{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:29:04Z","timestamp":1791210544791,"version":"4.1.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2014.104","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T15:59:38Z","timestamp":1395331178000},"page":"e1136-e1136","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Defects in TLR3 expression and RNase L activation lead to decreased MnSOD expression and insulin resistance in muscle cells of obese people"],"prefix":"10.1038","volume":"5","author":[{"given":"O","family":"Fabre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Breuker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Amouzou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Salehzada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kitzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Mercier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Bisbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,20]]},"reference":[{"key":"BFcddis2014104_CR1","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1038\/nature05482","volume":"444","author":"SE Kahn","year":"2006","unstructured":"Kahn SE, Hull RL, Utzschneider KM . Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006; 444: 840\u2013846.","journal-title":"Nature"},{"key":"BFcddis2014104_CR2","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1097\/MED.0b013e328357f0a3","volume":"19","author":"M Bluher","year":"2012","unstructured":"Bluher M . Are there still healthy obese patients? Curr Opin Endocrinol Diabetes Obes 2012; 19: 341\u2013346.","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"BFcddis2014104_CR3","doi-asserted-by":"publisher","first-page":"4145","DOI":"10.1210\/jc.2005-0482","volume":"90","author":"AD Karelis","year":"2005","unstructured":"Karelis AD, Faraj M, Bastard JP, St-Pierre DH, Brochu M, Prud'homme D et al. The metabolically healthy but obese individual presents a favorable inflammation profile. J Clin Endocrinol Metab 2005; 90: 4145\u20134150.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFcddis2014104_CR4","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1097\/MCO.0b013e32833a5559","volume":"13","author":"C Bisbal","year":"2010","unstructured":"Bisbal C, Lambert K, Avignon A . Antioxidants and glucose metabolism disorders. Curr Opin Clin Nutr Metab Care 2010; 13: 439\u2013446.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"BFcddis2014104_CR5","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","volume":"29","author":"MF Gregor","year":"2011","unstructured":"Gregor MF, Hotamisligil GS . Inflammatory mechanisms in obesity. Annu Rev Immunol 2011; 29: 415\u2013445.","journal-title":"Annu Rev Immunol"},{"key":"BFcddis2014104_CR6","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/MED.0b013e3283444b09","volume":"18","author":"G Boden","year":"2011","unstructured":"Boden G . Obesity, insulin resistance and free fatty acids. Curr Opin Endocrinol Diabetes Obes 2011; 18: 139\u2013143.","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"BFcddis2014104_CR7","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.cmet.2012.04.001","volume":"15","author":"CK Glass","year":"2012","unstructured":"Glass CK, Olefsky JM . Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab 2012; 15: 635\u2013645.","journal-title":"Cell Metab"},{"key":"BFcddis2014104_CR8","doi-asserted-by":"publisher","first-page":"5261","DOI":"10.1210\/en.2012-1400","volume":"153","author":"MA Carvalho-Filho","year":"2012","unstructured":"Carvalho-Filho MA, Carvalho BM, Oliveira AG, Guadagnini D, Ueno M, Dias MM et al. Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice. Endocrinology 2012; 153: 5261\u20135274.","journal-title":"Endocrinology"},{"key":"BFcddis2014104_CR9","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.cell.2010.01.001","volume":"140","author":"T Nakamura","year":"2010","unstructured":"Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N et al. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell 2010; 140: 338\u2013348.","journal-title":"Cell"},{"key":"BFcddis2014104_CR10","first-page":"pe47","volume":"5","author":"R Kang","year":"2010","unstructured":"Kang R, Tang D . PKR-dependent inflammatory signals. Sci Signal 2010; 5: pe47.","journal-title":"Sci Signal"},{"key":"BFcddis2014104_CR11","doi-asserted-by":"publisher","first-page":"E145","DOI":"10.1152\/ajpendo.00490.2010","volume":"300","author":"MR Dasu","year":"2011","unstructured":"Dasu MR, Jialal I . Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. Am J Physiol Endocrinol Metab 2011; 300: E145\u2013E154.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFcddis2014104_CR12","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1161\/ATVBAHA.109.188813","volume":"29","author":"E Maloney","year":"2009","unstructured":"Maloney E, Sweet IR, Hockenbery DM, Pham M, Rizzo NO, Tateya S et al. Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation. Arterioscler Thromb Vasc Biol 2009; 29: 1370\u20131375.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BFcddis2014104_CR13","doi-asserted-by":"publisher","first-page":"27384","DOI":"10.1074\/jbc.M109.044065","volume":"284","author":"SW Wong","year":"2009","unstructured":"Wong SW, Kwon MJ, Choi AM, Kim HP, Nakahira K, Hwang DH . Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. J Biol Chem 2009; 284: 27384\u201327392.","journal-title":"J Biol Chem"},{"key":"BFcddis2014104_CR14","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1152\/physrev.00014.2008","volume":"89","author":"N Bashan","year":"2009","unstructured":"Bashan N, Kovsan J, Kachko I, Ovadia H, Rudich A . Positive and negative regulation of insulin signaling by reactive oxygen and nitrogen species. Physiol Rev 2009; 89: 27\u201371.","journal-title":"Physiol Rev"},{"key":"BFcddis2014104_CR15","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1089\/ars.2005.7.1021","volume":"7","author":"BJ Goldstein","year":"2005","unstructured":"Goldstein BJ, Mahadev K, Wu X, Zhu L, Motoshima H . Role of insulin-induced reactive oxygen species in the insulin signaling pathway. Antioxid Redox Signal 2005; 7: 1021\u20131031.","journal-title":"Antioxid Redox Signal"},{"key":"BFcddis2014104_CR16","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1089\/ars.2010.3794","volume":"15","author":"AA Szypowska","year":"2011","unstructured":"Szypowska AA, Burgering BM . The peroxide dilemma: opposing and mediating insulin action. Antioxid Redox Signal 2011; 15: 219\u2013232.","journal-title":"Antioxid Redox Signal"},{"key":"BFcddis2014104_CR17","doi-asserted-by":"publisher","first-page":"2463","DOI":"10.1007\/s00125-006-0349-6","volume":"49","author":"A Bloch-Damti","year":"2006","unstructured":"Bloch-Damti A, Potashnik R, Gual P, Le Marchand-Brustel Y, Tanti JF, Rudich A et al. Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress. Diabetologia 2006; 49: 2463\u20132473.","journal-title":"Diabetologia"},{"key":"BFcddis2014104_CR18","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1677\/JOE-08-0061","volume":"197","author":"R Vinayagamoorthi","year":"2008","unstructured":"Vinayagamoorthi R, Bobby Z, Sridhar MG . Antioxidants preserve redox balance and inhibit c-Jun-N-terminal kinase pathway while improving insulin signaling in fat-fed rats: evidence for the role of oxidative stress on IRS-1 serine phosphorylation and insulin resistance. J Endocrinol 2008; 197: 287\u2013296.","journal-title":"J Endocrinol"},{"key":"BFcddis2014104_CR19","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1089\/jir.2011.0101","volume":"31","author":"D Choubey","year":"2011","unstructured":"Choubey D, Moudgil KD . Interferons in autoimmune and inflammatory diseases: regulation and roles. J Interferon Cytokine Res 2011; 31: 857\u2013865.","journal-title":"J Interferon Cytokine Res"},{"key":"BFcddis2014104_CR20","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.biochi.2007.02.006","volume":"89","author":"C Bisbal","year":"2007","unstructured":"Bisbal C, Silverman RH . Diverse functions of RNase L and implications in pathology. Biochimie 2007; 89: 789\u2013798.","journal-title":"Biochimie"},{"key":"BFcddis2014104_CR21","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/nature06042","volume":"448","author":"K Malathi","year":"2007","unstructured":"Malathi K, Dong B, Gale M Jr., Silverman RH . Small self-RNA generated by RNase L amplifies antiviral innate immunity. Nature 2007; 448: 816\u2013819.","journal-title":"Nature"},{"key":"BFcddis2014104_CR22","doi-asserted-by":"publisher","first-page":"20816","DOI":"10.1073\/pnas.0807265105","volume":"105","author":"XL Li","year":"2008","unstructured":"Li XL, Ezelle HJ, Kang TJ, Zhang L, Shirey KA, Harro J et al. An essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunity. Proc Natl Acad Sci USA 2008; 105: 20816\u201320821.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2014104_CR23","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/nsmb944","volume":"12","author":"F Le Roy","year":"2005","unstructured":"Le Roy F, Salehzada T, Bisbal C, Dougherty JP, Peltz SW . A newly discovered function for RNase L in regulating translation termination. Nat Struct Mol Biol 2005; 12: 505\u2013512.","journal-title":"Nat Struct Mol Biol"},{"key":"BFcddis2014104_CR24","doi-asserted-by":"publisher","first-page":"12542","DOI":"10.1074\/jbc.M310175200","volume":"279","author":"K Kariko","year":"2004","unstructured":"Kariko K, Ni H, Capodici J, Lamphier M, Weissman D . mRNA is an endogenous ligand for Toll-like receptor 3. J Biol Chem 2004; 279: 12542\u201312550.","journal-title":"J Biol Chem"},{"key":"BFcddis2014104_CR25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","volume":"16","author":"K Takeda","year":"2004","unstructured":"Takeda K, Akira S . TLR signaling pathways. Semin Immunol 2004; 16: 3\u20139.","journal-title":"Semin Immunol"},{"key":"BFcddis2014104_CR26","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1089\/jir.2010.0095","volume":"31","author":"JJ Khoo","year":"2011","unstructured":"Khoo JJ, Forster S, Mansell A . Toll-like receptors as interferon-regulated genes and their role in disease. J Interferon Cytokine Res 2011; 31: 13\u201325.","journal-title":"J Interferon Cytokine Res"},{"key":"BFcddis2014104_CR27","doi-asserted-by":"publisher","first-page":"13308","DOI":"10.1074\/jbc.270.22.13308","volume":"270","author":"C Bisbal","year":"1995","unstructured":"Bisbal C, Martinand C, Silhol M, Lebleu B, Salehzada T . Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway. J Biol Chem 1995; 270: 13308\u201313317.","journal-title":"J Biol Chem"},{"key":"BFcddis2014104_CR28","doi-asserted-by":"publisher","first-page":"4959","DOI":"10.1128\/MCB.20.14.4959-4969.2000","volume":"20","author":"C Bisbal","year":"2000","unstructured":"Bisbal C, Silhol M, Laubenthal H, Kaluza T, Carnac G, Milligan L et al. The 2\u2032-5\u2032 oligoadenylate\/RNase L\/RNase L inhibitor pathway regulates both MyoD mRNA stability and muscle cell differentiation. Mol Cell Biol 2000; 20: 4959\u20134969.","journal-title":"Mol Cell Biol"},{"key":"BFcddis2014104_CR29","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1038\/cdd.2012.23","volume":"19","author":"O Fabre","year":"2012","unstructured":"Fabre O, Salehzada T, Lambert K, Boo Seok Y, Zhou A, Mercier J et al. RNase L controls terminal adipocyte differentiation, lipids storage and insulin sensitivity via CHOP10 mRNA regulation. Cell Death Differ 2012; 19: 1470\u20131481.","journal-title":"Cell Death Differ"},{"key":"BFcddis2014104_CR30","doi-asserted-by":"publisher","first-page":"e7563","DOI":"10.1371\/journal.pone.0007563","volume":"4","author":"T Salehzada","year":"2009","unstructured":"Salehzada T, Cambier L, Vu Thi N, Manchon L, Regnier L, Bisbal C . Endoribonuclease L (RNase L) regulates the myogenic and adipogenic potential of myogenic cells. PLoS ONE 2009; 4: e7563.","journal-title":"PLoS ONE"},{"key":"BFcddis2014104_CR31","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1080\/07853890600888413","volume":"38","author":"CS Stump","year":"2006","unstructured":"Stump CS, Henriksen EJ, Wei Y, Sowers JR . The metabolic syndrome: role of skeletal muscle metabolism. Ann Med 2006; 38: 389\u2013402.","journal-title":"Ann Med"},{"key":"BFcddis2014104_CR32","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1476-511X-11-30","volume":"11","author":"AR Martins","year":"2012","unstructured":"Martins AR, Nachbar RT, Gorjao R, Vinolo MA, Festuccia WT, Lambertucci RH et al. Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function. Lipids Health Dis 2012; 11: 30.","journal-title":"Lipids Health Dis"},{"key":"BFcddis2014104_CR33","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.bbrc.2009.08.106","volume":"389","author":"R Ragheb","year":"2009","unstructured":"Ragheb R, Shanab GM, Medhat AM, Seoudi DM, Adeli K, Fantus IG . Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: evidence for PKC activation and oxidative stress-activated signaling pathways. Biochem Biophys Res Commun 2009; 389: 211\u2013216.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcddis2014104_CR34","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.2337\/db06-1595","volume":"56","author":"DM Tsukumo","year":"2007","unstructured":"Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA et al. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 2007; 56: 1986\u20131998.","journal-title":"Diabetes"},{"key":"BFcddis2014104_CR35","doi-asserted-by":"publisher","first-page":"7950","DOI":"10.1074\/jbc.M607939200","volume":"282","author":"XL Li","year":"2007","unstructured":"Li XL, Andersen JB, Ezelle HJ, Wilson GM, Hassel BA . Post-transcriptional regulation of RNase-L expression is mediated by the 3\u2032-untranslated region of its mRNA. J Biol Chem 2007; 282: 7950\u20137960.","journal-title":"J Biol Chem"},{"key":"BFcddis2014104_CR36","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1089\/jir.2005.25.595","volume":"25","author":"A Zhou","year":"2005","unstructured":"Zhou A, Molinaro RJ, Malathi K, Silverman RH . Mapping of the human RNASEL promoter and expression in cancer and normal cells. J Interferon Cytokine Res 2005; 25: 595\u2013603.","journal-title":"J Interferon Cytokine Res"},{"key":"BFcddis2014104_CR37","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.sbi.2005.05.006","volume":"15","author":"W Filipowicz","year":"2005","unstructured":"Filipowicz W, Jaskiewicz L, Kolb FA, Pillai RS . Post-transcriptional gene silencing by siRNAs and miRNAs. Curr Opin Struct Biol 2005; 15: 331\u2013341.","journal-title":"Curr Opin Struct Biol"},{"key":"BFcddis2014104_CR38","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.2337\/diabetes.49.7.1169","volume":"49","author":"S Jackson","year":"2000","unstructured":"Jackson S, Bagstaff SM, Lynn S, Yeaman SJ, Turnbull DM, Walker M . Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells from insulin-resistant nondiabetic relatives of type 2 diabetic families. Diabetes 2000; 49: 1169\u20131177.","journal-title":"Diabetes"},{"key":"BFcddis2014104_CR39","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.2337\/diab.47.8.1281","volume":"47","author":"A Krook","year":"1998","unstructured":"Krook A, Roth RA, Jiang XJ, Zierath JR, Wallberg-Henriksson H . Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects. Diabetes 1998; 47: 1281\u20131286.","journal-title":"Diabetes"},{"key":"BFcddis2014104_CR40","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.bbrc.2004.06.051","volume":"320","author":"G Vlotides","year":"2004","unstructured":"Vlotides G, Sorensen AS, Kopp F, Zitzmann K, Cengic N, Brand S et al. SOCS-1 and SOCS-3 inhibit IFN-alpha-induced expression of the antiviral proteins 2,5-OAS and MxA. Biochem Biophys Res Commun 2004; 320: 1007\u20131014.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcddis2014104_CR41","doi-asserted-by":"publisher","first-page":"56","DOI":"10.2337\/db12-0443","volume":"62","author":"SB Jorgensen","year":"2013","unstructured":"Jorgensen SB, O'Neill HM, Sylow L, Honeyman J, Hewitt KA, Palanivel R et al. Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity. Diabetes 2013; 62: 56\u201364.","journal-title":"Diabetes"},{"key":"BFcddis2014104_CR42","doi-asserted-by":"publisher","first-page":"e47493","DOI":"10.1371\/journal.pone.0047493","volume":"7","author":"Z Yang","year":"2012","unstructured":"Yang Z, Hulver M, McMillan RP, Cai L, Kershaw EE, Yu L et al. Regulation of insulin and leptin signaling by muscle suppressor of cytokine signaling 3 (SOCS3). PLoS ONE 2012; 7: e47493.","journal-title":"PLoS ONE"},{"key":"BFcddis2014104_CR43","doi-asserted-by":"publisher","first-page":"20124","DOI":"10.1074\/jbc.M208766200","volume":"278","author":"KS Khabar","year":"2003","unstructured":"Khabar KS, Siddiqui YM, al-Zoghaibi F, al-Haj L, Dhalla M, Zhou A et al. RNase L mediates transient control of the interferon response through modulation of the double-stranded RNA-dependent protein kinase PKR. J Biol Chem 2003; 278: 20124\u201320132.","journal-title":"J Biol Chem"},{"key":"BFcddis2014104_CR44","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.jneuroim.2012.11.002","volume":"255","author":"E Borysiewicz","year":"2013","unstructured":"Borysiewicz E, Doppalapudi S, Kirschman LT, Konat GW . TLR3 ligation protects human astrocytes against oxidative stress. J Neuroimmunol 2013; 255: 54\u201359.","journal-title":"J Neuroimmunol"},{"key":"BFcddis2014104_CR45","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1002\/pmic.200600582","volume":"7","author":"R Rakkola","year":"2007","unstructured":"Rakkola R, Matikainen S, Nyman TA . Proteome analysis of human macrophages reveals the upregulation of manganese-containing superoxide dismutase after toll-like receptor activation. Proteomics 2007; 7: 378\u2013384.","journal-title":"Proteomics"},{"key":"BFcddis2014104_CR46","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.cmet.2010.11.015","volume":"12","author":"X Qiu","year":"2010","unstructured":"Qiu X, Brown K, Hirschey MD, Verdin E, Chen D . Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab 2010; 12: 662\u2013667.","journal-title":"Cell Metab"},{"key":"BFcddis2014104_CR47","doi-asserted-by":"publisher","first-page":"e88","DOI":"10.1038\/nutd.2013.30","volume":"3","author":"IA Samjoo","year":"2013","unstructured":"Samjoo IA, Safdar A, Hamadeh MJ, Raha S, Tarnopolsky MA . The effect of endurance exercise on both skeletal muscle and systemic oxidative stress in previously sedentary obese men. Nutr Diabetes 2013; 3: e88.","journal-title":"Nutr Diabetes"},{"key":"BFcddis2014104_CR48","doi-asserted-by":"publisher","first-page":"E798","DOI":"10.1152\/ajpendo.00577.2011","volume":"303","author":"MJ Boden","year":"2012","unstructured":"Boden MJ, Brandon AE, Tid-Ang JD, Preston E, Wilks D, Stuart E et al. Overexpression of manganese superoxide dismutase ameliorates high-fat diet-induced insulin resistance in rat skeletal muscle. Am J Physiol Endocrinol Metab 2012; 303: E798\u2013E805.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFcddis2014104_CR49","doi-asserted-by":"publisher","first-page":"8852","DOI":"10.1073\/pnas.0308096101","volume":"101","author":"JP McClung","year":"2004","unstructured":"McClung JP, Roneker CA, Mu W, Lisk DJ, Langlais P, Liu F et al. Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase. Proc Natl Acad Sci USA 2004; 101: 8852\u20138857.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2014104_CR50","doi-asserted-by":"publisher","first-page":"8665","DOI":"10.1073\/pnas.0903485106","volume":"106","author":"M Ristow","year":"2009","unstructured":"Ristow M, Zarse K, Oberbach A, Kloting N, Birringer M, Kiehntopf M et al. Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci USA 2009; 106: 8665\u20138670.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2014104_CR51","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1002\/glia.20328","volume":"53","author":"M Bsibsi","year":"2006","unstructured":"Bsibsi M, Persoon-Deen C, Verwer RW, Meeuwsen S, Ravid R, Van Noort JM . Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators. Glia 2006; 53: 688\u2013695.","journal-title":"Glia"},{"key":"BFcddis2014104_CR52","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1073\/pnas.1018515108","volume":"108","author":"JE Cole","year":"2011","unstructured":"Cole JE, Navin TJ, Cross AJ, Goddard ME, Alexopoulou L, Mitra AT et al. Unexpected protective role for Toll-like receptor 3 in the arterial wall. Proc Natl Acad Sci USA 2011; 108: 2372\u20132377.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2014104_CR53","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s10753-013-9712-1","volume":"37","author":"J Holfeld","year":"2013","unstructured":"Holfeld J, Tepekoylu C, Kozaryn R, Urbschat A, Zacharowski K, Grimm M et al. Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via Toll-like receptor 3. Inflammation 2013; 37: 65\u201370.","journal-title":"Inflammation"},{"key":"BFcddis2014104_CR54","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.molimm.2012.11.005","volume":"54","author":"AK Patel","year":"2013","unstructured":"Patel AK, Hackam AS . Toll-like receptor 3 (TLR3) protects retinal pigmented epithelium (RPE) cells from oxidative stress through a STAT3-dependent mechanism. Mol Immunol 2013; 54: 122\u2013131.","journal-title":"Mol Immunol"},{"key":"BFcddis2014104_CR55","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/j.1582-4934.2008.00368.x","volume":"14","author":"M Barro","year":"2010","unstructured":"Barro M, Carnac G, Flavier S, Mercier J, Vassetzky Y, Laoudj-Chenivesse D . Myoblasts from affected and non-affected FSHD muscles exhibit morphological differentiation defects. J Cell Mol Med 2010; 14: 275\u2013289.","journal-title":"J Cell Mol Med"},{"key":"BFcddis2014104_CR56","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/j.1432-1033.1984.tb08284.x","volume":"142","author":"B Bayard","year":"1984","unstructured":"Bayard B, Bisbal C, Silhol M, Cnockaert J, Huez G, Lebleu B . Increased stability and antiviral activity of 2'-O-phosphoglyceryl derivatives of (2\u2032-5\u2032)oligo(adenylate). Eur J Biochem 1984; 142: 291\u2013298.","journal-title":"Eur J Biochem"},{"key":"BFcddis2014104_CR57","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1089\/107999000750053762","volume":"20","author":"L Rusch","year":"2000","unstructured":"Rusch L, Zhou A, Silverman RH . Caspase-dependent apoptosis by 2',5'-oligoadenylate activation of RNase L is enhanced by IFN-beta. J Interferon Cytokine Res 2000; 20: 1091\u20131100.","journal-title":"J Interferon Cytokine Res"},{"key":"BFcddis2014104_CR58","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1093\/nar\/9.7.1571","volume":"9","author":"DH Wreschner","year":"1981","unstructured":"Wreschner DH, James TC, Silverman RH, Kerr IM . Ribosomal RNA cleavage, nuclease activation and 2-5A(ppp(A2\u2032p)nA) in interferon-treated cells. Nucleic Acids Res 1981; 9: 1571\u20131581.","journal-title":"Nucleic Acids Res"},{"key":"BFcddis2014104_CR59","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1055\/s-0030-1252069","volume":"118","author":"X Wang","year":"2010","unstructured":"Wang X, Yu W, Nawaz A, Guan F, Sun S, Wang C . Palmitate induced insulin resistance by PKCtheta-dependent activation of mTOR\/S6K pathway in C2C12 myotubes. Exp Clin Endocrinol Diabetes 2010; 118: 657\u2013661.","journal-title":"Exp Clin Endocrinol Diabetes"}],"container-title":["Cell Death & Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis2014104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis2014104","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2014104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T23:39:59Z","timestamp":1672961999000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis2014104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,20]]},"references-count":59,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3]]}},"alternative-id":["BFcddis2014104"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2014.104","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,20]]},"assertion":[{"value":"6 September 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}