{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:29:56Z","timestamp":1790890196711,"version":"4.1.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T00:00:00Z","timestamp":1394064000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"DOI":"10.1038\/cddis.2014.80","type":"journal-article","created":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T10:16:12Z","timestamp":1394100972000},"page":"e1105-e1105","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury"],"prefix":"10.1038","volume":"5","author":[{"given":"S Y","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M S","family":"Shim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K-Y","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R N","family":"Weinreb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L A","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W-K","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,6]]},"reference":[{"key":"BFcddis201480_CR1","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","volume":"363","author":"RN Weinreb","year":"2004","unstructured":"Weinreb RN, Khaw PT . Primary open-angle glaucoma. Lancet 2004; 363: 1711\u20131720.","journal-title":"Lancet"},{"key":"BFcddis201480_CR2","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1097\/00004647-199907000-00002","volume":"19","author":"S Matsumoto","year":"1999","unstructured":"Matsumoto S, Friberg H, Ferrand-Drake M, Wieloch T . Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab 1999; 19: 736\u2013741.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFcddis201480_CR3","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/S0079-6123(08)01139-4","volume":"173","author":"R Russo","year":"2008","unstructured":"Russo R, Cavaliere F, Rombola L, Gliozzi M, Cerulli A, Nucci C et al. Rational basis for the development of coenzyme Q10 as a neurotherapeutic agent for retinal protection. Prog Brain Res 2008; 173: 575\u2013582.","journal-title":"Prog Brain Res"},{"key":"BFcddis201480_CR4","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.expneurol.2010.06.009","volume":"230","author":"PL Leger","year":"2011","unstructured":"Leger PL, De Paulis D, Branco S, Bonnin P, Couture-Lepetit E, Baud O et al. Evaluation of cyclosporine A in a stroke model in the immature rat brain. Exp Neurol 2011; 230: 58\u201366.","journal-title":"Exp Neurol"},{"key":"BFcddis201480_CR5","doi-asserted-by":"publisher","first-page":"12005","DOI":"10.1073\/pnas.0505294102","volume":"102","author":"AC Schinzel","year":"2005","unstructured":"Schinzel AC, Takeuchi O, Huang Z, Fisher JK, Zhou Z, Rubens J et al. Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proc Natl Acad Sci USA 2005; 102: 12005\u201312010.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis201480_CR6","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/s10495-006-0525-7","volume":"12","author":"Y Tsujimoto","year":"2007","unstructured":"Tsujimoto Y, Shimizu S . Role of the mitochondrial membrane permeability transition in cell death. Apoptosis 2007; 12: 835\u2013840.","journal-title":"Apoptosis"},{"key":"BFcddis201480_CR7","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/434578a","volume":"434","author":"A Halestrap","year":"2005","unstructured":"Halestrap A . Biochemistry: a pore way to die. Nature 2005; 434: 578\u2013579.","journal-title":"Nature"},{"key":"BFcddis201480_CR8","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0074-7742(07)82022-8","volume":"82","author":"C Nucci","year":"2007","unstructured":"Nucci C, Tartaglione R, Cerulli A, Mancino R, Spano A, Cavaliere F et al. Retinal damage caused by high intraocular pressure-induced transient ischemia is prevented by coenzyme Q10 in rat. Int Rev Neurobiol 2007; 82: 397\u2013406.","journal-title":"Int Rev Neurobiol"},{"key":"BFcddis201480_CR9","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1046\/j.1432-1327.1998.2580729.x","volume":"258","author":"M Crompton","year":"1998","unstructured":"Crompton M, Virji S, Ward JM . Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore. Eur J Biochem 1998; 258: 729\u2013735.","journal-title":"Eur J Biochem"},{"issue":"Part 2","key":"BFcddis201480_CR10","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1042\/bj3360287","volume":"336","author":"K Woodfield","year":"1998","unstructured":"Woodfield K, Ruck A, Brdiczka D, Halestrap AP . Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition. Biochem J 1998; 336 (Part 2): 287\u2013290.","journal-title":"Biochem J"},{"key":"BFcddis201480_CR11","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nature02229","volume":"427","author":"JE Kokoszka","year":"2004","unstructured":"Kokoszka JE, Waymire KG, Levy SE, Sligh JE, Cai J, Jones DP et al. The ADP\/ATP translocator is not essential for the mitochondrial permeability transition pore. Nature 2004; 427: 461\u2013465.","journal-title":"Nature"},{"key":"BFcddis201480_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000103747","volume":"20","author":"S Javadov","year":"2007","unstructured":"Javadov S, Karmazyn M . Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection. Cell Physiol Biochem 2007; 20: 1\u201322.","journal-title":"Cell Physiol Biochem"},{"issue":"8","key":"BFcddis201480_CR13","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/j.bbadis.2013.09.003","volume":"1842","author":"Valasani Koteswara Rao","year":"2014","unstructured":"Rao VK, Carlson EA, Yan SS . Mitochondrial permeability transition pore is a potential drug target for neurodegeneration. Biochim Biophys Acta 2013; e-pub ahead of print 18 September 2013; doi:10.1016\/j.bbadis.2013.09.003.","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"key":"BFcddis201480_CR14","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1523\/JNEUROSCI.4065-10.2011","volume":"31","author":"SA Barrientos","year":"2011","unstructured":"Barrientos SA, Martinez NW, Yoo S, Jara JS, Zamorano S, Hetz C et al. Axonal degeneration is mediated by the mitochondrial permeability transition pore. J Neurosci 2011; 31: 966\u2013978.","journal-title":"J Neurosci"},{"key":"BFcddis201480_CR15","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1038\/nature03434","volume":"434","author":"CP Baines","year":"2005","unstructured":"Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA et al. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 2005; 434: 658\u2013662.","journal-title":"Nature"},{"key":"BFcddis201480_CR16","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/nature03317","volume":"434","author":"T Nakagawa","year":"2005","unstructured":"Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Yamagata H et al. Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature 2005; 434: 652\u2013658.","journal-title":"Nature"},{"key":"BFcddis201480_CR17","doi-asserted-by":"publisher","first-page":"7469","DOI":"10.1523\/JNEUROSCI.0646-07.2007","volume":"27","author":"KK Naga","year":"2007","unstructured":"Naga KK, Sullivan PG, Geddes JW . High cyclophilin D content of synaptic mitochondria results in increased vulnerability to permeability transition. J Neurosci 2007; 27: 7469\u20137475.","journal-title":"J Neurosci"},{"key":"BFcddis201480_CR18","doi-asserted-by":"publisher","first-page":"e46498","DOI":"10.1371\/journal.pone.0046498","volume":"7","author":"J Li","year":"2012","unstructured":"Li J, Ma X, Yu W, Lou Z, Mu D, Wang Y et al. Reperfusion promotes mitochondrial dysfunction following focal cerebral ischemia in rats. PLoS One 2012; 7: e46498.","journal-title":"PLoS One"},{"key":"BFcddis201480_CR19","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/ng0398-231","volume":"18","author":"NG Larsson","year":"1998","unstructured":"Larsson NG, Wang J, Wilhelmsson H, Oldfors A, Rustin P, Lewandoski M et al. Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat Genet 1998; 18: 231\u2013236.","journal-title":"Nat Genet"},{"key":"BFcddis201480_CR20","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1146\/annurev.biochem.76.060305.152028","volume":"76","author":"M Falkenberg","year":"2007","unstructured":"Falkenberg M, Larsson NG, Gustafsson CM . DNA replication and transcription in mammalian mitochondria. Annu Rev Biochem 2007; 76: 679\u2013699.","journal-title":"Annu Rev Biochem"},{"key":"BFcddis201480_CR21","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1038\/nsmb.2159","volume":"18","author":"HB Ngo","year":"2011","unstructured":"Ngo HB, Kaiser JT, Chan DC . The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA. Nat Struct Mol Biol 2011; 18: 1290\u20131296.","journal-title":"Nat Struct Mol Biol"},{"key":"BFcddis201480_CR22","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1111\/j.1440-1789.2009.01086.x","volume":"30","author":"M Hokari","year":"2010","unstructured":"Hokari M, Kuroda S, Kinugawa S, Ide T, Tsutsui H, Iwasaki Y . Overexpression of mitochondrial transcription factor A (TFAM) ameliorates delayed neuronal death due to transient forebrain ischemia in mice. Neuropathology 2010; 30: 401\u2013407.","journal-title":"Neuropathology"},{"key":"BFcddis201480_CR23","doi-asserted-by":"publisher","first-page":"3057","DOI":"10.1161\/STROKEAHA.108.520114","volume":"39","author":"W Yin","year":"2008","unstructured":"Yin W, Signore AP, Iwai M, Cao G, Gao Y, Chen J . Rapidly increased neuronal mitochondrial biogenesis after hypoxic\u2013ischemic brain injury. Stroke 2008; 39: 3057\u20133063.","journal-title":"Stroke"},{"key":"BFcddis201480_CR24","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.bbagen.2011.08.007","volume":"1820","author":"Y Piao","year":"2012","unstructured":"Piao Y, Kim HG, Oh MS, Pak YK . Overexpression of TFAM, NRF-1 and myr-AKT protects the MPP(+)-induced mitochondrial dysfunctions in neuronal cells. Biochim Biophys Acta 2012; 1820: 577\u2013585.","journal-title":"Biochim Biophys Acta"},{"key":"BFcddis201480_CR25","doi-asserted-by":"publisher","first-page":"e47098","DOI":"10.1371\/journal.pone.0047098","volume":"7","author":"D Lee","year":"2012","unstructured":"Lee D, Kim KY, Noh YH, Chai S, Lindsey JD, Ellisman MH et al. Brimonidine blocks glutamate excitotoxicity-induced oxidative stress and preserves mitochondrial transcription factor a in ischemic retinal injury. PLoS One 2012; 7: e47098.","journal-title":"PLoS One"},{"key":"BFcddis201480_CR26","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/978-3-7091-1434-6_61","volume":"118","author":"H Uchino","year":"2013","unstructured":"Uchino H, Hatakeyama K, Morota S, Tanoue T, Nishiyama T, Usui D et al. Cyclophilin-D inhibition in neuroprotection: dawn of a new era of mitochondrial medicine. Acta Neurochir Suppl 2013; 118: 311\u2013315.","journal-title":"Acta Neurochir Suppl"},{"key":"BFcddis201480_CR27","doi-asserted-by":"publisher","first-page":"5151","DOI":"10.1523\/JNEUROSCI.18-14-05151.1998","volume":"18","author":"H Friberg","year":"1998","unstructured":"Friberg H, Ferrand-Drake M, Bengtsson F, Halestrap AP, Wieloch T . Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death. J Neurosci 1998; 18: 5151\u20135159.","journal-title":"J Neurosci"},{"key":"BFcddis201480_CR28","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0006-8993(92)91465-Q","volume":"595","author":"Y Shiga","year":"1992","unstructured":"Shiga Y, Onodera H, Matsuo Y, Kogure K . Cyclosporin A protects against ischemia\u2013reperfusion injury in the brain. Brain Res 1992; 595: 145\u2013148.","journal-title":"Brain Res"},{"key":"BFcddis201480_CR29","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1006\/exnr.2000.7459","volume":"165","author":"PA Li","year":"2000","unstructured":"Li PA, Kristian T, He QP, Siesjo BK . Cyclosporin A enhances survival, ameliorates brain damage, and prevents secondary mitochondrial dysfunction after a 30-minute period of transient cerebral ischemia. Exp Neurol 2000; 165: 153\u2013163.","journal-title":"Exp Neurol"},{"key":"BFcddis201480_CR30","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/1479-5876-9-141","volume":"9","author":"CM Yuen","year":"2011","unstructured":"Yuen CM, Sun CK, Lin YC, Chang LT, Kao YH, Yen CH et al. Combination of cyclosporine and erythropoietin improves brain infarct size and neurological function in rats after ischemic stroke. J Transl Med 2011; 9: 141.","journal-title":"J Transl Med"},{"key":"BFcddis201480_CR31","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1097\/00004647-199904000-00010","volume":"19","author":"DO Okonkwo","year":"1999","unstructured":"Okonkwo DO, Povlishock JT . An intrathecal bolus of cyclosporin A before injury preserves mitochondrial integrity and attenuates axonal disruption in traumatic brain injury. J Cereb Blood Flow Metab 1999; 19: 443\u2013451.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFcddis201480_CR32","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1006\/exnr.1999.7197","volume":"160","author":"PG Sullivan","year":"1999","unstructured":"Sullivan PG, Thompson MB, Scheff SW . Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury. Exp Neurol 1999; 160: 226\u2013234.","journal-title":"Exp Neurol"},{"key":"BFcddis201480_CR33","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.neuroscience.2007.02.034","volume":"146","author":"Q Cui","year":"2007","unstructured":"Cui Q, Hodgetts SI, Hu Y, Luo JM, Harvey AR . Strain-specific differences in the effects of cyclosporin A and FK506 on the survival and regeneration of axotomized retinal ganglion cells in adult rats. Neuroscience 2007; 146: 986\u2013999.","journal-title":"Neuroscience"},{"key":"BFcddis201480_CR34","first-page":"2545","volume":"38","author":"LA Levin","year":"1997","unstructured":"Levin LA, Schlamp CL, Spieldoch RL, Geszvain KM, Nickells RW . Identification of the bcl-2 family of genes in the rat retina. Invest Ophthalmol Vis Sci 1997; 38: 2545\u20132553.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFcddis201480_CR35","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0300-9084(02)01381-0","volume":"84","author":"H Friberg","year":"2002","unstructured":"Friberg H, Wieloch T . Mitochondrial permeability transition in acute neurodegeneration. Biochimie 2002; 84: 241\u2013250.","journal-title":"Biochimie"},{"key":"BFcddis201480_CR36","first-page":"76","volume":"4","author":"S Javadov","year":"2013","unstructured":"Javadov S, Kuznetsov A . Mitochondrial permeability transition and cell death: the role of cyclophilin d. Front Physiol 2013; 4: 76.","journal-title":"Front Physiol"},{"key":"BFcddis201480_CR37","doi-asserted-by":"publisher","first-page":"739","DOI":"10.2174\/138161206775474242","volume":"12","author":"M Christophe","year":"2006","unstructured":"Christophe M, Nicolas S . Mitochondria: a target for neuroprotective interventions in cerebral ischemia\u2013reperfusion. Curr Pharm Des 2006; 12: 739\u2013757.","journal-title":"Curr Pharm Des"},{"key":"BFcddis201480_CR38","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1016\/j.biochi.2011.08.001","volume":"93","author":"Y Gouriou","year":"2011","unstructured":"Gouriou Y, Demaurex N, Bijlenga P, De Marchi U . Mitochondrial calcium handling during ischemia-induced cell death in neurons. Biochimie 2011; 93: 2060\u20132067.","journal-title":"Biochimie"},{"key":"BFcddis201480_CR39","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/S0006-291X(03)00628-4","volume":"304","author":"K Blomgren","year":"2003","unstructured":"Blomgren K, Zhu C, Hallin U, Hagberg H . Mitochondria and ischemic reperfusion damage in the adult and in the developing brain. Biochem Biophys Res Commun 2003; 304: 551\u2013559.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcddis201480_CR40","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.expneurol.2009.05.026","volume":"218","author":"AT Mazzeo","year":"2009","unstructured":"Mazzeo AT, Beat A, Singh A, Bullock MR . The role of mitochondrial transition pore, and its modulation, in traumatic brain injury and delayed neurodegeneration after TBI. Exp Neurol 2009; 218: 363\u2013370.","journal-title":"Exp Neurol"},{"key":"BFcddis201480_CR41","doi-asserted-by":"publisher","first-page":"12024","DOI":"10.1073\/pnas.1305538110","volume":"110","author":"A Linkermann","year":"2013","unstructured":"Linkermann A, Brasen JH, Darding M, Jin MK, Sanz AB, Heller JO et al. Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury. Proc Natl Acad Sci USA 2013; 110: 12024\u201312029.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis201480_CR42","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1177\/0192623310389475","volume":"39","author":"LJ Martin","year":"2011","unstructured":"Martin LJ . An approach to experimental synaptic pathology using green fluorescent protein-transgenic mice and gene knockout mice to show mitochondrial permeability transition pore-driven excitotoxicity in interneurons and motoneurons. Toxicol Pathol 2011; 39: 220\u2013233.","journal-title":"Toxicol Pathol"},{"issue":"Part 2","key":"BFcddis201480_CR43","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1042\/bj3020321","volume":"302","author":"CP Connern","year":"1994","unstructured":"Connern CP, Halestrap AP . Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel. Biochem J 1994; 302 (Part 2): 321\u2013324.","journal-title":"Biochem J"},{"key":"BFcddis201480_CR44","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1042\/BJ20090332","volume":"425","author":"S Malouitre","year":"2010","unstructured":"Malouitre S, Dube H, Selwood D, Crompton M . Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation. Biochem J 2010; 425: 137\u2013148.","journal-title":"Biochem J"},{"key":"BFcddis201480_CR45","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1093\/jnen\/59.3.241","volume":"59","author":"WK Ju","year":"2000","unstructured":"Ju WK, Kim KY, Hofmann HD, Kim IB, Lee MY, Oh SJ et al. Selective neuronal survival and upregulation of PCNA in the rat inner retina following transient ischemia. J Neuropathol Exp Neurol 2000; 59: 241\u2013250.","journal-title":"J Neuropathol Exp Neurol"},{"key":"BFcddis201480_CR46","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.preteyeres.2006.05.003","volume":"25","author":"A Bringmann","year":"2006","unstructured":"Bringmann A, Pannicke T, Grosche J, Francke M, Wiedemann P, Skatchkov SN et al. Muller cells in the healthy and diseased retina. Prog Retin Eye Res 2006; 25: 397\u2013424.","journal-title":"Prog Retin Eye Res"},{"key":"BFcddis201480_CR47","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0304-3940(00)00931-9","volume":"283","author":"WK Ju","year":"2000","unstructured":"Ju WK, Lee MY, Hofmann HD, Kirsch M, Oh SJ, Chung JW et al. Increased expression of ciliary neurotrophic factor receptor alpha mRNA in the ischemic rat retina. Neurosci Lett 2000; 283: 133\u2013136.","journal-title":"Neurosci Lett"},{"key":"BFcddis201480_CR48","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.preteyeres.2011.06.001","volume":"30","author":"A Wurm","year":"2011","unstructured":"Wurm A, Pannicke T, Iandiev I, Francke M, Hollborn M, Wiedemann P et al. Purinergic signaling involved in Muller cell function in the mammalian retina. Prog Retin Eye Res 2011; 30: 324\u2013342.","journal-title":"Prog Retin Eye Res"},{"issue":"Part 2","key":"BFcddis201480_CR49","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1042\/bj3410233","volume":"341","author":"M Crompton","year":"1999","unstructured":"Crompton M . The mitochondrial permeability transition pore and its role in cell death. Biochem J 1999; 341 (Part 2): 233\u2013249.","journal-title":"Biochem J"},{"key":"BFcddis201480_CR50","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/0896-6273(95)90186-8","volume":"15","author":"M Ankarcrona","year":"1995","unstructured":"Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA et al. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 1995; 15: 961\u2013973.","journal-title":"Neuron"},{"key":"BFcddis201480_CR51","doi-asserted-by":"publisher","first-page":"7162","DOI":"10.1073\/pnas.92.16.7162","volume":"92","author":"E Bonfoco","year":"1995","unstructured":"Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA . Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide\/superoxide in cortical cell cultures. Proc Natl Acad Sci USA 1995; 92: 7162\u20137166.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis201480_CR52","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S1097-2765(00)80307-X","volume":"3","author":"MG Vander Heiden","year":"1999","unstructured":"Vander Heiden MG, Chandel NS, Schumacker PT, Thompson CB . Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP\/ADP exchange. Mol Cell 1999; 3: 159\u2013167.","journal-title":"Mol Cell"},{"key":"BFcddis201480_CR53","doi-asserted-by":"publisher","first-page":"E209","DOI":"10.1038\/70237","volume":"1","author":"MG Vander Heiden","year":"1999","unstructured":"Vander Heiden MG, Thompson CB . Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? Nat Cell Biol 1999; 1: E209\u2013E216.","journal-title":"Nat Cell Biol"},{"key":"BFcddis201480_CR54","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1017\/S0952523802191152","volume":"19","author":"RK Lai","year":"2002","unstructured":"Lai RK, Chun T, Hasson D, Lee S, Mehrbod F, Wheeler L . Alpha-2 adrenoceptor agonist protects retinal function after acute retinal ischemic injury in the rat. Vis Neurosci 2002; 19: 175\u2013185.","journal-title":"Vis Neurosci"},{"key":"BFcddis201480_CR55","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/S0006-8993(01)02220-X","volume":"899","author":"T Yoshimoto","year":"2001","unstructured":"Yoshimoto T, Uchino H, He QP, Li PA, Siesjo BK . Cyclosporin A, but not FK506, prevents the downregulation of phosphorylated Akt after transient focal ischemia in the rat. Brain Res 2001; 899: 148\u2013158.","journal-title":"Brain Res"},{"key":"BFcddis201480_CR56","first-page":"4471","volume":"55","author":"S Krajewski","year":"1995","unstructured":"Krajewski S, Blomqvist C, Franssila K, Krajewska M, Wasenius VM, Niskanen E et al. Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res 1995; 55: 4471\u20134478.","journal-title":"Cancer Res"},{"key":"BFcddis201480_CR57","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1006\/nbdi.2002.0514","volume":"10","author":"H Uchino","year":"2002","unstructured":"Uchino H, Minamikawa-Tachino R, Kristian T, Perkins G, Narazaki M, Siesjo BK et al. Differential neuroprotection by cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhibit calcineurin and the mitochondrial permeability transition. Neurobiol Dis 2002; 10: 219\u2013233.","journal-title":"Neurobiol Dis"},{"key":"BFcddis201480_CR58","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.1161\/hs1001.097099","volume":"32","author":"H Chen","year":"2001","unstructured":"Chen H, Hu CJ, He YY, Yang DI, Xu J, Hsu CY . Reduction and restoration of mitochondrial dna content after focal cerebral ischemia\/reperfusion. Stroke 2001; 32: 2382\u20132387.","journal-title":"Stroke"},{"key":"BFcddis201480_CR59","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/978-1-61779-108-6_16","volume":"740","author":"WK Ju","year":"2011","unstructured":"Ju WK, Kim KY . Measuring glutamate receptor activation-induced apoptotic cell death in ischemic rat retina using the TUNEL assay. Methods Mol Biol 2011; 740: 149\u2013156.","journal-title":"Methods Mol Biol"},{"key":"BFcddis201480_CR60","doi-asserted-by":"publisher","first-page":"2837","DOI":"10.1167\/iovs.09-5010","volume":"52","author":"SW Park","year":"2011","unstructured":"Park SW, Kim KY, Lindsey JD, Dai Y, Heo H, Nguyen DH et al. A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. Invest Ophthalmol Vis Sci 2011; 52: 2837\u20132843.","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Cell Death & Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cddis201480.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cddis201480","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis201480.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T20:05:04Z","timestamp":1689019504000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis201480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,6]]},"references-count":60,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3]]}},"alternative-id":["BFcddis201480"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2014.80","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,6]]},"assertion":[{"value":"27 November 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Dr. Ju received funding from Allergan Inc. for these studies. Dr. Wheeler was employed by Allergan Inc. during these studies. Dr. Weinreb is a consultant for Allergan Inc. SY Kim, Dr. Shim and Dr. Kim declare no potential conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}