{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:15:35Z","timestamp":1791328535502,"version":"4.3.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T00:00:00Z","timestamp":1394064000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2014.65","type":"journal-article","created":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T15:16:12Z","timestamp":1394118972000},"page":"e1107-e1107","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Intermittent selective clamping improves rat liver regeneration by attenuating oxidative and endoplasmic reticulum stress"],"prefix":"10.1038","volume":"5","author":[{"given":"I","family":"Ben Mosbah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Duval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S-F","family":"Mbatchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ribault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Grandadam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Pajaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Morel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Boudjema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Compagnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Corlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,6]]},"reference":[{"key":"BFcddis201465_CR1","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1097\/00000658-199712000-00007","volume":"226","author":"K Man","year":"1997","unstructured":"Man K, Fan ST, Ng IO, Lo CM, Liu CL, Wong J . Prospective evaluation of Pringle maneuver in hepatectomy for liver tumors by a randomized study. Ann Surg 1997; 226: 704\u2013711 discussion 711\u2013703.","journal-title":"Ann Surg"},{"key":"BFcddis201465_CR2","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/00000658-199903000-00010","volume":"229","author":"J Belghiti","year":"1999","unstructured":"Belghiti J, Noun R, Malafosse R, Jagot P, Sauvanet A, Pierangeli F et al. Continuous versus intermittent portal triad clamping for liver resection: a controlled study. Ann Surg 1999; 229: 369\u2013375.","journal-title":"Ann Surg"},{"key":"BFcddis201465_CR3","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1002\/bjs.4018","volume":"90","author":"AC Wei","year":"2003","unstructured":"Wei AC, Tung-Ping Poon R, Fan ST, Wong J . Risk factors for perioperative morbidity and mortality after extended hepatectomy for hepatocellular carcinoma. Br J Surg 2003; 90: 33\u201341.","journal-title":"Br J Surg"},{"key":"BFcddis201465_CR4","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1097\/00000658-200203000-00012","volume":"235","author":"HA Rudiger","year":"2002","unstructured":"Rudiger HA, Kang KJ, Sindram D, Riehle HM, Clavien PA . Comparison of ischemic preconditioning and intermittent and continuous inflow occlusion in the murine liver. Ann Surg 2002; 235: 400\u2013407.","journal-title":"Ann Surg"},{"key":"BFcddis201465_CR5","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.jhep.2010.11.005","volume":"54","author":"H Malhi","year":"2011","unstructured":"Malhi H, Kaufman RJ . Endoplasmic reticulum stress in liver disease. J Hepatol 2011; 54: 795\u2013809.","journal-title":"J Hepatol"},{"key":"BFcddis201465_CR6","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3109\/08941939.2010.496036","volume":"23","author":"WJ Chang","year":"2010","unstructured":"Chang WJ, Chehab M, Kink S, Toledo-Pereyra LH . Intracellular calcium signaling pathways during liver ischemia and reperfusion. J Invest Surg 2010; 23: 228\u2013238.","journal-title":"J Invest Surg"},{"key":"BFcddis201465_CR7","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1002\/lt.20504","volume":"11","author":"GK Glantzounis","year":"2005","unstructured":"Glantzounis GK, Salacinski HJ, Yang W, Davidson BR, Seifalian AM . The contemporary role of antioxidant therapy in attenuating liver ischemia-reperfusion injury: a review. Liver Transpl 2005; 11: 1031\u20131047.","journal-title":"Liver Transpl"},{"key":"BFcddis201465_CR8","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1055\/s-2007-991513","volume":"27","author":"N Kaplowitz","year":"2007","unstructured":"Kaplowitz N, Than TA, Shinohara M, Ji C . Endoplasmic reticulum stress and liver injury. Semin Liver Dis 2007; 27: 367\u2013377.","journal-title":"Semin Liver Dis"},{"key":"BFcddis201465_CR9","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1126\/science.1209038","volume":"334","author":"P Walter","year":"2011","unstructured":"Walter P, Ron D . The unfolded protein response: from stress pathway to homeostatic regulation. Science 2011; 334: 1081\u20131086.","journal-title":"Science"},{"key":"BFcddis201465_CR10","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/nature07203","volume":"454","author":"K Zhang","year":"2008","unstructured":"Zhang K, Kaufman RJ . From endoplasmic-reticulum stress to the inflammatory response. Nature 2008; 454: 455\u2013462.","journal-title":"Nature"},{"key":"BFcddis201465_CR11","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1002\/hep.24783","volume":"55","author":"C Zhang","year":"2012","unstructured":"Zhang C, Wang G, Zheng Z, Maddipati KR, Zhang X, Dyson G et al. Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. Hepatology 2012; 55: 1070\u20131082.","journal-title":"Hepatology"},{"key":"BFcddis201465_CR12","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.2174\/092986711795590039","volume":"18","author":"C Peralta","year":"2011","unstructured":"Peralta C, Brenner C . Endoplasmic reticulum stress inhibition enhances liver tolerance to ischemia\/reperfusion. Curr Med Chem 2011; 18: 2016\u20132024.","journal-title":"Curr Med Chem"},{"key":"BFcddis201465_CR13","doi-asserted-by":"publisher","first-page":"e52","DOI":"10.1038\/cddis.2010.29","volume":"1","author":"I Ben Mosbah","year":"2010","unstructured":"Ben Mosbah I, Alfany-Fernandez I, Martel C, Zaouali MA, Bintanel-Morcillo M, Rimola A et al. Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion. Cell Death Dis 2010; 1: e52.","journal-title":"Cell Death Dis"},{"key":"BFcddis201465_CR14","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1053\/j.gastro.2008.03.002","volume":"134","author":"H Malhi","year":"2008","unstructured":"Malhi H, Gores GJ . Cellular and molecular mechanisms of liver injury. Gastroenterology 2008; 134: 1641\u20131654.","journal-title":"Gastroenterology"},{"key":"BFcddis201465_CR15","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/S0076-6879(08)01420-1","volume":"442","author":"K Zhang","year":"2008","unstructured":"Zhang K, Kaufman RJ . Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivo. Methods Enzymol 2008; 442: 395\u2013419.","journal-title":"Methods Enzymol"},{"key":"BFcddis201465_CR16","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1126\/science.1128294","volume":"313","author":"U Ozcan","year":"2006","unstructured":"Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006; 313: 1137\u20131140.","journal-title":"Science"},{"key":"BFcddis201465_CR17","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1126\/science.287.5453.664","volume":"287","author":"F Urano","year":"2000","unstructured":"Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP et al. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000; 287: 664\u2013666.","journal-title":"Science"},{"key":"BFcddis201465_CR18","doi-asserted-by":"publisher","first-page":"2656","DOI":"10.1172\/JCI26373","volume":"115","author":"C Xu","year":"2005","unstructured":"Xu C, Bailly-Maitre B, Reed JC . Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 2005; 115: 2656\u20132664.","journal-title":"J Clin Invest"},{"key":"BFcddis201465_CR19","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.jhep.2010.01.013","volume":"52","author":"H Duval","year":"2010","unstructured":"Duval H, Mbatchi SF, Grandadam S, Legendre C, Loyer P, Ribault C et al. Reperfusion stress induced during intermittent selective clamping accelerates rat liver regeneration through JNK pathway. J Hepatol 2010; 52: 560\u2013569.","journal-title":"J Hepatol"},{"key":"BFcddis201465_CR20","doi-asserted-by":"publisher","first-page":"176723","DOI":"10.1155\/2012\/176723","volume":"2012","author":"K Weigand","year":"2012","unstructured":"Weigand K, Brost S, Steinebrunner N, Buchler M, Schemmer P, Muller M . Ischemia\/reperfusion injury in liver surgery and transplantation: pathophysiology. HPB Surg 2012; 2012: 176723.","journal-title":"HPB Surg"},{"key":"BFcddis201465_CR21","first-page":"1587","volume":"50","author":"DE Giakoustidis","year":"2003","unstructured":"Giakoustidis DE, Iliadis S, Tsantilas D, Papageorgiou G, Kontos N, Kostopoulou E et al. Blockade of Kupffer cells by gadolinium chloride reduces lipid peroxidation and protects liver from ischemia\/reperfusion injury. Hepatogastroenterology 2003; 50: 1587\u20131592.","journal-title":"Hepatogastroenterology"},{"key":"BFcddis201465_CR22","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/sj.onc.1210638","volume":"27","author":"A Deniaud","year":"2008","unstructured":"Deniaud A, Sharaf el dein O, Maillier E, Poncet D, Kroemer G, Lemaire C et al. Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis. Oncogene 2008; 27: 285\u2013299.","journal-title":"Oncogene"},{"key":"BFcddis201465_CR23","first-page":"1122","volume":"16","author":"F Chai","year":"2010","unstructured":"Chai F, Luo R, Li Y, Bai Y, He Y, Wei Y et al. Down-regulation of GRP78 in human glaucomatous trabecular meshwork cells. Mol Vis 2010; 16: 1122\u20131131.","journal-title":"Mol Vis"},{"key":"BFcddis201465_CR24","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.devcel.2007.07.018","volume":"13","author":"K Yamamoto","year":"2007","unstructured":"Yamamoto K, Sato T, Matsui T, Sato M, Okada T, Yoshida H et al. Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP-1 (S). Dev Cell 2007; 13: 365\u2013376.","journal-title":"Dev Cell"},{"key":"BFcddis201465_CR25","doi-asserted-by":"publisher","first-page":"4248","DOI":"10.1091\/mbc.e03-11-0851","volume":"15","author":"DT Nguyen","year":"2004","unstructured":"Nguyen DT, Kebache S, Fazel A, Wong HN, Jenna S, Emadali A et al. Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress. Mol Biol Cell 2004; 15: 4248\u20134260.","journal-title":"Mol Biol Cell"},{"key":"BFcddis201465_CR26","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1124\/jpet.108.147835","volume":"329","author":"FS Ramalho","year":"2009","unstructured":"Ramalho FS, Alfany-Fernandez I, Casillas-Ramirez A, Massip-Salcedo M, Serafin A, Rimola A et al. Are angiotensin II receptor antagonists useful strategies in steatotic and nonsteatotic livers in conditions of partial hepatectomy under ischemia-reperfusion? J Pharmacol Exp Ther 2009; 329: 130\u2013140.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFcddis201465_CR27","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.biocel.2010.08.002","volume":"43","author":"JS Campbell","year":"2011","unstructured":"Campbell JS, Argast GM, Yuen SY, Hayes B, Fausto N . Inactivation of p38 MAPK during liver regeneration. Int J Biochem Cell Biol 2011; 43: 180\u2013188.","journal-title":"Int J Biochem Cell Biol"},{"key":"BFcddis201465_CR28","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1002\/hep.24560","volume":"54","author":"Y Mei","year":"2011","unstructured":"Mei Y, Thevananther S . Endothelial nitric oxide synthase is a key mediator of hepatocyte proliferation in response to partial hepatectomy in mice. Hepatology 2011; 54: 1777\u20131789.","journal-title":"Hepatology"},{"key":"BFcddis201465_CR29","first-page":"186","volume":"12","author":"GM Higgins","year":"1931","unstructured":"Higgins GM, Anderson RM . Experimental pathology of the liver. I: restoration of the liver of the white rat following partial surgical removal. Arch Pathol 1931; 12: 186\u2013202.","journal-title":"Arch Pathol"},{"key":"BFcddis201465_CR30","doi-asserted-by":"publisher","first-page":"e50235","DOI":"10.1371\/journal.pone.0050235","volume":"7","author":"I Ben Mosbah","year":"2012","unstructured":"Ben Mosbah I, Mouchel Y, Pajaud J, Ribault C, Lucas C, Laurent A et al. Pretreatment with mangafodipir improves liver graft tolerance to ischemia\/reperfusion injury in rat. PLoS One 2012; 7: e50235.","journal-title":"PLoS One"},{"key":"BFcddis201465_CR31","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1478-3231.2006.01416.x","volume":"27","author":"K Furrer","year":"2007","unstructured":"Furrer K, Deoliveira ML, Graf R, Clavien PA . Improving outcome in patients undergoing liver surgery. Liver Int 2007; 27: 26\u201339.","journal-title":"Liver Int"},{"key":"BFcddis201465_CR32","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1053\/j.gastro.2007.10.039","volume":"134","author":"P Puri","year":"2008","unstructured":"Puri P, Mirshahi F, Cheung O, Natarajan R, Maher JW, Kellum JM et al. Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 2008; 134: 568\u2013576.","journal-title":"Gastroenterology"},{"key":"BFcddis201465_CR33","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1111\/j.1600-6143.2004.00580.x","volume":"4","author":"NA t Hart","year":"2004","unstructured":"t Hart NA, van der Plaats A, Leuvenink HG, Wiersema-Buist J, Olinga P, van Luyn MJ et al. Initial blood washout during organ procurement determines liver injury and function after preservation and reperfusion. Am J Transplant 2004; 4: 1836\u20131844.","journal-title":"Am J Transplant"}],"container-title":["Cell Death & Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis201465.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis201465","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis201465.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T23:37:19Z","timestamp":1672961839000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis201465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,6]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3]]}},"alternative-id":["BFcddis201465"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2014.65","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,6]]},"assertion":[{"value":"28 October 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}