{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:46:14Z","timestamp":1789141574026,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T00:00:00Z","timestamp":1369872000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2013.161","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T14:13:19Z","timestamp":1369923199000},"page":"e649-e649","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["A critical role of toll-like receptor 4 (TLR4) and its\u2019 in vivo ligands in basal radio-resistance"],"prefix":"10.1038","volume":"4","author":[{"given":"C","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R EJ","family":"Mitchel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,30]]},"reference":[{"key":"BFcddis2013161_CR1","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/nrc1735","volume":"5","author":"MH Barcellos-Hoff","year":"2005","unstructured":"Barcellos-Hoff MH, Park C, Wright EG . Radiation and the microenvironment\u2014tumorigenesis and therapy. Nat Rev Cancer 2005; 5: 867\u2013875.","journal-title":"Nat Rev Cancer"},{"key":"BFcddis2013161_CR2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/nrclinonc.2010.207","volume":"8","author":"J Thoms","year":"2011","unstructured":"Thoms J, Goda JS, Zlotta AR, Fleshner NE, van der Kwast TH, Supiot S et al. Neoadjuvant radiotherapy for locally advanced and high-risk prostate cancer. Nat Rev Clin Oncol 2011; 8: 107\u2013113.","journal-title":"Nat Rev Clin Oncol"},{"key":"BFcddis2013161_CR3","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/nrclinonc.2010.138","volume":"7","author":"PJ Eifel","year":"2010","unstructured":"Eifel PJ . Radiotherapy: intermediate-risk endometrial cancer\u2014adjuvant treatment. Nat Rev Clin Oncol 2010; 7: 553\u2013554.","journal-title":"Nat Rev Clin Oncol"},{"key":"BFcddis2013161_CR4","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1126\/science.1154986","volume":"320","author":"LG Burdelya","year":"2008","unstructured":"Burdelya LG, Krivokrysenko VI, Tallant TC, Strom E, Gleiberman AS, Gupta D et al. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 2008; 320: 226\u2013230.","journal-title":"Science"},{"key":"BFcddis2013161_CR5","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1126\/science.1166202","volume":"327","author":"DG Kirsch","year":"2010","unstructured":"Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T et al. p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science 2010; 327: 593\u2013596.","journal-title":"Science"},{"key":"BFcddis2013161_CR6","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.freeradbiomed.2004.04.029","volume":"37","author":"JH Lee","year":"2004","unstructured":"Lee JH, Park JW . A manganese porphyrin complex is a novel radiation protector. Free Radic Biol Med 2004; 37: 272\u2013283.","journal-title":"Free Radic Biol Med"},{"key":"BFcddis2013161_CR7","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.freeradbiomed.2006.09.016","volume":"42","author":"JH Lee","year":"2007","unstructured":"Lee JH, Park JW . Oxalomalate regulates ionizing radiation-induced apoptosis in mice. Free Radic Biol Med 2007; 42: 44\u201351.","journal-title":"Free Radic Biol Med"},{"key":"BFcddis2013161_CR8","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/35100529","volume":"1","author":"R Medzhitov","year":"2001","unstructured":"Medzhitov R . Toll-like receptors and innate immunity. Nat Rev Immunol 2001; 1: 135\u2013145.","journal-title":"Nat Rev Immunol"},{"key":"BFcddis2013161_CR9","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1126\/science.1085536","volume":"300","author":"GM Barton","year":"2003","unstructured":"Barton GM, Medzhitov R . Toll-like receptor signaling pathways. Science 2003; 300: 1524\u20131525.","journal-title":"Science"},{"key":"BFcddis2013161_CR10","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nri1391","volume":"4","author":"S Akira","year":"2004","unstructured":"Akira S, Takeda K . Toll-like receptor signalling. Nat Rev Immunol 2004; 4: 499\u2013511.","journal-title":"Nat Rev Immunol"},{"key":"BFcddis2013161_CR11","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/nri1957","volume":"6","author":"A Marshak-Rothstein","year":"2006","unstructured":"Marshak-Rothstein A . Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol 2006; 6: 823\u2013835.","journal-title":"Nat Rev Immunol"},{"key":"BFcddis2013161_CR12","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1002\/eji.200838907","volume":"39","author":"L Janot","year":"2009","unstructured":"Janot L, Sirard JC, Secher T, Noulin N, Fick L, Akira S et al. Radioresistant cells expressing TLR5 control the respiratory epithelium\u2019s innate immune responses to flagellin. Eur J Immunol 2009; 39: 1587\u20131596.","journal-title":"Eur J Immunol"},{"key":"BFcddis2013161_CR13","doi-asserted-by":"publisher","first-page":"8280","DOI":"10.4049\/jimmunol.180.12.8280","volume":"180","author":"M Vijay-Kumar","year":"2008","unstructured":"Vijay-Kumar M, Aitken JD, Sanders CJ, Frias A, Sloane VM, Xu J et al. Flagellin treatment protects against chemicals, bacteria, viruses, and radiation. J Immunol 2008; 180: 8280\u20138285.","journal-title":"J Immunol"},{"key":"BFcddis2013161_CR14","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1667\/RR1931.1","volume":"173","author":"D Schaue","year":"2010","unstructured":"Schaue D, McBride WH . Links between innate immunity and normal tissue radiobiology. Radiat Res Apr 2010; 173: 406\u2013417.","journal-title":"Radiat Res Apr"},{"key":"BFcddis2013161_CR15","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/nri2079","volume":"7","author":"LA O\u2019Neill","year":"2007","unstructured":"O\u2019Neill LA, Bowie AG . The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 2007; 7: 353\u2013364.","journal-title":"Nat Rev Immunol"},{"key":"BFcddis2013161_CR16","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1111\/j.1365-2249.2004.02464.x","volume":"136","author":"B Schmausser","year":"2004","unstructured":"Schmausser B, Andrulis M, Endrich S, Lee SK, Josenhans C, Muller-Hermelink HK et al. Expression and subcellular distribution of toll-like receptors TLR4, TLR5 and TLR9 on the gastric epithelium in Helicobacter pylori infection. Clin Exp Immunol 2004; 136: 521\u2013526.","journal-title":"Clin Exp Immunol"},{"key":"BFcddis2013161_CR17","doi-asserted-by":"publisher","first-page":"240365","DOI":"10.1155\/2010\/240365","volume":"2010","author":"M Yamamoto","year":"2010","unstructured":"Yamamoto M, Takeda K . Current views of toll-like receptor signaling pathways. Gastroenterol Res Pract 2010; 2010: 240365.","journal-title":"Gastroenterol Res Pract"},{"key":"BFcddis2013161_CR18","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.cell.2004.07.002","volume":"118","author":"S Rakoff-Nahoum","year":"2004","unstructured":"Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R . Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004; 118: 229\u2013241.","journal-title":"Cell"},{"key":"BFcddis2013161_CR19","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1126\/science.1077336","volume":"298","author":"S Fagarasan","year":"2002","unstructured":"Fagarasan S, Muramatsu M, Suzuki K, Nagaoka H, Hiai H, Honjo T . Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Science 2002; 298: 1424\u20131427.","journal-title":"Science"},{"key":"BFcddis2013161_CR20","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1093\/jn\/135.10.2411","volume":"135","author":"SM Kuo","year":"2005","unstructured":"Kuo SM, Tan CH, Dragan M, Wilson JX . Endotoxin increases ascorbate recycling and concentration in mouse liver. J Nutr 2005; 135: 2411\u20132416.","journal-title":"J Nutr"},{"key":"BFcddis2013161_CR21","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/1423-0127-16-74","volume":"16","author":"Y Yao","year":"2009","unstructured":"Yao Y, Zhang F, Wang L, Zhang G, Wang Z, Chen J et al. Lipopolysaccharide preconditioning enhances the efficacy of mesenchymal stem cells transplantation in a rat model of acute myocardial infarction. J Biomed Sci 2009; 16: 74.","journal-title":"J Biomed Sci"},{"key":"BFcddis2013161_CR22","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1038\/leu.2011.113","volume":"25","author":"C Liu","year":"2011","unstructured":"Liu C, Gao F, Li B, Mitchel RE, Liu X, Lin J et al. TLR4 knockout protects mice from radiation-induced thymic lymphoma by downregulation of IL6 and miR-21. Leukemia 2011; 25: 1516\u20131519.","journal-title":"Leukemia"},{"key":"BFcddis2013161_CR23","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.immuni.2006.10.014","volume":"25","author":"H An","year":"2006","unstructured":"An H, Zhao W, Hou J, Zhang Y, Xie Y, Zheng Y et al. SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production. Immunity 2006; 25: 919\u2013928.","journal-title":"Immunity"},{"key":"BFcddis2013161_CR24","doi-asserted-by":"publisher","first-page":"347","DOI":"10.7150\/ijbs.7.347","volume":"7","author":"C Liu","year":"2011","unstructured":"Liu C, Li B, Cheng Y, Lin J, Hao J, Zhang S et al. MiR-21 plays an important role in radiation induced carcinogenesis in BALB\/c mice by directly targeting the tumor suppressor gene Big-h3. Int J Biol Sci 2011; 7: 347\u2013363.","journal-title":"Int J Biol Sci"},{"key":"BFcddis2013161_CR25","doi-asserted-by":"publisher","first-page":"221","DOI":"10.7150\/ijbs.7.221","volume":"7","author":"C Liu","year":"2011","unstructured":"Liu C, Zhou C, Gao F, Cai S, Zhang C, Zhao L et al. MiR-34a in age and tissue related radio-sensitivity and serum miR-34a as a novel indicator of radiation injury. Int J Biol Sci 2011; 7: 221\u2013233.","journal-title":"Int J Biol Sci"},{"key":"BFcddis2013161_CR26","doi-asserted-by":"publisher","first-page":"168","DOI":"10.7150\/ijbs.7.168","volume":"7","author":"C Liu","year":"2011","unstructured":"Liu C, Lin J, Zhao L, Yang Y, Gao F, Li B et al. Gamma-ray irradiation impairs dendritic cell migration to CCL19 by down-regulation of CCR7 and induction of cell apoptosis. Int J Biol Sci 2011; 7: 168\u2013179.","journal-title":"Int J Biol Sci"},{"key":"BFcddis2013161_CR27","first-page":"390","volume":"401","author":"E Gussoni","year":"1999","unstructured":"Gussoni E, Soneoka Y, Strickland CD, Buzney EA, Khan MK, Flint AF et al. Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature 1999; 401: 390\u2013394.","journal-title":"Nature"},{"key":"BFcddis2013161_CR28","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1172\/JCI32205","volume":"117","author":"CM Paulos","year":"2007","unstructured":"Paulos CM, Wrzesinski C, Kaiser A, Hinrichs CS, Chieppa M, Cassard L et al. Microbial translocation augments the function of adoptively transferred self\/tumor-specific CD8+ T cells via TLR4 signaling. J Clin Invest 2007; 117: 2197\u20132204.","journal-title":"J Clin Invest"},{"key":"BFcddis2013161_CR29","doi-asserted-by":"publisher","first-page":"38969","DOI":"10.1074\/jbc.M509352200","volume":"280","author":"HY Qi","year":"2005","unstructured":"Qi HY, Shelhamer JH . Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopolysaccharide-stimulated macrophages. J Biol Chem 2005; 280: 38969\u201338975.","journal-title":"J Biol Chem"},{"key":"BFcddis2013161_CR30","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/ni.1604","volume":"9","author":"H An","year":"2008","unstructured":"An H, Hou J, Zhou J, Zhao W, Xu H, Zheng Y et al. Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1. Nat Immunol 2008; 9: 542\u2013550.","journal-title":"Nat Immunol"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis2013161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis2013161","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2013161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T23:53:50Z","timestamp":1672962830000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis2013161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,30]]},"references-count":30,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5]]}},"alternative-id":["BFcddis2013161"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2013.161","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,30]]},"assertion":[{"value":"23 February 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}