, Shu YY et al. Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity. J Mol Med (Berl) 2011; 90: 575\u2013585.","journal-title":"J Mol Med (Berl)"},{"key":"BFcddis2012202_CR24","doi-asserted-by":"publisher","first-page":"4217","DOI":"10.4161\/cc.10.24.18595","volume":"10","author":"MV Blagosklonny","year":"2011","unstructured":"Blagosklonny MV . Rapamycin-induced glucose intolerance: Hunger or starvation diabetes. Cell Cycle 2011; 10: 4217\u20134224.","journal-title":"Cell Cycle"},{"key":"BFcddis2012202_CR25","doi-asserted-by":"publisher","first-page":"350","DOI":"10.18632\/aging.100461","volume":"4","author":"MV Blagosklonny","year":"2012","unstructured":"Blagosklonny MV . Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to. Aging (Albany NY) 2012; 4: 350\u2013358.","journal-title":"Aging (Albany NY)"},{"key":"BFcddis2012202_CR26","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/nrd2060","volume":"5","author":"JA Baur","year":"2006","unstructured":"Baur JA, Sinclair DA . Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 2006; 5: 493\u2013506.","journal-title":"Nat Rev Drug Discov"},{"key":"BFcddis2012202_CR27","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1038\/cddis.2009.8","volume":"1","author":"E Morselli","year":"2010","unstructured":"Morselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K et al. Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis 2010; 1: e10.","journal-title":"Cell Death Dis"},{"key":"BFcddis2012202_CR28","doi-asserted-by":"publisher","first-page":"146","DOI":"10.18632\/aging.100445","volume":"4","author":"S Timmers","year":"2012","unstructured":"Timmers S, Auwerx J, Schrauwen P . The journey of resveratrol from yeast to human. Aging (Albany NY) 2012; 4: 146\u2013158.","journal-title":"Aging (Albany NY)"},{"key":"BFcddis2012202_CR29","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature05354","volume":"444","author":"JA Baur","year":"2006","unstructured":"Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006; 444: 337\u2013342.","journal-title":"Nature"},{"key":"BFcddis2012202_CR30","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.cell.2006.11.013","volume":"127","author":"M Lagouge","year":"2006","unstructured":"Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006; 127: 1109\u20131122.","journal-title":"Cell"},{"key":"BFcddis2012202_CR31","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.metabol.2011.08.003","volume":"61","author":"W Kang","year":"2012","unstructured":"Kang W, Hong HJ, Guan J, Kim DG, Yang EJ, Koh G et al. Resveratrol improves insulin signaling in a tissue-specific manner under insulin-resistant conditions only: in vitro and in vivo experiments in rodents. Metabolism 2012; 61: 424\u2013433.","journal-title":"Metabolism"},{"key":"BFcddis2012202_CR32","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1017\/S0007114511000316","volume":"106","author":"P Brasnyo","year":"2011","unstructured":"Brasnyo P, Molnar GA, Mohas M, Marko L, Laczy B, Cseh J et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br J Nutr 2011; 106: 383\u2013389.","journal-title":"Br J Nutr"},{"key":"BFcddis2012202_CR33","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/nature06261","volume":"450","author":"JC Milne","year":"2007","unstructured":"Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007; 450: 712\u2013716.","journal-title":"Nature"},{"key":"BFcddis2012202_CR34","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1126\/science.329.5995.1012","volume":"329","author":"JA Baur","year":"2010","unstructured":"Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R et al. Dietary restriction: standing up for sirtuins. Science 2010; 329: 1012\u20131013 author reply 1013-1014.","journal-title":"Science"},{"key":"BFcddis2012202_CR35","doi-asserted-by":"publisher","first-page":"444","DOI":"10.18632\/aging.100304","volume":"3","author":"L Vetterli","year":"2011","unstructured":"Vetterli L, Maechler P . Resveratrol-activated SIRT1 in liver and pancreatic beta-cells: a Janus head looking to the same direction of metabolic homeostasis. Aging (Albany NY) 2011; 3: 444\u2013449.","journal-title":"Aging (Albany NY)"},{"key":"BFcddis2012202_CR36","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.cmet.2012.04.003","volume":"15","author":"NL Price","year":"2012","unstructured":"Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab 2012; 15: 675\u2013690.","journal-title":"Cell Metab"},{"key":"BFcddis2012202_CR37","doi-asserted-by":"publisher","first-page":"515","DOI":"10.18632\/aging.100056","volume":"1","author":"SM Armour","year":"2009","unstructured":"Armour SM, Baur JosephA, Sherry N, Hsieh SN, Land-Bracha A, Thomas SM et al. Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy. Aging 2009; 1: 515\u2013528.","journal-title":"Aging"},{"key":"BFcddis2012202_CR38","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.4161\/cc.8.12.8810","volume":"8","author":"ZN Demidenko","year":"2009","unstructured":"Demidenko ZN, Blagosklonny MV . At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence. Cell Cycle 2009; 8: 1901\u20131904.","journal-title":"Cell Cycle"},{"key":"BFcddis2012202_CR39","doi-asserted-by":"crossref","unstructured":"Blagosklonny MV . Linking calorie restriction to longevity through sirtuins and autophagy: any role for TOR. Cell Death Dis 1: e12 2010 doi:10.1038\/cddis.2009.17.","DOI":"10.1038\/cddis.2009.17"},{"key":"BFcddis2012202_CR40","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/mnfr.201100400","volume":"56","author":"E Scott","year":"2012","unstructured":"Scott E, Steward WP, Gescher AJ, Brown K . Resveratrol in human cancer chemoprevention--choosing the 'right' dose. Mol Nutr Food Res 2012; 56: 7\u201313.","journal-title":"Mol Nutr Food Res"},{"key":"BFcddis2012202_CR41","first-page":"953","volume":"12","author":"AJ Gescher","year":"2003","unstructured":"Gescher AJ, Steward WP . Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: a conundrum. Cancer Epidemiol Biomarkers Prev 2003; 12: 953\u2013957.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"BFcddis2012202_CR42","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.jchromb.2006.10.017","volume":"848","author":"DJ Boocock","year":"2007","unstructured":"Boocock DJ, Patel KR, Faust GE, Normolle DP, Marczylo TH, Crowell JA et al. Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci 2007; 848: 182\u2013187.","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"BFcddis2012202_CR43","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1158\/1055-9965.EPI-07-0022","volume":"16","author":"DJ Boocock","year":"2007","unstructured":"Boocock DJ, Faust GE, Patel KR, Schinas AM, Brown VA, Ducharme MP et al. Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol Biomarkers Prev 2007; 16: 1246\u20131252.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"BFcddis2012202_CR44","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.4161\/cc.10.10.15789","volume":"10","author":"ZN Demidenko","year":"2011","unstructured":"Demidenko ZN, Blagosklonny MV . The purpose of the HIF-1\/PHD feedback loop: to limit mTOR-induced HIF-1alpha. Cell Cycle 2011; 10: 1557\u20131562.","journal-title":"Cell Cycle"},{"key":"BFcddis2012202_CR45","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1177\/0960327110383625","volume":"29","author":"EJ Calabrese","year":"2010","unstructured":"Calabrese EJ, Mattson MP, Calabrese V . Resveratrol commonly displays hormesis: occurrence and biomedical significance. Hum Exp Toxicol 2010; 29: 980\u20131015.","journal-title":"Hum Exp Toxicol"},{"key":"BFcddis2012202_CR46","doi-asserted-by":"publisher","first-page":"821","DOI":"10.18632\/aging.100380","volume":"3","author":"I Martins","year":"2011","unstructured":"Martins I, Galluzzi L, Hormesis KroemerG . cell death and aging. Aging (Albany NY) 2011; 3: 821\u2013828.","journal-title":"Aging (Albany NY)"},{"key":"BFcddis2012202_CR47","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.4161\/cc.8.12.8606","volume":"8","author":"ZN Demidenko","year":"2009","unstructured":"Demidenko ZN, Zubova SG, Bukreeva EI, Pospelov VA, Pospelova TV, Blagosklonny MV . Rapamycin decelerates cellular senescence. Cell Cycle 2009; 8: 1888\u20131895.","journal-title":"Cell Cycle"},{"key":"BFcddis2012202_CR48","doi-asserted-by":"publisher","first-page":"9660","DOI":"10.1073\/pnas.1002298107","volume":"107","author":"ZN Demidenko","year":"2010","unstructured":"Demidenko ZN, Korotchkina LG, Gudkov AV, Blagosklonny MV . Paradoxical suppression of cellular senescence by p53. Proc Natl Acad Sci USA 2010; 107: 9660\u20139664.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2012202_CR49","doi-asserted-by":"publisher","first-page":"13314","DOI":"10.1073\/pnas.1205690109","volume":"109","author":"OV Leontieva","year":"2012","unstructured":"Leontieva OV, Natarajan V, Demidenko ZN, Burdelya LG, Gudkov AV, Blagosklonny MV . Hypoxia suppresses conversion from proliferative arrest to cellular senescence. Proc Natl Acad Sci USA 2012; 109: 13314\u201313318.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2012202_CR50","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.18632\/aging.100402","volume":"3","author":"OV Leontieva","year":"2011","unstructured":"Leontieva OV, Blagosklonny MV . Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression. Aging (Albany NY) 2011; 3: 1078\u20131091.","journal-title":"Aging (Albany NY)"},{"key":"BFcddis2012202_CR51","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.4161\/cc.8.8.8287","volume":"8","author":"CR Burtner","year":"2009","unstructured":"Burtner CR, Murakami CJ, Kennedy BK, Kaeberlein M . A molecular mechanism of chronological aging in yeast. Cell Cycle 2009; 8: 1256\u20131270.","journal-title":"Cell Cycle"},{"key":"BFcddis2012202_CR52","doi-asserted-by":"publisher","first-page":"760","DOI":"10.18632\/aging.100230","volume":"2","author":"VN Anisimov","year":"2010","unstructured":"Anisimov VN . Metformin for aging and cancer prevention. Aging (Albany NY) 2010; 2: 760\u2013774.","journal-title":"Aging (Albany NY)"},{"key":"BFcddis2012202_CR53","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s11357-009-9118-z","volume":"32","author":"L Fontana","year":"2010","unstructured":"Fontana L, Klein S, Holloszy JO . Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production. Age (Dordr) 2010; 32: 97\u2013108.","journal-title":"Age (Dordr)"},{"key":"BFcddis2012202_CR54","first-page":"E890","volume":"270","author":"G Paolisso","year":"1996","unstructured":"Paolisso G, Gambardella A, Ammendola S, D'Amore A, Balbi V, Varricchio M et al. Glucose tolerance and insulin action in healty centenarians. Am J Physiol 1996; 270: E890\u2013E894.","journal-title":"Am J Physiol"},{"key":"BFcddis2012202_CR55","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jnutbio.2004.12.007","volume":"16","author":"MP Mattson","year":"2005","unstructured":"Mattson MP, Wan R . Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems. J Nutr Biochem 2005; 16: 129\u2013137.","journal-title":"J Nutr Biochem"},{"key":"BFcddis2012202_CR56","doi-asserted-by":"publisher","first-page":"e31","DOI":"10.1111\/j.1755-3768.2011.02243.x","volume":"90","author":"YH Kim","year":"2012","unstructured":"Kim YH, Kim YS, Roh GS, Choi WS, Cho GJ . Resveratrol blocks diabetes-induced early vascular lesions and vascular endothelial growth factor induction in mouse retinas. Acta Ophthalmol 2012; 90: e31\u2013e37.","journal-title":"Acta Ophthalmol"},{"key":"BFcddis2012202_CR57","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.ajpath.2012.04.018","volume":"181","author":"NG Kolosova","year":"2012","unstructured":"Kolosova NG, Muraleva NA, Zhdankina AA, Stefanova NA, Fursova AZ, Blagosklonny MV . Prevention of age-related macular degeneration (AMD)-like retinopathy by rapamycin in rats. Am J Pathol 2012; 181: 472\u2013477.","journal-title":"Am J Pathol"},{"key":"BFcddis2012202_CR58","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1093\/gerona\/gls070","volume":"68","author":"R Strong","year":"2012","unstructured":"Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E et al. Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice. J Gerontol A Biol Sci Med Sci 2012; 68: 6\u201316.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"BFcddis2012202_CR59","doi-asserted-by":"publisher","first-page":"4808","DOI":"10.1038\/sj.onc.1203078","volume":"18","author":"BD Chang","year":"1999","unstructured":"Chang BD, Xuan Y, Broude EV, Zhu H, Schott B, Fang J et al. Role of p53 and p21waf1\/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. Oncogene 1999; 18: 4808\u20134818.","journal-title":"Oncogene"},{"key":"BFcddis2012202_CR60","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1038\/sj.onc.1203573","volume":"19","author":"BD Chang","year":"2000","unstructured":"Chang BD, Broude EV, Fang J, Kalinichenko TV, Abdryashitov R, Poole JC et al. p21Waf1\/Cip1\/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells. Oncogene 2000; 19: 2165\u20132170.","journal-title":"Oncogene"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis2012202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis2012202","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2012202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T23:56:35Z","timestamp":1672962995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis2012202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,24]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1]]}},"alternative-id":["BFcddis2012202"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2012.202","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,24]]},"assertion":[{"value":"30 November 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}