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However, the specific effect and mechanism of SPRC in Dox-induced cardiotoxicity remain elusive. Given gp130 with its main downstream signaling molecule, signal transducer and activator of transcription 3 (STAT3), is involved in cardiac myocyte survival and growth; the present study was performed to elucidate whether SPRC counteracts Dox-induced cardiotoxicity, and if so, whether the gp130\/STAT3 pathway is involved in this cardioprotective activity. SPRC stimulated the activation of STAT3 via gp130-mediated transduction tunnel<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>. In Dox-stimulated cardiotoxicity, SPRC enhanced cell viability, restored expression of gp130\/STAT3-regulated downstream genes, inhibited apoptosis and oxidative stress, and antagonized mitochondrial dysfunction and intracellular Ca<jats:sup>2+<\/jats:sup>overload. Intriguingly, blockade of gp130\/STAT3 signaling abrogated all these beneficial capacities of SPRC. Our findings present the first piece of evidence for the therapeutic properties of SPRC in alleviating Dox cardiotoxicity, which could be attributed to the activation of gp130-mediated STAT3 signaling. This will offer a novel molecular basis and therapeutic strategy of H<jats:sub>2<\/jats:sub>S donor for the treatment of heart failure.<\/jats:p>","DOI":"10.1038\/cddis.2016.209","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T12:48:54Z","timestamp":1471524534000},"page":"e2339-e2339","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity"],"prefix":"10.1038","volume":"7","author":[{"given":"J","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S-Z","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z-J","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-T","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S-Y","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y-Z","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,18]]},"reference":[{"key":"BFcddis2016209_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1046\/j.1365-2613.2000.00139.x","volume":"81","author":"K Yamauchi-Takihara","year":"2000","unstructured":"Yamauchi-Takihara K, Kishimoto T . 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