{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:02:03Z","timestamp":1790539323977,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T00:00:00Z","timestamp":1371686400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2013.209","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T17:22:41Z","timestamp":1371748961000},"page":"e686-e686","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Survival motor neuron protein reduction deregulates autophagy in spinal cord motoneurons in vitro"],"prefix":"10.1038","volume":"4","author":[{"given":"A","family":"Garcera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Bahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Periyakaruppiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Arumugam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R M","family":"Soler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,6,20]]},"reference":[{"key":"BFcddis2013209_CR1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","volume":"80","author":"S Lefebvre","year":"1995","unstructured":"Lefebvre S, Burglen L, Reboullet S, Clermont O, Burlet P, Viollet L et al. Identification and characterization of a spinal muscular atrophy-determining gene. Cell 1995; 80: 155\u2013165.","journal-title":"Cell"},{"key":"BFcddis2013209_CR2","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/(SICI)1098-1004(200003)15:3<228::AID-HUMU3>3.0.CO;2-9","volume":"15","author":"B Wirth","year":"2000","unstructured":"Wirth B . An update of the mutation spectrum of the survival motor neuron gene (SMN1) in autosomal recessive spinal muscular atrophy (SMA). Hum Mutat 2000; 15: 228\u2013237.","journal-title":"Hum Mutat"},{"key":"BFcddis2013209_CR3","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.nurx.2006.01.010","volume":"3","author":"CJ Sumner","year":"2006","unstructured":"Sumner CJ . Therapeutics development for spinal muscular atrophy. NeuroRx 2006; 3: 235\u2013245.","journal-title":"NeuroRx"},{"key":"BFcddis2013209_CR4","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.cell.2008.03.031","volume":"133","author":"Z Zhang","year":"2008","unstructured":"Zhang Z, Lotti F, Dittmar K, Younis I, Wan L, Kasim M et al. SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing. Cell 2008; 133: 585\u2013600.","journal-title":"Cell"},{"key":"BFcddis2013209_CR5","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1093\/hmg\/11.12.1439","volume":"11","author":"C Cifuentes-Diaz","year":"2002","unstructured":"Cifuentes-Diaz C, Nicole S, Velasco ME, Borra-Cebrian C, Panozzo C, Frugier T et al. Neurofilament accumulation at the motor endplate and lack of axonal sprouting in a spinal muscular atrophy mouse model. Hum Mol Genet 2002; 11: 1439\u20131447.","journal-title":"Hum Mol Genet"},{"key":"BFcddis2013209_CR6","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1523\/JNEUROSCI.4434-08.2009","volume":"29","author":"L Kong","year":"2009","unstructured":"Kong L, Wang X, Choe DW, Polley M, Burnett BG, Bosch-Marce M et al. Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice. J Neurosci 2009; 29: 842\u2013851.","journal-title":"J Neurosci"},{"key":"BFcddis2013209_CR7","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1093\/hmg\/ddm367","volume":"17","author":"LM Murray","year":"2008","unstructured":"Murray LM, Comley LH, Thomson D, Parkinson N, Talbot K, Gillingwater TH . Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy. Hum Mol Genet 2008; 17: 949\u2013962.","journal-title":"Hum Mol Genet"},{"key":"BFcddis2013209_CR8","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1083\/jcb.200304128","volume":"163","author":"W Rossoll","year":"2003","unstructured":"Rossoll W, Jablonka S, Andreassi C, Kroning AK, Karle K, Monani UR et al. Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons. J Cell Biol 2003; 163: 801\u2013812.","journal-title":"J Cell Biol"},{"key":"BFcddis2013209_CR9","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1093\/brain\/awf155","volume":"125","author":"C Soler-Botija","year":"2002","unstructured":"Soler-Botija C, Ferrer I, Gich I, Baiget M, Tizzano EF . Neuronal death is enhanced and begins during foetal development in type I spinal muscular atrophy spinal cord 2002 Brain 125: 1624\u20131634.","journal-title":"Brain"},{"key":"BFcddis2013209_CR10","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.ymthe.2006.02.008","volume":"13","author":"MS Tsai","year":"2006","unstructured":"Tsai MS, Chiu YT, Wang SH, Hsieh-Li HM, Lian WC, Li H . Abolishing Bax-dependent apoptosis shows beneficial effects on spinal muscular atrophy model mice. Mol Ther 2006; 13: 1149\u20131155.","journal-title":"Mol Ther"},{"key":"BFcddis2013209_CR11","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/nature05293","volume":"443","author":"DE Bredesen","year":"2006","unstructured":"Bredesen DE, Rao RV, Mehlen P . Cell death in the nervous system. Nature 2006; 443: 796\u2013802.","journal-title":"Nature"},{"key":"BFcddis2013209_CR12","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.ceb.2010.10.001","volume":"23","author":"G Marino","year":"2011","unstructured":"Marino G, Madeo F, Kroemer G . Autophagy for tissue homeostasis and neuroprotection. Curr Opin Cell Biol 2011; 23: 198\u2013206.","journal-title":"Curr Opin Cell Biol"},{"key":"BFcddis2013209_CR13","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nature06639","volume":"451","author":"N Mizushima","year":"2008","unstructured":"Mizushima N, Levine B, Cuervo AM, Klionsky DJ . Autophagy fights disease through cellular self-digestion. Nature 2008; 451: 1069\u20131075.","journal-title":"Nature"},{"key":"BFcddis2013209_CR14","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/ng1362","volume":"36","author":"B Ravikumar","year":"2004","unstructured":"Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet 2004; 36: 585\u2013595.","journal-title":"Nat Genet"},{"key":"BFcddis2013209_CR15","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1126\/science.1101738","volume":"305","author":"AM Cuervo","year":"2004","unstructured":"Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D . Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 2004; 305: 1292\u20131295.","journal-title":"Science"},{"key":"BFcddis2013209_CR16","doi-asserted-by":"publisher","first-page":"6926","DOI":"10.1523\/JNEUROSCI.0800-08.2008","volume":"28","author":"B Boland","year":"2008","unstructured":"Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH et al. Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci 2008; 28: 6926\u20136937.","journal-title":"J Neurosci"},{"key":"BFcddis2013209_CR17","doi-asserted-by":"publisher","first-page":"8506","DOI":"10.1523\/JNEUROSCI.0924-09.2009","volume":"29","author":"JA Lee","year":"2009","unstructured":"Lee JA, Gao FB . Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementia. J Neurosci 2009; 29: 8506\u20138511.","journal-title":"J Neurosci"},{"key":"BFcddis2013209_CR18","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1111\/j.1750-3639.2011.00546.x","volume":"22","author":"S Chen","year":"2012","unstructured":"Chen S, Zhang X, Song L, Le W . Autophagy dysregulation in amyotrophic lateral sclerosis. Brain Pathol 2012; 22: 110\u2013116.","journal-title":"Brain Pathol"},{"key":"BFcddis2013209_CR19","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.nbd.2008.09.009","volume":"33","author":"H Kanno","year":"2009","unstructured":"Kanno H, Ozawa H, Sekiguchi A, Itoi E . Spinal cord injury induces upregulation of Beclin 1 and promotes autophagic cell death. Neurobiol Dis 2009; 33: 143\u2013148.","journal-title":"Neurobiol Dis"},{"key":"BFcddis2013209_CR20","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.1111\/j.1460-9568.2007.05914.x","volume":"26","author":"Y Yang","year":"2007","unstructured":"Yang Y, Fukui K, Koike T, Zheng X . Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons. Eur J Neurosci 2007; 26: 2979\u20132988.","journal-title":"Eur J Neurosci"},{"key":"BFcddis2013209_CR21","doi-asserted-by":"publisher","first-page":"243","DOI":"10.4161\/auto.5431","volume":"4","author":"Y Yang","year":"2008","unstructured":"Yang Y, Xu K, Koike T, Zheng X . Transport of autophagosomes in neurites of PC12 cells during serum deprivation. Autophagy 2008; 4: 243\u2013245.","journal-title":"Autophagy"},{"key":"BFcddis2013209_CR22","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.nbd.2011.02.003","volume":"42","author":"A Garcera","year":"2011","unstructured":"Garcera A, Mincheva S, Gou-Fabregas M, Caraballo-Miralles V, Llado J, Comella JX et al. A new model to study spinal muscular atrophy: neurite degeneration and cell death is counteracted by BCL-X(L) overexpression in motoneurons. Neurobiol Dis 2011; 42: 415\u2013426.","journal-title":"Neurobiol Dis"},{"key":"BFcddis2013209_CR23","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1016\/j.biocel.2004.02.005","volume":"36","author":"N Mizushima","year":"2004","unstructured":"Mizushima N . Methods for monitoring autophagy. Int J Biochem Cell Biol 2004; 36: 2491\u20132502.","journal-title":"Int J Biochem Cell Biol"},{"key":"BFcddis2013209_CR24","doi-asserted-by":"crossref","unstructured":"Menzies FM, Moreau K, Puri C, Renna M, Rubinsztein DC . Measurement of autophagic activity in mammalian cells. Curr Protoc Cell Biol 2012; Chapter 15 Unit15.16.","DOI":"10.1002\/0471143030.cb1516s54"},{"key":"BFcddis2013209_CR25","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1247\/csf.23.33","volume":"23","author":"A Yamamoto","year":"1998","unstructured":"Yamamoto A, Tagawa Y, Yoshimori T, Moriyama Y, Masaki R, Tashiro Y . Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct Funct 1998; 23: 33\u201342.","journal-title":"Cell Struct Funct"},{"key":"BFcddis2013209_CR26","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/cdd.2008.168","volume":"16","author":"CM Fader","year":"2009","unstructured":"Fader CM, Colombo MI . Autophagy and multivesicular bodies: two closely related partners. Cell Death Differ 2009; 16: 70\u201378.","journal-title":"Cell Death Differ"},{"key":"BFcddis2013209_CR27","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/path.2694","volume":"221","author":"S Barth","year":"2010","unstructured":"Barth S, Glick D, Macleod KF . Autophagy: assays and artifacts. J Pathol 2010; 221: 117\u2013124.","journal-title":"J Pathol"},{"key":"BFcddis2013209_CR28","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.cell.2005.07.002","volume":"122","author":"S Pattingre","year":"2005","unstructured":"Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122: 927\u2013939.","journal-title":"Cell"},{"key":"BFcddis2013209_CR29","doi-asserted-by":"publisher","first-page":"6398","DOI":"10.1038\/onc.2008.307","volume":"27","author":"KW Yip","year":"2008","unstructured":"Yip KW, Reed JC . Bcl-2 family proteins and cancer. Oncogene 2008; 27: 6398\u20136406.","journal-title":"Oncogene"},{"key":"BFcddis2013209_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0076-6879(08)03601-X","volume":"452","author":"S Kimura","year":"2009","unstructured":"Kimura S, Fujita N, Noda T, Yoshimori T . Monitoring autophagy in mammalian cultured cells through the dynamics of LC3. Methods Enzymol 2009; 452: 1\u201312.","journal-title":"Methods Enzymol"},{"key":"BFcddis2013209_CR31","doi-asserted-by":"publisher","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","volume":"19","author":"Y Kabeya","year":"2000","unstructured":"Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. Embo J 2000; 19: 5720\u20135728.","journal-title":"Embo J"},{"key":"BFcddis2013209_CR32","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1093\/embo-reports\/kve061","volume":"2","author":"A Kihara","year":"2001","unstructured":"Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T . Beclin-phosphatidylinositol 3-kinase complex functions at the trans-golgi network. EMBO Rep 2001; 2: 330\u2013335.","journal-title":"EMBO Rep"},{"key":"BFcddis2013209_CR33","doi-asserted-by":"publisher","first-page":"561","DOI":"10.4161\/auto.4713","volume":"3","author":"S Erlich","year":"2007","unstructured":"Erlich S, Mizrachy L, Segev O, Lindenboim L, Zmira O, Adi-Harel S et al. Differential interactions between Beclin 1 and Bcl-2 family members. Autophagy 2007; 3: 561\u2013568.","journal-title":"Autophagy"},{"key":"BFcddis2013209_CR34","doi-asserted-by":"publisher","first-page":"13123","DOI":"10.1074\/jbc.M700492200","volume":"282","author":"A Oberstein","year":"2007","unstructured":"Oberstein A, Jeffrey PD, Shi Y . Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem 2007; 282: 13123\u201313132.","journal-title":"J Biol Chem"},{"key":"BFcddis2013209_CR35","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/cdd.2010.191","volume":"18","author":"R Kang","year":"2011","unstructured":"Kang R, Zeh HJ, Lotze MT, Tang D . The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ 2011; 18: 571\u2013580.","journal-title":"Cell Death Differ"},{"key":"BFcddis2013209_CR36","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/embor.2008.246","volume":"10","author":"E Zalckvar","year":"2009","unstructured":"Zalckvar E, Berissi H, Mizrachy L, Idelchuk Y, Koren I, Eisenstein M et al. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep 2009; 10: 285\u2013292.","journal-title":"EMBO Rep"},{"key":"BFcddis2013209_CR37","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1089\/neu.2005.22.750","volume":"22","author":"T Diskin","year":"2005","unstructured":"Diskin T, Tal-Or P, Erlich S, Mizrachy L, Alexandrovich A, Shohami E et al. Closed head injury induces upregulation of Beclin 1 at the cortical site of injury. J Neurotrauma 2005; 22: 750\u2013762.","journal-title":"J Neurotrauma"},{"key":"BFcddis2013209_CR38","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1038\/cdd.2011.24","volume":"18","author":"C Penas","year":"2011","unstructured":"Penas C, Font-Nieves M, Fores J, Petegnief V, Planas A, Navarro X et al. Autophagy, and BiP level decrease are early key events in retrograde degeneration of motoneurons. Cell Death Differ 2011; 18: 1617\u20131627.","journal-title":"Cell Death Differ"},{"key":"BFcddis2013209_CR39","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/nn.2575","volume":"13","author":"E Wong","year":"2010","unstructured":"Wong E, Cuervo AM . Autophagy gone awry in neurodegenerative diseases. Nat Neurosci 2010; 13: 805\u2013811.","journal-title":"Nat Neurosci"},{"key":"BFcddis2013209_CR40","doi-asserted-by":"publisher","first-page":"590","DOI":"10.4161\/auto.6259","volume":"4","author":"RA Nixon","year":"2008","unstructured":"Nixon RA, Yang DS, Lee JH . Neurodegenerative lysosomal disorders: a continuum from development to late age. Autophagy 2008; 4: 590\u2013599.","journal-title":"Autophagy"},{"key":"BFcddis2013209_CR41","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1083\/jcb.200505082","volume":"171","author":"WH Yu","year":"2005","unstructured":"Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH et al. Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol 2005; 171: 87\u201398.","journal-title":"J Cell Biol"},{"key":"BFcddis2013209_CR42","doi-asserted-by":"publisher","first-page":"2900","DOI":"10.1093\/hmg\/ddn189","volume":"17","author":"VL McGovern","year":"2008","unstructured":"McGovern VL, Gavrilina TO, Beattie CE, Burghes AH . Embryonic motor axon development in the severe SMA mouse. Hum Mol Genet 2008; 17: 2900\u20132909.","journal-title":"Hum Mol Genet"},{"key":"BFcddis2013209_CR43","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/nrn2670","volume":"10","author":"AH Burghes","year":"2009","unstructured":"Burghes AH, Beattie CE . Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick? Nat Rev Neurosci 2009; 10: 597\u2013609.","journal-title":"Nat Rev Neurosci"},{"key":"BFcddis2013209_CR44","doi-asserted-by":"publisher","first-page":"14489","DOI":"10.1073\/pnas.0701311104","volume":"104","author":"M Komatsu","year":"2007","unstructured":"Komatsu M, Wang QJ, Holstein GR, Friedrich VL Jr, Iwata J, Kominami E et al. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci USA 2007; 104: 14489\u201314494.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2013209_CR45","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1111\/j.1471-4159.2009.06278.x","volume":"110","author":"M Gou-Fabregas","year":"2009","unstructured":"Gou-Fabregas M, Garcera A, Mincheva S, Perez-Garcia MJ, Comella JX, Soler RM . Specific vulnerability of mouse spinal cord motoneurons to membrane depolarization. J Neurochem 2009; 110: 1842\u20131854.","journal-title":"J Neurochem"},{"key":"BFcddis2013209_CR46","doi-asserted-by":"publisher","first-page":"6132","DOI":"10.1074\/jbc.M308367200","volume":"279","author":"MJ Perez-Garcia","year":"2004","unstructured":"Perez-Garcia MJ, Cena V, de Pablo Y, Llovera M, Comella JX, Soler RM . Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium\/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway. J Biol Chem 2004; 279: 6132\u20136142.","journal-title":"J Biol Chem"},{"key":"BFcddis2013209_CR47","doi-asserted-by":"publisher","first-page":"6493","DOI":"10.1523\/JNEUROSCI.0206-11.2011","volume":"31","author":"S Mincheva","year":"2011","unstructured":"Mincheva S, Garcera A, Gou-Fabregas M, Encinas M, Dolcet X, Soler RM . The canonical nuclear factor-{kappa}B pathway regulates cell survival in a developmental model of spinal cord motoneurons. J Neurosci 2011; 31: 6493\u20136503.","journal-title":"J Neurosci"},{"key":"BFcddis2013209_CR48","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1038\/cr.2008.76","volume":"18","author":"R Gozzelino","year":"2008","unstructured":"Gozzelino R, Sole C, Llecha N, Segura MF, Moubarak RS, Iglesias-Guimarais V et al. BCL-XL regulates TNF-alpha-mediated cell death independently of NF-kappaB, FLIP and IAPs. Cell Res 2008; 18: 1020\u20131036.","journal-title":"Cell Res"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis2013209.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis2013209","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2013209.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:04:55Z","timestamp":1672963495000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis2013209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,20]]},"references-count":48,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6]]}},"alternative-id":["BFcddis2013209"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2013.209","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,20]]},"assertion":[{"value":"13 March 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}