{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T03:31:55Z","timestamp":1780457515769,"version":"3.54.1"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2013.126","type":"journal-article","created":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T17:01:29Z","timestamp":1366909289000},"page":"e609-e609","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":137,"title":["Interleukin-6 contributes to CNS axon regeneration upon inflammatory stimulation"],"prefix":"10.1038","volume":"4","author":[{"given":"M","family":"Leibinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Gobrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Diekmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Andreadaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,4,25]]},"reference":[{"key":"BFcddis2013126_CR1","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/nrn1326","volume":"5","author":"J Silver","year":"2004","unstructured":"Silver J, Miller JH . Regeneration beyond the glial scar. Nat Rev Neurosci 2004; 5: 146\u2013156.","journal-title":"Nat Rev Neurosci"},{"key":"BFcddis2013126_CR2","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/nrn1956","volume":"7","author":"G Yiu","year":"2006","unstructured":"Yiu G, He Z . Glial inhibition of CNS axon regeneration. Nat Rev Neurosci 2006; 7: 617\u2013627.","journal-title":"Nat Rev Neurosci"},{"key":"BFcddis2013126_CR3","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.preteyeres.2012.06.005","volume":"31","author":"D Fischer","year":"2012","unstructured":"Fischer D, Leibinger M . Promoting optic nerve regeneration. Progress in retinal and eye research 2012; 31: 688\u2013701.","journal-title":"Progress in retinal and eye research"},{"key":"BFcddis2013126_CR4","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.conb.2004.08.012","volume":"14","author":"JL Goldberg","year":"2004","unstructured":"Goldberg JL . Intrinsic neuronal regulation of axon and dendrite growth. Curr Opin Neurobiol 2004; 14: 551\u2013557.","journal-title":"Curr Opin Neurobiol"},{"key":"BFcddis2013126_CR5","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1146\/annurev-neuro-061010-113723","volume":"34","author":"K Liu","year":"2011","unstructured":"Liu K, Tedeschi A, Park KK, He Z . Neuronal intrinsic mechanisms of axon regeneration. Annu Rev Neurosci 2011; 34: 131\u2013152.","journal-title":"Annu Rev Neurosci"},{"key":"BFcddis2013126_CR6","doi-asserted-by":"publisher","first-page":"4368","DOI":"10.1523\/JNEUROSCI.14-07-04368.1994","volume":"14","author":"M Berkelaar","year":"1994","unstructured":"Berkelaar M, Clarke DB, Wang YC, Bray GM, Aguayo AJ . Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J Neurosci 1994; 14: 4368\u20134374.","journal-title":"J Neurosci"},{"key":"BFcddis2013126_CR7","first-page":"3943","volume":"41","author":"D Fischer","year":"2000","unstructured":"Fischer D, Pavlidis M, Thanos S . Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture. Invest Ophthalmol Vis Sci 2000; 41: 3943\u20133954.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFcddis2013126_CR8","doi-asserted-by":"publisher","first-page":"4615","DOI":"10.1523\/JNEUROSCI.20-12-04615.2000","volume":"20","author":"S Leon","year":"2000","unstructured":"Leon S, Yin Y, Nguyen J, Irwin N, Benowitz LI . Lens injury stimulates axon regeneration in the mature rat optic nerve. J Neurosci 2000; 20: 4615\u20134626.","journal-title":"J Neurosci"},{"key":"BFcddis2013126_CR9","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/nature10594","volume":"480","author":"F Sun","year":"2011","unstructured":"Sun F, Park KK, Belin S, Wang D, Lu T, Chen G et al. Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature 2011; 480: 372\u2013375.","journal-title":"Nature"},{"key":"BFcddis2013126_CR10","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.neuron.2009.11.021","volume":"64","author":"PD Smith","year":"2009","unstructured":"Smith PD, Sun F, Park KK, Cai B, Wang C, Kuwako K et al. SOCS3 deletion promotes optic nerve regeneration in vivo. Neuron 2009; 64: 617\u2013623.","journal-title":"Neuron"},{"key":"BFcddis2013126_CR11","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1126\/science.1161566","volume":"322","author":"KK Park","year":"2008","unstructured":"Park KK, Liu K, Hu Y, Smith PD, Wang C, Cai B et al. Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway. Science 2008; 322: 963\u2013966.","journal-title":"Science"},{"key":"BFcddis2013126_CR12","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1111\/j.1460-9568.2005.04034.x","volume":"21","author":"B Lorber","year":"2005","unstructured":"Lorber B, Berry M, Logan A . Lens injury stimulates adult mouse retinal ganglion cell axon regeneration via both macrophage- and lens-derived factors. Eur J Neurosci 2005; 21: 2029\u20132034.","journal-title":"Eur J Neurosci"},{"key":"BFcddis2013126_CR13","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1006\/exnr.2001.7822","volume":"172","author":"D Fischer","year":"2001","unstructured":"Fischer D, Heiduschka P, Thanos S . Lens-injury-stimulated axonal regeneration throughout the optic pathway of adult rats. Exp Neurol 2001; 172: 257\u2013272.","journal-title":"Exp Neurol"},{"issue":"Pt 4","key":"BFcddis2013126_CR14","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1093\/brain\/awl015","volume":"129","author":"V Pernet","year":"2006","unstructured":"Pernet V, Di Polo A . Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivo. Brain 2006; 129 (Pt 4): 1014\u20131026.","journal-title":"Brain"},{"key":"BFcddis2013126_CR15","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.mcn.2007.11.002","volume":"37","author":"D Fischer","year":"2008","unstructured":"Fischer D, Hauk TG, Muller A, Thanos S . Crystallins of the beta\/gamma-superfamily mimic the effects of lens injury and promote axon regeneration. Mol Cell Neurosci 2008; 37: 471\u2013479.","journal-title":"Mol Cell Neurosci"},{"key":"BFcddis2013126_CR16","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.expneurol.2007.09.020","volume":"209","author":"TG Hauk","year":"2008","unstructured":"Hauk TG, Muller A, Lee J, Schwendener R, Fischer D . Neuroprotective and axon growth promoting effects of intraocular inflammation do not depend on oncomodulin or the presence of large numbers of activated macrophages. Exp Neurol 2008; 209: 469\u2013482.","journal-title":"Exp Neurol"},{"key":"BFcddis2013126_CR17","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1523\/JNEUROSCI.23-06-02284.2003","volume":"23","author":"Y Yin","year":"2003","unstructured":"Yin Y, Cui Q, Li Y, Irwin N, Fischer D, Harvey AR et al. Macrophage-derived factors stimulate optic nerve regeneration. J Neurosci 2003; 23: 2284\u20132293.","journal-title":"J Neurosci"},{"key":"BFcddis2013126_CR18","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1167\/iovs.09-4203","volume":"51","author":"TG Hauk","year":"2009","unstructured":"Hauk TG, Leibinger M, Muller A, Andreadaki N, Knippschild U, Fischer D . Intravitreal application of the Toll-like receptor 2 agonist Pam3Cys stimulates axon regeneration in the mature optic nerve. Invest Ophthalmol Vis Sci 2009; 51: 459\u2013464.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFcddis2013126_CR19","doi-asserted-by":"publisher","first-page":"14334","DOI":"10.1523\/JNEUROSCI.2770-09.2009","volume":"29","author":"M Leibinger","year":"2009","unstructured":"Leibinger M, Muller A, Andreadaki A, Hauk TG, Kirsch M, Fischer D . Neuroprotective and axon growth-promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on ciliary neurotrophic factor and leukemia inhibitory factor. J Neurosci 2009; 29: 14334\u201314341.","journal-title":"J Neurosci"},{"issue":"Pt 12","key":"BFcddis2013126_CR20","doi-asserted-by":"publisher","first-page":"3308","DOI":"10.1093\/brain\/awm257","volume":"130","author":"A Muller","year":"2007","unstructured":"Muller A, Hauk TG, Fischer D . Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation. Brain 2007; 130 (Pt 12): 3308\u20133320.","journal-title":"Brain"},{"key":"BFcddis2013126_CR21","doi-asserted-by":"publisher","first-page":"E8","DOI":"10.1073\/pnas.0912942107","volume":"107","author":"D Fischer","year":"2010","unstructured":"Fischer D . What are the principal mediators of optic nerve regeneration after inflammatory stimulation in the eye? Proc Natl Acad Sci USA 2010; 107: E8 author reply E9.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2013126_CR22","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.mcn.2009.06.005","volume":"42","author":"Z Ahmed","year":"2009","unstructured":"Ahmed Z, Berry M, Logan A . ROCK inhibition promotes adult retinal ganglion cell neurite outgrowth only in the presence of growth promoting factors. Mol Cell Neurosci 2009; 42: 128\u2013133.","journal-title":"Mol Cell Neurosci"},{"key":"BFcddis2013126_CR23","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.nbd.2012.01.004","volume":"46","author":"M Leibinger","year":"2012","unstructured":"Leibinger M, Andreadaki A, Fischer D . Role of mTOR in neuroprotection and axon regeneration after inflammatory stimulation. Neurobiol Dis 2012; 46: 314\u2013324.","journal-title":"Neurobiol Dis"},{"issue":"Pt 1","key":"BFcddis2013126_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj20030407","volume":"374","author":"PC Heinrich","year":"2003","unstructured":"Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G, Schaper F . Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 2003; 374 (Pt 1): 1\u201320.","journal-title":"Biochem J"},{"key":"BFcddis2013126_CR25","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1182\/blood-2007-01-067918","volume":"110","author":"A Chalaris","year":"2007","unstructured":"Chalaris A, Rabe B, Paliga K, Lange H, Laskay T, Fielding CA et al. Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils. Blood 2007; 110: 1748\u20131755.","journal-title":"Blood"},{"key":"BFcddis2013126_CR26","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1093\/oxfordjournals.jbchem.a123261","volume":"108","author":"K Yasukawa","year":"1990","unstructured":"Yasukawa K, Saito T, Fukunaga T, Sekimori Y, Koishihara Y, Fukui H et al. Purification and characterization of soluble human IL-6 receptor expressed in CHO cells. J Biochem 1990; 108: 673\u2013676.","journal-title":"J Biochem"},{"key":"BFcddis2013126_CR27","doi-asserted-by":"publisher","first-page":"13743","DOI":"10.1074\/jbc.M112.349167","volume":"287","author":"J Sommer","year":"2012","unstructured":"Sommer J, Effenberger T, Volpi E, Waetzig GH, Bernhardt M, Suthaus J et al. Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling. J Biol Chem 2012; 287: 13743\u201313751.","journal-title":"J Biol Chem"},{"key":"BFcddis2013126_CR28","doi-asserted-by":"publisher","first-page":"5173","DOI":"10.1182\/blood-2011-09-377705","volume":"119","author":"J Suthaus","year":"2012","unstructured":"Suthaus J, Stuhlmann-Laeisz C, Tompkins VS, Rosean TR, Klapper W, Tosato G et al. HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice. Blood 2012; 119: 5173\u20135181.","journal-title":"Blood"},{"key":"BFcddis2013126_CR29","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/j.imbio.2012.01.015","volume":"217","author":"J Sodenkamp","year":"2012","unstructured":"Sodenkamp J, Waetzig GH, Scheller J, Seegert D, Grotzinger J, Rose-John S et al. Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis. Immunobiology 2012; 217: 996\u20131004.","journal-title":"Immunobiology"},{"key":"BFcddis2013126_CR30","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/1471-2202-12-116","volume":"12","author":"U Oberlander","year":"2011","unstructured":"Oberlander U, Pletinckx K, Dohler A, Muller N, Lutz MB, Arzberger T et al. Neuromelanin is an immune stimulator for dendritic cells in vitro. BMC neuroscience 2011; 12: 116.","journal-title":"BMC neuroscience"},{"key":"BFcddis2013126_CR31","doi-asserted-by":"publisher","first-page":"42959","DOI":"10.1074\/jbc.M111.295758","volume":"286","author":"C Garbers","year":"2011","unstructured":"Garbers C, Thaiss W, Jones GW, Waetzig GH, Lorenzen I, Guilhot F et al. Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor. J Biol Chem 2011; 286: 42959\u201342970.","journal-title":"J Biol Chem"},{"key":"BFcddis2013126_CR32","doi-asserted-by":"publisher","first-page":"5565","DOI":"10.1523\/JNEUROSCI.0815-06.2006","volume":"26","author":"Z Cao","year":"2006","unstructured":"Cao Z, Gao Y, Bryson JB, Hou J, Chaudhry N, Siddiq M et al. The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth. J Neurosci 2006; 26: 5565\u20135573.","journal-title":"J Neurosci"},{"key":"BFcddis2013126_CR33","doi-asserted-by":"publisher","first-page":"4432","DOI":"10.1523\/JNEUROSCI.2245-02.2004","volume":"24","author":"WB Cafferty","year":"2004","unstructured":"Cafferty WB, Gardiner NJ, Das P, Qiu J, McMahon SB, Thompson SW . Conditioning injury-induced spinal axon regeneration fails in interleukin-6 knock-out mice. J Neurosci 2004; 24: 4432\u20134443.","journal-title":"J Neurosci"},{"key":"BFcddis2013126_CR34","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.expneurol.2012.03.019","volume":"236","author":"P Yang","year":"2012","unstructured":"Yang P, Wen H, Ou S, Cui J, Fan D . IL-6 promotes regeneration and functional recovery after cortical spinal tract injury by reactivating intrinsic growth program of neurons and enhancing synapse formation. Exp Neurol 2012; 236: 19\u201327.","journal-title":"Exp Neurol"},{"key":"BFcddis2013126_CR35","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1111\/j.1471-4159.2006.04257.x","volume":"100","author":"D Hakkoum","year":"2007","unstructured":"Hakkoum D, Stoppini L, Muller D . Interleukin-6 promotes sprouting and functional recovery in lesioned organotypic hippocampal slice cultures. J Neurochem 2007; 100: 747\u2013757.","journal-title":"J Neurochem"},{"key":"BFcddis2013126_CR36","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.1523\/JNEUROSCI.4885-10.2011","volume":"31","author":"V Sengottuvel","year":"2011","unstructured":"Sengottuvel V, Leibinger M, Pfreimer M, Andreadaki A, Fischer D . Taxol facilitates axon regeneration in the mature CNS. J Neurosci 2011; 31: 2688\u20132699.","journal-title":"J Neurosci"},{"key":"BFcddis2013126_CR37","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.mcn.2009.03.002","volume":"41","author":"A Muller","year":"2009","unstructured":"Muller A, Hauk TG, Leibinger M, Marienfeld R, Fischer D . Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF. Mol Cell Neurosci 2009; 41: 233\u2013246.","journal-title":"Mol Cell Neurosci"},{"key":"BFcddis2013126_CR38","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jaut.2012.08.002","volume":"40","author":"UK Samavedam","year":"2012","unstructured":"Samavedam UK, Kalies K, Scheller J, Sadeghi H, Gupta Y, Jonkman MF et al. Recombinant IL-6 treatment protects mice from organ specific autoimmune disease by IL-6 classical signalling-dependent IL-1ra induction. J Autoimmun 2012; 40: 74\u201385.","journal-title":"J Autoimmun"},{"key":"BFcddis2013126_CR39","doi-asserted-by":"publisher","first-page":"5244","DOI":"10.1021\/bi0263311","volume":"42","author":"D Aasland","year":"2003","unstructured":"Aasland D, Schuster B, Grotzinger J, Rose-John S, Kallen KJ . Analysis of the leukemia inhibitory factor receptor functional domains by chimeric receptors and cytokines. Biochemistry 2003; 42: 5244\u20135252.","journal-title":"Biochemistry"},{"key":"BFcddis2013126_CR40","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/nbt0297-142","volume":"15","author":"M Fischer","year":"1997","unstructured":"Fischer M, Goldschmitt J, Peschel C, Brakenhoff JP, Kallen KJ, Wollmer A et al. I. A bioactive designer cytokine for human hematopoietic progenitor cell expansion. Nat Biotechnol 1997; 15: 142\u2013145.","journal-title":"Nat Biotechnol"},{"issue":"Pt 2","key":"BFcddis2013126_CR41","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1042\/bj3340297","volume":"334","author":"PC Heinrich","year":"1998","unstructured":"Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graeve L . Interleukin-6-type cytokine signalling through the gp130\/Jak\/STAT pathway. Biochem J 1998; 334 (Pt 2): 297\u2013314.","journal-title":"Biochem J"},{"issue":"Pt 1","key":"BFcddis2013126_CR42","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1093\/brain\/awm284","volume":"131","author":"P Lingor","year":"2008","unstructured":"Lingor P, T\u00f6nges L, Pieper N, Bermel C, Barski E, Planchamp V et al. ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells. Brain 2008; 131 (Pt 1): 250\u2013263.","journal-title":"Brain"},{"key":"BFcddis2013126_CR43","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/neu.20117","volume":"63","author":"BA van Adel","year":"2005","unstructured":"van Adel BA, Arnold JM, Phipps J, Doering LC, Ball AK . Ciliary neurotrophic factor protects retinal ganglion cells from axotomy-induced apoptosis via modulation of retinal glia in vivo. J Neurobiol 2005; 63: 215\u2013234.","journal-title":"J Neurobiol"},{"key":"BFcddis2013126_CR44","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.mcn.2009.04.002","volume":"41","author":"KK Park","year":"2009","unstructured":"Park KK, Hu Y, Muhling J, Pollett MA, Dallimore EJ, Turnley AM et al. Cytokine-induced SOCS expression is inhibited by cAMP analogue: impact on regeneration in injured retina. Mol Cell Neurosci 2009; 41: 313\u2013324.","journal-title":"Mol Cell Neurosci"},{"key":"BFcddis2013126_CR45","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0301-0082(97)00021-X","volume":"52","author":"RA Gadient","year":"1997","unstructured":"Gadient RA, Otten UH . Interleukin-6 (IL-6)--a molecule with both beneficial and destructive potentials. Prog Neurobiol 1997; 52: 379\u2013390.","journal-title":"Prog Neurobiol"},{"key":"BFcddis2013126_CR46","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1038\/jcbfm.2008.141","volume":"29","author":"S Suzuki","year":"2009","unstructured":"Suzuki S, Tanaka K, Suzuki N . Ambivalent aspects of interleukin-6 in cerebral ischemia: inflammatory versus neurotrophic aspects. J Cereb Blood Flow Metab 2009; 29: 464\u2013479.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFcddis2013126_CR47","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.nbd.2012.07.026","volume":"48","author":"G Chidlow","year":"2012","unstructured":"Chidlow G, Wood JP, Ebneter A, Casson RJ . Interleukin-6 is an efficacious marker of axonal transport disruption during experimental glaucoma and stimulates neuritogenesis in cultured retinal ganglion cells. Neurobiol Dis 2012; 48: 568\u2013581.","journal-title":"Neurobiol Dis"},{"key":"BFcddis2013126_CR48","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.expneurol.2009.12.032","volume":"223","author":"KK Park","year":"2010","unstructured":"Park KK, Liu K, Hu Y, Kanter JL, He Z . PTEN\/mTOR and axon regeneration. Exp Neurol 2010; 223: 45\u201350.","journal-title":"Exp Neurol"},{"key":"BFcddis2013126_CR49","doi-asserted-by":"publisher","first-page":"391","DOI":"10.4161\/cib.15552","volume":"4","author":"V Sengottuvel","year":"2011","unstructured":"Sengottuvel V, Fischer D . Facilitating axon regeneration in the injured CNS by microtubules stabilization. Commun Integr Biol 2011; 4: 391\u2013393.","journal-title":"Commun Integr Biol"},{"key":"BFcddis2013126_CR50","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.1167\/iovs.05-1407","volume":"47","author":"RM Sappington","year":"2006","unstructured":"Sappington RM, Chan M, Calkins DJ . Interleukin-6 protects retinal ganglion cells from pressure-induced death. Invest Ophthalmol Vis Sci 2006; 47: 2932\u20132942.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFcddis2013126_CR51","doi-asserted-by":"publisher","first-page":"3860","DOI":"10.1167\/iovs.05-1408","volume":"47","author":"RM Sappington","year":"2006","unstructured":"Sappington RM, Calkins DJ . Pressure-induced regulation of IL-6 in retinal glial cells: involvement of the ubiquitin\/proteasome pathway and NFkappaB. Invest Ophthalmol Vis Sci 2006; 47: 3860\u20133869.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFcddis2013126_CR52","doi-asserted-by":"publisher","first-page":"8726","DOI":"10.1523\/JNEUROSCI.2774-04.2004","volume":"24","author":"D Fischer","year":"2004","unstructured":"Fischer D, Petkova V, Thanos S, Benowitz LI . Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation. J Neurosci 2004; 24: 8726\u20138740.","journal-title":"J Neurosci"},{"key":"BFcddis2013126_CR53","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.nbd.2012.11.011","volume":"51","author":"V Pernet","year":"2013","unstructured":"Pernet V, Joly S, Dalkara D, Jordi N, Schwarz O, Christ F et al. Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve. Neurobiol Dis 2013; 51: 202\u2013213.","journal-title":"Neurobiol Dis"},{"key":"BFcddis2013126_CR54","doi-asserted-by":"publisher","first-page":"8066","DOI":"10.1523\/JNEUROSCI.2111-05.2005","volume":"25","author":"MP Steinmetz","year":"2005","unstructured":"Steinmetz MP, Horn KP, Tom VJ, Miller JH, Busch SA, Nair D et al. Chronic enhancement of the intrinsic growth capacity of sensory neurons combined with the degradation of inhibitory proteoglycans allows functional regeneration of sensory axons through the dorsal root entry zone in the mammalian spinal cord. J Neurosci 2005; 25: 8066\u20138076.","journal-title":"J Neurosci"},{"key":"BFcddis2013126_CR55","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.expneurol.2011.04.017","volume":"233","author":"R Harel","year":"2012","unstructured":"Harel R, Iannotti CA, Hoh D, Clark M, Silver J, Steinmetz MP . Oncomodulin affords limited regeneration to injured sensory axons in vitro and in vivo. Exp Neurol 2012; 233: 708\u2013716.","journal-title":"Exp Neurol"},{"key":"BFcddis2013126_CR56","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.mcn.2009.03.002","volume":"41","author":"A M\u00fcller","year":"2009","unstructured":"M\u00fcller A, Hauk TG, Leibinger M, Marienfeld R, Fischer D . Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF. Mol Cell Neurosci 2009; 41: 233\u2013246.","journal-title":"Mol Cell Neurosci"},{"key":"BFcddis2013126_CR57","first-page":"22","volume":"Chapter 3","author":"V Grozdanov","year":"2010","unstructured":"Grozdanov V, Muller A, Sengottuvel V, Leibinger M, Fischer D . A method for preparing primary retinal cell cultures for evaluating the neuroprotective and neuritogenic effect of factors on axotomized mature CNS neurons. Curr Protoc Neurosci 2010; Chapter 3: 22.","journal-title":"Curr Protoc Neurosci"},{"key":"BFcddis2013126_CR58","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1096\/fj.05-5339fje","volume":"20","author":"Z Ahmed","year":"2006","unstructured":"Ahmed Z, Mazibrada G, Seabright RJ, Dent RG, Berry M, Logan A . TACE-induced cleavage of NgR and p75NTR in dorsal root ganglion cultures disinhibits outgrowth and promotes branching of neurites in the presence of inhibitory CNS myelin. FASEB J 2006; 20: 1939\u20131941.","journal-title":"FASEB J"},{"key":"BFcddis2013126_CR59","doi-asserted-by":"publisher","first-page":"4623","DOI":"10.1523\/JNEUROSCI.17-12-04623.1997","volume":"17","author":"AE Fournier","year":"1997","unstructured":"Fournier AE, McKerracher L . Expression of specific tubulin isotypes increases during regeneration of injured CNS neurons, but not after the application of brain-derived neurotrophic factor (BDNF). J Neurosci 1997; 17: 4623\u20134632.","journal-title":"J Neurosci"},{"key":"BFcddis2013126_CR60","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1523\/JNEUROSCI.5119-03.2004","volume":"24","author":"D Fischer","year":"2004","unstructured":"Fischer D, He Z, Benowitz LI . Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state. J Neurosci 2004; 24: 1646\u20131651.","journal-title":"J Neurosci"}],"container-title":["Cell Death & Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis2013126.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis2013126","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2013126.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:06:06Z","timestamp":1672963566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis2013126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,25]]},"references-count":60,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4]]}},"alternative-id":["BFcddis2013126"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2013.126","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,25]]},"assertion":[{"value":"7 January 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}