{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:47:31Z","timestamp":1791305251734,"version":"4.3.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T00:00:00Z","timestamp":1373500800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2013.249","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T14:10:36Z","timestamp":1373551836000},"page":"e719-e719","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":163,"title":["Development of a human three-dimensional organotypic skin-melanoma spheroid model for in vitro drug testing"],"prefix":"10.1038","volume":"4","author":[{"given":"H","family":"V\u00f6rsmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Groeber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Walles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Busch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Beissert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Walczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Kulms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,11]]},"reference":[{"issue":"36","key":"BFcddis2013249_CR1","doi-asserted-by":"publisher","first-page":"6199","DOI":"10.1200\/JCO.2009.23.4799","volume":"27","author":"Charles M. Balch","year":"2009","unstructured":"Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR et al. Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol 2009 27: 6199\u20136206.","journal-title":"Journal of Clinical Oncology"},{"key":"BFcddis2013249_CR2","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/BF00049406","volume":"10","author":"WH Clark Jr","year":"1991","unstructured":"Clark WH Jr . Human cutaneous malignant melanoma as a model for cancer. Cancer. Metastasis Rev 1991; 10: 83\u201388.","journal-title":"Metastasis Rev"},{"key":"BFcddis2013249_CR3","first-page":"18","volume":"10","author":"DE Elder","year":"1993","unstructured":"Elder DE, Clark WH Jr., Elenitsas R, Guerry D, Halpern AC . The early and intermediate precursor lesions of tumor progression in the melanocytic system: common acquired nevi and atypical (dysplastic) nevi. Semin Diagn Pathol 1993; 10: 18\u201335.","journal-title":"Semin Diagn Pathol"},{"key":"BFcddis2013249_CR4","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1200\/JCO.1999.17.9.2745","volume":"17","author":"PB Chapman","year":"1999","unstructured":"Chapman PB, Einhorn LH, Meyers ML, Saxman S, Destro AN, Panageas KS et al. Phase III multicenter randomized trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma. J Clin Oncol 1999; 17: 2745\u20132751.","journal-title":"J Clin Oncol"},{"key":"BFcddis2013249_CR5","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1200\/JCO.1995.13.4.910","volume":"13","author":"NM Bleehen","year":"1995","unstructured":"Bleehen NM, Newlands ES, Lee SM, Thatcher N, Selby P, Calvert AH et al. Cancer Research Campaign phase II trial of temozolomide in metastatic melanoma. J Clin Oncol 1995; 13: 910\u2013913.","journal-title":"J Clin Oncol"},{"key":"BFcddis2013249_CR6","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.1200\/JCO.1997.15.7.2579","volume":"15","author":"U Keilholz","year":"1997","unstructured":"Keilholz U, Goey SH, Punt CJ, Proebstle TM, Salzmann R, Scheibenbogen C et al. Interferon alfa-2a and interleukin-2 with or without cisplatin in metastatic melanoma: a randomized trial of the European Organization for Research and Treatment of Cancer Melanoma Cooperative Group. J Clin Oncol 1997; 15: 2579\u20132588.","journal-title":"J Clin Oncol"},{"key":"BFcddis2013249_CR7","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1200\/JCO.2005.07.168","volume":"23","author":"DL Dai","year":"2005","unstructured":"Dai DL, Martinka M, Li G . Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 cases. J Clin Oncol 2005; 23: 1473\u20131482.","journal-title":"J Clin Oncol"},{"key":"BFcddis2013249_CR8","doi-asserted-by":"publisher","first-page":"2986","DOI":"10.2741\/1755","volume":"10","author":"F Meier","year":"2005","unstructured":"Meier F, Schittek B, Busch S, Garbe C, Smalley K, Satyamoorthy K et al. The RAS\/RAF\/MEK\/ERK and PI3K\/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma. Front Biosci 2005; 10: 2986\u20133001.","journal-title":"Front Biosci"},{"key":"BFcddis2013249_CR9","first-page":"756","volume":"63","author":"K Satyamoorthy","year":"2003","unstructured":"Satyamoorthy K, Li G, Gerrero MR, Brose MS, Volpe P, Weber BL et al. Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation. Cancer Res 2003; 63: 756\u2013759.","journal-title":"Cancer Res"},{"key":"BFcddis2013249_CR10","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1056\/NEJMoa1103782","volume":"364","author":"PB Chapman","year":"2011","unstructured":"Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011; 364: 2507\u20132516.","journal-title":"N Engl J Med"},{"key":"BFcddis2013249_CR11","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1056\/NEJMoa1002011","volume":"363","author":"KT Flaherty","year":"2010","unstructured":"Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 2010; 363: 809\u2013819.","journal-title":"N Engl J Med"},{"key":"BFcddis2013249_CR12","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1111\/j.1365-2133.2007.07821.x","volume":"156","author":"F Meier","year":"2007","unstructured":"Meier F, Busch S, Lasithiotakis K, Kulms D, Garbe C, Maczey E et al. Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment. Br J Dermatol 2007; 156: 1204\u20131213.","journal-title":"Br J Dermatol"},{"key":"BFcddis2013249_CR13","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/onc.2008.397","volume":"28","author":"B Thayaparasingham","year":"2009","unstructured":"Thayaparasingham B, Kunz A, Peters N, Kulms D . Sensitization of melanoma cells to TRAIL by UVB-induced and NF-kappaB-mediated downregulation of xIAP. Oncogene 2009; 28: 345\u2013362.","journal-title":"Oncogene"},{"key":"BFcddis2013249_CR14","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/onc.2010.434","volume":"30","author":"M Hornle","year":"2011","unstructured":"Hornle M, Peters N, Thayaparasingham B, Vorsmann H, Kashkar H, Kulms D . Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis. Oncogene 2011; 30: 575\u2013587.","journal-title":"Oncogene"},{"key":"BFcddis2013249_CR15","first-page":"2720","volume":"51","author":"R Foty","year":"2011","unstructured":"Foty R . A simple hanging drop cell culture protocol for generation of 3D spheroids. J Vis Exp 2011; 51 pii 2720.","journal-title":"J Vis Exp"},{"key":"BFcddis2013249_CR16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jbiotec.2010.01.012","volume":"148","author":"F Hirschhaeuser","year":"2010","unstructured":"Hirschhaeuser F, Menne H, Dittfeld C, West J, Mueller-Klieser W, Kunz-Schughart LA . Multicellular tumor spheroids: an underestimated tool is catching up again. J Biotechnol 2010; 148: 3\u201315.","journal-title":"J Biotechnol"},{"key":"BFcddis2013249_CR17","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/978-3-642-82340-4_2","volume":"95","author":"RM Sutherland","year":"1984","unstructured":"Sutherland RM, Durand RE . Growth and cellular characteristics of multicell spheroids. Recent Results Cancer Res 1984; 95: 24\u201349.","journal-title":"Recent Results Cancer Res"},{"key":"BFcddis2013249_CR18","doi-asserted-by":"publisher","first-page":"2890","DOI":"10.1200\/JCO.2007.15.5465","volume":"26","author":"SE Zabierowski","year":"2008","unstructured":"Zabierowski SE, Herlyn M . Melanoma stem cells: the dark seed of melanoma. J Clin Oncol 2008; 26: 2890\u20132894.","journal-title":"J Clin Oncol"},{"key":"BFcddis2013249_CR19","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/S1470-2045(03)01280-4","volume":"4","author":"TK Eigentler","year":"2003","unstructured":"Eigentler TK, Caroli UM, Radny P, Garbe C . Palliative therapy of disseminated malignant melanoma: a systematic review of 41 randomised clinical trials. Lancet Oncol 2003; 4: 748\u2013759.","journal-title":"Lancet Oncol"},{"key":"BFcddis2013249_CR20","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.critrevonc.2009.08.005","volume":"74","author":"R Mouawad","year":"2010","unstructured":"Mouawad R, Sebert M, Michels J, Bloch J, Spano JP, Khayat D . Treatment for metastatic malignant melanoma: old drugs and new strategies. Crit Rev Oncol Hematol 2010; 74: 27\u201339.","journal-title":"Crit Rev Oncol Hematol"},{"key":"BFcddis2013249_CR21","doi-asserted-by":"publisher","first-page":"47156","DOI":"10.1074\/jbc.M308700200","volume":"278","author":"NY Frank","year":"2003","unstructured":"Frank NY, Pendse SS, Lapchak PH, Margaryan A, Shlain D, Doeing C et al. Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. J Biol Chem 2003; 278: 47156\u201347165.","journal-title":"J Biol Chem"},{"key":"BFcddis2013249_CR22","doi-asserted-by":"publisher","first-page":"4320","DOI":"10.1158\/0008-5472.CAN-04-3327","volume":"65","author":"NY Frank","year":"2005","unstructured":"Frank NY, Margaryan A, Huang Y, Schatton T, Waaga-Gasser AM, Gasser M et al. ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res 2005; 65: 4320\u20134333.","journal-title":"Cancer Res"},{"key":"BFcddis2013249_CR23","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1002\/ijc.23211","volume":"122","author":"A Roesch","year":"2008","unstructured":"Roesch A, Mueller AM, Stempfl T, Moehle C, Landthaler M, Vogt T . RBP2-H1\/JARID1B is a transcriptional regulator with a tumor suppressive potential in melanoma cells. Int J Cancer 2008; 122: 1047\u20131057.","journal-title":"Int J Cancer"},{"key":"BFcddis2013249_CR24","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.cell.2010.04.020","volume":"141","author":"A Roesch","year":"2010","unstructured":"Roesch A, Fukunaga-Kalabis M, Schmidt EC, Zabierowski SE, Brafford PA, Vultur A et al. A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell 2010; 141: 583\u2013594.","journal-title":"Cell"},{"key":"BFcddis2013249_CR25","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1046\/j.1523-1747.2002.19638.x","volume":"7","author":"D Kulms","year":"2002","unstructured":"Kulms D, Schwarz T . 20 years after--milestones in molecular photobiology. J Investig Dermatol Symp Proc 2002; 7: 46\u201350.","journal-title":"J Investig Dermatol Symp Proc"},{"key":"BFcddis2013249_CR26","doi-asserted-by":"publisher","first-page":"6239","DOI":"10.1038\/sj.onc.1209655","volume":"25","author":"E Strozyk","year":"2006","unstructured":"Strozyk E, Poppelmann B, Schwarz T, Kulms D . Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome. Oncogene 2006; 25: 6239\u20136251.","journal-title":"Oncogene"},{"key":"BFcddis2013249_CR27","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/1476-4598-6-66","volume":"6","author":"LL Belyanskaya","year":"2007","unstructured":"Belyanskaya LL, Marti TM, Hopkins-Donaldson S, Kurtz S, Felley-Bosco E, Stahel RA . Human agonistic TRAIL receptor antibodies Mapatumumab and Lexatumumab induce apoptosis in malignant mesothelioma and act synergistically with cisplatin. Mol Cancer 2007; 6: 66.","journal-title":"Mol Cancer"},{"key":"BFcddis2013249_CR28","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1093\/carcin\/bgq220","volume":"32","author":"BO Vondalova","year":"2011","unstructured":"Vondalova BO, Jelinkova I, Szoor A, Skender B, Soucek K, Horvath V et al. Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway. Carcinogenesis 2011; 32: 42\u201351.","journal-title":"Carcinogenesis"},{"key":"BFcddis2013249_CR29","doi-asserted-by":"publisher","first-page":"3507","DOI":"10.1073\/pnas.1222878110","volume":"110","author":"J Seok","year":"2013","unstructured":"Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci USA 2013; 110: 3507\u20133512.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2013249_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00418-009-0586-0","volume":"132","author":"D Breitkreutz","year":"2009","unstructured":"Breitkreutz D, Mirancea N, Nischt R . Basement membranes in skin: unique matrix structures with diverse functions? Histochem Cell Biol 2009; 132: 1\u201310.","journal-title":"Histochem Cell Biol"},{"key":"BFcddis2013249_CR31","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1002\/biot.200700228","volume":"3","author":"RZ Lin","year":"2008","unstructured":"Lin RZ, Chang HY . Recent advances in three-dimensional multicellular spheroid culture for biomedical research. Biotechnol J 2008; 3: 1172\u20131184.","journal-title":"Biotechnol J"},{"key":"BFcddis2013249_CR32","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1182\/blood-2012-02-362624","volume":"120","author":"JA Woyach","year":"2012","unstructured":"Woyach JA, Johnson AJ, Byrd JC . The B-cell receptor signaling pathway as a therapeutic target in CLL. Blood 2012; 120: 1175\u20131184.","journal-title":"Blood"},{"key":"BFcddis2013249_CR33","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1053\/j.seminhematol.2012.04.010","volume":"49","author":"P Kapoor","year":"2012","unstructured":"Kapoor P, Ramakrishnan V, Rajkumar SV . Bortezomib combination therapy in multiple myeloma. Semin Hematol 2012; 49: 228\u2013242.","journal-title":"Semin Hematol"},{"key":"BFcddis2013249_CR34","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1097\/CAD.0b013e32832ced78","volume":"20","author":"DJ Chen","year":"2009","unstructured":"Chen DJ, Huerta S . Smac mimetics as new cancer therapeutics. Anticancer Drugs 2009; 20: 646\u2013658.","journal-title":"Anticancer Drugs"},{"key":"BFcddis2013249_CR35","doi-asserted-by":"publisher","first-page":"5848","DOI":"10.1002\/cncr.27540","volume":"11","author":"C Curiel-Lewandrowski","year":"2012","unstructured":"Curiel-Lewandrowski C, Swetter SM, Einspahr JG, Hsu CH, Nagle R, Sagerman P et al. Randomized, double-blind, placebo-controlled trial of sulindac in individuals at risk for melanoma: evaluation of potential chemopreventive activity. Cancer 2012; 11: 5848\u20135856.","journal-title":"Cancer"},{"key":"BFcddis2013249_CR36","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/978-0-387-89520-8_14","volume":"647","author":"C Falschlehner","year":"2009","unstructured":"Falschlehner C, Ganten TM, Koschny R, Schaefer U, Walczak H . TRAIL and other TRAIL receptor agonists as novel cancer therapeutics. Adv Exp Med Biol 2009; 647: 195\u2013206.","journal-title":"Adv Exp Med Biol"},{"key":"BFcddis2013249_CR37","first-page":"966s","volume":"7","author":"T Nguyen","year":"2001","unstructured":"Nguyen T, Zhang XD, Hersey P . Relative resistance of fresh isolates of melanoma to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Clin Cancer Res 2001; 7: 966s\u2013973s.","journal-title":"Clin Cancer Res"},{"key":"BFcddis2013249_CR38","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/nature11249","volume":"487","author":"TR Wilson","year":"2012","unstructured":"Wilson TR, Fridlyabd J, Yan Y, Penuel E, Burton L, Chan E et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature 2012; 487: 505\u2013509.","journal-title":"Nature"},{"key":"BFcddis2013249_CR39","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nprot.2009.241","volume":"5","author":"T Aasen","year":"2010","unstructured":"Aasen T, Izpisua Belmonte JC . Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells. Nat Protoc 2010; 5: 371\u2013382.","journal-title":"Nat Protoc"},{"key":"BFcddis2013249_CR40","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1136\/jms.6.1.42","volume":"6","author":"PC Edmondson","year":"1999","unstructured":"Edmondson PC, Curley RK, Marsden RA, Robinson D, Allaway SL, Willson CD . Screening for malignant melanoma using instant photography. J Med Screen 1999; 6: 42\u201346.","journal-title":"J Med Screen"},{"key":"BFcddis2013249_CR41","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.1158\/1078-0432.CCR-05-2635","volume":"12","author":"TM Ganten","year":"2006","unstructured":"Ganten TM, Koschny R, Sykora J, Schulze-Bergkamen H, Buchler P, Haas TL et al. Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs. Clin Cancer Res 2006; 12: 2640\u20132646.","journal-title":"Clin Cancer Res"},{"key":"BFcddis2013249_CR42","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0002-9440(10)64719-0","volume":"156","author":"F Meier","year":"2000","unstructured":"Meier F, Nesbit M, Hsu MY, Martin B, Van Belle P, Elder DE et al. Human melanoma progression in skin reconstructs: biological significance of bFGF. Am J Pathol 2000; 156: 193\u2013200.","journal-title":"Am J Pathol"},{"key":"BFcddis2013249_CR43","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/1523-1747.ep12613595","volume":"104","author":"CS Chen","year":"1995","unstructured":"Chen CS, Lavker RM, Rodeck U, Risse B, Jensen PJ . Use of a serum-free epidermal culture model to show deleterious effects of epidermal growth factor on morphogenesis and differentiation. J Invest Dermatol 1995; 104: 107\u2013112.","journal-title":"J Invest Dermatol"},{"key":"BFcddis2013249_CR44","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1023\/A:1006333627271","volume":"18","author":"K Satyamoorthy","year":"1999","unstructured":"Satyamoorthy K, Meier F, Hsu MY, Berking C, Herlyn M . Human xenografts, human skin and skin reconstructs for studies in melanoma development and progression. Cancer Metastasis Rev 1999; 18: 401\u2013405.","journal-title":"Cancer Metastasis Rev"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis2013249.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis2013249","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2013249.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:08:52Z","timestamp":1672963732000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis2013249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,11]]},"references-count":44,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7]]}},"alternative-id":["BFcddis2013249"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2013.249","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,11]]},"assertion":[{"value":"23 April 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"HW declares the following conflict of interest: Inventor of TRAIL-R2-specific antibodies; founder of Apogenix, a biotech company that develops apoptosis-related therapeutics.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}