{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:30:50Z","timestamp":1790728250351,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T00:00:00Z","timestamp":1390435200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2013.537","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T11:04:25Z","timestamp":1390475065000},"page":"e1009-e1009","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["The interaction between mesenchymal stem cells and steroids during inflammation"],"prefix":"10.1038","volume":"5","author":[{"given":"X","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A I","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,23]]},"reference":[{"key":"BFcddis2013537_CR1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1002\/jcp.20636","volume":"208","author":"K Yoshimura","year":"2006","unstructured":"Yoshimura K, Shigeura T, Matsumoto D, Sato T, Takaki Y, Aiba-Kojima E et al. Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates. J Cell Physiol 2006; 208: 64\u201376.","journal-title":"J Cell Physiol"},{"key":"BFcddis2013537_CR2","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1634\/stemcells.2004-0013","volume":"22","author":"HS Wang","year":"2004","unstructured":"Wang HS, Hung SC, Peng ST, Huang CC, Wei HM, Guo YJ et al. Mesenchymal stem cells in the Wharton\u2019s jelly of the human umbilical cord. Stem Cells 2004; 22: 1330\u20131337.","journal-title":"Stem Cells"},{"key":"BFcddis2013537_CR3","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1038\/ncb0901-778","volume":"3","author":"JG Toma","year":"2001","unstructured":"Toma JG, Akhavan M, Fernandes KJ, Barnabe-Heider F, Sadikot A, Kaplan DR et al. Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 2001; 3: 778\u2013784.","journal-title":"Nat Cell Biol"},{"key":"BFcddis2013537_CR4","doi-asserted-by":"publisher","first-page":"95","DOI":"10.2217\/rme.10.98","volume":"6","author":"L Wang","year":"2011","unstructured":"Wang L, Ott L, Seshareddy K, Weiss ML, Detamore MS . Musculoskeletal tissue engineering with human umbilical cord mesenchymal stromal cells. Regen Med 2011; 6: 95\u2013109.","journal-title":"Regen Med"},{"key":"BFcddis2013537_CR5","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1016\/S0140-6736(08)60690-X","volume":"371","author":"K Le Blanc","year":"2008","unstructured":"Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008; 371: 1579\u20131586.","journal-title":"Lancet"},{"key":"BFcddis2013537_CR6","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1002\/art.27548","volume":"62","author":"L Sun","year":"2010","unstructured":"Sun L, Wang D, Liang J, Zhang H, Feng X, Wang H et al. Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. Arthritis Rheum 2010; 62: 2467\u20132475.","journal-title":"Arthritis Rheum"},{"key":"BFcddis2013537_CR7","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1007\/s10350-005-0052-6","volume":"48","author":"D Garcia-Olmo","year":"2005","unstructured":"Garcia-Olmo D, Garcia-Arranz M, Herreros D, Pascual I, Peiro C, Rodriguez-Montes JA . A phase I clinical trial of the treatment of Crohn\u2019s fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum 2005; 48: 1416\u20131423.","journal-title":"Dis Colon Rectum"},{"key":"BFcddis2013537_CR8","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.stem.2009.05.003","volume":"5","author":"RH Lee","year":"2009","unstructured":"Lee RH, Pulin AA, Seo MJ, Kota DJ, Ylostalo J, Larson BL et al. Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell 2009; 5: 54\u201363.","journal-title":"Cell Stem Cell"},{"key":"BFcddis2013537_CR9","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jneuroim.2010.07.013","volume":"227","author":"B Yamout","year":"2010","unstructured":"Yamout B, Hourani R, Salti H, Barada W, El-Hajj T, Al-Kutoubi A et al. Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study. J Neuroimmunol 2010; 227: 185\u2013189.","journal-title":"J Neuroimmunol"},{"key":"BFcddis2013537_CR10","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.nbd.2010.07.001","volume":"40","author":"J Jones","year":"2010","unstructured":"Jones J, Jaramillo-Merchan J, Bueno C, Pastor D, Viso-Leon M, Martinez S . Mesenchymal stem cells rescue Purkinje cells and improve motor functions in a mouse model of cerebellar ataxia. Neurobiol Dis 2010; 40: 415\u2013423.","journal-title":"Neurobiol Dis"},{"key":"BFcddis2013537_CR11","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.stem.2007.11.014","volume":"2","author":"G Ren","year":"2008","unstructured":"Ren G, Zhang L, Zhao X, Xu G, Zhang Y, Roberts AI et al. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2008; 2: 141\u2013150.","journal-title":"Cell Stem Cell"},{"key":"BFcddis2013537_CR12","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.1002\/stem.118","volume":"27","author":"G Ren","year":"2009","unstructured":"Ren G, Su J, Zhang L, Zhao X, Ling W, L'Huillie A et al. Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression. Stem Cells 2009; 27: 1954\u20131962.","journal-title":"Stem Cells"},{"issue":"2","key":"BFcddis2013537_CR13","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1002\/hep.26678","volume":"59","author":"Jamuna Karkhanis","year":"2013","unstructured":"Karkhanis J, Verna EC, Chang MS, Stravitz RT, Schilsky M, Lee WM et al. Steroid use in acute liver failure. Hepatology 2013 e-pub ahead of print 8 August 2013 doi:10.1002\/hep.26678.","journal-title":"Hepatology"},{"key":"BFcddis2013537_CR14","first-page":"276","volume":"18","author":"DM Almalki","year":"2013","unstructured":"Almalki DM, Al-Suwaidan FB . Steroid pulse therapy in herpes simplex encephalitis. Neurosciences (Riyadh) 2013; 18: 276\u2013277.","journal-title":"Neurosciences (Riyadh)"},{"key":"BFcddis2013537_CR15","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S1665-2681(19)31899-X","volume":"6","author":"RD Soloway","year":"2007","unstructured":"Soloway RD, Hewlett AT . The medical treatment for autoimmune hepatitis through corticosteroid to new immunosuppressive agents: a concise review. Ann Hepatol 2007; 6: 204\u2013207.","journal-title":"Ann Hepatol"},{"key":"BFcddis2013537_CR16","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/ar3848","volume":"14","author":"R Bucala","year":"2012","unstructured":"Bucala R . Approaching the immunophysiology of steroid resistance. Arthritis Res Ther 2012; 14: 118.","journal-title":"Arthritis Res Ther"},{"key":"BFcddis2013537_CR17","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.3109\/02770903.2013.831870","volume":"50","author":"D Reddy","year":"2013","unstructured":"Reddy D, Little FF . Steroid resistant asthma: more than meets the eye. J Asthma 2013; 50: 1036\u20131044.","journal-title":"J Asthma"},{"key":"BFcddis2013537_CR18","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1097\/TP.0b013e31821aba18","volume":"91","author":"KH Wu","year":"2011","unstructured":"Wu KH, Chan CK, Tsai C, Chang YH, Sieber M, Chiu TH et al. Effective treatment of severe steroid-resistant acute graft-versus-host disease with umbilical cord-derived mesenchymal stem cells. Transplantation 2011; 91: 1412\u20131416.","journal-title":"Transplantation"},{"key":"BFcddis2013537_CR19","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1097\/01.tp.0000209919.90630.7b","volume":"81","author":"S Inoue","year":"2006","unstructured":"Inoue S, Popp FC, Koehl GE, Piso P, Schlitt HJ, Geissler EK et al. Immunomodulatory effects of mesenchymal stem cells in a rat organ transplant model. Transplantation 2006; 81: 1589\u20131595.","journal-title":"Transplantation"},{"key":"BFcddis2013537_CR20","doi-asserted-by":"crossref","unstructured":"Baker M . Stem-cell drug fails crucial trials. Nature 2009 Available at http:\/\/www.nature.com\/news\/2009\/090909\/full\/news.2009.894.html.","DOI":"10.1038\/news.2009.894"},{"key":"BFcddis2013537_CR21","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1002\/hep.20452","volume":"40","author":"I Sakaida","year":"2004","unstructured":"Sakaida I, Terai S, Yamamoto N, Aoyama K, Ishikawa T, Nishina H et al. Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology 2004; 40: 1304\u20131311.","journal-title":"Hepatology"},{"issue":"Suppl 2","key":"BFcddis2013537_CR22","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/j.1440-1746.2011.07024.x","volume":"27","author":"Z Zhang","year":"2012","unstructured":"Zhang Z, Lin H, Shi M, Xu R, Fu J, Lv J et al. Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients. J Gastroenterol Hepatol 2012; 27 (Suppl 2): 112\u2013120.","journal-title":"J Gastroenterol Hepatol"},{"key":"BFcddis2013537_CR23","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1136\/gut.52.5.694","volume":"52","author":"F Xue","year":"2003","unstructured":"Xue F, Takahara T, Yata Y, Kuwabara Y, Shinno E, Nonome K et al. Hepatocyte growth factor gene therapy accelerates regeneration in cirrhotic mouse livers after hepatectomy. Gut 2003; 52: 694\u2013700.","journal-title":"Gut"},{"key":"BFcddis2013537_CR24","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1038\/cdd.2012.26","volume":"19","author":"W Li","year":"2012","unstructured":"Li W, Ren G, Huang Y, Su J, Han Y, Li J et al. Mesenchymal stem cells: a double-edged sword in regulating immune responses. Cell Death Differ 2012; 19: 1505\u20131513.","journal-title":"Cell Death Differ"},{"key":"BFcddis2013537_CR25","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1002\/hep.510300432","volume":"30","author":"AM Preaux","year":"1999","unstructured":"Preaux AM, Mallat A, Nhieu JT, D'Ortho MP, Hembry RM, Mavier P . Matrix metalloproteinase-2 activation in human hepatic fibrosis regulation by cell-matrix interactions. Hepatology 1999; 30: 944\u2013950.","journal-title":"Hepatology"},{"key":"BFcddis2013537_CR26","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/nri2395","volume":"8","author":"A Uccelli","year":"2008","unstructured":"Uccelli A, Moretta L, Pistoia V . Mesenchymal stem cells in health and disease. Nat Rev Immunol 2008; 8: 726\u2013736.","journal-title":"Nat Rev Immunol"},{"key":"BFcddis2013537_CR27","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.copbio.2009.08.009","volume":"20","author":"J Wagner","year":"2009","unstructured":"Wagner J, Kean T, Young R, Dennis JE, Caplan AI . Optimizing mesenchymal stem cell-based therapeutics. Curr Opin Biotechnol 2009; 20: 531\u2013536.","journal-title":"Curr Opin Biotechnol"},{"key":"BFcddis2013537_CR28","doi-asserted-by":"publisher","first-page":"3431","DOI":"10.3748\/wjg.v11.i22.3431","volume":"11","author":"DC Zhao","year":"2005","unstructured":"Zhao DC, Lei JX, Chen R, Yu WH, Zhang XM, Li SN et al. Bone marrow-derived mesenchymal stem cells protect against experimental liver fibrosis in rats. World J Gastroenterol 2005; 11: 3431\u20133440.","journal-title":"World J Gastroenterol"},{"key":"BFcddis2013537_CR29","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/cr.2010.44","volume":"20","author":"Y Shi","year":"2010","unstructured":"Shi Y, Hu G, Su J, Li W, Chen Q, Shou P et al. Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair. Cell Res 2010; 20: 510\u2013518.","journal-title":"Cell Res"},{"key":"BFcddis2013537_CR30","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1002\/jcb.22306","volume":"108","author":"XR Tao","year":"2009","unstructured":"Tao XR, Li WL, Su J, Jin CX, Wang XM, Li JX et al. Clonal mesenchymal stem cells derived from human bone marrow can differentiate into hepatocyte-like cells in injured livers of SCID mice. J Cell Biochem 2009; 108: 693\u2013704.","journal-title":"J Cell Biochem"},{"key":"BFcddis2013537_CR31","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1177\/0961203309348983","volume":"19","author":"F Carrion","year":"2010","unstructured":"Carrion F, Nova E, Ruiz C, Diaz F, Inostroza C, Rojo D et al. Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients. Lupus 2010; 19: 317\u2013322.","journal-title":"Lupus"},{"key":"BFcddis2013537_CR32","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1136\/gut.2010.215152","volume":"59","author":"M Duijvestein","year":"2010","unstructured":"Duijvestein M, Vos AC, Roelofs H, Wildenberg ME, Wendrich BB, Verspaget HW et al. Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn\u2019s disease: results of a phase I study. Gut 2010; 59: 1662\u20131669.","journal-title":"Gut"},{"key":"BFcddis2013537_CR33","doi-asserted-by":"publisher","first-page":"51","DOI":"10.5966\/sctm.2011-0019","volume":"1","author":"G Ren","year":"2012","unstructured":"Ren G, Chen X, Dong F, Li W, Ren X, Zhang Y et al. Concise review: mesenchymal stem cells and translational medicine: emerging issues. Stem Cells Transl Med 2012; 1: 51\u201358.","journal-title":"Stem Cells Transl Med"},{"key":"BFcddis2013537_CR34","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1755-7682-4-27","volume":"4","author":"CM Wernicke","year":"2011","unstructured":"Wernicke CM, Grunewald TG, Juenger H, Kuci S, Kuci Z, Koehl U et al. Mesenchymal stromal cells for treatment of steroid-refractory GvHD: a review of the literature and two pediatric cases. Int Arch Med 2011; 4: 27.","journal-title":"Int Arch Med"},{"key":"BFcddis2013537_CR35","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.exphem.2007.11.007","volume":"36","author":"M Di Ianni","year":"2008","unstructured":"Di Ianni M, Del Papa B, De Ioanni M, Moretti L, Bonifacio E, Cecchini D et al. Mesenchymal cells recruit and regulate T regulatory cells. Exp Hematol 2008; 36: 309\u2013318.","journal-title":"Exp Hematol"},{"key":"BFcddis2013537_CR36","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.bbrc.2007.07.052","volume":"361","author":"G Xu","year":"2007","unstructured":"Xu G, Zhang Y, Zhang L, Ren G, Shi Y . The role of IL-6 in inhibition of lymphocyte apoptosis by mesenchymal stem cells. Biochem Biophys Res Commun 2007; 361: 745\u2013750.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcddis2013537_CR37","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0168-8278(01)00260-4","volume":"36","author":"D Cassiman","year":"2002","unstructured":"Cassiman D, Libbrecht L, Desmet V, Denef C, Roskams T . Hepatic stellate cell\/myofibroblast subpopulations in fibrotic human and rat livers. J Hepatol 2002; 36: 200\u2013209.","journal-title":"J Hepatol"},{"issue":"Suppl 3","key":"BFcddis2013537_CR38","doi-asserted-by":"publisher","first-page":"S88","DOI":"10.1111\/j.1440-1746.2006.04586.x","volume":"21","author":"YP Han","year":"2006","unstructured":"Han YP . Matrix metalloproteinases, the pros and cons, in liver fibrosis. J Gastroenterol Hepatol 2006; 21 (Suppl 3): S88\u2013S91.","journal-title":"J Gastroenterol Hepatol"},{"key":"BFcddis2013537_CR39","doi-asserted-by":"publisher","first-page":"2508","DOI":"10.1091\/mbc.e02-11-0729","volume":"14","author":"B Hinz","year":"2003","unstructured":"Hinz B, Dugina V, Ballestrem C, Wehrle-Haller B, Chaponnier C . Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts. Mol Biol Cell 2003; 14: 2508\u20132519.","journal-title":"Mol Biol Cell"},{"key":"BFcddis2013537_CR40","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1006\/niox.2000.0319","volume":"5","author":"KM Miranda","year":"2001","unstructured":"Miranda KM, Espey MG, Wink DA . A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 2001; 5: 62\u201371.","journal-title":"Nitric Oxide"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis2013537.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis2013537","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2013537.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T18:29:48Z","timestamp":1672943388000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis2013537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,23]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1]]}},"alternative-id":["BFcddis2013537"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2013.537","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,23]]},"assertion":[{"value":"28 October 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}