{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:01:10Z","timestamp":1790974870498,"version":"4.1.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T00:00:00Z","timestamp":1360800000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2013.31","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T15:09:35Z","timestamp":1360854575000},"page":"e494-e494","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Myostatin induces mitochondrial metabolic alteration and typical apoptosis in cancer cells"],"prefix":"10.1038","volume":"4","author":[{"given":"Y","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,2,14]]},"reference":[{"key":"BFcddis201331_CR1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/387083a0","volume":"387","author":"AC McPherron","year":"1997","unstructured":"McPherron AC, Lawler AM, Lee SJ . Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 1997; 387: 83\u201390.","journal-title":"Nature"},{"key":"BFcddis201331_CR2","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1146\/annurev.cellbio.20.012103.135836","volume":"20","author":"SJ Lee","year":"2004","unstructured":"Lee SJ . Regulation of muscle mass by myostatin. Annu Rev Cell Dev Biol 2004; 20: 61\u201386.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"BFcddis201331_CR3","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.tig.2007.08.008","volume":"23","author":"SJ Lee","year":"2007","unstructured":"Lee SJ . Sprinting without myostatin: a genetic determinant of athletic prowess. Trends Genet 2007; 23: 475\u2013477.","journal-title":"Trends Genet"},{"key":"BFcddis201331_CR4","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1056\/NEJMoa040933","volume":"350","author":"M Schuelke","year":"2004","unstructured":"Schuelke M, Wagner KR, Stolz LE, Hubner C, Riebel T, Komen W et al. Myostatin mutation associated with gross muscle hypertrophy in a child. N Engl J Med 2004; 350: 2682\u20132688.","journal-title":"N Engl J Med"},{"key":"BFcddis201331_CR5","doi-asserted-by":"publisher","first-page":"9306","DOI":"10.1073\/pnas.151270098","volume":"98","author":"SJ Lee","year":"2001","unstructured":"Lee SJ, McPherron AC . Regulation of myostatin activity and muscle growth. Proc Natl Acad Sci USA 2001; 98: 9306\u20139311.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis201331_CR6","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1096\/fj.11-191189","volume":"26","author":"DU Kemaladewi","year":"2011","unstructured":"Kemaladewi DU, de Gorter DJ, Aartsma-Rus A, van Ommen GJ, ten Dijke P, t Hoen PA et al. Cell-type specific regulation of myostatin signaling. FASEB J 2011; 26: 1462\u20131472.","journal-title":"FASEB J"},{"key":"BFcddis201331_CR7","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/0092-8674(92)90395-S","volume":"71","author":"JL Wrana","year":"1992","unstructured":"Wrana JL, Attisano L, Carcamo J, Zentella A, Doody J, Laiho M et al. TGF beta signals through a heteromeric protein kinase receptor complex. cell 1992; 71: 1003\u20131014.","journal-title":"cell"},{"key":"BFcddis201331_CR8","doi-asserted-by":"publisher","first-page":"3799","DOI":"10.1074\/jbc.M610185200","volume":"282","author":"W Yang","year":"2007","unstructured":"Yang W, Zhang Y, Li Y, Wu Z, Zhu D . Myostatin induces cyclin D1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase\/AKT\/GSK-3 beta pathway and is antagonized by insulin-like growth factor 1. J Biol Chem 2007; 282: 3799\u20133808.","journal-title":"J Biol Chem"},{"key":"BFcddis201331_CR9","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1161\/01.RES.0000231290.45676.d4","volume":"99","author":"MR Morissette","year":"2006","unstructured":"Morissette MR, Cook SA, Foo S, McKoy G, Ashida N, Novikov M et al. Myostatin regulates cardiomyocyte growth through modulation of Akt signaling. Circ Res 2006; 99: 15\u201324.","journal-title":"Circ Res"},{"key":"BFcddis201331_CR10","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1016\/j.biocel.2010.09.017","volume":"42","author":"Y Chen","year":"2010","unstructured":"Chen Y, Ye J, Cao L, Zhang Y, Xia W, Zhu D . Myostatin regulates glucose metabolism via the AMP-activated protein kinase pathway in skeletal muscle cells. Int J Biochem Cell Biol 2010; 42: 2072\u20132081.","journal-title":"Int J Biochem Cell Biol"},{"key":"BFcddis201331_CR11","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1210\/jc.2005-2361","volume":"91","author":"MD Mitchell","year":"2006","unstructured":"Mitchell MD, Osepchook CC, Leung KC, McMahon CD, Bass JJ . Myostatin is a human placental product that regulates glucose uptake. J Clin Endocrinol Metab 2006; 91: 1434\u20131437.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFcddis201331_CR12","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1172\/JCI0213562","volume":"109","author":"AC McPherron","year":"2002","unstructured":"McPherron AC, Lee SJ . Suppression of body fat accumulation in myostatin-deficient mice. J Clin Invest 2002; 109: 595\u2013601.","journal-title":"J Clin Invest"},{"key":"BFcddis201331_CR13","doi-asserted-by":"publisher","first-page":"E1296","DOI":"10.1152\/ajpendo.00331.2007","volume":"293","author":"N Antony","year":"2007","unstructured":"Antony N, Bass JJ, McMahon CD, Mitchell MD . Myostatin regulates glucose uptake in BeWo cells. Am J Physiol Endocrinol Metab 2007; 293: E1296\u2013E1302.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFcddis201331_CR14","doi-asserted-by":"publisher","first-page":"e4937","DOI":"10.1371\/journal.pone.0004937","volume":"4","author":"T Guo","year":"2009","unstructured":"Guo T, Jou W, Chanturiya T, Portas J, Gavrilova O, McPherron AC . Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity. PLoS One 2009; 4: e4937.","journal-title":"PLoS One"},{"key":"BFcddis201331_CR15","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.cell.2010.07.011","volume":"142","author":"X Zhou","year":"2010","unstructured":"Zhou X, Wang JL, Lu J, Song Y, Kwak KS, Jiao Q et al. Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival. Cell 2010; 142: 531\u2013543.","journal-title":"Cell"},{"key":"BFcddis201331_CR16","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1126\/science.1069525","volume":"296","author":"TA Zimmers","year":"2002","unstructured":"Zimmers TA, Davies MV, Koniaris LG, Haynes P, Esquela AF, Tomkinson KN et al. Induction of cachexia in mice by systemically administered myostatin. Science 2002; 296: 1486\u20131488.","journal-title":"Science"},{"key":"BFcddis201331_CR17","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cell.2008.07.001","volume":"134","author":"J Massague","year":"2008","unstructured":"Massague J . TGFbeta in Cancer. Cell 2008; 134: 215\u2013230.","journal-title":"Cell"},{"key":"BFcddis201331_CR18","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"O Warburg","year":"1956","unstructured":"Warburg O . On the origin of cancer cells. Science 1956; 123: 309\u2013314.","journal-title":"Science"},{"key":"BFcddis201331_CR19","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1126\/science.1160809","volume":"324","author":"MG Vander Heiden","year":"2009","unstructured":"Vander Heiden MG, Cantley LC, Thompson CB . Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324: 1029\u20131033.","journal-title":"Science"},{"key":"BFcddis201331_CR20","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1038\/cdd.2011.13","volume":"18","author":"X Liu","year":"2011","unstructured":"Liu X, Hajnoczky G . Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia-reoxygenation stress. Cell Death Differ 2011; 18: 1561\u20131572.","journal-title":"Cell Death Differ"},{"key":"BFcddis201331_CR21","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/20959","volume":"399","author":"S Shimizu","year":"1999","unstructured":"Shimizu S, Narita M, Tsujimoto Y . Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 1999; 399: 483\u2013487.","journal-title":"Nature"},{"key":"BFcddis201331_CR22","doi-asserted-by":"publisher","first-page":"5787","DOI":"10.1073\/pnas.0600103103","volume":"103","author":"S Abu-Hamad","year":"2006","unstructured":"Abu-Hamad S, Sivan S, Shoshan-Barmatz V . The expression level of the voltage-dependent anion channel controls life and death of the cell. Proc Natl Acad Sci USA 2006; 103: 5787\u20135792.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis201331_CR23","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1042\/BJ20112079","volume":"444","author":"S Geula","year":"2012","unstructured":"Geula S, Ben-Hail D, Shoshan-Barmatz V . Structure-based analysis of VDAC1: N-terminus location, translocation, channel gating and association with anti-apoptotic proteins. Biochem J 2012; 444: 475\u2013485.","journal-title":"Biochem J"},{"key":"BFcddis201331_CR24","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1074\/jbc.M111.268920","volume":"287","author":"S Geula","year":"2012","unstructured":"Geula S, Naveed H, Liang J, Shoshan-Barmatz V . Structure-based analysis of VDAC1 protein: defining oligomer contact sites. J Biol Chem 2012; 287: 2179\u20132190.","journal-title":"J Biol Chem"},{"key":"BFcddis201331_CR25","doi-asserted-by":"publisher","first-page":"7610","DOI":"10.1074\/jbc.M109950200","volume":"277","author":"JG Pastorino","year":"2002","unstructured":"Pastorino JG, Shulga N, Hoek JB . Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis. J Biol Chem 2002; 277: 7610\u20137618.","journal-title":"J Biol Chem"},{"issue":"Pt 2","key":"BFcddis201331_CR26","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1042\/bj20031465","volume":"377","author":"H Azoulay-Zohar","year":"2004","unstructured":"Azoulay-Zohar H, Israelson A, Abu-Hamad S, Shoshan-Barmatz V . In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death. Biochem J 2004; 377 (Pt 2): 347\u2013355.","journal-title":"Biochem J"},{"key":"BFcddis201331_CR27","doi-asserted-by":"publisher","first-page":"20658","DOI":"10.1074\/jbc.273.32.20658","volume":"273","author":"RC Hresko","year":"1998","unstructured":"Hresko RC, Heimberg H, Chi MM, Mueckler M . Glucosamine-induced insulin resistance in 3T3-L1 adipocytes is caused by depletion of intracellular ATP. J Biol Chem 1998; 273: 20658\u201320668.","journal-title":"J Biol Chem"},{"key":"BFcddis201331_CR28","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1002\/ijc.21124","volume":"116","author":"L Binyamin","year":"2005","unstructured":"Binyamin L, Assaraf YG, Reiter Y . Probing ATP-dependent conformational changes in the multidrug resistance protein 1 (MRP1\/ABCC1) in live tumor cells with a novel recombinant single-chain Fv antibody targeted to the extracellular N-terminus. Int J Cancer 2005; 116: 703\u2013709.","journal-title":"Int J Cancer"},{"key":"BFcddis201331_CR29","doi-asserted-by":"publisher","first-page":"7315","DOI":"10.1128\/MCB.23.20.7315-7328.2003","volume":"23","author":"JC Rathmell","year":"2003","unstructured":"Rathmell JC, Fox CJ, Plas DR, Hammerman PS, Cinalli RM, Thompson CB . Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol 2003; 23: 7315\u20137328.","journal-title":"Mol Cell Biol"},{"key":"BFcddis201331_CR30","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.molcel.2004.11.014","volume":"16","author":"N Majewski","year":"2004","unstructured":"Majewski N, Nogueira V, Bhaskar P, Coy PE, Skeen JE, Gottlob K et al. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell 2004; 16: 819\u2013830.","journal-title":"Mol Cell"},{"key":"BFcddis201331_CR31","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1128\/MCB.22.5.1369-1378.2002","volume":"22","author":"BC Kim","year":"2002","unstructured":"Kim BC, Mamura M, Choi KS, Calabretta B, Kim SJ . Transforming growth factor beta 1 induces apoptosis through cleavage of BAD in a Smad3-dependent mechanism in FaO hepatoma cells. Mol Cell Biol 2002; 22: 1369\u20131378.","journal-title":"Mol Cell Biol"},{"key":"BFcddis201331_CR32","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cytogfr.2004.11.002","volume":"16","author":"A Sanchez-Capelo","year":"2005","unstructured":"Sanchez-Capelo A . Dual role for TGF-beta1 in apoptosis. Cytokine Growth Factor Rev 2005; 16: 15\u201334.","journal-title":"Cytokine Growth Factor Rev"},{"key":"BFcddis201331_CR33","doi-asserted-by":"publisher","first-page":"714","DOI":"10.2174\/092986712798992110","volume":"19","author":"V Shoshan-Barmatz","year":"2012","unstructured":"Shoshan-Barmatz V, Golan M . Mitochondrial VDAC1: function in cell life and death and a target for cancer therapy. Curr Med Chem 2012; 19: 714\u2013735.","journal-title":"Curr Med Chem"},{"key":"BFcddis201331_CR34","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/ncb1575","volume":"9","author":"CP Baines","year":"2007","unstructured":"Baines CP, Kaiser RA, Sheiko T, Craigen WJ, Molkentin JD . Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol 2007; 9: 550\u2013555.","journal-title":"Nat Cell Biol"},{"key":"BFcddis201331_CR35","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1126\/science.1099320","volume":"305","author":"DR Green","year":"2004","unstructured":"Green DR, Kroemer G . The pathophysiology of mitochondrial cell death. Science 2004; 305: 626\u2013629.","journal-title":"Science"},{"key":"BFcddis201331_CR36","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1038\/sj.onc.1207205","volume":"23","author":"Y Zheng","year":"2004","unstructured":"Zheng Y, Shi Y, Tian C, Jiang C, Jin H, Chen J et al. Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide. Oncogene 2004; 23: 1239\u20131247.","journal-title":"Oncogene"},{"key":"BFcddis201331_CR37","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1038\/sj.cdd.4400780","volume":"7","author":"Y Tsujimoto","year":"2000","unstructured":"Tsujimoto Y, Shimizu S . VDAC regulation by the Bcl-2 family of proteins. Cell Death Differ 2000; 7: 1174\u20131181.","journal-title":"Cell Death Differ"},{"key":"BFcddis201331_CR38","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s10863-008-9148-8","volume":"40","author":"JG Pastorino","year":"2008","unstructured":"Pastorino JG, Hoek JB . Regulation of hexokinase binding to VDAC. J Bioenerg Biomembr 2008; 40: 171\u2013182.","journal-title":"J Bioenerg Biomembr"},{"key":"BFcddis201331_CR39","doi-asserted-by":"publisher","first-page":"10545","DOI":"10.1158\/0008-5472.CAN-05-1925","volume":"65","author":"JG Pastorino","year":"2005","unstructured":"Pastorino JG, Hoek JB, Shulga N . Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity. Cancer Res 2005; 65: 10545\u201310554.","journal-title":"Cancer Res"},{"key":"BFcddis201331_CR40","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1073\/pnas.1108225109","volume":"109","author":"P Mergenthaler","year":"2012","unstructured":"Mergenthaler P, Kahl A, Kamitz A, van Laak V, Stohlmann K, Thomsen S et al. Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state. Proc Natl Acad Sci USA 2012; 109: 1518\u20131523.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis201331_CR41","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1111\/j.1471-4159.2006.03853.x","volume":"98","author":"J Banerjee","year":"2006","unstructured":"Banerjee J, Ghosh S . Phosphorylation of rat brain mitochondrial voltage-dependent anion as a potential tool to control leakage of cytochrome c. J Neurochem 2006; 98: 670\u2013676.","journal-title":"J Neurochem"},{"key":"BFcddis201331_CR42","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1096\/fj.08-107417","volume":"22","author":"S Yuan","year":"2008","unstructured":"Yuan S, Fu Y, Wang X, Shi H, Huang Y, Song X et al. Voltage-dependent anion channel 1 is involved in endostatin-induced endothelial cell apoptosis. FASEB J 2008; 22: 2809\u20132820.","journal-title":"FASEB J"},{"key":"BFcddis201331_CR43","doi-asserted-by":"publisher","first-page":"R716","DOI":"10.1152\/ajpregu.00121.2011","volume":"301","author":"KT Murphy","year":"2011","unstructured":"Murphy KT, Chee A, Gleeson BG, Naim T, Swiderski K, Koopman R et al. Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice. Am J Physiol Regul Integr Comp Physiol 2011; 301: R716\u2013R726.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFcddis201331_CR44","doi-asserted-by":"publisher","first-page":"157","DOI":"10.2174\/1568008043339901","volume":"4","author":"K Tsuchida","year":"2004","unstructured":"Tsuchida K . Activins, myostatin and related TGF-beta family members as novel therapeutic targets for endocrine, metabolic and immune disorders. Curr Drug Targets Immune Endocr Metabol Disord 2004; 4: 157\u2013166.","journal-title":"Curr Drug Targets Immune Endocr Metabol Disord"},{"key":"BFcddis201331_CR45","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.mito.2011.01.012","volume":"11","author":"C Rosano","year":"2011","unstructured":"Rosano C . Molecular model of hexokinase binding to the outer mitochondrial membrane porin (VDAC1): Implication for the design of new cancer therapies. Mitochondrion May 2011; 11: 513\u2013519.","journal-title":"Mitochondrion May"},{"key":"BFcddis201331_CR46","doi-asserted-by":"publisher","first-page":"4633","DOI":"10.1038\/onc.2008.114","volume":"27","author":"L Galluzzi","year":"2008","unstructured":"Galluzzi L, Kepp O, Tajeddine N, Kroemer G . Disruption of the hexokinase-VDAC complex for tumor therapy. Oncogene 2008; 27: 4633\u20134635.","journal-title":"Oncogene"},{"key":"BFcddis201331_CR47","doi-asserted-by":"publisher","first-page":"714","DOI":"10.2174\/092986712798992110","volume":"19","author":"V Shoshan-Barmatz","year":"2012","unstructured":"Shoshan-Barmatz V, Golan M . Mitochondrial VDAC1: function in cell life and death and a target for cancer therapy. Curr Med Chem 2012; 19: 714\u2013735.","journal-title":"Curr Med Chem"},{"key":"BFcddis201331_CR48","first-page":"393","volume":"68","author":"DJ Cannata","year":"2010","unstructured":"Cannata DJ, Ireland Z, Dickinson H, Snow RJ, Russell AP, West JM et al. Maternal creatine supplementation from mid-pregnancy protects the newborn spiny mouse diaphragm from intrapartum hypoxia-induced damage. Pediatr Res 2010; 68: 393\u2013398.","journal-title":"Pediatr Res"},{"key":"BFcddis201331_CR49","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.bbrc.2004.11.096","volume":"326","author":"W Yang","year":"2005","unstructured":"Yang W, Zhang Y, Ma G, Zhao X, Chen Y, Zhu D . Identification of gene expression modifications in myostatin-stimulated myoblasts. Biochem Biophys Res Commun 2005; 326: 660\u2013666.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcddis201331_CR50","doi-asserted-by":"publisher","first-page":"3339","DOI":"10.1038\/sj.onc.1208484","volume":"24","author":"Y Zheng","year":"2005","unstructured":"Zheng Y, Yamaguchi H, Tian C, Lee MW, Tang H, Wang HG et al. Arsenic trioxide (As(2)O(3)) induces apoptosis through activation of Bax in hematopoietic cells. Oncogene 2005; 24: 3339\u20133347.","journal-title":"Oncogene"},{"key":"BFcddis201331_CR51","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1007\/s13238-010-0048-4","volume":"1","author":"Y Zhu","year":"2010","unstructured":"Zhu Y, Zhao L, Liu L, Gao P, Tian W, Wang X et al. Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis. Protein Cell 2010; 1: 468\u2013477.","journal-title":"Protein Cell"},{"key":"BFcddis201331_CR52","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1158\/1078-0432.CCR-10-3450","volume":"18","author":"B Ni","year":"2012","unstructured":"Ni B, Ma Q, Li B, Zhao L, Liu Y, Zhu Y et al. Phenylarsine oxide induces apoptosis in Bax- and Bak-deficient cells through upregulation of Bim. Clin Cancer Res 2012; 18: 140\u2013151.","journal-title":"Clin Cancer Res"},{"key":"BFcddis201331_CR53","volume-title":"Mitochondria","author":"LA Pon","year":"2007","unstructured":"Pon LA, Schon EA . Mitochondria 2nd edn. Academic Press: Amsterdam; Boston, 2007 xxiv, 920 p.pp."},{"key":"BFcddis201331_CR54","doi-asserted-by":"publisher","first-page":"C125","DOI":"10.1152\/ajpcell.00247.2006","volume":"292","author":"M Wu","year":"2007","unstructured":"Wu M, Neilson A, Swift AL, Moran R, Tamagnine J, Parslow D et al. Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol 2007; 292: C125\u2013C136.","journal-title":"Am J Physiol Cell Physiol"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis201331.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis201331","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis201331.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T23:58:50Z","timestamp":1672963130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis201331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,14]]},"references-count":54,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2]]}},"alternative-id":["BFcddis201331"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2013.31","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,14]]},"assertion":[{"value":"10 July 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}