{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:47:10Z","timestamp":1789386430560,"version":"build-2803163510"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2013.258","type":"journal-article","created":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T10:20:00Z","timestamp":1374142800000},"page":"e733-e733","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesothelioma"],"prefix":"10.1038","volume":"4","author":[{"given":"N","family":"Crawford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Stasik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Holohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Majkut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"McGrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P G","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Chessari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G A","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Waugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A","family":"Fennell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D B","family":"Longley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,18]]},"reference":[{"key":"BFcddis2013258_CR1","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/sj.bjc.6602307","volume":"92","author":"JT Hodgson","year":"2005","unstructured":"Hodgson JT, McElvenny DM, Darnton AJ, Price MJ, Peto J . The expected burden of mesothelioma mortality in Great Britain from 2002 to 2050. Br J Cancer 2005; 92: 587\u2013593.","journal-title":"Br J Cancer"},{"issue":"Suppl 5","key":"BFcddis2013258_CR2","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1289\/ehp.97105s51257","volume":"105","author":"N Choe","year":"1997","unstructured":"Choe N, Tanaka S, Xia W, Hemenway DR, Roggli VL, Kagan E . Pleural macrophage recruitment and activation in asbestos-induced pleural injury. Environ Health Perspect 1997; 105 (Suppl 5): 1257\u20131260.","journal-title":"Environ Health Perspect"},{"key":"BFcddis2013258_CR3","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1016\/j.ajpath.2011.05.060","volume":"179","author":"Q Li","year":"2011","unstructured":"Li Q, Wang W, Yamada T, Matsumoto K, Sakai K, Bando Y et al. Pleural mesothelioma instigates tumor-associated fibroblasts to promote progression via a malignant cytokine network. Am J Pathol 2011; 179: 1483\u20131493.","journal-title":"Am J Pathol"},{"key":"BFcddis2013258_CR4","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1002\/path.2120","volume":"211","author":"GJ Gordon","year":"2007","unstructured":"Gordon GJ, Mani M, Mukhopadhyay L, Dong L, Yeap BY, Sugarbaker DJ et al. Inhibitor of apoptosis proteins are regulated by tumour necrosis factor-alpha in malignant pleural mesothelioma. J Pathol 2007; 211: 439\u2013446.","journal-title":"J Pathol"},{"key":"BFcddis2013258_CR5","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1136\/oem.52.5.316","volume":"52","author":"R Partanen","year":"1995","unstructured":"Partanen R, Koskinen H, Hemminki K . Tumour necrosis factor-alpha (TNF-alpha) in patients who have asbestosis and develop cancer. Occup Environ Med 1995; 52: 316\u2013319.","journal-title":"Occup Environ Med"},{"key":"BFcddis2013258_CR6","doi-asserted-by":"publisher","first-page":"631","DOI":"10.2174\/092986708783885273","volume":"15","author":"F Villanova","year":"2008","unstructured":"Villanova F, Procopio A, Rippo MR . Malignant mesothelioma resistance to apoptosis: recent discoveries and their implication for effective therapeutic strategies. Curr Med Chem 2008; 15: 631\u2013641.","journal-title":"Curr Med Chem"},{"key":"BFcddis2013258_CR7","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/S1470-2045(04)01492-5","volume":"5","author":"DA Fennell","year":"2004","unstructured":"Fennell DA, Rudd RM . Defective core-apoptosis signalling in diffuse malignant pleural mesothelioma: opportunities for effective drug development. Lancet Oncol 2004; 5: 354\u2013362.","journal-title":"Lancet Oncol"},{"key":"BFcddis2013258_CR8","first-page":"453","volume":"29","author":"N Zaffaroni","year":"2007","unstructured":"Zaffaroni N, Costa A, Pennati M, De Marco C, Affini E, Madeo M et al. Survivin is highly expressed and promotes cell survival in malignant peritoneal mesothelioma. Cell Oncol 2007; 29: 453\u2013466.","journal-title":"Cell Oncol"},{"key":"BFcddis2013258_CR9","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.humpath.2006.12.013","volume":"38","author":"L Kleinberg","year":"2007","unstructured":"Kleinberg L, Lie AK, Florenes VA, Nesland JM, Davidson B . Expression of inhibitor-of-apoptosis protein family members in malignant mesothelioma. Hum Pathol 2007; 38: 986\u2013994.","journal-title":"Hum Pathol"},{"key":"BFcddis2013258_CR10","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1002\/path.2121","volume":"211","author":"GJ Gordon","year":"2007","unstructured":"Gordon GJ, Mani M, Mukhopadhyay L, Dong L, Edenfield HR, Glickman JN et al. Expression patterns of inhibitor of apoptosis proteins in malignant pleural mesothelioma. J Pathol 2007; 211: 447\u2013454.","journal-title":"J Pathol"},{"key":"BFcddis2013258_CR11","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1101\/gad.13.3.239","volume":"13","author":"QL Deveraux","year":"1999","unstructured":"Deveraux QL, Reed JC . IAP family proteins--suppressors of apoptosis. Genes Dev 1999; 13: 239\u2013252.","journal-title":"Genes Dev"},{"key":"BFcddis2013258_CR12","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/nrm1621","volume":"6","author":"DL Vaux","year":"2005","unstructured":"Vaux DL, Silke J . IAPs, RINGs and ubiquitylation. Nat Rev Mol Cell Biol 2005; 6: 287\u2013297.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcddis2013258_CR13","doi-asserted-by":"publisher","first-page":"8662","DOI":"10.1073\/pnas.161506698","volume":"98","author":"Y Suzuki","year":"2001","unstructured":"Suzuki Y, Nakabayashi Y, Takahashi R . Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. Proc Natl Acad Sci USA 2001; 98: 8662\u20138667.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2013258_CR14","doi-asserted-by":"publisher","first-page":"5242","DOI":"10.1093\/emboj\/18.19.5242","volume":"18","author":"QL Deveraux","year":"1999","unstructured":"Deveraux QL, Leo E, Stennicke HR, Welsh K, Salvesen GS, Reed JC . Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J 1999; 18: 5242\u20135251.","journal-title":"EMBO J"},{"key":"BFcddis2013258_CR15","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/sj.emboj.7600544","volume":"24","author":"FL Scott","year":"2005","unstructured":"Scott FL, Denault JB, Riedl SJ, Shin H, Renatus M, Salvesen GS . XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs. EMBO J 2005; 24: 645\u2013655.","journal-title":"EMBO J"},{"key":"BFcddis2013258_CR16","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/0092-8674(95)90149-3","volume":"83","author":"M Rothe","year":"1995","unstructured":"Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV . The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 1995; 83: 1243\u20131252.","journal-title":"Cell"},{"key":"BFcddis2013258_CR17","doi-asserted-by":"publisher","first-page":"11778","DOI":"10.1073\/pnas.0711122105","volume":"105","author":"DJ Mahoney","year":"2008","unstructured":"Mahoney DJ, Cheung HH, Mrad RL, Plenchette S, Simard C, Enwere E et al. Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation. Proc Natl Acad Sci USA 2008; 105: 11778\u201311783.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2013258_CR18","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.molcel.2008.05.014","volume":"30","author":"MJ Bertrand","year":"2008","unstructured":"Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J et al. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell 2008; 30: 689\u2013700.","journal-title":"Mol Cell"},{"key":"BFcddis2013258_CR19","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0092-8674(03)00521-X","volume":"114","author":"O Micheau","year":"2003","unstructured":"Micheau O, Tschopp J . Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003; 114: 181\u2013190.","journal-title":"Cell"},{"key":"BFcddis2013258_CR20","doi-asserted-by":"publisher","first-page":"5299","DOI":"10.1128\/MCB.21.16.5299-5305.2001","volume":"21","author":"O Micheau","year":"2001","unstructured":"Micheau O, Lens S, Gaide O, Alevizopoulos K, Tschopp J . NF-kappaB signals induce the expression of c-FLIP. Mol Cell Biol 2001; 21: 5299\u20135305.","journal-title":"Mol Cell Biol"},{"key":"BFcddis2013258_CR21","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.cell.2009.05.021","volume":"137","author":"S He","year":"2009","unstructured":"He S, Wang L, Miao L, Wang T, Du F, Zhao L et al. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 2009; 137: 1100\u20131111.","journal-title":"Cell"},{"key":"BFcddis2013258_CR22","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0092-8674(00)00008-8","volume":"102","author":"C Du","year":"2000","unstructured":"Du C, Fang M, Li Y, Li L, Wang X . Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000; 102: 33\u201342.","journal-title":"Cell"},{"key":"BFcddis2013258_CR23","doi-asserted-by":"publisher","first-page":"17015","DOI":"10.1074\/jbc.M111.222919","volume":"286","author":"R Feltham","year":"2011","unstructured":"Feltham R, Bettjeman B, Budhidarmo R, Mace PD, Shirley S, Condon SM et al. Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization. J Biol Chem 2011; 286: 17015\u201317028.","journal-title":"J Biol Chem"},{"key":"BFcddis2013258_CR24","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.cell.2007.10.030","volume":"131","author":"E Varfolomeev","year":"2007","unstructured":"Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell 2007; 131: 669\u2013681.","journal-title":"Cell"},{"key":"BFcddis2013258_CR25","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.ccr.2007.08.029","volume":"12","author":"SL Petersen","year":"2007","unstructured":"Petersen SL, Wang L, Yalcin-Chin A, Li L, Peyton M, Minna J et al. Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell 2007; 12: 445\u2013456.","journal-title":"Cancer Cell"},{"key":"BFcddis2013258_CR26","unstructured":"Chessari G, Buck I, Chiarparin E, Day J, Frederickson M, Criffiths-Jones C et al Ann Oncol 2012: 24\u201324."},{"key":"BFcddis2013258_CR27","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1038\/cdd.2011.10","volume":"18","author":"M Darding","year":"2011","unstructured":"Darding M, Feltham R, Tenev T, Bianchi K, Benetatos C, Silke J et al. Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2. Cell Death Differ 2011; 18: 1376\u20131386.","journal-title":"Cell Death Differ"},{"key":"BFcddis2013258_CR28","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.molcel.2011.06.011","volume":"43","author":"M Feoktistova","year":"2011","unstructured":"Feoktistova M, Geserick P, Kellert B, Dimitrova DP, Langlais C, Hupe M et al. cIAPs block Ripoptosome formation, a RIP1\/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell 2011; 43: 449\u2013463.","journal-title":"Mol Cell"},{"key":"BFcddis2013258_CR29","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2008.03.036","volume":"133","author":"L Wang","year":"2008","unstructured":"Wang L, Du F, Wang X . TNF-alpha induces two distinct caspase-8 activation pathways. Cell 2008; 133: 693\u2013703.","journal-title":"Cell"},{"key":"BFcddis2013258_CR30","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.molcel.2011.06.006","volume":"43","author":"T Tenev","year":"2011","unstructured":"Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg F et al. The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell 2011; 43: 432\u2013448.","journal-title":"Mol Cell"},{"key":"BFcddis2013258_CR31","doi-asserted-by":"publisher","first-page":"20633","DOI":"10.1074\/jbc.M101780200","volume":"276","author":"A Krueger","year":"2001","unstructured":"Krueger A, Schmitz I, Baumann S, Krammer PH, Kirchhoff S . Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J Biol Chem 2001; 276: 20633\u201320640.","journal-title":"J Biol Chem"},{"key":"BFcddis2013258_CR32","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/sj.cdd.4402314","volume":"15","author":"N Ueffing","year":"2008","unstructured":"Ueffing N, Keil E, Freund C, Kuhne R, Schulze-Osthoff K, Schmitz I . Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment. Cell Death Differ 2008; 15: 773\u2013782.","journal-title":"Cell Death Differ"},{"key":"BFcddis2013258_CR33","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1002\/1097-0215(20001215)88:6<986::AID-IJC23>3.0.CO;2-B","volume":"88","author":"H Kinoshita","year":"2000","unstructured":"Kinoshita H, Yoshikawa H, Shiiki K, Hamada Y, Nakajima Y, Tasaka K . Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas\/CD95-mediated apoptosis by down-regulating FLIP-L expression. Int J Cancer 2000; 88: 986\u2013991.","journal-title":"Int J Cancer"},{"key":"BFcddis2013258_CR34","first-page":"4255","volume":"9","author":"JH Song","year":"2003","unstructured":"Song JH, Song DK, Herlyn M, Petruk KC, Hao C . Cisplatin down-regulation of cellular Fas-associated death domain-like interleukin-1beta-converting enzyme-like inhibitory proteins to restore tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human melanoma cells. Clin Cancer Res 2003; 9: 4255\u20134266.","journal-title":"Clin Cancer Res"},{"key":"BFcddis2013258_CR35","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1038\/cdd.2012.8","volume":"19","author":"E Kerr","year":"2012","unstructured":"Kerr E, Holohan C, McLaughlin KM, Majkut J, Dolan S, Redmond K et al. Identification of an acetylation-dependant Ku70\/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis. Cell Death Differ 2012; 19: 1317\u20131327.","journal-title":"Cell Death Differ"},{"key":"BFcddis2013258_CR36","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/j.ejca.2011.11.009","volume":"48","author":"JL Hurwitz","year":"2012","unstructured":"Hurwitz JL, Stasik I, Kerr EM, Holohan C, Redmond KM, McLaughlin KM et al. Vorinostat\/SAHA-induced apoptosis in malignant mesothelioma is FLIP\/caspase 8-dependent and HR23B-independent. Eur J Cancer 2012; 48: 1096\u20131107.","journal-title":"Eur J Cancer"},{"key":"BFcddis2013258_CR37","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1124\/jpet.108.143826","volume":"327","author":"C Wilson","year":"2008","unstructured":"Wilson C, Purcell C, Seaton A, Oladipo O, Maxwell PJ, O\u2019Sullivan JM et al. Chemotherapy-induced CXC-chemokine\/CXC-chemokine receptor signaling in metastatic prostate cancer cells confers resistance to oxaliplatin through potentiation of nuclear factor-kappaB transcription and evasion of apoptosis. J Pharmacol Exp Ther 2008; 327: 746\u2013759.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFcddis2013258_CR38","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1007\/s10495-010-0533-5","volume":"15","author":"AE Logan","year":"2010","unstructured":"Logan AE, Wilson TR, Fenning C, Cummins R, Kay E, Johnston PG et al. In vitro and in vivo characterisation of a novel c-FLIP-targeted antisense phosphorothioate oligonucleotide. Apoptosis 2010; 15: 1435\u20131443.","journal-title":"Apoptosis"},{"key":"BFcddis2013258_CR39","doi-asserted-by":"publisher","first-page":"8809","DOI":"10.1128\/MCB.25.20.8809-8823.2005","volume":"25","author":"A Panner","year":"2005","unstructured":"Panner A, James CD, Berger MS, Pieper RO . mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells. Mol Cell Biol 2005; 25: 8809\u20138823.","journal-title":"Mol Cell Biol"},{"key":"BFcddis2013258_CR40","doi-asserted-by":"publisher","first-page":"5754","DOI":"10.1158\/0008-5472.CAN-06-3585","volume":"67","author":"TR Wilson","year":"2007","unstructured":"Wilson TR, McLaughlin KM, McEwan M, Sakai H, Rogers KM, Redmond KM et al. c-FLIP: a key regulator of colorectal cancer cell death. Cancer Res 2007; 67: 5754\u20135762.","journal-title":"Cancer Res"},{"key":"BFcddis2013258_CR41","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/sj.onc.1209122","volume":"25","author":"DB Longley","year":"2006","unstructured":"Longley DB, Wilson TR, McEwan M, Allen WL, McDermott U, Galligan L et al. c-FLIP inhibits chemotherapy-induced colorectal cancer cell death. Oncogene 2006; 25: 838\u2013848.","journal-title":"Oncogene"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis2013258.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis2013258","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2013258.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T19:08:22Z","timestamp":1672945702000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis2013258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,18]]},"references-count":41,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7]]}},"alternative-id":["BFcddis2013258"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2013.258","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,18]]},"assertion":[{"value":"28 March 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Prof. Fennell has worked as a consultant for Merck, who manufacture Vorinostat. Drs. Gianni Chessari and George Ward are full-time employees of Astex Pharmaceuticals who manufacture the SMAC mimetic AT-IAP used in this study. All other authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}