{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T01:09:40Z","timestamp":1676855380235},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T00:00:00Z","timestamp":1382572800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2013.408","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T14:17:58Z","timestamp":1382624278000},"page":"e886-e886","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Increased plasma levels of CK-18 as potential cell death biomarker in patients with HELLP syndrome"],"prefix":"10.1038","volume":"4","author":[{"given":"K","family":"John","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Wielgosz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Schulze-Osthoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Bantel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Hass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,10,24]]},"reference":[{"key":"BFcddis2013408_CR1","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/sj.jp.7200165","volume":"19","author":"WM Curtin","year":"1999","unstructured":"Curtin WM, Weinstein L . A review of HELLP syndrome. J Perinatol 1999; 19: 138\u2013143.","journal-title":"J Perinatol"},{"key":"BFcddis2013408_CR2","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1136\/bmj.322.7291.917","volume":"322","author":"E Goodburn","year":"2001","unstructured":"Goodburn E, Campbell O . Reducing maternal mortality in the developing world: sector-wide approaches may be the key. BMJ 2001; 322: 917\u2013920.","journal-title":"BMJ"},{"key":"BFcddis2013408_CR3","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1080\/jmf.16.5.287.293","volume":"16","author":"J Smulian","year":"2004","unstructured":"Smulian J, Shen-Schwarz S, Scorza W, Kinzler W, Vintzileos A . A clinicohistopathologic comparison between HELLP syndrome and severe preeclampsia. J Matern Fetal Neonatal Med 2004; 16: 287\u2013293.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"BFcddis2013408_CR4","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1067\/mob.2000.108877","volume":"183","author":"ET McKinney","year":"2000","unstructured":"McKinney ET, Shouri R, Hunt RS, Ahokas RA, Sibai BM . Plasma urinary, and salivary 8-epi-prostaglandin f2alpha levels in normotensive and preeclamptic pregnancies. Am J Obstet Gynecol 2000; 183: 874\u2013877.","journal-title":"Am J Obstet Gynecol"},{"key":"BFcddis2013408_CR5","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1096\/fasebj.14.10.1289","volume":"14","author":"SW Walsh","year":"2000","unstructured":"Walsh SW, Vaughan JE, Wang Y, Roberts LJ II . Placental isoprostane is significantly increased in preeclampsia. FASEB J 2000; 14: 1289\u20131296.","journal-title":"FASEB J"},{"key":"BFcddis2013408_CR6","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/S0143-4004(03)00174-7","volume":"24","author":"R Hass","year":"2003","unstructured":"Hass R, Sohn C . Increased oxidative stress in pre-eclamptic placenta is associated with altered proteasome activity and protein patterns. Placenta 2003; 24: 979\u2013984.","journal-title":"Placenta"},{"key":"BFcddis2013408_CR7","doi-asserted-by":"publisher","first-page":"166","DOI":"10.2174\/157340407781387645","volume":"3","author":"R Hass","year":"2007","unstructured":"Hass R, Staboulidou I, W\u00fcstemann M, Kundu S, Oehler K, Scharf A . Preeclampsia as a multifactorial pregnancy disorder: Clinical symptoms, diagnostic tools and research strategies. Curr Women's Health Rev 2007; 3: 166\u2013176.","journal-title":"Curr Women's Health Rev"},{"key":"BFcddis2013408_CR8","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ejogrb.2012.09.026","volume":"166","author":"U Abildgaard","year":"2013","unstructured":"Abildgaard U, Heimdal K . Pathogenesis of the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP): a review. Eur J Obstet Gynecol Reprod Biol 2013; 166: 117\u2013123.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"BFcddis2013408_CR9","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1210\/er.2005-0003","volume":"26","author":"SL Straszewski-Chavez","year":"2005","unstructured":"Straszewski-Chavez SL, Abrahams VM, Mor G . The role of apoptosis in the regulation of trophoblast survival and differentiation during pregnancy. Endocr Rev 2005; 26: 877\u2013897.","journal-title":"Endocr Rev"},{"key":"BFcddis2013408_CR10","doi-asserted-by":"publisher","first-page":"4286","DOI":"10.4049\/jimmunol.173.7.4286","volume":"173","author":"VM Abrahams","year":"2004","unstructured":"Abrahams VM, Bole-Aldo P, Kim YM, Straszewski-Chavez SL, Chaiworapongsa T, Romero R et al. Divergent trophoblast responses to bacterial products mediated by TLRs. J Immunol 2004; 173: 4286\u20134296.","journal-title":"J Immunol"},{"key":"BFcddis2013408_CR11","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1067\/mob.2001.112906","volume":"184","author":"DN Leung","year":"2001","unstructured":"Leung DN, Smith SC, To KF, Sahota DS, Baker PN . Increased placental apoptosis in pregnancies complicated by preeclampsia. Am J Obstet Gynecol 2001; 184: 1249\u20131250.","journal-title":"Am J Obstet Gynecol"},{"key":"BFcddis2013408_CR12","first-page":"271","volume":"96","author":"AD Allaire","year":"2000","unstructured":"Allaire AD, Ballenger KA, Wells SR, McMahon MJ, Lessey BA . Placental apoptosis in preeclampsia. Obstet Gynecol 2000; 96: 271\u2013276.","journal-title":"Obstet Gynecol"},{"key":"BFcddis2013408_CR13","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1067\/mob.2002.119176","volume":"186","author":"N Ishihara","year":"2002","unstructured":"Ishihara N, Matsuo H, Murakoshi H, Laoag-Fernandez JB, Samoto T, Maruo T . Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation. Am J Obstet Gynecol 2002; 186: 158\u2013166.","journal-title":"Am J Obstet Gynecol"},{"key":"BFcddis2013408_CR14","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/S0002-9440(10)63857-6","volume":"162","author":"IP Crocker","year":"2003","unstructured":"Crocker IP, Cooper S, Ong SC, Baker PN . Differences in apoptotic susceptibility of cytotrophoblasts and syncytiotrophoblasts in normal pregnancy to those complicated with preeclampsia and intrauterine growth restriction. Am J Pathol 2003; 162: 637\u2013643.","journal-title":"Am J Pathol"},{"key":"BFcddis2013408_CR15","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1096\/fj.08-111005","volume":"23","author":"ME Guicciardi","year":"2009","unstructured":"Guicciardi ME, Gores GJ . Life and death by death receptors. FASEB J 2009; 23: 1625\u20131637.","journal-title":"FASEB J"},{"key":"BFcddis2013408_CR16","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1046\/j.1432-1327.1998.2540439.x","volume":"254","author":"K Schulze-Osthoff","year":"1998","unstructured":"Schulze-Osthoff K, Ferrari D, Los M, Wesselborg S, Peter ME . Apoptosis signaling by death receptors. Eur J Biochem 1998; 254: 439\u2013459.","journal-title":"Eur J Biochem"},{"key":"BFcddis2013408_CR17","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S1074-7613(00)80062-X","volume":"10","author":"M Los","year":"1999","unstructured":"Los M, Wesselborg S, Schulze-Osthoff K . The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice. Immunity 1999; 10: 629\u2013639.","journal-title":"Immunity"},{"key":"BFcddis2013408_CR18","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1078\/0171-9335-00154","volume":"80","author":"H Bantel","year":"2001","unstructured":"Bantel H, Ruck P, Gregor M, Schulze-Osthoff K . Detection of elevated caspase activation and early apoptosis in liver diseases. Eur J Cell Biol 2001; 80: 230\u2013239.","journal-title":"Eur J Cell Biol"},{"key":"BFcddis2013408_CR19","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1177\/107155760100800308","volume":"8","author":"LA Hefler","year":"2001","unstructured":"Hefler LA, Tempfer CB, Bancher-Todesca D, Schatten C, Husslein P, Heinze G et al. Placental expression and serum levels of cytokeratin-18 are increased in women with preeclampsia. J Soc Gynecol Investig 2001; 8: 169\u2013173.","journal-title":"J Soc Gynecol Investig"},{"key":"BFcddis2013408_CR20","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1002\/hep.20411","volume":"40","author":"H Bantel","year":"2004","unstructured":"Bantel H, Lugering A, Heidemann J, Volkmann X, Poremba C, Strassburg CP et al. Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury. Hepatology 2004; 40: 1078\u20131087.","journal-title":"Hepatology"},{"key":"BFcddis2013408_CR21","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1080\/00365510802474384","volume":"69","author":"RR Hamad","year":"2009","unstructured":"Hamad RR, Bremme K, Kallner A, Sten-Linder M . Increased levels of an apoptotic product in the sera from women with pre-eclampsia. Scand J Clin Lab Invest 2009; 69: 204\u2013208.","journal-title":"Scand J Clin Lab Invest"},{"key":"BFcddis2013408_CR22","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/hep.20747","volume":"42","author":"N Seidel","year":"2005","unstructured":"Seidel N, Volkmann X, Langer F, Flemming P, Manns MP, Schulze-Osthoff K et al. The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum. Hepatology 2005; 42: 113\u2013120.","journal-title":"Hepatology"},{"key":"BFcddis2013408_CR23","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/hep.24734","volume":"55","author":"D Joka","year":"2012","unstructured":"Joka D, Wahl K, Moeller S, Schlue J, Vaske B, Bahr MJ et al. Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis. Hepatology 2012; 55: 455\u2013465.","journal-title":"Hepatology"},{"key":"BFcddis2013408_CR24","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1083\/jcb.148.6.1239","volume":"148","author":"M MacFarlane","year":"2000","unstructured":"MacFarlane M, Merrison W, Dinsdale D, Cohen GM . Active caspases and cleaved cytokeratins are sequestered into cytoplasmic inclusions in TRAIL-induced apoptosis. J Cell Biol 2000; 148: 1239\u20131254.","journal-title":"J Cell Biol"},{"key":"BFcddis2013408_CR25","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1053\/j.gastro.2003.11.054","volume":"126","author":"S Strand","year":"2004","unstructured":"Strand S, Strand D, Seufert R, Mann A, Lotz J, Blessing M et al. Placenta-derived CD95 ligand causes liver damage in hemolysis, elevated liver enzymes, and low platelet count syndrome. Gastroenterology 2004; 126: 849\u2013858.","journal-title":"Gastroenterology"},{"key":"BFcddis2013408_CR26","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1111\/j.1600-0412.2011.01152.x","volume":"90","author":"IK Prusac","year":"2011","unstructured":"Prusac IK, Zekic Tomas S, Roje D . Apoptosis, proliferation and Fas ligand expression in placental trophoblast from pregnancies complicated by HELLP syndrome or pre-eclampsia. Acta Obstet Gynecol Scand 2011; 90: 1157\u20131163.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"BFcddis2013408_CR27","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jri.2006.11.002","volume":"74","author":"IP Eide","year":"2007","unstructured":"Eide IP, Isaksen CV, Salvesen KA, Langaas M, Gunther CC, Iversen AC et al. Fetal growth restriction is associated with reduced FasL expression by decidual cells. J Reprod Immunol 2007; 74: 7\u201314.","journal-title":"J Reprod Immunol"},{"key":"BFcddis2013408_CR28","first-page":"45","volume":"40","author":"U Cali","year":"2013","unstructured":"Cali U, Cavkaytar S, Sirvan L, Danisman N . Placental apoptosis in preeclampsia, intrauterine growth retardation, and HELLP syndrome: an immunohistochemical study with caspase-3 and bcl-2. Clin Exp Obstet Gynecol 2013; 40: 45\u201348.","journal-title":"Clin Exp Obstet Gynecol"},{"key":"BFcddis2013408_CR29","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1034\/j.1600-065X.2003.00047.x","volume":"193","author":"A Krueger","year":"2003","unstructured":"Krueger A, Fas SC, Baumann S, Krammer PH . The role of CD95 in the regulation of peripheral T-cell apoptosis. Immunol Rev 2003; 193: 58\u201369.","journal-title":"Immunol Rev"},{"key":"BFcddis2013408_CR30","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1002\/hep.21846","volume":"46","author":"X Volkmann","year":"2007","unstructured":"Volkmann X, Fischer U, Bahr MJ, Ott M, Lehner F, MacFarlane M et al. Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver. Hepatology 2007; 46: 1498\u20131508.","journal-title":"Hepatology"}],"container-title":["Cell Death & Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis2013408.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis2013408","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2013408.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T23:52:12Z","timestamp":1672962732000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis2013408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,24]]},"references-count":30,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10]]}},"alternative-id":["BFcddis2013408"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2013.408","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,24]]},"assertion":[{"value":"24 August 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}