{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:35:44Z","timestamp":1790724944536,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T00:00:00Z","timestamp":1400716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"},{"start":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T00:00:00Z","timestamp":1400716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2014.229","type":"journal-article","created":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T14:41:52Z","timestamp":1400769712000},"page":"e1251-e1251","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk\/MAP kinase pathway mediated by cAMP\/PKA signaling"],"prefix":"10.1038","volume":"5","author":[{"given":"D","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A D","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Holmberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,5,22]]},"reference":[{"key":"BFcddis2014229_CR1","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1152\/physrev.00041.2003","volume":"84","author":"GK Owens","year":"2004","unstructured":"Owens GK, Kumar MS, Wamhoff BR . Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 2004; 84: 767\u2013801.","journal-title":"Physiol Rev"},{"key":"BFcddis2014229_CR2","doi-asserted-by":"publisher","first-page":"e44","DOI":"10.1161\/CIRCRESAHA.107.158329","volume":"101","author":"WF Liu","year":"2007","unstructured":"Liu WF, Nelson CM, Tan JL, Chen CS . Cadherins RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. Circ Res 2007; 101: e44\u2013e52.","journal-title":"Circ Res"},{"key":"BFcddis2014229_CR3","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/S0014-5793(02)02370-0","volume":"514","author":"CM Nelson","year":"2002","unstructured":"Nelson CM, Chen CS . Cell\u2013cell signaling by direct contact increases cell proliferation via a PI3K-dependent signal. FEBS Lett 2002; 514: 238\u2013242.","journal-title":"FEBS Lett"},{"key":"BFcddis2014229_CR4","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/sj.onc.1201228","volume":"15","author":"M Kawada","year":"1997","unstructured":"Kawada M, Yamagoe S, Murakami Y, Suzuki K, Mizuno S, Uehara Y . Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway. Oncogene 1997; 15: 629\u2013637.","journal-title":"Oncogene"},{"key":"BFcddis2014229_CR5","doi-asserted-by":"publisher","first-page":"20608","DOI":"10.1074\/jbc.271.34.20608","volume":"271","author":"JN Lavoie","year":"1996","unstructured":"Lavoie JN, L'Allemain G, Brunet A, Muller R, Pouyssegur J . Cyclin D1 expression is regulated positively by the p42\/p44MAPK and negatively by the p38\/HOGMAPK pathway. J Biol Chem 1996; 271: 20608\u201320616.","journal-title":"J Biol Chem"},{"key":"BFcddis2014229_CR6","doi-asserted-by":"publisher","first-page":"5037","DOI":"10.1093\/emboj\/17.17.5037","volume":"17","author":"A Palmer","year":"1998","unstructured":"Palmer A, Gavin AC, Nebreda AR . A link between MAP kinase and p34(cdc2)\/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1. EMBO J 1998; 17: 5037\u20135047.","journal-title":"EMBO J"},{"key":"BFcddis2014229_CR7","doi-asserted-by":"publisher","first-page":"4187","DOI":"10.1091\/mbc.e06-01-0036","volume":"17","author":"TR Pacheco","year":"2006","unstructured":"Pacheco TR, Moita LF, Gomes AQ, Hacohen N, Carmo-Fonseca M . RNA interference knockdown of hU2AF35 impairs cell cycle progression and modulates alternative splicing of Cdc25 transcripts. Mol Biol Cell 2006; 17: 4187\u20134199.","journal-title":"Mol Biol Cell"},{"key":"BFcddis2014229_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2741\/3228","volume":"14","author":"NS Bryan","year":"2009","unstructured":"Bryan NS, Bian K, Murad F . Discovery of the nitric oxide signaling pathway and targets for drug development. Front Biosci 2009; 14: 1\u201318.","journal-title":"Front Biosci"},{"key":"BFcddis2014229_CR9","doi-asserted-by":"publisher","first-page":"2524","DOI":"10.1161\/ATVBAHA.107.151167","volume":"27","author":"JD Erusalimsky","year":"2007","unstructured":"Erusalimsky JD, Moncada S . Nitric oxide and mitochondrial signaling: from physiology to pathophysiology. Arterioscler Thromb Vasc Biol 2007; 27: 2524\u20132531.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BFcddis2014229_CR10","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","volume":"16","author":"R Wang","year":"2002","unstructured":"Wang R . Two's company, three's a crowd: can H\u00b7S be the third endogenous gaseous transmitter? FASEB J 2002; 16: 1792\u20131798.","journal-title":"FASEB J"},{"key":"BFcddis2014229_CR11","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1089\/ars.2011.4345","volume":"17","author":"H Kimura","year":"2012","unstructured":"Kimura H, Shibuya N, Kimura Y . Hydrogen sulfide is a signaling molecule and a cytoprotectant. Antioxid Redox Signal 2012; 17: 45\u201357.","journal-title":"Antioxid Redox Signal"},{"key":"BFcddis2014229_CR12","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1089\/ars.2011.4005","volume":"17","author":"YH Liu","year":"2012","unstructured":"Liu YH, Lu M, Hu LF, Wong PT, Webb GD, Bian JS . Hydrogen sulfide in the mammalian cardiovascular system. Antioxid Redox Signal 2012; 17: 141\u2013185.","journal-title":"Antioxid Redox Signal"},{"key":"BFcddis2014229_CR13","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.2353\/ajpath.2007.060939","volume":"170","author":"QH Meng","year":"2007","unstructured":"Meng QH, Yang G, Yang W, Jiang B, Wu L, Wang R . Protective effect of hydrogen sulfide on balloon injury-induced neointima hyperplasia in rat carotid arteries. Am J Pathol 2007; 170: 1406\u20131414.","journal-title":"Am J Pathol"},{"key":"BFcddis2014229_CR14","doi-asserted-by":"publisher","first-page":"26450","DOI":"10.1074\/jbc.M111.266643","volume":"286","author":"G Yang","year":"2011","unstructured":"Yang G, Pei Y, Teng H, Cao Q, Wang R . Specificity protein-1 as a critical regulator of human cystathionine gamma-lyase in smooth muscle cells. J Biol Chem 2011; 286: 26450\u201326460.","journal-title":"J Biol Chem"},{"key":"BFcddis2014229_CR15","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1093\/cvr\/cvp420","volume":"86","author":"G Yang","year":"2010","unstructured":"Yang G, Wu L, Bryan S, Khaper N, Mani S, Wang R . Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells. Cardiovasc Res 2010; 86: 487\u2013495.","journal-title":"Cardiovasc Res"},{"key":"BFcddis2014229_CR16","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s00380-003-0743-7","volume":"19","author":"J Du","year":"2004","unstructured":"Du J, Hui Y, Cheung Y, Bin G, Jiang H, Chen X et al. The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells. Heart Vessels 2004; 19: 75\u201380.","journal-title":"Heart Vessels"},{"key":"BFcddis2014229_CR17","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1096\/fj.04-2279fje","volume":"18","author":"G Yang","year":"2004","unstructured":"Yang G, Sun X, Wang R . Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3. FASEB J 2004; 18: 1782\u20131784.","journal-title":"FASEB J"},{"key":"BFcddis2014229_CR18","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.ejphar.2011.01.052","volume":"656","author":"R Baskar","year":"2011","unstructured":"Baskar R, Bian J . Hydrogen sulfide gas has cell growth regulatory role. Eur J Pharmacol 2011; 656: 5\u20139.","journal-title":"Eur J Pharmacol"},{"key":"BFcddis2014229_CR19","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/0076-6879(87)43065-6","volume":"143","author":"OW Griffith","year":"1987","unstructured":"Griffith OW . Mammalian sulfur amino acid metabolism: an overview. Methods Enzymol 1987; 143: 366\u2013376.","journal-title":"Methods Enzymol"},{"key":"BFcddis2014229_CR20","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1146\/annurev.nutr.24.012003.132418","volume":"24","author":"MH Stipanuk","year":"2004","unstructured":"Stipanuk MH . Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine. Annu Rev Nutr 2004; 24: 539\u2013577.","journal-title":"Annu Rev Nutr"},{"key":"BFcddis2014229_CR21","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1113\/expphysiol.2011.057455","volume":"96","author":"H Kimura","year":"2011","unstructured":"Kimura H . Hydrogen sulfide: its production and functions. Exp Physiol 2011; 96: 833\u2013835.","journal-title":"Exp Physiol"},{"key":"BFcddis2014229_CR22","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1161\/01.HYP.35.1.237","volume":"35","author":"S Hayashi","year":"2000","unstructured":"Hayashi S, Morishita R, Matsushita H, Nakagami H, Taniyama Y, Nakamura T et al. Cyclic AMP inhibited proliferation of human aortic vascular smooth muscle cells, accompanied by induction of p53 and p21. Hypertension 2000; 35: 237\u2013243.","journal-title":"Hypertension"},{"key":"BFcddis2014229_CR23","doi-asserted-by":"publisher","first-page":"10300","DOI":"10.1073\/pnas.90.21.10300","volume":"90","author":"LM Graves","year":"1993","unstructured":"Graves LM, Bornfeldt KE, Raines EW, Potts BC, Macdonald SG, Ross R et al. Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells. Proc Natl Acad Sci USA 1993; 90: 10300\u201310304.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2014229_CR24","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/S0006-2952(00)00328-2","volume":"60","author":"MT Osinski","year":"2000","unstructured":"Osinski MT, Schror K . Inhibition of platelet-derived growth factor-induced mitogenesis by phosphodiesterase 3 inhibitors: role of protein kinase A in vascular smooth muscle cell mitogenesis. Biochem Pharmacol 2000; 60: 381\u2013387.","journal-title":"Biochem Pharmacol"},{"key":"BFcddis2014229_CR25","doi-asserted-by":"publisher","first-page":"9303","DOI":"10.1128\/MCB.23.24.9303-9317.2003","volume":"23","author":"K Balmanno","year":"2003","unstructured":"Balmanno K, Millar T, McMahon M, Cook SJ . DeltaRaf-1:ER* bypasses the cyclic AMP block of extracellular signal-regulated kinase 1 and 2 activation but not CDK2 activation or cell cycle reentry. Mol Cell Biol 2003; 23: 9303\u20139317.","journal-title":"Mol Cell Biol"},{"key":"BFcddis2014229_CR26","doi-asserted-by":"publisher","first-page":"3717","DOI":"10.1128\/MCB.22.11.3717-3728.2002","volume":"22","author":"N Dumaz","year":"2002","unstructured":"Dumaz N, Light Y, Marais R . Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms. Mol Cell Biol 2002; 22: 3717\u20133728.","journal-title":"Mol Cell Biol"},{"key":"BFcddis2014229_CR27","doi-asserted-by":"publisher","first-page":"28688","DOI":"10.1074\/jbc.M909351199","volume":"275","author":"MF Sidovar","year":"2000","unstructured":"Sidovar MF, Kozlowski P, Lee JW, Collins MA, He Y, Graves LM . Phosphorylation of serine 43 is not required for inhibition of c-Raf kinase by the cAMP-dependent protein kinase. J Biol Chem 2000; 275: 28688\u201328694.","journal-title":"J Biol Chem"},{"key":"BFcddis2014229_CR28","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.abb.2007.08.028","volume":"467","author":"Z Meng","year":"2007","unstructured":"Meng Z, Li Y, Li J . Vasodilatation of sulfur dioxide derivatives and signal transduction. Arch Biochem Biophys 2007; 467: 291\u2013296.","journal-title":"Arch Biochem Biophys"},{"key":"BFcddis2014229_CR29","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/0003-9861(56)90363-0","volume":"61","author":"TP Singer","year":"1956","unstructured":"Singer TP, Kearney EB . Intermediary metabolism of L-cysteine sulfinic acid in animal tissues. Arch Biochem Biophys 1956; 61: 397\u2013409.","journal-title":"Arch Biochem Biophys"},{"key":"BFcddis2014229_CR30","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.bbrc.2003.10.055","volume":"311","author":"M Balazy","year":"2003","unstructured":"Balazy M, Abu-Yousef IA, Harpp DN, Park J . Identification of carbonyl sulfide and sulfur dioxide in porcine coronary artery by gas chromatography\/mass spectrometry, possible relevance to EDHF. Biochem Biophys Res Commun 2003; 311: 728\u2013734.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcddis2014229_CR31","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1177\/0115426593008006277","volume":"8","author":"VM Sardesai","year":"1993","unstructured":"Sardesai VM . Molybdenum: an essential trace element. Nutr Clin Pract 1993; 8: 277\u2013281.","journal-title":"Nutr Clin Pract"},{"key":"BFcddis2014229_CR32","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.bbrc.2011.10.012","volume":"415","author":"L Luo","year":"2011","unstructured":"Luo L, Chen S, Jin H, Tang C, Du J . Endogenous generation of sulfur dioxide in rat tissues. Biochem Biophys Res Commun 2011; 415: 61\u201367.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcddis2014229_CR33","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1111\/j.1745-7254.2008.00845.x","volume":"29","author":"SX Du","year":"2008","unstructured":"Du SX, Jin HF, Bu DF, Zhao X, Geng B, Tang CS et al. Endogenously generated sulfur dioxide and its vasorelaxant effect in rats. Acta Pharmacol Sin 2008; 29: 923\u2013930.","journal-title":"Acta Pharmacol Sin"},{"key":"BFcddis2014229_CR34","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/labinvest.2009.102","volume":"90","author":"Y Sun","year":"2010","unstructured":"Sun Y, Tian Y, Prabha M, Liu D, Chen S, Zhang R et al. Effects of sulfur dioxide on hypoxic pulmonary vascular structural remodeling. Lab Invest 2010; 90: 68\u201382.","journal-title":"Lab Invest"},{"key":"BFcddis2014229_CR35","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1371\/journal.pgen.0030164","volume":"3","author":"JT Chi","year":"2007","unstructured":"Chi JT, Rodriguez EH, Wang Z, Nuyten DS, Mukherjee S, van de Rijn M et al. Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers. PLoS Genet 2007; 3: 1770\u20131784.","journal-title":"PLoS Genet"},{"key":"BFcddis2014229_CR36","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1073\/pnas.70.6.1753","volume":"70","author":"EP Benditt","year":"1973","unstructured":"Benditt EP, Benditt JM . Evidence for a monoclonal origin of human atherosclerotic plaques. Proc Natl Acad Sci USA 1973; 70: 1753\u20131756.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2014229_CR37","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1161\/01.RES.75.4.669","volume":"75","author":"MG Frid","year":"1994","unstructured":"Frid MG, Moiseeva EP, Stenmark KR . Multiple phenotypically distinct smooth muscle cell populations exist in the adult and developing bovine pulmonary arterial media in vivo. Circ Res 1994; 75: 669\u2013681.","journal-title":"Circ Res"},{"key":"BFcddis2014229_CR38","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1161\/01.ATV.0000022407.91111.E4","volume":"22","author":"H Hao","year":"2002","unstructured":"Hao H, Ropraz P, Verin V, Camenzind E, Geinoz A, Pepper MS et al. Heterogeneity of smooth muscle cell populations cultured from pig coronary artery. Arterioscler Thromb Vasc Biol 2002; 22: 1093\u20131099.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BFcddis2014229_CR39","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1083\/jcb.200211015","volume":"161","author":"BK Garvalov","year":"2003","unstructured":"Garvalov BK, Higgins TE, Sutherland JD, Zettl M, Scaplehorn N, Kocher T et al. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. J Cell Biol 2003; 161: 33\u201339.","journal-title":"J Cell Biol"},{"key":"BFcddis2014229_CR40","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.cytogfr.2004.03.004","volume":"15","author":"EW Raines","year":"2004","unstructured":"Raines EW . PDGF and cardiovascular disease. Cytokine Growth Factor Rev 2004; 15: 237\u2013254.","journal-title":"Cytokine Growth Factor Rev"},{"key":"BFcddis2014229_CR41","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1016\/j.febslet.2005.03.024","volume":"579","author":"M Baccarini","year":"2005","unstructured":"Baccarini M . Second nature: biological functions of the Raf-1 \u2018kinase\u2019. FEBS Lett 2005; 579: 3271\u20133277.","journal-title":"FEBS Lett"},{"key":"BFcddis2014229_CR42","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0301-4622(99)00114-3","volume":"82","author":"Y Takakuwa","year":"1999","unstructured":"Takakuwa Y, Pack CG, An XL, Manno S, Ito E, Kinjo M . Fluorescence correlation spectroscopy analysis of the hydrophobic interactions of protein 4.1 with phosphatidyl serine liposomes. Biophys Chem 1999; 82: 149\u2013155.","journal-title":"Biophys Chem"},{"key":"BFcddis2014229_CR43","doi-asserted-by":"publisher","first-page":"3491","DOI":"10.1111\/j.1742-4658.2005.04763.x","volume":"272","author":"N Dumaz","year":"2005","unstructured":"Dumaz N, Marais R . Integrating signals between cAMP and the RAS\/RAF\/MEK\/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft fur Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels. FEBS J 2005; 272: 3491\u20133504.","journal-title":"FEBS J"},{"key":"BFcddis2014229_CR44","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1126\/science.7694366","volume":"262","author":"J Wu","year":"1993","unstructured":"Wu J, Dent P, Jelinek T, Wolfman A, Weber MJ, Sturgill TW . Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate. Science 1993; 262: 1065\u20131069.","journal-title":"Science"},{"key":"BFcddis2014229_CR45","doi-asserted-by":"publisher","first-page":"3390","DOI":"10.1128\/MCB.15.6.3390","volume":"15","author":"NR Michaud","year":"1995","unstructured":"Michaud NR, Fabian JR, Mathes KD, Morrison DK . 14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner. Mol Cell Biol 1995; 15: 3390\u20133397.","journal-title":"Mol Cell Biol"},{"key":"BFcddis2014229_CR46","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0014-5793(01)03288-4","volume":"513","author":"MB Yaffe","year":"2002","unstructured":"Yaffe MB . How do 14-3-3 proteins work? \u2013 Gatekeeper phosphorylation and the molecular anvil hypothesis. FEBS Lett 2002; 513: 53\u201357.","journal-title":"FEBS Lett"},{"key":"BFcddis2014229_CR47","doi-asserted-by":"publisher","first-page":"29819","DOI":"10.1074\/jbc.C300182200","volume":"278","author":"N Dumaz","year":"2003","unstructured":"Dumaz N, Marais R . Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras. J Biol Chem 2003; 278: 29819\u201329823.","journal-title":"J Biol Chem"},{"key":"BFcddis2014229_CR48","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.1128\/MCB.22.10.3237-3246.2002","volume":"22","author":"AS Dhillon","year":"2002","unstructured":"Dhillon AS, Pollock C, Steen H, Shaw PE, Mischak H, Kolch W . Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259. Mol Cell Biol 2002; 22: 3237\u20133246.","journal-title":"Mol Cell Biol"},{"key":"BFcddis2014229_CR49","doi-asserted-by":"publisher","first-page":"4984","DOI":"10.1128\/MCB.22.14.4984-4996.2002","volume":"22","author":"Y Light","year":"2002","unstructured":"Light Y, Paterson H, Marais R . 14-3-3 Antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity. Mol Cell Biol 2002; 22: 4984\u20134996.","journal-title":"Mol Cell Biol"},{"key":"BFcddis2014229_CR50","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1104\/pp.97.1.88","volume":"97","author":"NR Madamanchi","year":"1991","unstructured":"Madamanchi NR, Alscher RG . Metabolic bases for differences in sensitivity of two pea cultivars to sulfur dioxide. Plant Physiol 1991; 97: 88\u201393.","journal-title":"Plant Physiol"},{"key":"BFcddis2014229_CR51","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1126\/science.8052857","volume":"265","author":"SJ Mansour","year":"1994","unstructured":"Mansour SJ, Matten WT, Hermann AS, Candia JM, Rong S, Fukasawa K et al. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 1994; 265: 966\u2013970.","journal-title":"Science"}],"container-title":["Cell Death & Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/cddis2014229.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2014229","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2014229.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T23:33:23Z","timestamp":1672961603000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis2014229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,22]]},"references-count":51,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5]]}},"alternative-id":["BFcddis2014229"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2014.229","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,22]]},"assertion":[{"value":"29 November 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}