{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:21:05Z","timestamp":1793107265519,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T00:00:00Z","timestamp":1409184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"},{"start":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T00:00:00Z","timestamp":1409184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2014.361","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T13:05:06Z","timestamp":1409231106000},"page":"e1397-e1397","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Peroxisome proliferator-activated receptor \u03b1 activation attenuates the inflammatory response to protect the liver from acute failure by promoting the autophagy pathway"],"prefix":"10.1038","volume":"5","author":[{"given":"M","family":"Jiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,28]]},"reference":[{"key":"BFcddis2014361_CR1","first-page":"240","volume":"21","author":"JH Hoofnagle","year":"1995","unstructured":"Hoofnagle JH, Carithers RJ, Shapiro C, Ascher N . Acute hepatic failure: summary of a workshop. Hepatology 1995; 21: 240\u2013252.","journal-title":"Hepatology"},{"key":"BFcddis2014361_CR2","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1055\/s-2003-42639","volume":"23","author":"SM Riordan","year":"2003","unstructured":"Riordan SM, Williams R . Mechanisms of hepatocyte injury, multiorgan failure, and prognostic criteria in acute liver failure. Semin Liver Dis 2003; 23: 203\u2013215.","journal-title":"Semin Liver Dis"},{"key":"BFcddis2014361_CR3","first-page":"649","volume":"20","author":"B Desvergne","year":"1999","unstructured":"Desvergne B, Wahli W . Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 1999; 20: 649\u2013688.","journal-title":"Endocr Rev"},{"key":"BFcddis2014361_CR4","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.phrs.2004.07.012","volume":"51","author":"BP Kota","year":"2005","unstructured":"Kota BP, Huang TH, Roufogalis BD . An overview on biological mechanisms of PPARs. Pharmacol Res 2005; 51: 85\u201394.","journal-title":"Pharmacol Res"},{"key":"BFcddis2014361_CR5","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1161\/01.CIR.98.19.2088","volume":"98","author":"B Staels","year":"1998","unstructured":"Staels B, Dallongeville J, Auwerx J, Schoonjans K, Leitersdorf E, Fruchart JC . Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 1998; 98: 2088\u20132093.","journal-title":"Circulation"},{"key":"BFcddis2014361_CR6","doi-asserted-by":"publisher","first-page":"25573","DOI":"10.1074\/jbc.273.40.25573","volume":"273","author":"G Chinetti","year":"1998","unstructured":"Chinetti G, Griglio S, Antonucci M, Pineda TI, Delerive P, Majd Z et al. Activation of peroxisome proliferator activated receptors \u03b1 and \u03b3 induces apoptosis of human monocyte derived macrophages. J Biol Chem 1998; 273: 25573\u201325580.","journal-title":"J Biol Chem"},{"key":"BFcddis2014361_CR7","doi-asserted-by":"publisher","first-page":"32048","DOI":"10.1074\/jbc.274.45.32048","volume":"274","author":"P Delerive","year":"1999","unstructured":"Delerive P, De BK, Besnard S, Vanden BW, Peters JM, Gonzalez FJ et al. PPAR\u03b1 negatively regulates the vascular inflammatory gene response by negative cross talk with transcription factors NF-\u03baB and AP-1. J Biol Chem 1999; 274: 32048\u201332054.","journal-title":"J Biol Chem"},{"key":"BFcddis2014361_CR8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/384039a0","volume":"384","author":"PR Devchand","year":"1996","unstructured":"Devchand PR, Keller H, Peters JM, Vasquez M, Gonzalez FJ, Wahli W . The PPAR\u03b1-leukotriene B pathway to inflammation control. Nature 1996; 384: 39\u201343.","journal-title":"Nature"},{"key":"BFcddis2014361_CR9","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/31701","volume":"393","author":"B Staels","year":"1998","unstructured":"Staels B, Koenig W, Habib A, Merval R, Lebret M, Pineda-Torra I et al. Activation of human aortic smooth-muscle cells is inhibited by PPAR\u03b1 but not by PPAR\u03b3 activators. Nature 1998; 393: 790\u2013793.","journal-title":"Nature"},{"key":"BFcddis2014361_CR10","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1097\/00001756-200502280-00003","volume":"16","author":"JH Lee","year":"2005","unstructured":"Lee JH, Joe EH, Jou I . PPAR-alpha activators suppress STAT1 inflammatory signaling in lipopolysaccharide-activated rat glia. NeuroReport 2005; 16: 829\u2013833.","journal-title":"NeuroReport"},{"key":"BFcddis2014361_CR11","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/1465-9921-6-91","volume":"6","author":"OC Delayre","year":"2005","unstructured":"Delayre OC, Becker J, Guenon I, Lagente V, Auwerx J, Frossard N et al. PPARalpha downregulates airway inflammation induced by lipopolysaccharide in the mouse. Respir Res 2005; 6: 91\u2013100.","journal-title":"Respir Res"},{"key":"BFcddis2014361_CR12","first-page":"477","volume":"26","author":"PR Di","year":"2006","unstructured":"Di PR, Esposito E, Mazzon E, Genovese T, Muia C, Crisafulli C et al. Absence of peroxisome proliferators-activated receptors (PPAR)alpha enhanced the multiple organ failure induced by zymosan. Shock 2006; 26: 477\u2013484.","journal-title":"Shock"},{"key":"BFcddis2014361_CR13","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1046\/j.0022-202x.2001.01626.x","volume":"118","author":"MY Sheu","year":"2002","unstructured":"Sheu MY, Fowler AJ, Kao J, Schmuth M, Schoonjans K, Auwerx J et al. Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models. J Invest Dermatol 2002; 118: 94\u2013101.","journal-title":"J Invest Dermatol"},{"key":"BFcddis2014361_CR14","first-page":"0006-291X(13)00","volume":"9","author":"HY Seong","year":"2013","unstructured":"Seong HY, Mohamed AA, Byoung JS . Activation of PPARa by Wy-14,643 ameliorates systemic lipopolysaccharide-induced acute lung injury. Biochem Biophys Res Commun 2013; 9: 0006-291X(13)00870-X.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcddis2014361_CR15","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1097\/SHK.0b013e31823f1a00","volume":"37","author":"WS Stephen","year":"2012","unstructured":"Stephen WS, Charles CC, Basilia Z, Hector RW . Reduced peroxisome proliferator-activated receptor \u03b1 expression is associated with decreased survival and increased tissue bacterial load in sepsis. Shock 2012; 37: 164\u2013169.","journal-title":"Shock"},{"key":"BFcddis2014361_CR16","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.toxlet.2011.01.013","volume":"202","author":"HY Seong","year":"2011","unstructured":"Seong HY, Ogyi P, Lauren EH, Mohamed AA, Kwan HM, Byoung JS . Lack of PPAR\u03b1 exacerbates lipopolysaccharide-induced liver toxicity through STAT1 inflammatory signaling and increased oxidative\/nitrosative stress. Toxicol Lett 2011; 202: 23\u201329.","journal-title":"Toxicol Lett"},{"key":"BFcddis2014361_CR17","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1164\/ajrccm.159.4.9712012","volume":"159","author":"A Mignon","year":"1999","unstructured":"Mignon A, Rouquet N, Fabre M, Martin S, Pag\u00e8s JC, Dhainaut JF et al. LPS challenge in D-galactosamine-sensitized mice accounts for caspase-dependent fulminant hepatitis, not for septic shock. Am J Respir Crit Care Med 1999; 159: 1308\u20131315.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFcddis2014361_CR18","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1053\/jhep.2001.24561","volume":"33","author":"T Nakama","year":"2001","unstructured":"Nakama T, Hirono S, Moriuchi A, Hasuike S, Nagata K, Hori T et al. Etoposide prevents apoptosis inmouse liver with D-GalN\/LPS-induced fulminant hepatic failure resulting inreduction of lethality. Hepatology 2001; 33: 1441\u20131450.","journal-title":"Hepatology"},{"key":"BFcddis2014361_CR19","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/35056522","volume":"2","author":"Y Ohsumi","year":"2001","unstructured":"Ohsumi Y . Molecular dissection of autophagy: two ubiquitin-like systems. Nat Rev Mol Cell Biol 2001; 2: 211\u2013216.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcddis2014361_CR20","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nature06639","volume":"451","author":"N Mizushima","year":"2008","unstructured":"Mizushima N, Levine B, Cuervo AM, Klionsky DJ . Autophagy fights disease through cellular self-digestion. Nature 2008; 451: 1069\u20131075.","journal-title":"Nature"},{"key":"BFcddis2014361_CR21","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/nri2161","volume":"7","author":"B Levine","year":"2007","unstructured":"Levine B, Deretic V . Unveiling the roles of autophagy in innate and adaptive immunity. Nat Rev Immunol 2007; 7: 767\u2013777.","journal-title":"Nat Rev Immunol"},{"key":"BFcddis2014361_CR22","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nature09782","volume":"469","author":"L Beth","year":"2011","unstructured":"Beth L, Noboru M, Herbert WV . Autophagy in immunity and inflammation. Nature 2011; 469: 323\u2013335.","journal-title":"Nature"},{"key":"BFcddis2014361_CR23","first-page":"732798","volume":"2011","author":"JSC Alexander","year":"2011","unstructured":"Alexander JSC, Stefan WR . Autophagy in inflammatory diseases. Int J Cell Biol 2011; 2011: 732798.","journal-title":"Int J Cell Biol"},{"key":"BFcddis2014361_CR24","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1038\/emboj.2008.31","volume":"27","author":"MA Delgado","year":"2008","unstructured":"Delgado MA, Elmaoued RA, Davis AS, Kyei G, Deretic V . Toll-like receptors control autophagy. EMBO J 2008; 27: 1110\u20131121.","journal-title":"EMBO J"},{"key":"BFcddis2014361_CR25","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.immuni.2007.05.022","volume":"27","author":"Y Xu","year":"2007","unstructured":"Xu Y, Jagannath C, Liu XD, Sharafkhaneh A, Kolodziejska KE, Eissa NT . Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity 2007; 27: 135\u2013144.","journal-title":"Immunity"},{"key":"BFcddis2014361_CR26","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/nature07383","volume":"456","author":"T Saitoh","year":"2008","unstructured":"Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T et al. loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1\u03b2 production. Nature 2008; 456: 264\u2013268.","journal-title":"Nature"},{"key":"BFcddis2014361_CR27","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/ni.1980","volume":"12","author":"K Nakahira","year":"2011","unstructured":"Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol 2011; 12: 222\u2013230.","journal-title":"Nat Immunol"},{"key":"BFcddis2014361_CR28","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1055\/s-2007-991511","volume":"27","author":"S Gyongyi","year":"2007","unstructured":"Gyongyi S, Pranoti M . Angela D. Innate immune response and hepatic inflammation. Semin Liver Dis 2007; 27: 339\u2013350.","journal-title":"Semin Liver Dis"},{"key":"BFcddis2014361_CR29","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1016\/j.biocel.2009.06.007","volume":"41","author":"Z Jie","year":"2009","unstructured":"Jie Z, Zh Wei, Bing L, Mathew CC, Diana WM, Min W et al. PPAR\u03b3 activation induces autophagy in breast cancer cells. Int J Biochem Cell Biol 2009; 41: 2334\u20132342.","journal-title":"Int J Biochem Cell Biol"},{"key":"BFcddis2014361_CR30","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/1465-9921-6-91","volume":"6","author":"OC Delayre","year":"2005","unstructured":"Delayre OC, Becker J, Guenon I, Lagente V, Auwerx J, Frossard N et al. PPAR\u03b1 downregulates airway inflammation induced by lipopolysaccharide in the mouse. Respir Res 2005; 6: 91\u2013100.","journal-title":"Respir Res"},{"key":"BFcddis2014361_CR31","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1002\/hep.20399","volume":"40","author":"T Nakajima","year":"2004","unstructured":"Nakajima T, Kamijo Y, Tanaka N, Sugiyama E, Tanaka E, Kiyosawa K et al. Peroxisome proliferator-activated receptor \u03b1 protects against alcohol-induced liver damage. Hepatology 2004; 40: 972\u2013980.","journal-title":"Hepatology"},{"key":"BFcddis2014361_CR32","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1476-511X-12-11","volume":"12","author":"YM Nan","year":"2013","unstructured":"Nan YM, Kong LB, Ren WG, Wang RQ, Du JH, Li WC et al. Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol mediated liver fibrosis in mice. Lipids Health Dis 2013; 12: 11\u201320.","journal-title":"Lipids Health Dis"},{"key":"BFcddis2014361_CR33","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.toxlet.2011.01.013","volume":"202","author":"HY Seong","year":"2011","unstructured":"Seong HY, Ogyi P, Lauren EH, Mohamed AA, Kwan HM, Byoung JS . Lack of PPAR\u03b1 exacerbates lipopolysaccharide-induced liver toxicity through STAT1 inflammatory signaling and increased oxidative\/nitrosative stress. Toxicol Lett 2011; 202: 23\u201329.","journal-title":"Toxicol Lett"},{"key":"BFcddis2014361_CR34","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1002\/hep.20170","volume":"39","author":"I Emilia","year":"2004","unstructured":"Emilia I, Geoff F, Pauline H, Graham R, Isabelle L . Administration of the potent PPAR\u03b1 Agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice. Hepatology 2004; 39: 1286\u20131296.","journal-title":"Hepatology"},{"key":"BFcddis2014361_CR35","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1053\/jhep.2000.17687","volume":"32","author":"N Rolando","year":"2000","unstructured":"Rolando N, Wade J, Davalos M, Wendon J, Philpott-Howard J, Williams R . The systemic inflammatory response syndrome in acute liver failure. Hepatology 2000; 32: 734\u2013739.","journal-title":"Hepatology"},{"key":"BFcddis2014361_CR36","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.jhep.2004.06.011","volume":"41","author":"R Jalan","year":"2004","unstructured":"Jalan R, Olde Damink SW, Hayes PC, Deutz NE, Lee A . Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow. J Hepatol 2004; 41: 613\u2013620.","journal-title":"J Hepatol"},{"key":"BFcddis2014361_CR37","doi-asserted-by":"publisher","first-page":"G256","DOI":"10.1152\/ajpgi.00550.2001","volume":"283","author":"GL Su","year":"2002","unstructured":"Su GL . Lipopolysaccharides in liver injury: molicular mechanisms of kupffer cell activation. Am J Physiol Gastrointest Liver Physiol 2002; 283: G256\u2013G265.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"BFcddis2014361_CR38","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1080\/1044667031000137610","volume":"9","author":"K Matsuno","year":"2002","unstructured":"Matsuno K, Nomiyama H, Yoneyama H, Uwatoku R . Kupffer cell-mediated recruitment of dendritic cells to the liver crucial for a host defense. Dev Immunol 2002; 9: 143\u2013149.","journal-title":"Dev Immunol"},{"key":"BFcddis2014361_CR39","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.it.2004.09.006","volume":"25","author":"K Klugewitz","year":"2004","unstructured":"Klugewitz K, Adams DH, Emoto M, Eulenburg K, Hamann A . The composition of intrahepatic lymphocytes: shaped by selective recruitment? Trends Immunol 2004; 25: 590\u2013594.","journal-title":"Trends Immunol"},{"key":"BFcddis2014361_CR40","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1055\/s-2007-991512","volume":"27","author":"E Bertus","year":"2007","unstructured":"Bertus E, Simon CA, Stephen JW, Andrew PH, David HA . Immune-mediated liver injury. Semin Liver Dis 2007; 27: 351\u2013366.","journal-title":"Semin Liver Dis"},{"key":"BFcddis2014361_CR41","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/jlb.66.1.10","volume":"66","author":"JG Wagner","year":"1999","unstructured":"Wagner JG, Roth RA . Neutrophil migration during endotoxemia. J Leukoc Biol 1999; 66: 10\u201324.","journal-title":"J Leukoc Biol"},{"key":"BFcddis2014361_CR42","doi-asserted-by":"publisher","first-page":"445","DOI":"10.4161\/auto.19496","volume":"8","author":"DJ Klionsky","year":"2012","unstructured":"Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo A, Adeli K et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8: 445\u2013544.","journal-title":"Autophagy"},{"key":"BFcddis2014361_CR43","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1089\/ars.2010.3485","volume":"14","author":"L F\u00e9s\u00fcs","year":"2011","unstructured":"F\u00e9s\u00fcs L, Dem\u00e9ny M\u00c1, Petrovski G . Autophagy shapes inflammation. Antioxid Redox Signal 2011; 14: 2233\u20132243.","journal-title":"Antioxid Redox Signal"},{"key":"BFcddis2014361_CR44","doi-asserted-by":"publisher","first-page":"e34165","DOI":"10.1371\/journal.pone.0034165","volume":"7","author":"W Hu","year":"2012","unstructured":"Hu W, Wang X, Ding X, Li Y, Zhang X, Xie P et al. MicroRNA-141 represses HBV replication by targeting PPAR\u03b1. PLoS One 2012; 7: e34165.","journal-title":"PLoS One"},{"key":"BFcddis2014361_CR45","doi-asserted-by":"publisher","first-page":"824","DOI":"10.4161\/auto.9099","volume":"5","author":"YT Wu","year":"2009","unstructured":"Wu YT, Tan HL, Huang Q, Ong CN, Shen HM . Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy. Autophagy 2009; 5: 824\u2013834.","journal-title":"Autophagy"},{"key":"BFcddis2014361_CR46","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1152\/physrev.00030.2009","volume":"90","author":"S Sovan","year":"2010","unstructured":"Sovan S, Janet ED, Marie F, Moises GA, Zeyn GT, Maria JS et al. Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev 2010; 90: 1383\u20131435.","journal-title":"Physiol Rev"},{"key":"BFcddis2014361_CR47","doi-asserted-by":"publisher","first-page":"e45202","DOI":"10.1371\/journal.pone.0045202","volume":"7","author":"C Liyan","year":"2012","unstructured":"Liyan C, Feng R, Haiyan Z, Tao W, Zhengfu P, Li Z et al. Inhibition of GSK3\u03b2 ameliorates D-GalN\/LPS-induced liver injury by reducing ERS-triggered apoptosis. PLoS One 2012; 7: e45202.","journal-title":"PLoS One"},{"key":"BFcddis2014361_CR48","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/hep.24419","volume":"54","author":"R Feng","year":"2011","unstructured":"Feng R, Zhongping D, Xiuda S, Shen X, Gao F, Bai L et al. The inhibition of GSK3\u03b2 ameliorates liver ischemia reperfusion injury via an IL-10-mediated immune modulatory mechanism. Hepatology 2011; 54: 687\u2013696.","journal-title":"Hepatology"},{"key":"BFcddis2014361_CR49","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/BF02618288","volume":"17","author":"JE Klaunig","year":"1981","unstructured":"Klaunig JE, Goldblatt PJ, Hinton DE, Lipsky MM, Chacko J, Trump BF . Mouse liver cell culture. I. Hepatocyte isolation. In Vitro 1981; 17: 913\u2013925.","journal-title":"In Vitro"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/cddis2014361.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2014361","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2014361.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T23:10:00Z","timestamp":1672960200000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis2014361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,28]]},"references-count":49,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,8]]}},"alternative-id":["BFcddis2014361"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2014.361","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,28]]},"assertion":[{"value":"21 December 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}