{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:33:30Z","timestamp":1789385610678,"version":"build-2803163510"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T00:00:00Z","timestamp":1370476800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2013.186","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T14:20:08Z","timestamp":1370528408000},"page":"e654-e654","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1"],"prefix":"10.1038","volume":"4","author":[{"given":"H","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,6,6]]},"reference":[{"key":"BFcddis2013186_CR1","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0022-2836(03)00307-3","volume":"328","author":"PM Coutinho","year":"2003","unstructured":"Coutinho PM, Deleury E, Davies GJ, Henrissat B . An evolving hierarchical family classification for glycosyltransferases. J Mol Biol 2003; 328: 307\u2013317.","journal-title":"J Mol Biol"},{"key":"BFcddis2013186_CR2","doi-asserted-by":"publisher","first-page":"415","DOI":"10.3892\/etm.2011.430","volume":"3","author":"X Kang","year":"2012","unstructured":"Kang X, Wang N, Pei C, Sun L, Sun R, Chen J et al. Glycan-related gene expression signatures in human metastatic hepatocellular carcinoma cells. Exp Ther Med 2012; 3: 415\u2013422.","journal-title":"Exp Ther Med"},{"key":"BFcddis2013186_CR3","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s12038-010-0073-8","volume":"35","author":"M Li","year":"2010","unstructured":"Li M, Song L, Qin X . Glycan changes: cancer metastasis and anti-cancer vaccines. J Biosci 2010; 35: 665\u2013673.","journal-title":"J Biosci"},{"key":"BFcddis2013186_CR4","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1476-4598-6-32","volume":"6","author":"T Kudo","year":"2007","unstructured":"Kudo T, Nakagawa H, Takahashi M, Hamaguchi J, Kamiyama N, Yokoo H et al. N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma. Mol Cancer 2007; 6: 32\u201340.","journal-title":"Mol Cancer"},{"key":"BFcddis2013186_CR5","doi-asserted-by":"publisher","first-page":"M111.009001","DOI":"10.1074\/mcp.M111.009001","volume":"10","author":"M Nakano","year":"2011","unstructured":"Nakano M, Saldanha R, G\u00f6bel A, Kavallaris M, Packer NH . Identification of glycan structure alterations on cell membrane proteins in desoxyepothilone B resistant leukemia cells. Mol Cell Proteomics 2011; 10: M111.009001.","journal-title":"Mol Cell Proteomics"},{"key":"BFcddis2013186_CR6","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1016\/j.biocel.2012.04.026","volume":"44","author":"Z Zhang","year":"2012","unstructured":"Zhang Z, Zhao Y, Jiang L, Miao X, Zhou H, Jia L . Glycomic alterations are associated with multidrug resistance in human leukemia. Int J Biochem Cell Biol 2012; 44: 1244\u20131253.","journal-title":"Int J Biochem Cell Biol"},{"key":"BFcddis2013186_CR7","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0304-4165(99)00168-3","volume":"1473","author":"M Amado","year":"1999","unstructured":"Amado M, Almeida R, Schwientek T, Clausen H . Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. Biochim Biophys Acta 1999; 1473: 35\u201353.","journal-title":"Biochim Biophys Acta"},{"key":"BFcddis2013186_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cellimm.2009.08.004","volume":"262","author":"Y Han","year":"2010","unstructured":"Han Y, Zhou X, Ji Y, Shen A, Sun X, Hu Y et al. Expression of beta-1,4-galactosyltransferase-I affects cellular adhesion in human peripheral blood CD4+ T cells. Cell Immunol 2010; 262: 11\u201317.","journal-title":"Cell Immunol"},{"key":"BFcddis2013186_CR9","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1159\/000016805","volume":"168","author":"B Nixon","year":"2001","unstructured":"Nixon B, Lu Q, Wassler MJ, Foote CI, Ensslin MA, Shur BD . Galactosyltransferase function during mammalian fertilization. Cells Tissues Organs 2001; 168: 46\u201357.","journal-title":"Cells Tissues Organs"},{"key":"BFcddis2013186_CR10","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1046\/j.1471-4159.2001.00004.x","volume":"76","author":"N Nakamura","year":"2001","unstructured":"Nakamura N, Yamakawa N, Sato T, Tojo H, Tachi C, Furukawa K . Differential gene expression of beta-1,4-galactosyltransferases I, II and V during mouse brain development. J Neurochem 2001; 76: 29\u201338.","journal-title":"J Neurochem"},{"key":"BFcddis2013186_CR11","doi-asserted-by":"publisher","first-page":"46280","DOI":"10.1074\/jbc.M203873200","volume":"277","author":"Y Nakamura","year":"2002","unstructured":"Nakamura Y, Haines N, Chen J, Okajima T, Furukawa K, Urano T et al. Identification of a Drosophila gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis. J Biol Chem 2002; 277: 46280\u201346288.","journal-title":"J Biol Chem"},{"key":"BFcddis2013186_CR12","doi-asserted-by":"publisher","first-page":"12503","DOI":"10.1074\/jbc.M413631200","volume":"280","author":"X Zhu","year":"2005","unstructured":"Zhu X, Jiang J, Shen H, Wang H, Zong H, Li Z et al. Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator. J Biol Chem 2005; 280: 12503\u201312516.","journal-title":"J Biol Chem"},{"key":"BFcddis2013186_CR13","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.bbrc.2012.08.140","volume":"426","author":"HJ Choi","year":"2012","unstructured":"Choi HJ, Chung TW, Kim CH, Jeong HS, Joo M, Youn B et al. Estrogen induced \u03b2-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer MCF-7 cells. Biochem Biophys Res Commun 2012; 426: 620\u2013625.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcddis2013186_CR14","first-page":"330","volume":"35","author":"JE Park","year":"2002","unstructured":"Park JE, Lee KY, Do SI, Lee SS . Expression and characterization of beta-1,4-galactosyltransferase from Neisseria meningitidis and Neisseria gonorrhoeae. J Biochem Mol Biol 2002; 35: 330\u2013336.","journal-title":"J Biochem Mol Biol"},{"key":"BFcddis2013186_CR15","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s10719-008-9129-5","volume":"25","author":"M Yan","year":"2008","unstructured":"Yan M, Cheng C, Ding F, Jiang J, Gao L, Xia C et al. The expression patterns of beta1,4 galactosyltransferase I and V mRNAs, and Galbeta1-4GlcNAc group in rat gastrocnemius muscles post sciatic nerve injury. Glycoconj J 2008; 25: 685\u2013701.","journal-title":"Glycoconj J"},{"key":"BFcddis2013186_CR16","doi-asserted-by":"publisher","first-page":"3330","DOI":"10.1002\/jcb.24209","volume":"113","author":"S Villegas-Comonfort","year":"2012","unstructured":"Villegas-Comonfort S, Serna-Marquez N, Galindo-Hernandez O, Navarro-Tito N, Salazar EP . Arachidonic acid induces an increase of \u03b2-1,4-galactosyltransferase I expression in MDA-MB-231 breast cancer cells. J Cell Biochem 2012; 113: 3330\u20133341.","journal-title":"J Cell Biochem"},{"key":"BFcddis2013186_CR17","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1634\/stemcells.2007-1080","volume":"26","author":"MJ Wassler","year":"2008","unstructured":"Wassler MJ, Shur BD, Zhou W, Geng YJ . Characterization of a novel ubiquitin-conjugating enzyme that regulates beta1,4-galactosyltransferase-1 in embryonic stem cells. Stem Cells 2008; 26: 2006\u20132018.","journal-title":"Stem Cells"},{"key":"BFcddis2013186_CR18","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.canlet.2008.03.019","volume":"267","author":"Y Wei","year":"2008","unstructured":"Wei Y, Liu D, Ge Y, Zhou F, Xu J, Chen H et al. Down-regulation of beta1,4GalT V at protein level contributes to arsenic trioxide-induced glioma cell apoptosis. Cancer Lett 2008; 267: 96\u2013105.","journal-title":"Cancer Lett"},{"key":"BFcddis2013186_CR19","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1038\/nrc1229","volume":"3","author":"M Pasca di Magliano","year":"2003","unstructured":"Pasca di Magliano M, Hebrok M . Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer 2003; 3: 903\u2013911.","journal-title":"Nat Rev Cancer"},{"key":"BFcddis2013186_CR20","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1093\/jjco\/hyq217","volume":"41","author":"W Zhu","year":"2011","unstructured":"Zhu W, You Z, Li T, Yu C, Tao G, Hu M et al. Correlation of hedgehog signal activation with chemoradiotherapy sensitivity and survival in esophageal squamous cell carcinomas. Jpn J Clin Oncol 2011; 41: 386\u2013393.","journal-title":"Jpn J Clin Oncol"},{"key":"BFcddis2013186_CR21","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jns.2009.09.006","volume":"288","author":"D Cui","year":"2010","unstructured":"Cui D, Xu Q, Wang K, Che X . Gli1 is a potential target for alleviating multidrug resistance of gliomas. J Neurol Sci 2010; 288: 156\u2013166.","journal-title":"J Neurol Sci"},{"key":"BFcddis2013186_CR22","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1111\/j.1349-7006.2009.01111.x","volume":"100","author":"M Kobune","year":"2009","unstructured":"Kobune M, Takimoto R, Murase K, Iyama S, Sato T, Kikuchi S et al. Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemia cells. Cancer Sci 2009; 100: 948\u2013955.","journal-title":"Cancer Sci"},{"key":"BFcddis2013186_CR23","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/clpt.2008.195","volume":"85","author":"KS Fenner","year":"2009","unstructured":"Fenner KS, Troutman MD, Kempshall S, Cook JA, Ware JA, Smith DA et al. Drug-drug Interactions mediated through p-glycoprotein: clinical relevance and in vitro-in vivo correlation using digoxin as a probe drug. Clin Pharmacol Ther 2009; 85: 173\u2013181.","journal-title":"Clin Pharmacol Ther"},{"key":"BFcddis2013186_CR24","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1152\/physrev.00035.2005","volume":"86","author":"RG Deeley","year":"2006","unstructured":"Deeley RG, Westlake C, Cole SP . Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol Rev 2006; 86: 849\u2013899.","journal-title":"Physiol Rev"},{"key":"BFcddis2013186_CR25","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1002\/iub.1080","volume":"64","author":"H Zhou","year":"2012","unstructured":"Zhou H, Zhang Z, Liu C, Jin C, Zhang J, Miao X et al. B4GALT1 gene knockdown inhibits the hedgehog pathway and reverses multidrug resistance in the human leukemia K562\/adriamycin-resistant cell line. IUBMB Life 2012; 64: 889\u2013900.","journal-title":"IUBMB Life"},{"key":"BFcddis2013186_CR26","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1002\/gcc.21998","volume":"51","author":"ML Poeta","year":"2012","unstructured":"Poeta ML, Massi E, Parrella P, Pellegrini P, De Robertis M, Copetti M et al. Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors. Genes Chromosomes Cancer 2012; 51: 1133\u20131143.","journal-title":"Genes Chromosomes Cancer"},{"key":"BFcddis2013186_CR27","doi-asserted-by":"publisher","first-page":"4952","DOI":"10.1074\/jbc.M805782200","volume":"284","author":"JR Brown","year":"2009","unstructured":"Brown JR, Yang F, Sinha A, Ramakrishnan B, Tor Y, Qasba PK et al. Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis. J Biol Chem 2009; 284: 4952\u20134959.","journal-title":"J Biol Chem"},{"key":"BFcddis2013186_CR28","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1093\/jb\/mvn003","volume":"143","author":"J Zhou","year":"2008","unstructured":"Zhou J, Wei Y, Liu D, Ge X, Zhou F, Jiang XY et al. Identification of beta1,4GalT II as a target gene of p53-mediated HeLa cell apoptosis. J Biochem 2008; 143: 547\u2013554.","journal-title":"J Biochem"},{"key":"BFcddis2013186_CR29","doi-asserted-by":"publisher","first-page":"8615","DOI":"10.1158\/1078-0432.CCR-05-1006","volume":"11","author":"WS Chen","year":"2005","unstructured":"Chen WS, Chang HY, Li CP, Liu JM, Huang TS . Tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis. Clin Cancer Res 2005; 11: 8615\u20138622.","journal-title":"Clin Cancer Res"},{"key":"BFcddis2013186_CR30","first-page":"409","volume":"21","author":"S Xu","year":"2002","unstructured":"Xu S, Zhang S, Chen C, Yan J, Cai M, Zhu X et al. Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line. J Exp Clin Cancer Res 2002; 21: 409\u2013414.","journal-title":"J Exp Clin Cancer Res"},{"key":"BFcddis2013186_CR31","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.bbrc.2010.04.110","volume":"396","author":"Y Wei","year":"2010","unstructured":"Wei Y, Zhou F, Ge Y, Chen H, Cui C, Li Q et al. Beta1,4-galactosyltransferase V regulates self-renewal of glioma-initiating cell. Biochem Biophys Res Commun 2010; 396: 602\u2013607.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcddis2013186_CR32","doi-asserted-by":"publisher","first-page":"37342","DOI":"10.1074\/jbc.M110.151951","volume":"285","author":"I Talhaoui","year":"2010","unstructured":"Talhaoui I, Bui C, Oriol R, Mulliert G, Gulberti S, Netter P et al. Identification of key functional residues in the active site of human {beta}1,4-galactosyltransferase 7: a major enzyme in the glycosaminoglycan synthesis pathway. J Biol Chem 2010; 285: 37342\u201337358.","journal-title":"J Biol Chem"},{"key":"BFcddis2013186_CR33","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/ajmg.a.30005","volume":"128A","author":"M Faiyaz-Ul-Haque","year":"2004","unstructured":"Faiyaz-Ul-Haque M, Zaidi SH, Al-Ali M, Al-Mureikhi MS, Kennedy S, Al-Thani G et al. A novel missense mutation in the galactosyltransferase-I (B4GALT7) gene in a family exhibiting facioskeletal anomalies and Ehlers-Danlos syndrome resembling the progeroid type. Am J Med Genet A 2004; 128A: 39\u201345.","journal-title":"Am J Med Genet A"},{"key":"BFcddis2013186_CR34","doi-asserted-by":"publisher","first-page":"2282","DOI":"10.1021\/pr201070k","volume":"11","author":"WR Alley Jr","year":"2012","unstructured":"Alley WR Jr, Vasseur JA, Goetz JA, Svoboda M, Mann BF, Matei DE et al. N-linked glycan structures and their expressions change in the blood sera of ovarian cancer patients. J Proteome Res 2012; 11: 2282\u20132300.","journal-title":"J Proteome Res"},{"key":"BFcddis2013186_CR35","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1002\/ijc.26288","volume":"130","author":"SY Park","year":"2012","unstructured":"Park SY, Lee SH, Kawasaki N, Itoh S, Kang K, Hee Ryu S et al. \u03b11-3\/4 fucosylation at Asn 241 of \u03b2-haptoglobin is a novel marker for colon cancer: a combinatorial approach for development of glycan biomarkers. Int J Cancer 2012; 130: 2366\u20132376.","journal-title":"Int J Cancer"},{"key":"BFcddis2013186_CR36","doi-asserted-by":"publisher","first-page":"M110.002717","DOI":"10.1074\/mcp.M110.002717","volume":"10","author":"ML de Leoz","year":"2011","unstructured":"de Leoz ML, Young LJ, An HJ, Kronewitter SR, Kim J, Miyamoto S et al. High-mannose glycans are elevated during breast cancer progression. Mol Cell Proteomics 2011; 10: M110.002717.","journal-title":"Mol Cell Proteomics"},{"key":"BFcddis2013186_CR37","doi-asserted-by":"publisher","first-page":"5811","DOI":"10.1158\/0008-5472.CAN-08-0289","volume":"69","author":"T Satomaa","year":"2009","unstructured":"Satomaa T, Heiskanen A, Leonardsson I, Angstr\u00f6m J, Olonen A, Blomqvist M et al. Analysis of the human cancer glycome identifies a novel group of tumor-associated N-acetylglucosamine glycan antigens. Cancer Res 2009; 69: 5811\u20135819.","journal-title":"Cancer Res"},{"key":"BFcddis2013186_CR38","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1007\/s00432-011-1016-y","volume":"137","author":"Y Baran","year":"2011","unstructured":"Baran Y, Bielawski J, Gunduz U, Ogretmen B . Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation. J Cancer Res Clin Oncol 2011; 137: 1535\u20131544.","journal-title":"J Cancer Res Clin Oncol"},{"key":"BFcddis2013186_CR39","doi-asserted-by":"publisher","first-page":"156","DOI":"10.4161\/cc.6.2.3745","volume":"6","author":"M Agathocleous","year":"2007","unstructured":"Agathocleous M, Locker M, Harris WA, Perron M . A general role of hedgehog in the regulation of proliferation. Cell Cycle 2007; 6: 156\u2013159.","journal-title":"Cell Cycle"},{"key":"BFcddis2013186_CR40","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1101\/gad.1190304","volume":"18","author":"J Jeong","year":"2004","unstructured":"Jeong J, Mao J, Tenzen T, Kottmann AH, McMahon AP . Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev 2004; 18: 937\u2013951.","journal-title":"Genes Dev"},{"key":"BFcddis2013186_CR41","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1093\/carcin\/bgi130","volume":"26","author":"X Ma","year":"2005","unstructured":"Ma X, Chen K, Huang S, Zhang X, Adegboyega PA, Evers BM et al. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis 2005; 26: 1698\u20131705.","journal-title":"Carcinogenesis"},{"key":"BFcddis2013186_CR42","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1158\/1535-7163.MCT-11-1058","volume":"11","author":"AD Steg","year":"2012","unstructured":"Steg AD, Katre AA, Bevis KS, Ziebarth A, Dobbin ZC, Shah MM et al. Smoothened antagonists reverse taxane resistance in ovarian cancer. Mol Cancer Ther 2012; 11: 1587\u20131597.","journal-title":"Mol Cancer Ther"},{"key":"BFcddis2013186_CR43","doi-asserted-by":"publisher","first-page":"5674","DOI":"10.1038\/sj.onc.1210356","volume":"26","author":"J Sims-Mourtada","year":"2007","unstructured":"Sims-Mourtada J, Izzo JG, Ajani J, Chao KS . Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport. Oncogene 2007; 26: 5674\u20135679.","journal-title":"Oncogene"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis2013186.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis2013186","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2013186.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:06:20Z","timestamp":1672963580000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis2013186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,6]]},"references-count":43,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6]]}},"alternative-id":["BFcddis2013186"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2013.186","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,6]]},"assertion":[{"value":"19 March 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}