{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:04:44Z","timestamp":1789376684084,"version":"build-2803163510"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T00:00:00Z","timestamp":1340236800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2012.60","type":"journal-article","created":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T12:30:36Z","timestamp":1340281836000},"page":"e323-e323","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["TLR9 agonists induced cell death in Burkitt's lymphoma cells is variable and influenced by TLR9 polymorphism"],"prefix":"10.1038","volume":"3","author":[{"given":"J","family":"Noack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Jordi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Zauner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Alessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Burch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Tinguely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hersberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bernasconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Nadal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,6,21]]},"reference":[{"key":"BFcddis201260_CR1","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/ni1112","volume":"5","author":"A Iwasaki","year":"2004","unstructured":"Iwasaki A, Medzhitov R . Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004; 5: 987\u2013995.","journal-title":"Nat Immunol"},{"key":"BFcddis201260_CR2","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1182\/blood-2008-02-140673","volume":"112","author":"D Chiron","year":"2008","unstructured":"Chiron D, Bekeredjian-Ding I, Pellat-Deceunynck C, Bataille R, Jego G . Toll-like receptors: lessons to learn from normal and malignant human B cells. Blood 2008; 112: 2205\u20132213.","journal-title":"Blood"},{"key":"BFcddis201260_CR3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.0105-2896.2005.00239.x","volume":"204","author":"IR Rifkin","year":"2005","unstructured":"Rifkin IR, Leadbetter EA, Busconi L, Viglianti G, Marshak-Rothstein A . Toll-like receptors, endogenous ligands, and systemic autoimmune disease. Immunol Rev 2005; 204: 27\u201342.","journal-title":"Immunol Rev"},{"key":"BFcddis201260_CR4","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1182\/blood-2002-11-3355","volume":"102","author":"E Bourke","year":"2003","unstructured":"Bourke E, Bosisio D, Golay J, Polentarutti N, Mantovani A . The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells. Blood 2003; 102: 956\u2013963.","journal-title":"Blood"},{"key":"BFcddis201260_CR5","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1111\/j.1365-2567.2009.03143.x","volume":"128","author":"M Dorner","year":"2009","unstructured":"Dorner M, Brandt S, Tinguely M, Zucol F, Bourquin JP, Zauner L et al. Plasma cell toll-like receptor (TLR) expression differs from that of B cells, and plasma cell TLR triggering enhances immunoglobulin production. Immunology 2009; 128: 573\u2013579.","journal-title":"Immunology"},{"key":"BFcddis201260_CR6","doi-asserted-by":"publisher","first-page":"4531","DOI":"10.4049\/jimmunol.168.9.4531","volume":"168","author":"V Hornung","year":"2002","unstructured":"Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdorfer B, Giese T et al. Quantitative expression of toll-like receptor 1\u201310 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 2002; 168: 4531\u20134537.","journal-title":"J Immunol"},{"key":"BFcddis201260_CR7","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.addr.2008.12.008","volume":"61","author":"J Vollmer","year":"2009","unstructured":"Vollmer J, Krieg AM . Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists. Adv Drug Deliv Rev 2009; 61: 195\u2013204.","journal-title":"Adv Drug Deliv Rev"},{"key":"BFcddis201260_CR8","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.addr.2008.12.006","volume":"61","author":"GJ Weiner","year":"2009","unstructured":"Weiner GJ . CpG oligodeoxynucleotide-based therapy of lymphoid malignancies. Adv Drug Deliv Rev 2009; 61: 263\u2013267.","journal-title":"Adv Drug Deliv Rev"},{"key":"BFcddis201260_CR9","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/sj.onc.1210911","volume":"27","author":"AM Krieg","year":"2008","unstructured":"Krieg AM . Toll-like receptor 9 (TLR9) agonists in the treatment of cancer. Oncogene 2008; 27: 161\u2013167.","journal-title":"Oncogene"},{"key":"BFcddis201260_CR10","doi-asserted-by":"publisher","first-page":"5041","DOI":"10.1182\/blood-2009-03-213363","volume":"115","author":"X Liang","year":"2010","unstructured":"Liang X, Moseman EA, Farrar MA, Bachanova V, Weisdorf DJ, Blazar BR et al. Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells. Blood 2010; 115: 5041\u20135052.","journal-title":"Blood"},{"key":"BFcddis201260_CR11","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1158\/1078-0432.CCR-04-1890","volume":"11","author":"B Jahrsdorfer","year":"2005","unstructured":"Jahrsdorfer B, Muhlenhoff L, Blackwell SE, Wagner M, Poeck H, Hartmann E et al. B-cell lymphomas differ in their responsiveness to CpG oligodeoxynucleotides. Clin Cancer Res 2005; 11: 1490\u20131499.","journal-title":"Clin Cancer Res"},{"key":"BFcddis201260_CR12","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1182\/blood.V95.3.999.003k10_999_1006","volume":"95","author":"T Decker","year":"2000","unstructured":"Decker T, Schneller F, Sparwasser T, Tretter T, Lipford GB, Wagner H et al. Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells. Blood 2000; 95: 999\u20131006.","journal-title":"Blood"},{"key":"BFcddis201260_CR13","doi-asserted-by":"publisher","first-page":"5009","DOI":"10.1158\/0008-5472.CAN-05-0784","volume":"65","author":"B Huang","year":"2005","unstructured":"Huang B, Zhao J, Li H, He KL, Chen Y, Chen SH et al. Toll-like receptors on tumor cells facilitate evasion of immune surveillance. Cancer Res 2005; 65: 5009\u20135014.","journal-title":"Cancer Res"},{"key":"BFcddis201260_CR14","doi-asserted-by":"publisher","first-page":"248","DOI":"10.2478\/s11658-008-0048-z","volume":"14","author":"A Wolska","year":"2009","unstructured":"Wolska A, Lech-Maranda E, Robak T . Toll-like receptors and their role in carcinogenesis and anti-tumor treatment. Cell Mol Biol Lett 2009; 14: 248\u2013272.","journal-title":"Cell Mol Biol Lett"},{"key":"BFcddis201260_CR15","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1111\/j.1462-5822.2007.00937.x","volume":"9","author":"K Ladell","year":"2007","unstructured":"Ladell K, Dorner M, Zauner L, Berger C, Zucol F, Bernasconi M et al. Immune activation suppresses initiation of lytic Epstein-Barr virus infection. Cell Microbiol 2007; 9: 2055\u20132069.","journal-title":"Cell Microbiol"},{"key":"BFcddis201260_CR16","doi-asserted-by":"publisher","first-page":"4588","DOI":"10.1038\/onc.2010.203","volume":"29","author":"L Zauner","year":"2010","unstructured":"Zauner L, Melroe GT, Sigrist JA, Rechsteiner MP, Dorner M, Arnold M et al. TLR9 triggering in Burkitt's lymphoma cell lines suppresses the EBV BZLF1 transcription via histone modification. Oncogene 2010; 29: 4588\u20134598.","journal-title":"Oncogene"},{"key":"BFcddis201260_CR17","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/nrc1452","volume":"4","author":"LS Young","year":"2004","unstructured":"Young LS, Rickinson AB . Epstein-Barr virus: 40 years on. Nat Rev Cancer 2004; 4: 757\u2013768.","journal-title":"Nat Rev Cancer"},{"key":"BFcddis201260_CR18","first-page":"2575","volume-title":"Fields Virology","author":"A Rickinson","year":"2001","unstructured":"Rickinson A, Kieff E . Epstein-Barr virus In: Knipe DM (ed) Fields Virology 4th edn. Lippincott Williams & Wilkins: Philadelphia, PA, 2001 pp 2575\u20132627."},{"key":"BFcddis201260_CR19","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/nm1080","volume":"10","author":"E Traggiai","year":"2004","unstructured":"Traggiai E, Becker S, Subbarao K, Kolesnikova L, Uematsu Y, Gismondo MR et al. An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus. Nat Med 2004; 10: 871\u2013875.","journal-title":"Nat Med"},{"key":"BFcddis201260_CR20","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/gene.2011.59","volume":"13","author":"A Carvalho","year":"2012","unstructured":"Carvalho A, Cunha C, Almeida AJ, Osorio NS, Saraiva M, Teixeira-Coelho M et al. The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma. Genes Immun 2012; 13: 197\u2013210.","journal-title":"Genes Immun"},{"key":"BFcddis201260_CR21","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.coi.2005.03.003","volume":"17","author":"SL Peng","year":"2005","unstructured":"Peng SL . Signaling in B cells via Toll-like receptors. Curr Opin Immunol 2005; 17: 230\u2013236.","journal-title":"Curr Opin Immunol"},{"key":"BFcddis201260_CR22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1189\/jlb.69.1.81","volume":"69","author":"B Jahrsdorfer","year":"2001","unstructured":"Jahrsdorfer B, Hartmann G, Racila E, Jackson W, Muhlenhoff L, Meinhardt G et al. CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens. J Leukoc Biol 2001; 69: 81\u201388.","journal-title":"J Leukoc Biol"},{"key":"BFcddis201260_CR23","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1128\/JVI.74.2.710-720.2000","volume":"74","author":"PJ Jenkins","year":"2000","unstructured":"Jenkins PJ, Binne UK, Farrell PJ . Histone acetylation and reactivation of Epstein-Barr virus from latency. J Virol 2000; 74: 710\u2013720.","journal-title":"J Virol"},{"key":"BFcddis201260_CR24","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","volume":"19","author":"KW Moore","year":"2001","unstructured":"Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A . Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001; 19: 683\u2013765.","journal-title":"Annu Rev Immunol"},{"key":"BFcddis201260_CR25","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.4049\/jimmunol.158.9.4045","volume":"158","author":"PR Beatty","year":"1997","unstructured":"Beatty PR, Krams SM, Martinez OM . Involvement of IL-10 in the autonomous growth of EBV-transformed B cell lines. J Immunol 1997; 158: 4045\u20134051.","journal-title":"J Immunol"},{"key":"BFcddis201260_CR26","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1182\/blood.V94.8.2871.420k25_2871_2879","volume":"94","author":"KD Jones","year":"1999","unstructured":"Jones KD, Aoki Y, Chang Y, Moore PS, Yarchoan R, Tosato G . Involvement of interleukin-10 (IL-10) and viral IL-6 in the spontaneous growth of Kaposi's sarcoma herpesvirus-associated infected primary effusion lymphoma cells. Blood 1999; 94: 2871\u20132879.","journal-title":"Blood"},{"key":"BFcddis201260_CR27","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1128\/IAI.01226-09","volume":"78","author":"MT Ng","year":"2010","unstructured":"Ng MT, Van't Hof R, Crockett JC, Hope ME, Berry S, Thomson J et al. Increase in NF-kappaB binding affinity of the variant C allele of the toll-like receptor 9 -1237T\/C polymorphism is associated with Helicobacter pylori-induced gastric disease. Infect Immun 2010; 78: 1345\u20131352.","journal-title":"Infect Immun"},{"key":"BFcddis201260_CR28","first-page":"128","volume":"49","author":"N Soriano-Sarabia","year":"2008","unstructured":"Soriano-Sarabia N, Vallejo A, Ramirez-Lorca R, Rodriguez Mdel M, Salinas A, Pulido I et al. Influence of the Toll-like receptor 9 1635A\/G polymorphism on the CD4 count, HIV viral load, and clinical progression. JAIDS 2008; 49: 128\u2013135.","journal-title":"JAIDS"},{"key":"BFcddis201260_CR29","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1073\/pnas.89.5.1890","volume":"89","author":"F Rousset","year":"1992","unstructured":"Rousset F, Garcia E, Defrance T, Peronne C, Vezzio N, Hsu DH et al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci USA 1992; 89: 1890\u20131893.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis201260_CR30","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1182\/blood.V85.12.3423.bloodjournal85123423","volume":"85","author":"R Masood","year":"1995","unstructured":"Masood R, Zhang Y, Bond MW, Scadden DT, Moudgil T, Law RE et al. Interleukin-10 is an autocrine growth factor for acquired immunodeficiency syndrome-related B-cell lymphoma. Blood 1995; 85: 3423\u20133430.","journal-title":"Blood"},{"key":"BFcddis201260_CR31","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/nri2711","volume":"10","author":"M Saraiva","year":"2010","unstructured":"Saraiva M, O'Garra A . The regulation of IL-10 production by immune cells. Nat Rev Immunol 2010; 10: 170\u2013181.","journal-title":"Nat Rev Immunol"},{"key":"BFcddis201260_CR32","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/ni1479","volume":"8","author":"E Latz","year":"2007","unstructured":"Latz E, Verma A, Visintin A, Gong M, Sirois CM, Klein DC et al. Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat Immunol 2007; 8: 772\u2013779.","journal-title":"Nat Immunol"},{"key":"BFcddis201260_CR33","doi-asserted-by":"publisher","first-page":"6720","DOI":"10.4049\/jimmunol.181.10.6720","volume":"181","author":"OM Grauer","year":"2008","unstructured":"Grauer OM, Molling JW, Bennink E, Toonen LW, Sutmuller RP, Nierkens S et al. TLR ligands in the local treatment of established intracerebral murine gliomas. J Immunol 2008; 181: 6720\u20136729.","journal-title":"J Immunol"},{"key":"BFcddis201260_CR34","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/sj.leu.2404144","volume":"20","author":"JE Castro","year":"2006","unstructured":"Castro JE, Prada CE, Aguillon RA, Kitada S, Fukuda T, Motta M et al. Thymidine-phosphorothioate oligonucleotides induce activation and apoptosis of CLL cells independently of CpG motifs or BCL-2 gene interference. Leukemia 2006; 20: 680\u2013688.","journal-title":"Leukemia"},{"key":"BFcddis201260_CR35","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1083\/jcb.200508058","volume":"172","author":"MA Sanjuan","year":"2006","unstructured":"Sanjuan MA, Rao N, Lai KT, Gu Y, Sun S, Fuchs A et al. CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion. J Cell Biol 2006; 172: 1057\u20131068.","journal-title":"J Cell Biol"},{"key":"BFcddis201260_CR36","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1128\/IAI.01226-09","volume":"78","author":"MT Ng","year":"2010","unstructured":"Ng MT, Van't Hof R, Crockett JC, Hope ME, Berry S, Thomson J et al. Increase in NF-kappaB binding affinity of the variant C allele of the toll-like receptor 9 -1237T\/C polymorphism is associated with Helicobacter pylori-induced gastric disease. Infect Immun 2010; 78: 1345\u20131352.","journal-title":"Infect Immun"},{"key":"BFcddis201260_CR37","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"SH Swerdlow","year":"2008","unstructured":"Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H et al WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. IARC: Lyon, 2008."},{"key":"BFcddis201260_CR38","first-page":"971","volume":"43","author":"J Muntwyler","year":"2005","unstructured":"Muntwyler J, Marti-Jaun J, Luscher TF, Hanseler E, Hersberger M . The Asp298 but not the C-786 genotype of the endothelial nitric oxide synthase is reduced with age in healthy Swiss men. Clin chem lab med: CCLM\/FESCC 2005; 43: 971\u2013973.","journal-title":"Clin chem lab med: CCLM\/FESCC"},{"key":"BFcddis201260_CR39","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1097\/MEG.0b013e3283322067","volume":"22","author":"PA Krayenbuehl","year":"2010","unstructured":"Krayenbuehl PA, Hersberger M, Truninger K, Mullhaupt B, Maly FE, Bargetzi M et al. Toll-like receptor 4 gene polymorphism modulates phenotypic expression in patients with hereditary hemochromatosis. Eur J Gastroenterol Hepato 2010; 22: 835\u2013841.","journal-title":"Eur J Gastroenterol Hepato"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis201260.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis201260","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis201260.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T23:42:31Z","timestamp":1672962151000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis201260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,21]]},"references-count":39,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,6]]}},"alternative-id":["BFcddis201260"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2012.60","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,21]]},"assertion":[{"value":"13 December 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}